• The Journal of Internal Korean Medicine
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• v.29 no.4
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• pp.846-855
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• 2008

Objects : The aim of this study was to investigate the influence of five herbal medicines on cytochrome P450 3A4 drug-metabolizing enzymes in human liver microsomes. Methods : To use human liver microsomes, an extract of five herbal medicines, which are Artemisia princeps Pampan, Sophora jeponica Linne, Panax notoginseng F. H. Chen, Lithospermum Erythrorhizon Sieb., and Cirsium maackii Maxim, which together are called Jihyulyak(止血藥, drugs for arresting bleeding, hemostatics), was co-incubated and measured for relative enzyme activity in incubation condition compared to ketoconazole, a representative inhibitor of CYP 3A4. Results : We showed that all five of the traditional herbal medicines had no inhibition effect of CYP 3A4 at 10, 20, 30, 40, and $50{\mu}g/ml$ doses in human liver microsomes, although Sophora japonica Linne(SJL) showed a little inhibition at about 81% inhibition rate of control. However, this result is not enough to prove that SJL has a CYP 3A4 inhibition effect. Moreover, we can't make sure that those rates had significant induction effect on CYP 3A4. Conclusions : The result of this study could support that those herbal medicines are safer than chemical drugs, even if this is the basic step to prove that result.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.9 no.11
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• pp.4662-4679
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• 2015

Currently, the leakage of internal information has emerged as one of the most significant security concerns in enterprise computing environments. Especially, damage due to internal information leakage by insiders is more serious than that by outsiders because insiders have considerable knowledge of the system's identification and password (ID&P/W), the security system, and the main location of sensitive data. Therefore, many security companies are developing internal data leakage prevention techniques such as data leakage protection (DLP), digital right management (DRM), and system access control, etc. However, these techniques cannot effectively block the leakage of internal information by insiders who have a legitimate access authorization. The security system does not easily detect cases which a legitimate insider changes, deletes, and leaks data stored on the server. Therefore, we focused on the insider as the detection target to address this security weakness. In other words, we switched the detection target from objects (internal information) to subjects (insiders). We concentrated on biometrics signals change when an insider conducts abnormal behavior. When insiders attempt to leak internal information, they appear to display abnormal emotional conditions due to tension, agitation, and anxiety, etc. These conditions can be detected by the changes of biometrics signals such as pulse, temperature, and skin conductivity, etc. We carried out experiments in two ways in order to verify the effectiveness of the emotional recognition technology based on biometrics signals. We analyzed the possibility of internal information leakage detection using an emotional recognition technology based on biometrics signals through experiments.

• The Journal of Internal Korean Medicine
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• v.28 no.4
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• pp.779-790
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• 2007

Objective : Although chronic non-bacterial prostatitis is a common disease, it is very difficult to treat effectively. GLS (Gleditsiae Spina) has traditionally been used in treatment of urinary tract inflammation and voiding disturbance. In this study, we investigated the therapeutic effects and action mechanism of GLS in the rat model of non-bacterial prostatitis induced by castration and testosterone treatment. Method : We observed four experimental objects of normal group, control group, testosterone group, and GLS group. Rats were treated with 17$\beta$-estradiol after castration for induction of experimental non-bacteral prostatitis, which is similar to human chronic prostatitis in histophatological profiles. GLS and testosterone were administered as an experimental specimen and a positive control, respectively. The prostates were evaluated by histopahological parameters including the epithelial score and epithelio-stromal ratio for glandular damage. Also, the prostates were observed by hematological alterations of WBC, RBC, hemoglobin, hematocrit and platelet. Results : While prostates of control rats revealed severe acinar gland atrophy and stromal proliferation, the rats treated with GLS showed a diminished range of tissue damage. Epithelial score was improved in GLS over that of the control. The epithelial-stromal ratio was lower in GLS when compared to that of the control. Conclusion : These findings suggest that GLS may protect the glandular epithelial cells. We concluded that GLS could be a useful remedy agent for treating chronic non-bacterial prostatitis.

• Journal of the Institute of Electronics Engineers of Korea SC
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• v.43 no.1 s.307
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• pp.1-6
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• 2006

The noncontact optical sensor using the hologram laser and automatic power controller is developed to measure a thickness of transparent objects and achieve excellent performance. Due to the contact between the tip of the sensor and the surface of objects, the tip is abraded. In addition the casting glass under high temperature results in extending the size of sensor body. The accuracy of the sensor is degraded due to these reasons. In this paper, to overcome these problems, we proposed a low cost non-contact optical sensor that is composed of a hologram laser unit used for optical pickup of CD player and a plastic lens. Therefore the problems caused by the contact sensor are solved by using the noncontact sensor. The noncontact sensor has to move toward the objects and obtain the focus error signal to measure a position of transparent objects. While the internal temperature of the sensor is controlled under ${\pm}0.1^{\circ}$, many trials shows ${\pm}2{\mu}m$ measurement error as excellent performance.

• KSII Transactions on Internet and Information Systems (TIIS)
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• v.17 no.8
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• pp.1976-1995
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• 2023

The anchor-free object detector CenterNet regards the object as a center point and predicts it based on the Gaussian circle region. For each object's center point, CenterNet directly regresses the width and height of the objects and finally gets the boundary range of the objects. However, the critical range of the object's center point can not be accurately limited by using the Gaussian circle region to constrain the prediction region, resulting in many low-quality centers' predicted values. In addition, because of the large difference between the width and height of different objects, directly regressing the width and height will make the model difficult to converge and lose the intrinsic relationship between them, thereby reducing the stability and consistency of accuracy. For these problems, we proposed a center point prediction method based on the Gaussian elliptic region and a size component regression method based on the small solution space. First, we constructed a Gaussian ellipse region that can accurately predict the object's center point. Second, we recode the width and height of the objects, which significantly reduces the regression solution space and improves the convergence speed of the model. Finally, we jointly decode the predicted components, enhancing the internal relationship between the size components and improving the accuracy consistency. Experiments show that when using CenterNet as the improved baseline and Hourglass-104 as the backbone, on the MS COCO dataset, our improved model achieved 44.7%, which is 2.6% higher than the baseline.

