• Journal of the Korean Society of Propulsion Engineers
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• v.8 no.2
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• pp.25-31
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• 2004

This paper describes a new vibration-suppression technique for flexible cantilevered structures by using a pipe containing an internal flow. The stability and dynamic response are analyzed based on the finite element method. The flutter limit and optimum stabilizing fluid velocity are determined in root locus diagrams. The impulse responses of the system are studied by the mode superposition method to observe the damping rate of the motion. The stabilizing effect of an internal flow is demonstrated by impulse responses of the structures with and without an material damping. It is found that the response of the pipe with flow of liquid has a larger effect of, stabilizing than that with flow of gas.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.13 no.4
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• pp.387-394
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• 2000

The nonlinear modal interaction of an autoparametric system under a broadband random excitation is investigated. The specific system examined is an autoparametric vibration absorber with internal resonance, which is typical of many common structural configurations. By means of Gaussian closure scheme the dynamic moment equations explaining the random responses of the system are reduced to a system of autonomous ordinary differential equations of the first and second moments. In view of equilibrium solutions of this system and their stability we examine the system responses. We could not find the destabilizing effect of damping, which was reported in References (18) and (20). The saturation phenomenon, which is well known in deterministic nonlinear system, did not take place lot this system subject to broadband random excitation.

• Journal of Digital Convergence
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• v.21 no.1
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• pp.9-13
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• 2023

Although low-carbon vehicles are recognized as leading the automobile market in the future, there are still many difficulties in expanding supply due to obstacles such as higher prices than conventional internal combustion engine vehicles and lack of related infrastructure. This study compares the current status of low-carbon vehicle sales and policy responses in Korea and Japan, which are ahead of the maturity of advanced Asian countries and automobile markets. The results of this study are intended to provide implications for academia and related industries and policies for the future direction of next-generation low-carbon vehicles.

• Infection and chemotherapy
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• v.50 no.4
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• pp.311-318
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• 2018

Background: Zoster vaccination is recommended for people with a history of herpes zoster (HZ), but the most effective timing of vaccine administration after zoster illness is unresolved. This prospective observational study compared the immunogenicity and safety of administering HZ vaccine at 6-12 months and 1-5 years after zoster illness. Materials and Methods: Blood samples were collected before the administration of live zoster vaccine and 6 weeks after vaccination. Varicella-zoster virus (VZV) IgG concentrations and T-cell responses were assessed by glycoprotein enzyme-linked immunosorbent assay and interferon-${\gamma}$ enzyme-linked immunospot assay (ELISPOT), respectively. Results: The baseline geometric mean value (GMV) of VZV IgG was higher in the 6-12 months group than in the 1-5 years group (245.5 IU/mL vs. 125.9 IU/mL; P = 0.021). However, the GMV increased significantly in both groups (P = 0.002 in the 6-12 months group; P <0.001 in the 1-5 years group). The results of the ELISPOT assay were not significant for differences of the GMV between baseline and 6-week post-vaccination groups, while the GMV increased significantly in both groups (P = 0.001 in the 6-12 months group; P <0.001 in the 1-5 years group). Conclusion: The immunogenicity of zoster vaccine may be similar whether administered 6-12 months, or >1 year after zoster illness. Trial Registration: ClinicalTrials.gov Identifier: NCT02704572

• Tuberculosis and Respiratory Diseases
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• v.46 no.2
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• pp.229-240
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• 1999

