• Biomolecules & Therapeutics
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• v.24 no.6
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• pp.561-571
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• 2016

Marine biosphere is the largest one of the earth and harbors an enormous number of different organisms. Living conditions differ fundamentally from those in terrestrial environment. The production of specific secondary metabolites is an important adaption mechanism of marine organisms to survive in the sea. These metabolites possess biological activities which make them interesting as possible drugs for human. The review presents sources, chemistry, production and pharmacology of FDA approved marine derived pharmaceuticals arranged according to their therapeutic indication. Four of the presently seven approved drugs are used for the treatment of cancer. Each another one is applicated for treatment of viral diseases, chronic pain and to lower triglyceride level in blood. Some other products are of interest in diagnostic and as experimental tools. Besides, this article describes challenges in drug development from marine sources, especially the supply problem.

• The Korean Journal of Food And Nutrition
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• v.16 no.3
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• pp.224-231
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• 2003

The development of food science in the near future probably depends on the advance in functional food science. Actually, a number of substances and products with potential for disease risk reduction rather than simply for health maintenance have been investigated for their body-modulating functions. Some of them have been applied in practice to the industrialization of functional foods in terms of foods for health uses. Health is becoming a more important aspect of food. Consumers increasingly see the link between food and health, thus generating growing levels of consumer interest in more actively managing their diets and, by implication, their health. there is demand from consumers and strong manufacturer push towards the development of food as medicine. Pharmaceutical companies are currently focused on the medical aspects of food as medicine, but it is expected that there will be an increase in the rate of active ingredients for lifestyle application.

• Journal of Contemporary Eastern Asia
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• v.13 no.2
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• pp.69-85
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• 2014

This paper explores the convergence process by focusing on the massively multiplayer online game(MMOG) industry and the online broadcasting industry in South Korea. In doing so, the paper seeks to establish the concept of Hidden catalysts for the integration process between the two industries and explore the roles of the Hidden catalysts in triggering the industry's transition. Further, the modified multi-level socio-technical model we applied in our research allows us both to understand each industry's development towards convergence in various dimensions and also to focus on the activities of the Hidden catalysts. In assessing the role of Hidden catalysts in industry convergence, we found that Hidden catalysts depend on two essential features: first, appropriate technology leading to the new industry dominance; and second, managerial capabilities to deal with conflicts among other new interest groups, to harmonise with government initiatives for industry development and to create new value in the integrated market to please the demand of mixed customers.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 2006.04a
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• pp.50-57
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• 2006

In recent years, a mm1ber of construction robots have been developed, but few practical examples can be found on construction sites today. Nevertheless, automation and robotics are proposed as apparent solutions to problems in productivity, quality, safety, and skilled-labor availability in future construction industry. Since the early 2000s, there has been growing interest in construction automation and robotics in Korea, and significant progresses have also been made. This paper mainly describes the needs of research and development program to introduce robots on construction sites, and primary outcomes which are developed in domestic construction industry. Essential technologies required for the development of construction robots, future prospects of the technology advances, and several suggestions are also presented in this paper.

• Proceedings of the Korean Society of Veterinary Pathology Conference
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• 2003.10a
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• pp.18-18
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• 2003

Hepatitis C virus (HCV) has become a major public health issue and is prevalent in most countries. HCV infection starts frequently without clinical symptoms, and progresses in the majority of patients (70 to 85％) to persistent viremia and chronic hepatitis including cirrhosis and hepatocellularcarcinoma (HCC) [1]. Alcohol is one of the independent cofactors accelerating the development of HCC in chronic hepatitis C patients. This is of great interest because a synergy between excessive alcohol intake and HCV infection has been documented in the development of HCC in chronic hepatitis C patients [2]. The aim of this study is to investigate liver changes in ethanol feeding HCV-transgenic (Tg) mouse and to establish an animal model system. (omitted)

• Journal of Ocean Engineering and Technology
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• v.11 no.4
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• pp.239-248
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• 1997

The nesting of parts cut on raw steel plate has been a subject of interest to the shipbuilding industry for many years. "Nesting" is defined operation of layout of the parts on the raw material with minimizing the waste rate. Therefore, it is very important to optimize the cutting area. Since the existing nesting programs are prepared for expensive workstations and the expert, it is needed to develop nesting program for personal computer to improve the technology of small/middle sized shipyards and their productivity. This study involves development and application of appropriate optimization technique to solve the problem of plate nesting. And the appropriate D/B for storing nesting data developed, the function of D/B is introduced in this paper.his paper.