• Journal of KIISE:Databases
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• v.33 no.5
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• pp.495-512
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• 2006

Recently, researches on a future position prediction of moving objects have been progressed as the importance of the future position retrieval increases. New index structures are required to efficiently retrieve the consecutive positions of moving objects. Existing index structures significantly degrade the search performance of the moving objects because the search operation makes the unnecessary extension of the node in the index structure. To solve this problem, we propose a space partition based index structure considering the mobility of moving objects. To deal with the overflow of a node, our index structure first merges it and the sibling node. If it is impossible to merge them, our method splits the overflow node in which moving properties of objects are considered. Our index structure is always partitioned into overlap free subregions when a node is split. Our split strategy chooses the split position by considering the parameters such as velocities, the escape time of the objects, and the update time of a node. In the internal node, the split position Is determined from preventing the cascading split of the child node. We perform various experiments to show that our index structure outperforms the existing index structures in terms of retrieval performance. Our experimental results show that our proposed index structure achieves about $17%{\sim}264%$ performance gains on current position retrieval and about $107%{\sim}19l%$ on future position retrieval over the existing methods.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2007.11a
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• pp.1-5
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• 2007

A majority of piping vibration problems are induced by internal fluid pulsation; turbulent flow, vortex shedding at internal discontinuities, and pressure pulsation at equipment nozzles. The pulsation at the pressure sources resonates acoustically with the piping and the amplified pressure pulsation can generate shell mode vibration in the piping. Reheater attemperator piping supplies water from feedwater pump to reheater attemperator to control the boiler temperature. In normal operating condition, the high frequency shell mode vibration occurred in the piping with the high level of sound(105 ${\sim}$ 117 dB). The vibration sources are pressure pulsation in the pump nozzle and the frequencies are related to the blade passing frequencies. The objects of this paper are to analyze the cause of the high frequency vibration and to establish corrective actions.

• Proceedings of the Korean Society of Precision Engineering Conference
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• 1995.04b
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• pp.377-382
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• 1995

Conventional measurement methods using ultrasonic wave or x-ray, eddy current for non-destructive testing(NDT) in nuclear power plants and other industrial plants have been performed as the method of contact with objects to be inspected. With this reason these methods have been taken relatively much time and the inspected area is limited by the location of probe or film. But holographic interferometry which is a non-contact optical measurement method using a coherent light source has an advantage that the quantitative measurement can be performed at a time. In this paper a new method using holographic interferometry and image processing for detecting internal flaws of pressure vessels is presented.

• The Journal of Internal Korean Medicine
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• v.27 no.2
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• pp.316-326
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• 2006

Backgrounds & Objects: The aim of this study was to investigate the radioprotective effect of Shengmai-san(SMS), a herbal medicine, on mice jejunal crypt cell survival and Apoptosis. Methods: Mice were devided into 4 groups according to radiation dose and SMS treatment: Normal was the group without irradiation. Control was the group treated with D.W before 10 Gy irradiation. SMS 2.9 was sample group treated with 2.9 mg/10 g of SMS extract before 10 Gy irradiation and SMS 29 was sample group treated with 29 mg/10 g of SMS extract before 10 Gy irradiation. And Each group were sacrificedat 24 hours and 72 hours after irradiation. To analyze the crypt survival, hematoxylin-eosin staining was used and to analyze the apoptosis, the TUNEL assay was done. Results: 1. From the microcolony survival assay, the SMS 2.9 and SMS 29 showed the radioprotective effect with a statistical significance compared to the control group at 24 hr (P < 0.01) and 72 hr (p < 0.001) after 10 Gy irradiatien. And the differences of radioprotective effect between SMS 2.9 and SMS 29 were net significant. 2. The results of the TUNEL assay showed that the apoptotic index in SMS 2.9 and SMS 29 was significantly decreased, as compared to the control group at both 24 hr ( p < 0.01) and 72 hr (SMS 2.9 : p < 0.001. SMS 29 : P < 0.01) after 10Gy irradiation And the differences of between SMS 2.9 and SMS 29 were not significant. Conclusions: It could be suggested that the Shengmai-san has a prominent Protective effect in mice intestines against the radiation damage. And the radieprotective effect seems to be related to inhibition of the apoptosis.

• 제어로봇시스템학회:학술대회논문집
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• 1991.10b
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• pp.1681-1686
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• 1991

In robotics and other fields of engineering, techniques for artificial reality or virtual reality are focused on and studied extensively, e.g., virtual existence for tele-operator systems in robotics, and virtual reality of designed objects in architecture. In order to realize the system we should create physical stimulations according to internal models created by experiences in a human brain. The internal model does not have to have direct connections to the real world, however, the stimulation must be signals such that the internal model are retrieved in a human brain. In this paper we propose a technique for tele-virtual reality of dynamic mechanical models, which means that one dynamic mechanical model can be shared by peoples in distant places. Since a stability issue due to time delays arises in the system, we employed a scattering technique developed for a tele-operator system and a kind of passive adaptive controllers. Furthermore, restrictions due to a simple digital implementation of the scattering transformation are discussed and some conditions for stability are shown. The proposed method is applied to a remote tug of war system and the effectiveness is verified.