• 한국동물학회지
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• 제32권4호
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• pp.329-338
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• 1989

Present study examined the effect of intermittent versus continuous infusion of progesterone(P) on LHRH release in uiuo from the mediobasal hvpothalamus of ovariectomiEed, estradiol-primed adult rats bearing push-pull cannulae. Three experimental groups were studied: 1) control (perfusion medium only),2) intermittent perfusion of P (10-min on,20-min off, and 3) continuous perfusion of p. p (10 ng/mll was directly infused into the MBH following a 3 hr basal collection. Perfusates were collected at 10 min intents린s on ice and LHRH release was measured by LHRH radioimmunoassav. Cycle detector analysis revealed that the spontaneous HRH output in the control group was pulsatile over a 7 hr push-pull perfusion period. The mean basal LHRH release, pulse amplitude and pl서se period were 0.68 $\pm$ 0.03 ps110 min, 1.15 $\pm$0.08 pg and 60 $\pm$ 9 min, respectivelv. Intermi구eat perfusion of P clearly stimulated the mean LHRH release (pre-P vs post-P: 1.14 $\pm$ 0.18 vs 1.99 $\pm$ 0.53 pg) without changes in LHRH pulse frequency. In contrast to intermittent infusion of p, continuous administration of P faithed to modify LHRH release, since the mean LHRH release and pulse amplitude between pre-P and post-P perfusion urere similar. The in vitro study clearly showed that intermittent, but not continuous administration of P is effective in stimulating LHRH release. Therefore, it appears that rhythmic secretion of P mal be the erective signal for activating the neural LHRH apparatus.

• 한국환경과학회지
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• 제13권7호
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• pp.675-680
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• 2004

This study was conducted to remove organics and nutrients using 2 stage intermittent aeration reactor. First reactor, using suspended microbial growth in intermittent aeration instead of anaerobic reactor in the typical BNR process, used minimum carbon source to release P, and it was possible to reduce ammonia loading going to second reactor. In the second reactor, using moving media intermittent aeration, it was effective to reduce nitrate in non-aeration time by attached microorganisms having long retention time. In aeration time, nitrification and P uptake were taken place simultaneously. From the experiment, two major results were as follows. First, the removal of organics was more than 90%, and optimum aeration/non-aeration time ratio for organic removal was corresponded with aeration/non-aeration time ratio for nitrogen removal. Second, in the first reactor, optimum aeration/non-aeration time ratio was 15/75 (min.) because it was necessary to maintain 75 min. of non-aeration time to suppress of impediment of return nitrate and to lead release of phosphate. In the second reactor, optimum aeration/non-aeration time ratio was 45/90 (min.).

• 복식
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• 제16권
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• pp.173-185
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• 1991

We measured change of peripheral skin temperature and mean skin temperature when the upper arm and thigh pressured in order to know the effect of skin pressure applied by clothing on blood circulation. After release from pressure, we observed also recovery condition. At the same time, we examined relation between pressure and a feeling of tightness. Three physiques of healthy females, namely slender, standard and plump, served as subjects. We used intermittent method with skin pressure applied by experimental fabric at l-minute intervals. Besides we made a comparative study with results according to different restraint method (continuous method and intermittent method). As a result of this experiment, we obtained following findings. 1. The significant difference was marked at the pressure, measuring time, physique and measuring region with change of skin temperature under upper arm and thigh restraint by intermittent method. The peripheral skin temperature decreased with the lapse of restraint time. A remarkable tendency observed according to the. increase of restraint pressure. Recovery condition after release from pressure not yet recovered to original state, for all after a lapse of 10 min. The mean skin temperature decreased with the lapse of restraint time in case of upper arm restraint, it was not an obvious tendency except 60mmHg under thigh restraint. 2. Main factor affecting the evaluation of a feeling of tightness was restraint pressure, when the upper arm and thigh restraint by intermittent method. The respondence rate of 'very tight' grew larger according to the increase of restraint pressure. The value of pressure sensation declined after restraint ten times as compared with one time, but there was difference according to restraint pressure. 3. We reexamined change of skin temperature and feeling of tightness by different restraint method(continuous method and intermittent method). The results were as follows. 1) The skin temperature decreased more greatly during skin pressure by continuous method than intermittent method, especially in the peripheral. Without different restraint method, the skin temperature of slender plysique decreased more greatly than that of plump physique. 2) The value of pressure sensation by intermittent method was highly on both sites of upper arm and thigh.

