• Geomechanics and Engineering
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• v.37 no.6
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• pp.599-614
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• 2024

To evaluate the safety status of deteriorated segments in a submarine shield tunnel during its service life, a seepage model was established based on a cross-sea shield tunnel project. This model was used to study the migration patterns of erosive ions within the shield segments. Based on these laws, the degree of deterioration of the segments was determined. Using the derived analytical solution, the internal forces within the segments were calculated. Lastly, by applying the formula for calculating safety factors, the variation trends in the safety factors of segments with different degrees of deterioration were obtained. The findings demonstrate that corrosive seawater presents the evolution characteristics of continuous seepage from the outside to the inside of the tunnel. The nearby seepage field shows locally concentrated characteristics when there is leakage at the joint, which causes the seepage field's depth and scope to significantly increase. The chlorine ion content decreases gradually with the increase of the distance from the outer surface of the tunnel. The penetration of erosion ions in the segment is facilitated by the presence of water pressure. The ion content of the entire ring segment lining structure is related in the following order: vault < haunch < springing. The difference in the segment's rate of increase in chlorine ion content decreases as service time increases. Based on the analytical solution calculation, the segment's safety factor drops more when the joint leaks than when its intact, and the change rate between the two states exhibits a general downward trend. The safety factor shows a similar change rule at different water depths and continuously decreases at the same segment position as the water depth increases. The three phases of "sudden drop-rise-stability" are represented by a "spoon-shaped" change rule on the safety factor's change curve. The issue of the poor applicability of indicators in earlier studies is resolved by the analytical solution, which only requires determining the loss degree of the segment lining's effective bearing thickness to calculate the safety factor of any cross-section of the shield tunnel. The analytical solution's computation results, however, have some safety margins and are cautious. The process of establishing the evaluation model indicates that the secondary lining made of molded concrete can also have its safety status assessed using the analytical solution. It is very important for the safe operation of the tunnel and the safety of people's property and has a wide range of applications.

• The Journal of Korean Philosophical History
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• no.42
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• pp.197-232
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• 2014

Taoism is very political orientation from the start have. Internal alchemy has several factions, but southern school and northern school of taoism is typical of this. southern school begun from Zhang Bo-duan in north Song dynasty. Northern school is under Jin dynasty rule by Wang Chung-yang been established. Southern school did not create the platform, but northern school is developed mainly by the denomination from the first. Taoism is basically seek eternal life. Internal alchemy was created a unique discipline to reach the such stage with only Internal alchemy. Southern school's training methods were an elaborate series of logical structure with a counterpart, but northern school's methods is somewhat lacking logically. Southern school claim a training methods from the physical to mental through how to achieve it's ultimate goals, northern school took from mental to spiritual retreat methods that the way to achieve objectives. But northern school's theory of ascetic Practice is difficult to see that the contents are pure. Also, the labours of penance during his training process is the other way with Southern school. These differences are they closely associated with Confucianism and Buddhism, to understand the point of view. Southern school put a primary objective in the personal Practice, while northern school is fundamental to the relief of the people. This can see that has how long life times in southern school and northern school's main members. Because the members of southern school enjoyed great longevity, but northern school's main members was not enjoyed longevity. As a result, the southern school's flow is cut off and northern school became the center form a major organization in the history of china taoism. The southern school assimilated to the northern school. In a pure sense, host and guest's changed.

• Journal of KIISE:Information Networking
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• v.32 no.4
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• pp.543-550
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• 2005

Demand for better services in the Internet has been increasing due to the rapid growth of the Internet, and hence next generation routers are required to perform intelligent packet classification. For a given classifier defining packet attributes or contents, packet classification is the process of identifying the highest priority rule to which a packet conforms. A notable characteristic of real classifiers is that a packet matches only a small number of distinct source-destination prefix pairs. Therefore, a lot of schemes have been proposed to filter rules based on source and destination prefix pairs. However, most of the schemes are based on sequential one-dimensional searches using trio which requires huge memory. In this paper, we proposea memory-efficient two-dimensional search scheme using source and destination prefix pairs. By constructing binary prefix tree, source prefix search and destination prefix search are simultaneously performed in a binary tree. Moreover, the proposed two-dimensional binary prefix tree does not include any empty internal nodes, and hence memory waste of previous trio-based structures is completely eliminated.

