• Title/Summary/Keyword: internal capability

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Parametric modeling and shape optimization of four typical Schwedler spherical reticulated shells

  • Wu, J.;Lu, X.Y.;Li, S.C.;Xu, Z.H.;Li, L.P.;Zhang, D.L.;Xue, Y.G.
    • Structural Engineering and Mechanics
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    • v.56 no.5
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    • pp.813-833
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    • 2015
  • Spherical reticulated shells are widely applied in structural engineering due to their good bearing capability and attractive appearance. Parametric modeling of spherical reticulated shells is the basis of internal analysis and optimization design. In the present study, generation methods of nodes and the corresponding connection methods of rod elements are proposed. Modeling programs are compiled by adopting the ANSYS Parametric Design Language (APDL). A shape optimization method based on the two-stage algorithm is presented, and the corresponding optimization program is compiled in FORTRAN environment. Shape optimization is carried out based on the objective function of the minimum total steel consumption and the restriction condition of strength, stiffness, slenderness ratio, stability. The shape optimization of four typical Schwedler spherical reticulated shells is calculated with the span of 30 m~80 m and rise to span ratio of 1/7~1/2. Compared with the shape optimization results, the variation rules of total steel consumption along with the span and rise to span ratio are discussed. The results show that: (1) The left and right rod-Schwedler spherical reticulated shell is the most optimized and should be preferentially adopted in structural engineering. (2) The left diagonal rod-Schwedler spherical reticulated shell is second only to left and right rod regarding the mechanical behavior and optimized results. It can be applied to medium and small-span structures. (3) Double slash rod-Schwedler spherical reticulated shell is advantageous in mechanical behavior but with the largest total weight. Thus, this type can be used in large-span structures as far as possible. (4) The mechanical performance of no latitudinal rod-Schwedler spherical reticulated shell is the worst and with the second largest weight. Thus, this spherical reticulated shell should not be adopted generally in engineering.

MR Imaging Findings of Parosteal Lipoma: Case Report (뼈주위 지방종의 자기공명영상 소견: 증례 보고)

  • Bae, Hyoung-Ju;Hong, Suk-Joo;Kim, Ye-Lim;Kang, Eun-Young;Kim, Hak-Jun;Ryu, Young-Jun;Jung, Woon-Yong
    • Investigative Magnetic Resonance Imaging
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    • v.14 no.2
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    • pp.134-138
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    • 2010
  • Parosteal lipoma is a rare benign tumor containing mature adipose tissue having an intimate relationship to the periosteum. Characteristically, this tumor presents as a lipomatous mass adjacent to bone, eliciting variable reactive changes in the underlying cortex. We report a case of parosteal lipoma of the foot. The MR findings consisted of juxtacortical lipomatous mass abutting to bony protuberance, with internal fibrous striations, and osseous reaction in the adjacent bone. By the aid of multiplanar imaging capability, high spatial and contrast resolution of MRI, characteristic features of parosteal lipoma can lead to diagnosis on imaging.

A Study on the Development of Educational Curriculum Model for Labor Manager's Empowerment : Focusing on NCS Labor Management Capability Unit

  • KIM, Jae-Sung
    • East Asian Journal of Business Economics (EAJBE)
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    • v.8 no.1
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    • pp.21-40
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    • 2020
  • Purpose - The labor management department is an important area in charge of the labor-management relations that affects the competitiveness of the company. This study seeks to diagnose labor management education focusing on labor manager competency strengthening curriculum that is currently being conducted domestically and propose an educational model that can contribute to the labor manager competency development by researching improvement measures. Research design, data, and methodology - In this study, the first phase is a Delphi open form survey and 15 expert panels participated. The second phase had 31 expert panels participating and in the final IPA analysis, targeting 111 on-site subjects, it conducted a survey regarding desired level of current educational level and future education requirement. Results - A final 57 subjects regarding 11 items to increase the competency of the labor managers through the first and second Delphi survey was deduced through this study. To add, regarding the current education level and desired level that the current workers are thinking with respect to analysis results of the 57 subjects through the IPA analysis, an educational model could be deduced to increase competency of the labor managers based on the result. Conclusions - Thus far, research regarding labor management has been insufficient as it was defined as a subordinate role to human resources. This study reviews the role and competency of labor managers and presented an educational model to strengthen the capabilities of internal labor managers to re-illuminate the labor manager. However, this study is limited in terms of the diversity of the types of companies participating and the small number of panels. Better data can be produced if such parts are supplemented in the future.