Background: The impact of the immune response on cancer gene therapy using viral vectors to deliver a "suicide gene" is currently unclear. A vigrous immune response targeted at viral proteins or transgene may enhance the efficacy of tumor destruction and even augment responses to tumor antigens. These responses may involve the release of cytokines and stimulation of tumor specific cytotoxic T-lymphocytes that enhance therapeutic efficacy. On the other hand, a vigorous rapid cellular immune response may destroy cells expressing the therapeutic gene and attenuate the response to therapy. Furthermore, development of neutralizing antibody responses may prevent readministration of virus, a potentially significant limitation. Evaluating the significance of these limitations in animal models and developing solutions are therefore of obvious importance. Methods: After retroviral transduction of mouse mesothelioma cell line(AB12) with Herpes Simplex Virus thymidine kinase (HSVtk) gene in vitro, subcutaneous flank tumors were established. To study the effect of intact immune system on efficacy of tumor erradication, the ability of the HSVtk/ganciclovir system to inhibit tumor growth was compared among normal Balb/c mice, immunodeficient Balb/c-nude and SCID mice, and Balb/c mice immunosuppressed with cyclosporin. Results: Ganciclovir treatment resulted in greater inhibition of tumor growth in Balb/c mice compared with immunodeficient Balb/c-nude mice and SCID mice(in immunodeficient mice, there were no growth inhibition by ganciclovir treatment). Ganciclovir treatment resulted in greater inhibition of tumor growth in noncyclosporin (CSA) treated Balb/c mice compared with CSA treated Balb/c mice. On day 8, mean ganciclovir-treated tumor volume were 65% of control tumor volume in Balb/c mice versus 77% control tumor volume in CSA-treated Balb/c mice. This effect was still evident during therapy (day 11 and 13). On day 13, non-CSA treated tumor volume was 35% of control tumor volume versus 60% of control tumor volume in CSA treated Balb/c mice. Duration of expression of HSVtk was not affected by the immunosuppression with CSA. Conclusion: These results indicate that the immune responses against retrovirally transduced cells enhance the efficacy of the HSVtk/ganciclovir system. These findings have important implications for clinical trials using currently available retrovirus vectors as well as for future vector design.

• Journal of Mechanical Science and Technology
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• v.17 no.1
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• pp.97-104
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• 2003

The main objectives of this study are to examine the random responses of a vibration absorber system with autoparametric coupling in the neighborhood of internal resonance subjected to narrow band random excitation by Gaussian closure scheme and to compare the results with those obtained by Monte Carlo simulation. The Monte Carlo simulation is found to support the main features of the nonlinear modal interaction in the neighborhood of internal resonance conditions. The jump phenomenon of the cantilever mode and saturation phenomenon of the main system are shown to occur if the excitation bandwidth is sufficiently small.

• Journal of the Korea Safety Management & Science
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• v.11 no.2
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• pp.179-185
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• 2009

This paper reviewed the relationship between boundary spanning behaviors and service quality, and the moderating effect of gender. Based on the responses from 204 employees in outdoor-food franchising system, hierarchical regression analysis showed that service delivery has positive relationships with all service quality factors, and external representation and internal influence have partly positive relationship with them. Gender appeared to have partly moderating effect on the relationship between only internal influence and service quality.

• International journal of advanced smart convergence
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• v.7 no.2
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• pp.112-118
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• 2018

This paper describes the design and implementation of a vehicle internal alarm system using raspberry-pie and gas sensor. It provides a notification system for sleepiness during driving, a driving time notification system and a smoking detection system. We coded using 'Python'. And we use 'MySQL' and 'PHP' to build the necessary servers and web pages for gathering sensing data and monitoring. The developed system was tested by several methods. All experiments showed satisfactory response signals and detected with immediate responses.

• Korean Journal of Veterinary Research
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• v.56 no.2
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• pp.121-123
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• 2016

A 7-year-old castrated male domestic short-hair cat presented with anorexia, constipation, depression, and voice alteration. Physical and neurological examinations revealed hyperthermia ($40.5^{\circ}C$), ventroflexion of the neck, reduced responses to external stimuli, generalized muscle weakness, and exercise intolerance. Thoracic radiographs revealed the presence of a cranial mediastinal mass. The history, clinical signs, and other examination results were compatible with acquired myasthenia gravis (MG). Acetylcholine receptor (AChR) antibody titers were determined to confirm MG and the serum AChR antibody concentration was 1.24 nmol/L (reference interval, < 0.3 nmol/L). This is the first diagnosis of acquired MG in a cat in Korea.

• International Journal of Computer Science & Network Security
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• v.21 no.1
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• pp.64-69
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• 2021

In this paper, we have proposed a new internal model control structure (IMC). It is aimed at unstable overactuated multivariable systems whose transfer matrices are singular and unstable. The model inversion problem is essential to understand this structure. Indeed, the precision between the output of the process and the setpoint is linked to the quality of the inversion. This property is preserved in the presence of an additive disturbance at the output. This inversion approach proposed in this article can be applied to multivariable systems with no minimum phase or minimum phase shift with or without delays in their transfer matrices. It is proven by an example of simulation through which we have shown its good performance as a guarantee of stability, precision as well as rapidity of system responses despite the presence of external disturbances and we have tested this control structure in the frequency domain hence the robustness of the IMC.