• Journal of Physiology & Pathology in Korean Medicine
• /
• v.17 no.6
• /
• pp.1500-1508
• /
• 2003

This study was performed to clarify the neurotoxic mechanism of nerve cells damage by brain ischemia. The cytotoxic effect of ischemia was determined by XTT assay, NR assay, superoxide dismutase(SOD) activity, amount of malondialdehyde(MDA), lactate dehydrogenase(LDH) activity, protein synthesis and tumor necrosis factor(TNF)-α activities after cerebral neurons derived from mouse were exposed to ischemia for 1∼30 minutes. In addition, the protective effect of extract of Daejo-whan(DJW) on ischemia-induced neurotoxicity was examined in these cultures. 1. Ischemia decreased cell number and viability by XTT assay or NR assay when cultured cerebral neurons were exposed to 95% N2/5% CO₂ for 1∼20 minutes in these cultures. 2. Ischemia decreased SOD and protein syntheses, but it increased amount of MDA and, LDH and TNF-α activities in these cultures. 3. In the neuroprotective effect of DJW extracts on cerebral neurons damaged by ischemia, DJW extracts increased SOD activity and protein synthesis. While, it decreased amount of MDA and, LDH and TNF-α activities after cerebral neurons preincubated with herb extracts. It suggests that brain ischemia has neurotoxicity on cultured mouse cerebral neurons, and the herb extract such as DJW was very effective in blocking the neurotoxicity induced by ischemia in cultured mouse cerebral neurons.

• Proceedings of the PSK Conference
• /
• 2002.10a
• /
• pp.256.2-257
• /
• 2002

Intestinal epithelial cells can produce cytokines and chemokines that play an important role in the mucosal immune response. Regulation of this secretion is important to prevent inflammatory tissue damage. Lonicera japonica have been shown to inhibit inflammation. We tested the effect of luteolin, a major ingredient of Lonicera japonica, on TNF-${\alpha}$-stimulated IL-8 secretion from lntestinal epithelial cells. (omitted)

• Proceedings of the Korean Society of Veterinary Clinics Conference
• /
• 2007.05a
• /
• pp.114-114
• /
• 2007

• Journal of Korean Medical classics
• /
• v.29 no.4
• /
• pp.17-36
• /
• 2016

Objectives : This paper seeks to study the provenances of 10 Symptoms of Para-cold damage from Yixuerumen, and discovers the rationality and originality of para-cold damages recognized by Li Chan. Methods : The paper looks through the books referenced by Yixuerumen to investigate the source text for Yixuerumen's Para-cold Damage chapter, and the contents of the referenced books will be compared to that of Yixuerumen. Results : The sources of the 10 symptoms of para-cold damage from Yixuerumen Chapter of Cold Damage can be traced to Leizhenghuorenshu (expectoration, indigestion, rising temperature due to lack of energy, and beriberi), Wang Zhen's Shanghanzhengzhimingtiao Xinzengxuleishanghansizheng(the infection in a boil, blood sattis, caused overexertion, and pox), and Liu Chun's Yujiweiyi's chapter on Common Cold. Here, Li Chan made his own addition of internal damage and damage of overworking. Li Chan seems to have considered para-cold damage not as a type of cold damage but as a "concept relative to the broader range of cold damage." In reflection of this understanding, Li Chan limited the number of categories to ten in accordance with the developmental trace leading from Leizhenghuorenshu to Shanghanzhengzhimingtiao. When we understand para-cold damage as a "concept relative to the narrower range of cold damage," it could be used as a mean as for "Wenbin diagnosis," but Yixuerumen's para-cold damage is only utilized for the "diagnosis of a broader concept of cold damage." Conclusions : Li Chan deserves credits for his academic rationality and originality displayed by the method he used to form para-cold damages where he used real cold damage and para-cold damage as principles, by the division of para-cold damage symptoms into ten provenances, by the creation of the concept of para-cold damage, and by his broad collection of prescription and treatment corresponding to each type.

• Journal of Korean Institute of Fire Investigation
• /
• v.11 no.1
• /
• pp.37-40
• /
• 2008

This paper deals with damage patterns of cabinet panel for low voltage deteriorated by flame. In order to analyze damage patterns, we used Metallurgical Microscope, x-ray system, and Fourier Transform Infrared spectroscopy. Firstly, Metallurgical microscope was used for analysis of electrical causes, such as electric short and overload Secondly, X-ray system was used for analysis of internal characteristics of circuit breakers. Lastly, Fourier Transform Infrared spectroscopy was used for analysis of damage direction by flame.

