• Journal of Yeungnam Medical Science
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• 제36권2호
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• pp.155-158
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• 2019

Imatinib mesylate is currently used as the first-line treatment for metastatic gastrointestinal stromal tumors (GISTs). Imatinib-induced hepatotoxicity in patients with GIST is very rare. Its features vary from subclinical elevation of serum aminotransferase to clinically apparent acute hepatitis, which is associated with immunologic reactions. Imatinib-induced hepatotoxicity with autoimmune-like features can be treated by the discontinuation of imatinib mesylate and the administration of oral steroids. Here, we report a case of late-onset imatinib-induced hepatitis with autoimmune-like features in a patient with metastatic GIST, which was improved by oral corticosteroids.

• Tuberculosis and Respiratory Diseases
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• 제38권4호
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• pp.401-405
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• 1991

Bronchioloalveolar cell carcinoma accounts for less than 6% of all primary lung cancer but has distinct clinical and radiological features and unusual pathologic appearance. The characteristic features are its peripheral location and tendency of rapid progression to diffuse type via aeroginous and lymphatic route without surgical intervention. Among them, mucin secretory type bronchioloalveolar cell carcinoma is the rarest and most distinctive. We experienced a case of mucin secretory type bronchioloalveolar cell carcinoma in a 47 year old female with roentgenographic findings of chronic progressive pulmonary consolidation with muliple cavities.

• 대한한방내과학회지
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• 제34권1호
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• pp.86-99
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• 2013

Objectives : The purpose of this study was to analyze the general features of patients with idiopathic faical paralysis. Methods : We investigated the various features and HBGS (House-Brackmann Grading System) of 505 patients who were diagnosed with idiopathic facial paralysis. Results and Conclusions : 1. The sex distribution was 264 male cases, and 241 female cases, and the majority of them were in their 40s. 2. Overwork was the most frequent contributing factor to their paralysis. 3. The treatment of most patients was completed within 2 months. 4. Their recovery was faster if their first hospital visit was sooner and their paralysis was partial. On average, the patients recovered within 19.5 to 27.8 days and it took much less time than natural recovery. 5. When looking at the BMI of the selected patients for this study, 62.00% were obese while 14.37% were under-weight. Among the obese patients, there were more with Xu mai (虛脈) than Shi mai (實脈). For the under-weight patients, most had Shuo mai (數脈) while none had Chi mai (遲脈).

• 대한한방내과학회지
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• 제36권4호
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• pp.498-506
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• 2015

Objectives This study was conducted to report the safety of vomit-inducing treatment (Tu Fa, 吐法) by Melonis Calyx, particularly with respect to clinical features and liver and kidney functions.Methods Patients treated with Melonis Calyx powder between September 2013 and September 2014 were assessed retrospectively.Results Less than 3 grams of Melonis Calyx powder can induce mild abdominal discomfort and produce no harmful effects on liver and kidney functions.Conclusions Through this study, a vomit-inducing treatment using less than 3 grams of Melonis Calyx can be considered safe enough to be used in clinics, with a cautious approach with respect to dehydration.

• Tuberculosis and Respiratory Diseases
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• 제43권3호
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• pp.449-454
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• 1996

저자등은 호흡곤란을 주소로 내원한 성대 운동이상에 의한 기능성 상기도 폐색증 1예를 기관지내시경 및 폐기능검사로 확진하고 치료하였기에 문헌고찰과 함께 보고하는 바이다.

• 한국임상수의학회지
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• 제36권5호
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• pp.271-273
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• 2019

A 12-year-old intact male Cocker spaniel dog was presented for evaluation of lethargy and abdominal distension. Clinical examination revealed a round, palpable mass in the middle of the abdomen. Abdominal computed tomography showed a round soft tissue mass ($width{\times}height{\times}length$, $25{\times}13{\times}15cm^3$) without regional invasion and distant metastasis. Cytologic evaluation of the mass revealed adipose tissue-derived cells having vacuolated cytoplasm, indistinct borders, large nucleus and ropy chromatin pattern with variable sized lipid droplets. Complete surgical resection of the mass was performed and the mass was histopathologically diagnosed as primary omental lipoma. The dog has been recovered well without any additional clinical signs, and there was no relapse over the 8 months follow-up period. The clinical features and prognosis of the dog with primary omental adipocytic tumors have been described in this report.

