• IMMUNE NETWORK
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• v.11 no.5
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• pp.227-244
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• 2011

MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively regulate gene expression via degradation or translational repression of their target messenger RNAs (mRNAs). Recent studies have clearly demonstrated that miRNAs play critical roles in several biologic processes, including cell cycle, differentiation, cell development, cell growth, and apoptosis and that miRNAs are highly expressed in regulatory T (Treg) cells and a wide range of miRNAs are involved in the regulation of immunity and in the prevention of autoimmunity. It has been increasingly reported that miRNAs are associated with various human diseases like autoimmune disease, skin disease, neurological disease and psychiatric disease. Recently, the identification of miRNAs in skin has added a new dimension in the regulatory network and attracted significant interest in this novel layer of gene regulation. Although miRNA research in the field of dermatology is still relatively new, miRNAs have been the subject of much dermatological interest in skin morphogenesis and in regulating angiogenesis. In addition, miRNAs are moving rapidly center stage as key regulators of neuronal development and function in addition to important contributions to neurodegenerative disorder. Moreover, there is now compelling evidence that dysregulation of miRNA networks is implicated in the development and onset of human neruodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Tourette's syndrome, Down syndrome, depression and schizophrenia. In this review, I briefly summarize the current studies about the roles of miRNAs in various autoimmune diseases, skin diseases, psychoneurological disorders and mental stress.

• Journal of Agricultural Extension & Community Development
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• v.22 no.3
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• pp.245-260
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• 2015

Since the Discussion on responsible tourism sector began in the 1980s, the interest in responsible tourism has increased. Responsible tourism aims to preserve the local culture and environment, and make the benefits return benefits to local stakeholders. This study aims to obtain an empirical understanding of the responsible tourism market by using a segmentation approach to provide better information for responsible tourism marketers in Korea. A self-administered survey was obtained from 471 tourists in seven responsible tourism sites. As for the motivations of responsible tourism, seven factors ('faimly togetherness', 'escape relaxation', 'personal growth', 'social interaction', 'various experience', 'learning' and 'natural experience') were extracted. Six distinct segments were identified based on the motivation: escape from daily life relaxation seekers (19.15%), overall low motivation (7.8%), family togetherness seekers (21.18%). various experience seekers (12.77%), noverlty learning seekers (22.46%) and want-it-all (16.55%). Socio-demographic characteristics and tourism behaviors of each segmentation were also analyzed. The findings should be of interest to practitioners of responsible tourism marketing and operation.

• Journal of The Korean Association For Science Education
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• v.21 no.2
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• pp.357-384
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• 2001

In this paper, we described practical teaching-learning plans based on three different theoretical approaches to Integrated Science Education (ISE): a knowledge centered ISE, a social problem centered ISE, and an individual interest centered ISE. We believe that science teachers can understand integrated science education through this paper and they are able to apply simultaneously our integrated science teaching materials to their real instruction in classroom. For this we developed integrated science teaching-learning plans for the topic of energy which has a integrated feature strongly among integrated science subject contents. These modules were based upon the teaching strategies of 'Energy' following each integrated directions organized in the previous paper (Three Strategies for Integrated Science Teaching of "Energy" Applying Knowledge, Social Problem, and Individual Interest Centered Approaches) and we applied instruction models fitting each features of integrated directions to the teaching strategies of 'Energy'. There is a concrete describing on the above three integrated science teaching-learning plans as follows. 1. For the knowledge centered integration, we selected the topic, 'Journey of Energy' and we tried to integrate the knowledge of physics, chemistry, biology, and earth science applying the instruction model of 'Free Discovery Learning' which is emphasized on concepts and inquiry. 2. For the social problem centered integration, we selected the topic, 'Future of Energy' to resolve the science-related social problems and we applied the instruction model of 'Project Learning' which is emphasized on learner's cognitive process to the topic. 3. For the individual interest centered integration, we selected the topic, 'Transformation of Energy' for the integration of science and individual interest and we applied the instruction model of 'Project Learning' centering learner's interest and concern. Based upon the above direction, we developed the integrated science teaching-learning plans as following steps. First, we organized 'Integrated Teaching-Learning Contents' according to the topics. Second, based upon the above organization, we designed 'Instructional procedures' to integrate within the topics. Third, in accordance with the above 'Instructional Procedures', we created 'Instructional Coaching Plan' that can be applied in the practical world of real classrooms. These plans can be used as models for the further development of integrated science instruction for teacher preparation, textbook development, and classroom learning.

• International Journal of Quality Innovation
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• v.8 no.3
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• pp.23-34
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• 2007

Many practitioners strive to increase the efficiency of their product development. In addition, smaller companies must satisfy customers' expectations of their product development. These expectations can be e.g. use of specific methodologies such as Lean Product Development (LPD) and/or Design for Six Sigma (DFSS). This study attempts to identify differences and similarities between these methodologies and the connection between them. This comparison is of interest to practitioners that must choose a strategy for their product development as well as to researchers. The aim of both methodologies is to reduce waste and time of development and to raise the quality of a product at the very roots of the product: its development. LPD and DFSS help development managers to structure projects and focus as much as possible on customer expectations and satisfaction.