• Strategy21
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• s.39
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• pp.47-81
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• 2016

This paper has attempted to examine the political and operational contexts within which North Korea's latest acts of nuclear blackmail, its test-firing of an SLBM on April 23rd 2016 and its fourth nuclear test on January 6^th 2016, should be understood. Analysis of the KN-11 SLBM and the Sinpo-class SSB is based on official South Korean, US and others sources, especially the ROK MND, as well as other resources from South Korea, US and others. Unfortunately, the results of this exploration are inconclusive: there is simply not enough evidence available at present to either confirm or refute the existence of a functional North Korean SLBM and SSB. Nevertheless, the North Korean determination to possess such assets should not be taken lightly. But even accepting North Korea's claims about its SLBMs at face value, which is undermined by news of apparently unsuccessful follow-up test-firings in November, and probably December 2015, there is little proof that North Korea has yet succeeded in miniaturizing its nuclear warhead, so the most extravagant fears are not yet justified. Taken together with North Korea's latest announcement of a supposed successful SLBM ejection-test, on March 23^th 2016, the KN-11 SLBM claims should probably be seen as primarily about proving North Korea's status as a nuclear power, both to exert external political pressure and to bolster internal political support for Kim Jong-un's rule. In conclusion, this paper recommends formulating a preemptive anti-access strategy for the ROKN, proposes acquiring an ASW CV and SSNs to implement submarine strategic deterrent patrols, and urges extending the existing limited AORs to facilitate the preemptive anti-access strategy. Other deterrence options may be suggested, but it is surely significant that the ROKN has recently publically referred to the deployment of an ASW CV and SSNs for the first time.

• Archives of design research
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• v.20
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• pp.99-109
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• 1997

The Bauhaus movement can be said to be the by-product of forming work pursued through the method of constituents even under endless discord between the so-called modern ages and anti-modern ages rather than to say that it was progressed consistently on the assumption of a design. Accordingly, all instruments of Bauhaus education which contributed to form the source of the modern ages realized educational value related to the actual problem at the point of time when the student evercomes all internal and production can be managed most effectively under one system was originated inevitably. The most exential point of the work of Bauhaus workshop is the fact that all products show homogeneity as time passes, which is appeared as the result of the spirit of consciously developed community based on cooperation between various characters and personalities. Also, the homogeneity does not exist in formative detailed aspect appeared externally but in the basis of effort having produced things simply and faithfully, and on the other hand, in accordance with essential rule. Therefore, the original form of Bauhaus products can be said not to be fashionable but the crystal of work process at the workshop through much thought and contemplation in view of endowed form following art, technology and economy.

• Journal of Pharmaceutical Investigation
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• v.35 no.4
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• pp.287-293
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two glimepiride tablets, Amaryl tablet (Handok & Aventis Korea, reference drug) and Mepiril tablet (Myungmoon Pharm. Co., Ltd., Korea, test drug), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (glibenclamide) to human plasma, plasma samples were extracted using 1mL of methyl tertiary butyl ether. Compounds extracted were analyzed by reverse-phase HPLC with multiple reaction monitoring (MRM) mode analyte detection. This method for determination glimepiride proved accurate and reproducible, with a limit of quantitation of 2 ng/mL in human plasma. Twenty-four healthy male Korean volunteers received each medicine at the glimepiride dose of 2 mg in a $2{\times}2$ crossover study. There was a one-week washout period between the doses. Plasma concentrations of glimepiride were monitored by a LC-MS/MS for over a period of 12 hr after the administration. $AUC_t$ (the area under the plasma concentration-time curve from time zero to 12 hr) was calculated by the linear trapezoidal rule method. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed $AUC_t$ and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals of the $AUC_t$ ratio and the $C_{max}$ ratio for Amaryl/Mepiril were log 0.9583-log 1.1357 and log 1.0570-log 1.2376, respectively. These values were within the acceptable bioequivalence intervals of log 0.80-log 1.25. Taken together, our study demonstrated the bioequivalence of Amaryl and Mepiril with respect to the rate and extent of absorption.

• Journal of Pharmaceutical Investigation
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• v.35 no.5
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• pp.355-360
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• 2005

The purpose of the present study was to evaluate the bioequivalence of two cetirizine HCl tablets, Zyrtec tablet (UCB Pharm. Co., Ltd. Korea, reference product) and Zyrix tablet (Kukje Pharm. Co., Ltd., Korea, test product), according to the guidelines of Korea Food and Drug Administration (KFDA). After adding an internal standard (diazepam), plasma samples were extracted using 1 mL of dichloromethane. Compounds extracted were analyzed by reverse-phase HPLC with ultra-violet detector. This method for determination cetirizine is proved accurate and reproducible with a limit of quantitation of 10 ng/mL in male plasma. Twenty-four healthy male Korean volunteers received each medicine at the cetirizine HCl dose of 10 mg in a $2{\times}2$ crossover study. There was a one-week wash out period between the doses. Plasma concentrations of cetirizine were monitored for over a period of 24 hr after the administration. AUC (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. Analysis of variance was carried out using logarithmically transformed AUC and $C_{max}$. No significant sequence effect was found for all of the bioavailability parameters indicating that the crossover design was properly performed. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 $(e.g.,\;log\;0.93-log\;1.08\;for\;AUC_{0-t},\;log\;0.91-log\;1.08\;for\;AUC_{0-{\infty}}\;and\;log\;1.01-log\;1.11\;for\;C_{max})$. The major parameters, AUC and $C_{max}$ met the criteria of KFDA for bioequivalence indicating that Zyrix tablet is bioequivalent to Zyrtec tablet.