• IMMUNE NETWORK
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• 제21권3호
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• pp.19.1-19.18
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• 2021

Clinical and molecular phenotypes of asthma are complex. The main phenotypes of adult asthma are characterized by eosinophil and/or neutrophil cell dominant airway inflammation that represent distinct clinical features. Upper and lower airways constitute a unique system and their interaction shows functional complementarity. Although human upper airway contains various indigenous commensals and opportunistic pathogenic microbiome, imbalance of this interactions lead to pathogen overgrowth and increased inflammation and airway remodeling. Competition for epithelial cell attachment, different susceptibilities to host defense molecules and antimicrobial peptides, and the production of proinflammatory cytokine and pattern recognition receptors possibly determine the pattern of this inflammation. Exposure to environmental factors, including infection, air pollution, smoking is commonly associated with asthma comorbidity, severity, exacerbation and resistance to anti-microbial and steroid treatment, and these effects may also be modulated by host and microbial genetics. Administration of probiotic, antibiotic and corticosteroid treatment for asthma may modify the composition of resident microbiota and clinical features. This review summarizes the effect of some environmental factors on the upper respiratory microbiome, the interaction between host-microbiome, and potential impact of asthma treatment on the composition of the upper airway microbiome.

• Kidney Research and Clinical Practice
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• 제34권1호
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• pp.53-56
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• 2015

MYH9-related disorder is an autosomal dominant disease caused by a mutation in the MYH9 gene, which encodes nonmuscle myosin heavy chain IIA (NMMHC-IIA). This disease is characterized by giant platelets, thrombocytopenia, granulocyte inclusion bodies, proteinuria, and high-pitch sensorineural deafness. Nephropathy has been observed in 30% of patients with MYH9-related disorder. The characteristic features are early onset proteinuria and rapidly progressing renal disorder. However, the prognosis of MYH9 nephropathy remains unclear. Herein, we describe a 36-year-old woman who presented with proteinuria and was diagnosed with MYH9 nephropathy via renal biopsy and gene analysis. Her proteinuria improved after administration of an angiotensin II receptor blocker, but was aggravated after changing to a calcium channel blocker.

• Tuberculosis and Respiratory Diseases
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• 제38권2호
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• pp.108-115
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• 1991

Endobronchial tuberculosis is a serious disease which is frequently complicated with bronchial stenosis, and it may simulate a bronchial asthma or bronchogenic carcinoma. We have analyzed the clinical characteristics of endobronchial tuberculosis in 166 patients, and we introduce new classification of endobronchial tuberculosis. Endobronchial tuberculosis is classified into seven subtypes as stenotic type with fibrosis, stenotic type without fibrosis, actively caseating type, tumorous type, ulcerative type, granular type and nonspecific bronchitic type, according to the bronchoscopic findings. Actively caseaing type, stenotic type without fibrosis, nonspecific bronchitic type and stenotic type with fibrosis are predominant in the order of frequency, but ulcerative type and granular type are relatively rare. Stenotic type with or without fibrosis, actively caseating type and tumorous type of endobronchial tuberculosis are closely related to bronchial stenoses. We believe that our new classification of endobronchial tuberculosis, which is based on bronchoscopic features, is helpful to understand the pathogenesis of disease and to make a therapeutic plan for preventing or minimizing bronchial stenosis.

• 대한치과의사협회지
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• 제54권3호
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• pp.184-190
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• 2016

The osseointegration of titanium implants has been examined over the past 50 years. Many implant systems have been introduced and have become popular to the implant dentistry. The designs of the connection between implant fixture and abutment are divided into external vs internal connection. From beginning, the $Br{\aa}nemark$ system was characterized by an external hexagon. Internal connection has been developed to reduce stress transferred to the bone. These differences may have impact on the clinical procedures and protocols, laboratory and components costs, and incidence of complications. Therefore, the clinician has to know the different biomechanical features and understand their implications to produce successful implant-supported prosthesis with an external or an internal connection system.