• Structural Monitoring and Maintenance
• /
• v.4 no.3
• /
• pp.269-299
• /
• 2017

This paper presents a Level III damage evaluation methodology, which simultaneously, identifies the location, the extent, and the severity of stiffness damage in deep beams. Deep beams are structural elements with relatively high aspect (depth-to-length) ratios whose response are no longer based on the simplified Euler-Bernoulli theory. The proposed methodology is developed on the bases of the force-displacement relations of the Timoshenko beam theory and the concept of invariant stress resultants, which states that the net internal force existing at any cross-section of the beam is not affected by the inflicted damage, provided that the external loadings in the undamaged and damaged beams are identical. Irrespective of the aspect ratios, local changes in both the flexural and the shear stiffnesses of beam-type structures may be detected using the approach presented in this paper.

• Proceedings of the Korea Institute of Fire Science and Engineering Conference
• /
• 2008.04a
• /
• pp.269-272
• /
• 2008

This paper deals with damage patterns of cabinet panel for low voltage deteriorated by flame. In order to analyze damage patterns, we used Metallurgical Microscope, x-ray system, and Fourier Transform Infrared spectroscopy. Firstly, Metallurgical microscope was used for analysis of electrical causes, such as electric short and overload. Secondly, X-ray system was used for analysis of internal characteristics of circuit breakers. Lastly, Fourier Transform Infrared spectroscopy was used for analysis of damage direction by flame. The following results were obtained.

• Tuberculosis and Respiratory Diseases
• /
• v.65 no.4
• /
• pp.313-317
• /
• 2008

Lipoma is a common neoplasm in soft tissues. However, an intrapulmonary lipoma is a rare benign tumor. Patients with a bronchial lipoma might have a malignant potential related to their smoking history due to the case reports of lung cancer accompanied with lipoma. Endobronchial lipoma can cause irreversible parenchymal lung damage if not diagnosed and treated early. Therefore, it should initially be treated by fiberoptic bronchoscopy or surgery depending on the status of distal parenchymal lung damage. Bronchiolitis obliterans with organizing pneumonia (BOOP) is a pathological syndrome that is defined by the presence of buds of granulation tissue consisting of fibroblasts and collagen within the lumen of the distal air spaces. BOOP is caused by drug intoxication, connective tissue disease, infection, obstructive pneumonia, tumors, or an unknown etiology. We encountered a 58 year-old male patient with endobronchial lipoma, causing the collapse of the right middle and lower lobes, and BOOP due to obstructive pneumonia.

• The Journal of Internal Korean Medicine
• /
• v.32 no.4
• /
• pp.530-541
• /
• 2011

Objectives : Categorized as 'cheongyeol' herbs, Herba Prunellae, Flos Lonicerae and Radix Scutellaria have been proven to have effect on degenerative brain disease, cerebrovascular disease and brain tumor because of their anti inflammation, antioxidant, or anticancer effects. In this study, we studied activity against reactive oxygen species and anti inflammation effect of these three 'Cheongyeol' herbs. Methods : We measured each herb's yield of ethanol extracts, phenolic contents and activities against DPPH, hydroxyl radical and superoxide anion. Also through 6-hydroxydopamine (6-OHDA) induced oxidative damage in SH-SY5Y human neuroblastoma cell line, we measured antioxidant effect and NO activity of the three herbs. From the three herbs, we chose Prunella Herba, which showed the highest antioxidant effect, and studied its cell survival rate and anti inflammation effect through COX-2 and iNOS. Results : All three herbs showed significant results, and especially Prunella Herba showed significant effect on phenol contents, antioxidant effect on various active oxygen and antioxidant, and anti inflammation effect through cell line. Conclusions : Further study of the origin concept of 'cheongyeol' and research into specific mechanisms and role in treatment of cranial nerve disease, seems warranted.

• The Journal of Internal Korean Medicine
• /
• v.21 no.2
• /
• pp.319-327
• /
• 2000

To evaluate the effect of Bangpungdangkwi-eum extracts on reperfusion following the middle cerebral artery occulsion in Sprague Dawley rats, the neuron protection effect were investigated through examining the size of cerebral infarction, cerebral edema, and the morphologic change of neuron. The results were obtained as follows; 1. The size of cerabral infarction in sample group is significantly decreased compared with that in control group. Sample group has approximately 17% cerebral infarction parts induced by ischemia in cerebrum while control group has approximately 22%. 2. The volume of cerebral edema in sample group is significantly decreased compared with that in control group. The volumn in sample group is increased by approximately 4.4% compared with that in normal group while that in control group is increased by approximately 7.7%. 3. The optical microscopic examination reveals that the damage of neurons in the ischemic parts and CA1 and CA3 region of hippocampus in the same side of the ischemic parts was the most high and the damage in sample group is decreased compared with that in control group.