• Journal of Pharmaceutical Investigation
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• v.41 no.5
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• pp.309-315
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• 2011

A sensitive and specific liquid chromatographic method coupled with tandem mass spectrometry (LC-MS/MS) was developed for the analysis of ambroxol (active moiety of acebrophylline). After acetonitrile precipitation of proteins from plasma samples, ambroxol and the domperidone (internal standard, IS) were eluted on a C18 column. The isocratic mobile phase was consisted of 10 mM ammonium acetate and methanol (10 : 90, v/v), with flow rate at 0.2 mL/min. A tandem mass spectrometer, as detector, was used for quantitative analysis in positive mode by a multiple reaction monitoring mode to monitor the m/z 379.2${\rightarrow}$264.0 and the m/z 426.2${\rightarrow}$175.1 transitions for ambroxol and the IS, respectively. Twenty four healthy Korean male subjects received two capsules (100 mg ${\times}$ 2) of either the test or the reference formulation of acebrophylline HCl in a 2 ${\times}$ 2 crossover study, this was followed by a 1week washout period between either formulation. $AUC_{0-t}$ (the area under the plasma concentration-time curve) was calculated by the linear trapezoidal rule. $C_{max}$ (maximum plasma drug concentration) and $T_{max}$ (time to reach $C_{max}$) were compiled from the plasma concentration-time data. The 90% confidence intervals for the log transformed data were acceptable range of log 0.8 to log 1.25 (e.g., log 0.8964 - log 0.9910 for $AUC_{0-t}$ log 0.8690 - log 1.0750 for $C_{max}$). The major parameters, $AUC_{0-t}$ and $C_{max}$ met the criteria of Korea Food and Drug Administration for bioequivalence indicating that Acephyll$^{(R)}$ capsule (test) is bioequivalent to Surfolase$^{(R)}$ capsule (reference).

• Journal of the Earthquake Engineering Society of Korea
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• v.12 no.6
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• pp.65-71
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• 2008

A one-dimensional site response analysis program (KODSAP) was developed using cyclic soil behavior model by using the modified parallel IWAN model. The model is able to predict the cyclic hardening and degradation of soil through the adjustment of the internal slip stresses of its elements beyond the cyclic threshold, and satisfies Bauschinger's effect and the Masing rule in terms of its own behavior characteristics. The program (KODSAP) used the direct integration method in the time domain. The elasticity of the base rock was considered as a viscous damper boundary condition. The effects of cyclic hardening or degradation of soil on site response analysis were evaluated through parametric studies. Three types of analyses were performed to compare the effect of analysis and cyclic parameter on site response. The first type was equivalent linear analysis, the second was nonlinear analysis, and a third was nonlinear analysis using the cyclic hardening or degradation model.

• KIEAE Journal
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• v.8 no.4
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• pp.63-69
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• 2008

The thesis is a comparative analysis of Infill Technologies between Korea's long-life Mock-up House, a study driven by 'Durability and Flexibility of Long-life Housing Technology Development' of R&D, and Japan's KSI experimental house, the major example of Japan's long-llfe housing. In terms of the domestic Mock-up House, a system of building the floor first was applied. The floor material of each housing unit required a development of dry heating component that is partially substitutable in order to avoid conflict with the finishing. Also, a development of a floor system that can counteract against the construction inaccuracy was required. In the Case of an outer wall, need to make the wall with the chassis. In the case of ceiling, need to develop the double ceiling system which is good for sound insulation. Also, in comparison to KSI experimental house in Japan, it would require to develop a wiring system of the ceiling which can react to the movement of the wall. Especially, to assure the flexible nature of an internal wall, it would desperately require the research and development of the products related to components and flexible system of mechanical/electrical/communication parts as well as supporting institutionalized system for this development. Furthermore, for KSI experimental house in Japan, it would be necessary to formulate a construction manual as well as a systematic and practical planning guide to invent a new interface rule which will secure simplicity of assembling, dismantling, installation and replacement of architectural components for which research development is quite insignificant at the moment. This effort will have to continue to give a solid direction for better application of such reference manual during construction and development of long life span apartment by public sector as well as private corporations.