• Parasites, Hosts and Diseases
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• v.52 no.2
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• pp.193-196
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• 2014

Fascioliasis is a zoonotic infection caused by Fasciola hepatica or Fasciola gigantica. We report an 87-year-old Korean male patient with postprandial abdominal pain and discomfort due to F. hepatica infection who was diagnosed and managed by endoscopic retrograde cholangiopancreatography (ERCP) with extraction of 2 worms. At his first visit to the hospital, a gallbladder stone was suspected. CT and magnetic retrograde cholangiopancreatography (MRCP) showed an intraductal mass in the common bile duct (CBD) without proximal duct dilatation. Based on radiological findings, the presumed diagnosis was intraductal cholangiocarcinoma. However, in ERCP which was performed for biliary decompression and tissue diagnosis, movable materials were detected in the CBD. Using a basket, 2 living leaf-like parasites were removed. The worms were morphologically compatible with F. hepatica. To rule out the possibility of the worms to be another morphologically close species, in particular F. gigantica, 1 specimen was processed for genetic analysis of its ITS-1 region. The results showed that the present worms were genetically identical (100%) with F. hepatica but different from F. gigantica.

• Tuberculosis and Respiratory Diseases
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• v.41 no.5
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• pp.579-583
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• 1994

A 22-year old female visited CNUH due to palpable neck mass. Cytologic examination of a fine needle aspiration was performed and the result was Pap class II. Routine chest x-ray shows solitary pulmonary nodule. For rule-out malignancy, FNA at neck mass was repeated and pathologic finding was dysplasia. She was admitted to MI department for evaluation of solitary pulmonary nodule and percutaneous needle aspiration was done. Pathologic diagnosis was adenoid cystic carcinoma. Thereafter, the lesions were treated by excisional biopsy of submandibular gland mass with left supraomohyoid neck dissection and wedge resection of right lower lobe at ENT department and thoracic and cardiovascular surgery department, respectively. Final diagnosis was adenoid cystic carcinoma arising in submandibular gland with solitary lung metastasis. According to TMN staging system, surgical staging is stage IV of T2N0M1. Clinical follow-up to postoperative 13 months in this case showed that she is alive and well without evidence of recurrence.

• Tuberculosis and Respiratory Diseases
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• v.66 no.3
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• pp.211-215
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• 2009

Pulmonary thromboembolism occurs in old patients with risk factors, such as, immobilization, chronic medical disease, trauma, a hereditary hypercoagulable state, and others. However, we experienced a young man with a massive pulmonary thromboembolism attributed to immobilization due to computer gaming. The patient had been playing computer games in a seated position for at least five hour continually, and for twelve hours per day over a two-week period. The 36-year-old patient was transferred to our institute rule out the possibility of an acute myocardial infarction. Computer tomography revealed intraluminal filling defects in the distal main pulmonary artery and the left popliteal vein. He received thrombolytic therapy and subsequently recovered without complications. This case raises the possibility that prolonged computer gaming is a risk factor of thromboembolism in young adults.

• Wind and Structures
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• v.27 no.1
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• pp.11-27
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• 2018

The straight-cone steel cooling tower is a novel type of structure, which has a distinct aerodynamic distribution on the internal surface of the tower cylinder compared with conventional hyperbolic concrete cooling towers. Especially in the extreme weather conditions of strong wind and heavy rain, heavy rain also has a direct impact on aerodynamic force on the internal surface and changes the turbulence effect of pulsating wind, but existing studies mainly focus on the impact effect brought by wind-driven rain to structure surface. In addition, for the indirect air cooled cooling tower, different additional ventilation rate of shutters produces a considerable interference to air movement inside the tower and also to the action mechanism of loads. To solve the problem, a straight-cone steel cooling towerstanding 189 m high and currently being constructed is taken as the research object in this study. The algorithm for two-way coupling between wind and rain is adopted. Simulation of wind field and raindrops is performed with continuous phase and discrete phase models, respectively, under the general principles of computational fluid dynamics (CFD). Firstly, the rule of influence of 9 combinations of wind sped and rainfall intensity on flow field mechanism, the volume of wind-driven rain, additional action force of raindrops and equivalent internal pressure coefficient of the tower cylinder is analyzed. On this basis, the internal pressures of the cooling tower under the most unfavorable working condition are compared between four ventilation rates of shutters (0%, 15%, 30% and 100%). The results show that the 3D effect of equivalent internal pressure coefficient is the most significant when considering two-way coupling between wind and rain. Additional load imposed by raindrops on the internal surface of the tower accounts for an extremely small proportion of total wind load, the maximum being only 0.245%. This occurs under the combination of 20 m/s wind velocity and 200 mm/h rainfall intensity. Ventilation rate of shutters not only changes the air movement inside the tower, but also affects the accumulated amount and distribution of raindrops on the internal surface.

• Advances in concrete construction
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• v.9 no.3
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• pp.327-335
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• 2020

Concrete pipes are considered important structures playing integral role in spread of cities besides transportation of gas as well as oil for far distances. Further, concrete structures under seismic load, show behaviors which require to be investigated and improved. Therefore, present research concerns dynamic stress and strain alongside deflection assessment of a concrete pipe carrying water-based nanofluid subjected to seismic loads. This pipe placed in soil is modeled through spring as well as damper. Navier-Stokes equation is utilized in order to gain force created via fluid and, moreover, mixture rule is applied to regard the influences related to nanoparticles. So as to model the structure mathematically, higher order refined shear deformation theory is exercised and with respect to energy method, the motion equations are obtained eventually. The obtained motion equations will be solved with Galerkin and Newmark procedures and consequently, the concrete pipe's dynamic stress, strain as well as deflection can be evaluated. Further, various parameters containing volume percent of nanoparticles, internal fluid, soil foundation, damping and length to diameter proportion of the pipe and their influences upon dynamic stress and strain besides displacement will be analyzed. According to conclusions, increase in volume percent of nanoparticles leads to decrease in dynamic stress, strain as well as displacement of structure.