• Journal of the Korea Safety Management & Science
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• v.15 no.4
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• pp.435-448
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• 2013

The aim of this study is to investigate and develop the extended models for Economic Cash Amount(ECA), Cash Break Even-Point(BEP), and Cash Flow Statement(CFS) by referencing systematic literature review in the field. The study develops three extended models to determine the optimal cash amount: ECA model with interest opportunity cost, financing transaction cost and financing fail cost, ECA model with daily cash supply and interest opportunity cost, ECA model with financing fail cost and interest opportunity cost. Earnings Before Interests, Tax, Depreciation and Amortization(EBITDA) is obtained by subtracting noncash depreciation costs from Earning Before Interest and Tax(EBIT), which is efficient metric to evaluate operating cash flow. The research also develops two extended Cash BEP models, considered as interest and corporate tax, in order to indentify the break-even point as EBITDA equals zero. Furthermore, this paper proposes the modified version of CFS by introducing the reclassification of operating and financing accounts in the statement of financial position. In addition, the study also present the reclassification of five types of profit, such as gross profit, EBIT, ordinary profit, special profit, and net profit within the statement of comprehensive income. In order to provide a better understanding of the proposed cash flow models, numerical examples, such as two-sample t test and Analysis of Variance(ANOVA), are presented to demonstrate the statistical significance according to the industrial types for net working capital(i.e cash-to-cash), net profit, operating cash flow and free cash flow.

• Health Policy and Management
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• v.27 no.4
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• pp.324-335
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• 2017

Background: The aim of this study is to analyze determinants of welfare attitudes toward healthcare services in South Korea, using three main theories: self-interest (positive welfare attitudes if the policy fulfills people's personal interests), symbolic attitudes (positive welfare attitudes if the person is politically progressive or egalitarian), and sociotropic perception (positive welfare attitudes if the person experienced positive aggregated collective experiences of societal events and trends regarding the policy). Although the definition of the welfare attitude is rather ambiguous in literatures, in this investigation, we operationalize the concept as the 'willingness to pay higher taxes to improve the level of health care services for all people in Korea' which shows individuals' actional propensity. Methods: We used the health module from the International Social Survey Program 2011 for the analysis (N= 1,391). Five logistic regression models were built successively using two variables for each theory to measure key concepts of self-interest, symbolic attitudes, and sociotropic perceptions as independent variables. Results: The result showed self-interest and symbolic attitudes factors to be strong determinants of welfare attitudes towards healthcare services in South Korea, whereas sociotropic perception factors have inconsistent effects. Conclusion: For a more politically elaborated healthcare reform in South Korea and elsewhere, there needs to be further research on various dimensions and determinants of welfare attitudes to understand popular basis of welfare expansion, especially in the era of inequality.

• Journal of Elementary Mathematics Education in Korea
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• v.9 no.1
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• pp.1-18
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• 2005

The purpose of this study is to plan and apply the problem posing program to each unit of elementary mathematics 5-Ga stage, and to make an analysis of their effects on mathematics learning achievements, attitude and interesting. In order to achieve these purposes, the following research problems were set up for the present study: First, we design problem posing program which can be applied to the actual instruction with analyzing the curriculum of mathematics on 5-Ga stage in the seventh national curriculum. Second, we analyze the effect of applying problem posing program on students' mathematics learning achievements. Third, we analyze the effect of applying problem posing program on students' mathematical attitude and interest. The results of this study are as follows: First, the problem posing program developed in this study was more affirmative effects for improving the students' mathematics learning achievements. Second, the problem posing program also had affirmative effects on students' attitude and interest on mathematics. Third, after applying the problem posing program turned out to have a statistical significant correlation between mathematics learning achievements and attitude, and mathematics learning achievements and interest.

• Journal of the Korean association of regional geographers
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• v.16 no.4
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• pp.417-427
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• 2010

The purpose of this study was to investigate the possibility of ecotourism with an endangered species, Crested ibis (Nipponia nippon). To achieve the goal, this study evaluated the concern on the Crested ibis and wetland environment by the public, the interest on the regional development, restoration of the Crested ibis, and interest to the region, and also, the behavioral intentions of the visitors to the Upo wetland. It was found that there were significant relationship between perceptions on the Crested ibis and the interests of the environment, perceptions of Crested ibis and the interest to region, perceptions of the Crested ibis restoration and interest to the environment, perceptions of Crested ibis restoration and the interests to the region, and the interest to the environment and behavioral intentions. But there was no significant relationship between the interests to the region and behavioral intentions.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2010.05a
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• pp.437-440
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• 2010

In modern society, people will obtain the necessary goods and find meaning of himself and his community through jobs. The meaning of job for people with disabilities is identical with people's with non-disabilities and people with disabilities will live as a member of society through jobs. Because people with hearing impairment have a problem about job such as the short longevity and high turnover, vocational aptitude test which evaluates psychological characteristics, aptitudes and interests is necessary for them. In this paper, we design and evaluate the picture vocational interest inventory supporting the Internet as a vocational aptitude test for people with hearing impairment. We use the picture vocational interest inventory of Korean Employment Development Institute as a implementation target. The previous tests for people with hearing impairment have a problem which an examinee, an examiner and a sign language interpreter are involved in the test at the same space and time. Therefore, our picture vocational interest inventory has no limitation of time and space because it processes on the Internet.

• Communications of Mathematical Education
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• v.31 no.1
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• pp.125-147
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• 2017

The purpose of this study was to investigate the effects of mathematics-centered STEAM program which was operated in free semester system classes on middle school students' interest in science, technology/engineering, and mathematics(STEM) career and integrated problem solving ability. The study was conducted with 40 first graders in a middle school for 12 weeks using mathematics-centered STEAM program developed for the use of free semester system classes by the support of the Ministry of Education/KOFAC in 2016. According to the results of STEM career interest survey, mathematics-centered STEAM program was effective for improving middle school students' interest in STEM career. And it was also effective in the development of students' integrated problem solving ability.