Overview of Region-oriented Technologies through R&D Topographical Landscape (연구지형탐색을 통한 지역특화 미래기술전망)

  • Hahn, Hyuk;Lee, June-Young;Kang, Jong-Seok
    • The Journal of the Korea institute of electronic communication sciences
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    • v.8 no.11
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    • pp.1625-1632
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    • 2013
  • R&D productivity(P) and qualification(Q) for 16 regions in Korea were measured using all scientific output (articles) from several kinds of specific R&D program under the 3rd regional science and technology promotion policy(2008-2012). R&D capabilities of 16 regions were evaluated from Q-P position analysis and also compared between these regions for the purpose of examining their R&D capability status. Especially, R&D topographical map was created using the output of research and development over 5 years for investigating GyeongNam district's activities in science and technology and also analyzing co-relationship between basic research areas (or fields) and specialized strategic industrial sectors of GyeongNam district. As results of this study, 20 future-oriented research fields were suggested from this topographical map, which reflected internal R&D potentials and industrial infrastructure of GyeongNam district.

Event based Rule Processing in Ubiquitous Web Services Environments (유비쿼터스 웹서비스 환경에서 이벤트 기반의 룰 처리 기법)

  • Lee Kang-Chan;Lee Won-Suk;Jeon Jong-Hong;Lee Seung-Yun;Park Jong-Hun
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.10 no.6
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    • pp.1101-1105
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    • 2006
  • Ubiquitous computing network comprises a variety of distributed service devices. Today Web services technology enables the heterogeneous devices to provide their own services and interact with each other via well-defined Internet protocol. Nevertheless, service devices in ubiquitous environments require more event-driven, autonomous interaction beyond rather passive service-oriented architecture of the present time. This paper presents an ECA (Event-Condition-Action) rule description language in an attempt to support capability for autonomous interactions among service-oriented devices in ubiquitous computing network. Specifically, the proposed WS-ECA is an XML-based ECA rule description language for web service-enabled devices. The rules are embedded in distributed devices which invoke appropriate services in the network if the rules are triggered by some internal or external events. The presented ECA-based device coordination approach is expected to facilitate seamless inter-operation among the web service-enabled devices in the emerging ubiquitous computing environment.

Modified Borresen's Coarse-Mesh Method for Improved Power Distribution Monitoring System Program Development for PWR (개선된 노심출력분포 감시 프로그램 개발을 위한 수정형 Borresen 모형)

  • Lee, Duk-Jung;Kim, Chang-Hyo
    • Nuclear Engineering and Technology
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    • v.27 no.4
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    • pp.555-561
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    • 1995
  • This paper examines the applicability of the modified Borresen's coarse-mesh method(MBSN) to the core power distribution monitoring program development for the Yonggwang nuclear power plant unit 3(YGN 3) which uses fixed incore detectors for monitoring core power distribution. In so doing the modified Borresen's coarse-mesh equations are solved with core internal boundary conditions provided by the fixed incore detectors and three-dimensional core power distributions are com puted for the first-cycle core of the YGN 3 PWR. The results are compared with predictions of the COLSS(Core Operating Limit Supervisory System) which is the axial power shape monitoring program of the YGN 3. It is shown that the modified Borresen's method can reproduce the core axial power shape more closely than the COLSS. Because of other advantages in computing speed and predictive capability, n conclude that the proposed MBSN has a promising practical application for core power distribution monitoring program development.

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A small molecule approach to degrade RAS with EGFR repression is a potential therapy for KRAS mutation-driven colorectal cancer resistance to cetuximab

  • Lee, Sang-Kyu;Cho, Yong-Hee;Cha, Pu-Hyeon;Yoon, Jeong-Soo;Ro, Eun Ji;Jeong, Woo-Jeong;Park, Jieun;Kim, Hyuntae;Kim, Tae Il;Min, Do Sik;Han, Gyoonhee;Choi, Kang-Yell
    • Experimental and Molecular Medicine
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    • v.50 no.11
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    • pp.12.1-12.12
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    • 2018
  • Drugs targeting the epidermal growth factor receptor (EGFR), such as cetuximab and panitumumab, have been prescribed for metastatic colorectal cancer (CRC), but patients harboring KRAS mutations are insensitive to them and do not have an alternative drug to overcome the problem. The levels of ${\beta}$-catenin, EGFR, and RAS, especially mutant KRAS, are increased in CRC patient tissues due to mutations of adenomatous polyposis coli (APC), which occur in 90% of human CRCs. The increases in these proteins by APC loss synergistically promote tumorigenesis. Therefore, we tested KYA1797K, a recently identified small molecule that degrades both ${\beta}$-catenin and Ras via $GSK3{\beta}$ activation, and its capability to suppress the cetuximab resistance of KRAS-mutated CRC cells. KYA1797K suppressed the growth of tumor xenografts induced by CRC cells as well as tumor organoids derived from CRC patients having both APC and KRAS mutations. Lowering the levels of both ${\beta}$-catenin and RAS as well as EGFR via targeting the $Wnt/{\beta}$-catenin pathway is a therapeutic strategy for controlling CRC and other types of cancer with aberrantly activated the $Wnt/{\beta}$-catenin and EGFR-RAS pathways, including those with resistance to EGFR-targeting drugs attributed to KRAS mutations.