• The Korean Journal of Physiology and Pharmacology
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• 제3권4호
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• pp.393-404
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• 1999

We have reported that hypoxia stimulates EDRF(s) release from endothelial cells and the release may be augmented by previous hypoxia. As a mechanism, it was hypothesized that reoxygenation can stimulate EDRF(s) release from endothelial cells and we tested the hypothesis via bioassay experiment. In the bioassay experiment, rabbit aorta with endothelium was used as EDRF donor vessel and rabbit carotid artery without endothelium as a bioassay test ring. The test ring was contracted by prostaglandin $F_{2a}\;(3{\times}10^{-6}\;M)$ which was added to the solution perfusing through the aorta. Hypoxia was evoked by switching the solution aerated with 95% $O_2/5%\;CO_2$ mixed gas to one aerated with 95% $O_2/5%\;CO_2$ mixed gas. Hypoxia/reoxygenation were interexchanged at intervals of 2 minutes (intermittent hypoxia). In some experiments, endothelial cells were exposed to 10-minute hypoxia (continuous hypoxia) and then exposed to reoxygenation and intermittent hypoxia. In other experiments, the duration of reoxygenation was extended from 2 minutes to 5 minutes. When the donor aorta was exposed to intermittent hypoxia, hypoxia stimulated EDRF(s) release from endothelial cells and the hypoxia-induced EDRF(s) release was augmented by previous hypoxia/reoxygenation. When the donor aorta was exposed to continuous hypoxia, there was no increase of hypoxia-induced EDRF(s) release during hypoxia. But, after the donor aorta was exposed to reoxygenation, hypoxia-induced EDRF(s) release was markedly increased. When the donor aorta was pretreated with nitro-L-arginine $(10^{-5}$ M for 30 minutes), the initial hypoxia-induced EDRF(s) release was almost completely abolished, but the mechanism for EDRF(s) release by the reoxygenation and subsequent hypoxia still remained to be clarified. TEA also blocked incompletely hypoxia-induced and hypoxia/reoxygenation-induced EDRF(s) release. EDRF(s) release by repetitive hypoxia and reoxygenation was completely blocked by the combined treatment with nitro-L-arginine and TEA. Cytochrome P450 blocker, SKF-525A, inhibited the EDRF(s) release reversibly and endothelin antgonists, BQ 123 and BQ 788, had no effect on the release of endothelium-derived vasoactive factors. Superoxide dismutase (SOD) and catalase inhibited the EDRF(s) release from endothelial cells. From these data, it could be concluded that reoxygenation stimulates EDRF(s) release and hypoxia/reoxygenation can release not only NO but also another EDRF from endothelial cells by the production of oxygen free radicals.

• 상하수도학회지
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• 제28권1호
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• pp.1-11
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• 2014

The water distribution system should be invariably operated on continuous pattern for 24 hours a day. Occasionally, it is not practically possible to operate for 24 hours due to water shortage or financial constraints. Therefore an intermittent water supply is unavoidable in water shortage area and developing countries. But the intermittent water supply can introduce large pressure forces and rapid fluid accelerations into a water supply network. These disturbances may result in new pipe failure, leakage and secondary contamination. This paper proposed an improvement methodology to prevent the disturbances by intermittent water supply. For the study, the hydraulic variation of intermittent flow in water distribution system was measured and analyzed in the field by comparing with simulation of hydraulic model. Installations of control valves such as, pressure reducing and sustaining and air valves were employed for pressure and flow control. The effectiveness of the methods are presented by comparing hydraulic conditions before and after introducing the proposed solutions.

• 한국대기환경학회지
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• 제14권5호
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• pp.397-410
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• 1998

Tracer experiments were performed 4 times in December 1992 on the relatively flat terrain and nearby building area adjacent to the Taedok Science Town in Korea. Each experiment was continued for relatively short period of 1 or 2 hours with intermittent release of SF6 up to 2.07g/s at 10m height. Movement of tracer plume was tracked by a continuous tracer analyzer installed on an air monitoring van. Simulation with INPUFF was carried out to analyze and predict experiments. Measured profiles of tracer plume were narrow and sharp while predicted profiles by INPUFF were broad and slowly varied. Tracer plumes were detected at a short distance of 0.5 to 2.2 km mainly due to intermittent release and high value of lower detectable limit. Various experimental conditions were tested by INPUFF simulation in order to find desirable conditions. Higher wind speed and less variable wind direction could yield longer distance of plume tracking only when the lower detectable limit was sufficiently low. Distance of plume tracking was long and did not much depend on the lower detectable limit in stable atmospheric conditions.

• 상하수도학회지
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• 제20권2호
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• pp.257-264
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• 2006

In this study, the treatment of domestic wastewater in a field-scale membrane submerged intermittently aerated activated sludge process($210m^3/day$) was investigated under difference aeration methods. Operating temperature was 5.4 to 25.0 and membrane used in this study is a polyethylene hollow fiber membrane(pore size $0.4{\mu}m$). The range of operating flux was $9.7{\sim}24.4l/m^2-h$ and membrane permeates periodically operated for 7min followed idle for 3 min. The results showed that MIA(modified intermittent aeration) was more efficient in nitrogen and phosphorus removal. The removal efficiencies of T-N and T-P were 73.0% and 69.6% for CIA(conventional intermittent aeration) and 57.5%, 58.6% for MIA (modified intermittent aeration). With application of modified intermittent aeration, DO reached nearly Omg/l within 10 minutes after air off. Organics of influent could be entirely consumed to the denitrification and the P-release without the influence by remained DO in intermittent aeration reactor. Therefore, newly developed KSMBR(Kowaco-KMS-Ssangyoung Membrane Bio-Reactor) process with modified intermittent aeration can be one of the useful process for stable nitrogen and phosphorus removal.

