Tuberculosis and Respiratory Diseases

The Korean Academy of Tuberculosis and Respiratory Diseases (대한결핵및호흡기학회)
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A Case of Giant Cell Interstitial Pneumonia without History of Exposure to Hard Metal

경금속에 대한 노출력이 없는 거대세포 간질성 폐렴(Giant Cell Interstitial Pneumonia) 1예

  • Hong, Ji Hyun (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Lee, Jae Myung (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Kang, Min Jong (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Kim, Dong Gyu (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jung, Ki-Suck (Department of Internal Medicine, College of Medicine, Hallym University) ;
  • Jang, Kee-Tark (Department of Pathology, College of Medicine, Hallym University) ;
  • Park, Hye-Rim (Department of Pathology, College of Medicine, Hallym University) ;
  • Lee, In Jae (Department of Radiology, College of Medicine, Hallym University)
  • 홍지현 (한림대학교 의과대학 내과학 교실) ;
  • 이재명 (한림대학교 의과대학 내과학 교실) ;
  • 강민종 (한림대학교 의과대학 내과학 교실) ;
  • 김동규 (한림대학교 의과대학 내과학 교실) ;
  • 정기석 (한림대학교 의과대학 내과학 교실) ;
  • 장기택 (한림대학교 의과대학 해부병리학교실) ;
  • 박혜림 (한림대학교 의과대학 해부병리학교실) ;
  • 이인재 (한림대학교 의과대학 진단방사선과학교실)
  • Published : 2002.04.30
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Abstract

A 44 year old man was admitted complaining fo exertional dyspnea. The patient denied any occupational history of hard metal exposure. Chest radiography showed an increased interstitial marking at the peripheral portion of both lower lung fields. The spirometric values were within the normal ranges. However, the diffusion capacity of the lungs was lower. In the bronchial lavage fluid, the characteristic multinucleated giant cells were noticed, and the macrophage compartment was 96% and the neutrophils were 4%. High-resolution CT scan revealed ground glass opacities with emphysematous lung changes at the peripheral portion of the whole lung. An open lung biopsy confirmed the presence of numerous multinucleated giant cells (define GIP) with an associated interstitial fibrosis throughout the lung. The radiographic abnormailities and symptoms subsequently improved following treatment with oral corticosteroids.

경금속 진폐증에 속하는 거대세포 간질성 폐렴은 경금속을 사용한 절삭, 연마의 과정 중 발생하는 분진을 흡입하여 발생하는 것으로 알려져 있으나 이러한 직업력이 불분명한 증례를 개흉생검술을 통해 진단하였기에 보고하는 바이다.

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