• Journal of the Korean Society of Costume
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• v.51 no.8
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• pp.159-170
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• 2001

The culture and society environment plays major role in the development of Fashion and now in the 21st century, interest in Fashion is getting increased along with the rapid progress of advanced media development and information surge. Now it s the time to extend visual efficiency not only transmitting fashion image but also develop a creative product that satisfy the demander s needs. Currently it is very hard to express our subjective Korean "nationalism" in the Fashion since the various expression skill using western fashion illustration are dominant in our society. I have classified two components, fashion illustration and Korean painting in the theoretical circumstance. In fashion illustration circumstance, I examined the concept, usage, expression skill and history referring to historical documents. In Korean painting section, I considered coloring portrait concept, pattern, history, concept, and feature of the four gentlemanly plants. including the basic material of Korean-paper, Writing- Brush, Ink-Stone, Traditional-ink and also the history of itself. I have designed 8 products applying the concept of plum blossoms, orchids, chrysanthemums and bamboos that represent the most important part of the four gentlemanly plants, and also the expression skill of Korean coloring portrait.rait.

• 한국전산유체공학회:학술대회논문집
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• 2005.04a
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• pp.65-69
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• 2005

Curretly, the development of MEMS(Micro Electronic Mechanical System) technology awakes many research's interest for the aerodynamics. This work presents the development of a compact synthetic jet actuator for flow separation control at the flat plate. The formation and evolution of fluidic actuators based on synthetic jet technology are investigated using Reynolds-Averaged Navier-Stokes equations. Also, 2-Dimensional, unsteady, incompressible Navier-Stokes equation solver with single partitioning method for Multi-Block grid to analyze and a modeled boundary condition in developed fo. the synthetic jet actuator. Both laminar and turbulent jets are investigated. Results show very good agreement with experimental measurements. A jet flow develops, even though no net mass flow is introduced. Pair of counter-rotating vortices are observed near the jet exit as are observed in the experiments.

• The Journal of the Korean life insurance medical association
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• v.31 no.1
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• pp.34-36
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• 2012

Lung cancer such as small cell lung cancer(SCLC) and non small cell lung cancer(NSCLC) have high mortality rate, so, we insurance doctors have little interest in their risk. But nowadays there's a lot of development in targeted therapy of NSCLC. Screening by CT scanning and early resection strategy also shows better prognosis. It is helpful for underwriters and insurance doctors to review the current development of targeted therapy of NSCLC and estimation of extra-risk of early lung cancer. The preferred treatment option for patients whose tumors contain EGFR-activating mutations are one of the EGFR-directed tyrosine kinase inhibitors, such as gefitinib or erlotinib. In patients with NSCLC whose tumors harboured an ALK rearrangement, there was 61% objective response rate to crizotinib in the phase 1 study. The median survival progression-free survival was 10 months. Mortality analysis of early lung cancer who were detected by CT screening, MR of 105% and EDR of 1‰ were calculated.

• Journal of Korea Multimedia Society
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• v.21 no.1
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• pp.69-76
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• 2018

Augmented Reality (AR) technology has rapidly been applied to various application areas including e-learning and e-education. Focusing on the design and development of android tablet application, this study targeted to develop infant music education using AR technology. We used a tablet instead of personal computer because it is more easily accessible and more convenient. Our system allows infant users to play with teaching aids like blocks or puzzles to mimic musical play like game. The user sets the puzzle piece on the playground in front of the tablet and presses the play button. Then, the system extracts a region of interest among the images acquired by internal camera and separates the foreground image from the background image. The block recognition software analyzes, recognizes and shows the result using AR technology. In order to have reasonably working recognition ratio, we did experiments with more than 5,000 frames of actual playing scenarios. We found that the recognition rate can be secured up to 95%, when the threshold values are selected well using various condition parameters.