• 한국물환경학회지
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• 제18권4호
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• pp.401-409
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• 2002

In this study, to evaluate the applicability of ORP and pH as process control parameters for an intermittent aeration process, a 200L/d bench-scale plant was installed and operated for 90 days. It was fed with synthetic wastewater which contained $COD_{Cr}$ : 400mg/L, TN : 40mg/L and TP : 7mg/L. ORP & pH were measured on-line and compared with the variation of nutrient concentrations. As the results, both of the ORP and pH were able to monitor successfully nitrification and denitrification. Bending-points on the ORP curve and peak points on the pH curve corresponded to the termination of nitrification and denitrification. For P uptake and release, pH was the best indicator for performance evaluation. The aerobic pH apex was appeared when P uptake was accomplished and there was a relationship between the P release and pH variation. But the pH curve needed filtering because there were many noises on it. In this study, the shape of the ORP & pH curves were varied as the operating conditions such as aeration rates and organic loads were changed. It allowed the operating states of biological systems to be effectively evaluated. If it is properly managed to show the bending points and peak points clearly, the on-line monitoring of ORP & pH will be a reliable and effective technique for process control of intermittent aeration processes.

• 한국시뮬레이션학회논문지
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• 제23권3호
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• pp.19-25
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• 2014

수요예측은 경영 전략을 포함한 모든 경영 활동의 기초가 된다. 특히 부품의 수요예측은 공급망관리 측면에서 매우 중요한 요소 중 하나이다. 부품의 수요는 다양한 산업에서 종종 간헐적 특성을 포함한다. 간헐적 특성이란 수요가 발생하지 않는 경우가 빈번한 현상을 지칭한다. 간헐적 수요 현상에서는 발생된 수요의 분산이 크고 그 발생간격이 확률적이다. 따라서 간헐적 특성을 갖는 수요를 예측하기 위해서 일반적인 시계열 분석기법이나 인과관계를 이용한 모형(회귀모형)을 사용하는 것은 적합하지 않다. 이는 기존의 방법들이 실제 수요행태를 묘사하기 어렵기 때문이다. 이러한 간헐적 수요의 예측을 위해 마코프 부트스트랩이 개발되었다. 이 방법은 1계차 자기상관성을 반영하며 리드타임 동안 수요의 합이 독립임을 가정하였다. 본 연구에서는 리드타임 내 수요 합의 독립가정을 완화한 부트스트랩 방법을 제안한다. 수정된 부트스트랩 방법에 의해 재추출된 데이터는 실측 데이터의 간헐적 특성을 근사적으로 반영한다. 마지막으로 실측 데이터에 수정된 방법을 적용한 예측 결과를 사례로 제시하고자 한다.

• The Korean Journal of Physiology and Pharmacology
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• 제2권2호
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• pp.209-216
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• 1998

The present study was designed: (1) to determine whether or not hypoxia stimulates the release of endothelium-derived relaxing factors (EDRFs) from endothelial cells, and (2) to examine whether or not the hypoxia-induced EDRFs release is further augmented by previous hypoxia-reoxygenation, using bioassay system. In the bioassay experiment, rabbit aorta with endothelium was used as EDRFs donor vessel and rabbit carotid artery without endothelium as a bioassay test ring. The test ring was contracted by prostaglandin $F_{2{\alpha}}$ $(3{\times}10^{-6}\;M/L)$, which was added to the solution perfusing through the aortic segment. Hypoxia was evoked by switching the solution aerated with 95% $O_2/5%\;CO_2$ mixed gas to one aerated with 95% $N_2/5%\;CO_2$ mixed gas. When the contraction induced by prostaglandin $F_{2{\alpha}}$ reached a steady state, the solution was exchanged for hypoxic one. And then, hypoxia and reoxygenation were interchanged at intervals of 2 minutes (intermittent hypoxia). The endothelial cells were also exposed to single 10-minute hypoxia (continuous hypoxia). When the bioassay ring was superfused with the perfusate through intact aorta, hypoxia relaxed the precontracted bioassay test ring markedly. Whereas, when bioassay ring was superfused with the perfusate through denuded aorta or polyethylene tubing, hypoxia relaxed the precontracted ring slightly. The relaxation was not inhibited by indomethacin but by nitro-L-arginine or methylene blue. The hypoxia-induced relaxation was further augmented by previous hypoxia-reoxygenation and the magnitude of the relaxation by intermittent hypoxia was significantly greater than that of the relaxation by continuous hypoxia. The results suggest that hypoxia stimulates EDNO release from endothelial cells and that the hypoxia-induced EDNO release is further augmented by previous hypoxia-reoxygenation.