Explaining One Less Nuclear Energy Policy from Governance Perspective: Energy Transition and Effectiveness of Urban Energy Policy (대안적 에너지 정책에 대한 탐색: 서울시 원전하나 줄이기 정책과 거버넌스의 역할)

  • Lee, Joo Hun
    • Korean Journal of Legislative Studies
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    • v.23 no.1
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    • pp.151-185
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    • 2017
  • Seoul's One Less Nuclear Power Plant is the major urban energy policy launched in April 2012. Its effort to respond to climate change and energy crisis in the aftermath of the Fukushima nuclear accident turned out very successful, considering huge decrease of energy consumption. However, the question of how the cut of energy consumption was possible remains unanswered. This paper introduces the concept of urban governance capacity as the cause of the success. It is the managing and governing capability to maintain the logical consistency policy system, comprising of policy perception, goals, policy tools and evaluation. Without this logical correspondence between the policy factors, any system including energy regime easily falls apart during the systemic transitional period. Governance capacity provides the integrating framework, so that the system as a whole maintains the internal homeostasis.

Roles of Mesenchymal Stem Cells in Tissue Regeneration and Immunomodulation

  • Ayala-Cuellar, Ana Patricia;Kang, Ji-Houn;Jeung, Eui-Bae;Choi, Kyung-Chul
    • Biomolecules & Therapeutics
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    • v.27 no.1
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    • pp.25-33
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    • 2019
  • Mesenchymal stem cells are classified as multipotent stem cells, due to their capability to transdifferentiate into various lineages that develop from mesoderm. Their popular appeal as cell-based therapy was initially based on the idea of their ability to restore tissue because of their differentiation potential in vitro; however, the lack of evidence of their differentiation to target cells in vivo led researchers to focus on their secreted trophic factors and their role as potential powerhouses on regulation of factors under different immunological environments and recover homeostasis. To date there are more than 800 clinical trials on humans related to MSCs as therapy, not to mention that in animals is actively being applied as therapeutic resource, though it has not been officially approved as one. But just as how results from clinical trials are important, so is to reveal the biological mechanisms involved on how these cells exert their healing properties to further enhance the application of MSCs on potential patients. In this review, we describe characteristics of MSCs, evaluate their benefits as tissue regenerative therapy and combination therapy, as well as their immunological properties, activation of MSCs that dictate their secreted factors, interactions with other immune cells, such as T cells and possible mechanisms and pathways involved in these interactions.

Development and Application of Multi-Function Valve to Solve Major Problems of Expansion and Off-Odor Leakage in the Packaging of Kimchi

  • Jeong, Suyeon;Cho, Chi Heung;Lee, Hyun-Gyu;Lee, Jung-Soo;Yoo, SeungRan
    • KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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    • v.24 no.3
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    • pp.113-120
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    • 2018
  • The one-way gas valve developed in this study was designed to prevent the breakage of packages from increased internal pressure, which is a problem in packaged Kimchi, and simultaneously reduce the outflow of the offodor release. The effect of the one-way gas valve on the headspace atmospheric compositions was investigated in the packaging system. The changes of atmospheric compositions and quality factors of Kimchi, such as $CO_2$ accumulation, pH, titratable acidity, and salinity, were measured during a 4-week storage period at $4^{\circ}C$. The Kimchi package with the one-way gas valve dramatically reduced pressure build-up in the pouch by allowing the controlled flow of gas to the atmosphere. In addition, the package design allows the possibility of controlling the gas generated from Kimchi by adjusting the viscosity of the open pressure control oil. The one-way gas valve did not affect the sensory characteristics of Kimchi products during the storage period. Furthermore, the deodorizing capability of the activated carbon contained in the one-way gas valve effectively reduced the off-odor of Kimchi products released along with carbon dioxide. The novel one-way gas valve is considered to be an active packaging system that can solve major problems of expansion and off-odor leakage in the packaging of Kimchi.