• Genomics & Informatics
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• v.14 no.4
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• pp.138-148
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• 2016

The success of genome-wide association studies (GWASs) has enabled us to improve risk assessment and provide novel genetic variants for diagnosis, prevention, and treatment. However, most variants discovered by GWASs have been reported to have very small effect sizes on complex human diseases, which has been a big hurdle in building risk prediction models. Recently, many statistical approaches based on penalized regression have been developed to solve the "large p and small n" problem. In this report, we evaluated the performance of several statistical methods for predicting a binary trait: stepwise logistic regression (SLR), least absolute shrinkage and selection operator (LASSO), and Elastic-Net (EN). We first built a prediction model by combining variable selection and prediction methods for type 2 diabetes using Affymetrix Genome-Wide Human SNP Array 5.0 from the Korean Association Resource project. We assessed the risk prediction performance using area under the receiver operating characteristic curve (AUC) for the internal and external validation datasets. In the internal validation, SLR-LASSO and SLR-EN tended to yield more accurate predictions than other combinations. During the external validation, the SLR-SLR and SLR-EN combinations achieved the highest AUC of 0.726. We propose these combinations as a potentially powerful risk prediction model for type 2 diabetes.

• Journal of Advanced Marine Engineering and Technology
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• v.38 no.10
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• pp.1297-1302
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• 2014

This paper presents modern optimization methods for determining the optimal parameters of proportional-integral-derivative (PID) controller for coupled tank systems. The main objective is to obtain a fast and stable control system for coupled tank systems by tuning of the PID controller using the Particle Swarm Optimization algorithm. The result is compared in terms of system transient characteristics in time domain. The obtained results using the Particle Swarm Optimization algorithm are also compared to conventional PID tuning method like the Ziegler-Nichols tuning method, the Cohen-Coon method and IMC (Internal Model Control). The simulation results have been simulated by MATLAB and show that tuning the PID controller using the Particle Swarm Optimization (PSO) algorithm provides a fast and stable control system with low overshoot, fast rise time and settling time.

• The Transactions of the Korean Institute of Electrical Engineers A
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• v.55 no.9
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• pp.376-383
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• 2006

In this paper, autonomous information exchange methodology is studied between IEDs using SOAP protocol based on XML and PtP communication to archive the safety and reliability of large-scale system operation. The SOAP protocol has the advantages in the independency Problem for operating systems, using language, platforms and the security problem because it is XML-based RPC protocol. Inference-based solution of the IED is designed as rule-based solution so that the IED internal status, the system status or the faulted zone can be inferred autonomously using the internal data as well as information data obtained from free information exchange among other IEDS, Also, it is designed so that the inference results and the operation information are transmitted to the above SCADA system, and determined autonomously whether the commands from the SCADA are executed or not. Finally, The inference-based solution of IED and information exchange system among IEDS is implemented using MS Visual C++ MFC, MS SOAP and MS XML. Availability and accuracy of the proposed methodology and the design is verified from diversity simulation reviews for typical distribution substation.

• Geomechanics and Engineering
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• v.16 no.6
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• pp.619-626
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• 2018

A simple prediction procedure was investigated for calculating the stresses and displacements of a circular opening. Unlike existed approaches, the proposed approach starts each step with a radius increment. The stress for each annulus could be obtained analytically, while strain increments for each step can be determinate numerically from the compatility equation by finite difference approximation, flow rule and Hooke's law. In the successive manner, the distributions of stresses and displacements could be found. It should be noted that the finial radial stress and displacement were equal to the internal supporting pressure and deformation at the tunnel wall, respectively. By assuming different plastic radii, GRC and the evolution curve of plastic radii and internal supporting pressures could be obtained conveniently. Then the real plastic radius can be calculated by using linear interpolation in the evolution curve. Some numerical and engineering examples were performed to demonstrate the accuracy and validity for the proposed procedure. The comparisons results show that the proposed procedure was faster than that in Lee and Pietrucszczak (2008). The influence of annulus number and dilation on the accuracy of solutions was also investigated. Results show that the larger the annulus number was, the more accurate the solutions were. Solutions in Park et al. (2008) were significantly influenced by dilation.

• Steel and Composite Structures
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• v.50 no.1
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• pp.63-75
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• 2024

In this paper, the modified couple stress theory (MCST) and first order shear deformation theory (FSDT) are employed to investigate the free vibration and bending analyses of a three-layered micro-shell sandwiched by piezoelectric layers subjected to an applied voltage and reinforced graphene nanoplatelets (GPLs) under external and internal pressure. The micro-shell is resting on an elastic foundation modeled as Pasternak model. The mixture's rule and Halpin-Tsai model are utilized to compute the effective mechanical properties. By applying Hamilton's principle, the motion equations and associated boundary conditions are derived. Static/ dynamic results are obtained using Navier's method. The results are validated with the previously published works. The numerical results are presented to study and discuss the influences of various parameters on the natural frequencies and deflection of the micro-shell, such as applied voltage, thickness of the piezoelectric layer to radius, length to radius ratio, volume fraction and various distribution pattern of the GPLs, thickness-to-length scale parameter, and foundation coefficients for the both external and internal pressure. The main novelty of this work is simultaneous effect of graphene nanoplatelets as reinforcement and piezoelectric layers on the bending and vibration characteristics of the sandwich micro shell.