• Journal of Interdisciplinary Genomics
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• 제5권2호
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• pp.32-34
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• 2023

Resistance to thyroid hormone syndrome (RTH) is a genetic disease caused by the mutation of either the thyroid hormone receptor-β (THRB) gene or the thyroid hormone receptor-α (THRA) gene. RTH caused by THRB mutations (RTH-β) is characterized by the target tissue's response to thyroid hormone, high levels of triiodothyronine and/or thyroxine, and inappropriate secretion of thyroid-stimulating hormone (TSH). THRA mutation is characterized by hypothyroidism that affects gastrointestinal, neurological, skeletal, and myocardial functions. Most patients do not require treatment, and some patients may benefit from medication therapy. These syndromes are characterized by decreased tissue sensitivity to thyroid hormones, generating various clinical manifestations. Thus, clinical changes of resistance to thyroid hormones must be recognized and differentiated, and an approach to the practice of personalized medicine through an interdisciplinary approach is needed.

• International Journal of Computer Science & Network Security
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• 제22권7호
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• pp.327-331
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• 2022

The article aims at studying the institution of human rights in an ever-evolving world in the context of the interdisciplinary approach. The main scientific method was deduction that allowed examining the specific interdisciplinary approach in relation to the institution of human rights on the global scale. To solve the issue set, it is necessary to study legal foundations and features of the interdisciplinary approach to the institution of human rights in the modern world. The article proves there is no theoretical anthropological understanding of the institution of human rights. It has been concluded that the appeal to anthropological jurisprudence requires the identification of the initial theoretical and methodological principles, parameters and axioms of cognition, the integration of a person into the subject field of legal science, linking jurisprudence with the chosen external environment (philosophy, sociology, theology, etc.), predetermining the existence (understanding) of a person, causing qualitative differences and the structure of subject-methodological phenomena. In addition to the identification of such hypotheses, prerequisites and axioms, the basic method (principle) of cognition and its heuristic potential are also being searched (defined). The terminological designation of the formed subject-methodological phenomenon (legal anthropology, anthropology of law, anthropological approach, etc.) reveals its role in the system of interdisciplinary relations of legal science.

• 대한음성학회:학술대회논문집
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• 대한음성학회 2006년도 추계학술대회 발표논문집
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• pp.31-36
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• 2006

Research in the Center for Pediatric Auditory and Speech Sciences (CPASS) is attempting to characterize or phenotype children with speech delays based on acoustic-phonetic evidence and relate those phenotypes to chromosome loci believed to be related to language and speech. To achieve this goal we have adopted a highly interdisciplinary approach that merges fields as diverse as automatic speech recognition, human genetics, neuroscience, epidemiology, and speech-language pathology. In this presentation I will trace the background of this project, and the rationale for our approach. Analyses based on a large amount of speech recorded from 18 children with speech delays will be presented to illustrate the approach we will be taking to characterize the acoustic phonetic properties of disordered speech in young children. The ultimate goal of our work is to develop non-invasive and objective measures of speech development that can be used to better identify which children with apparent speech delays are most in need of, or would receive the most benefit from the delivery of therapeutic services.

• 대한산업공학회지
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• 제43권3호
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• pp.164-175
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• 2017

Dual response surface optimization (DRSO) attempts to optimize mean and variability of a process response variable using a response surface methodology. In general, mean and variability of the response variable are often in conflict. In such a case, the process engineer need to understand the tradeoffs between the mean and variability in order to obtain a satisfactory solution. Recently, a Posterior preference articulation approach to DRSO (P-DRSO) has been proposed. P-DRSO generates a number of non-dominated solutions and allows the process engineer to select the most preferred solution. By observing the non-dominated solutions, the DM can explore and better understand the trade-offs between the mean and variability. However, the non-dominated solutions generated by the existing P-DRSO is often incomprehensive and unevenly distributed which limits the practicability of the method. In this regard, we propose a modified P-DRSO using multiple objective genetic algorithms. The proposed method has an advantage in that it generates comprehensive and evenly distributed non-dominated solutions.

• 한국심리학회지 : 문화 및 사회문제
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• 제10권2호
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• pp.17-37
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• 2004

아직까지 범죄학은 학문적 정체성을 제대로 찾지 못하고 있다. 그 주된 원인은 범죄학연구가 사회학적 접근방법에만 주로 의존했기 때문이다. 따라서 범죄학에는 생물학, 심리학, 그리고 사회학 등 여러 학문분야들을 모두 아우르는 간학문적 접근방법(interdisciplinary)이 동원되어야 한다. 그러나 이것은 생물학이나 심리학적 연구가 사회학적 접근방법을 대신하는 것을 의미하는 것은 아니다. 다만 다양한 분야의 학자들이 범죄를 연구하여 하나의 체계화 된 일반이론으로 정립될 수 있도록 노력해야 한다는 것이다. 본 연구는 그 이외에도 범죄학이 과학이 되기 위한 조건과 기타 앞으로 범죄학이 나아가야할 방향에 대해 논의하였다.

• Interdisciplinary Bio Central
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• 제2권2호
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• pp.4.1-4.6
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• 2010

The most common type of microarray experiment has a simple design using microarray data obtained from two different groups or conditions. A typical method to identify differentially expressed genes (DEGs) between two conditions is the conventional Student's t-test. The t-test is based on the simple estimation of the population variance for a gene using the sample variance of its expression levels. Although empirical Bayes approach improves on the t-statistic by not giving a high rank to genes only because they have a small sample variance, the basic assumption for this is same as the ordinary t-test which is the equality of variances across experimental groups. The t-test and empirical Bayes approach suffer from low statistical power because of the assumption of normal and unimodal distributions for the microarray data analysis. We propose a method to address these problems that is robust to outliers or skewed data, while maintaining the advantages of the classical t-test or modified t-statistics. The resulting data transformation to fit the normality assumption increases the statistical power for identifying DEGs using these statistics.

• 디지털융복합연구
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• 제19권3호
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• pp.353-361
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• 2021

고령화 사회에서 건강과 웰빙에 대한 요구 수준이 높아짐에 따라 의료 환경에서는 다양한 이해관계자가 얽힌 복잡한 문제가 발생한다. 본 논문의 목적은 여러 분야의 전문가들이 의료 환경에서 공동의 목표를 달성하기 위하여 협업하는 상황에서 디자이너의 역할과 능력을 알아내는 것이다. 학제간 접근법을 도입한 헬스케어 디자인 프로젝트에서의 효과적인 방법과 프로세스를 파악하기 위해 사례 연구를 진행하였다. 결과는 세 가지 연구 질문을 기반으로 프로세스 퍼실리테이션, 관계 관리, 시각화, 상상력과 같은 디자이너의 다면적인 역할을 분석하였다.

• 대한치과의사협회지
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• 제53권11호
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• pp.844-854
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• 2015

This clinical report describes an orthodontic-prosthodontic interdisciplinary treatment for a patient with multiple missing teeth and unilateral scissors bite. A 47-year-old female presented with multiple missing posterior teeth, anterior large overjet, deep bite, and posterior scissors bite on the right premolar area. Periodontal therapy was performed and followed by orthodontic treatment. The maxillary anterior teeth were initially aligned, then two implants were placed for the left mandibular molars to increase occlusal vertical dimension. The scissors bite between the right maxillary and mandibular premolars were corrected using the miniscrews as an anchorage. Other implants were placed for the right maxillary and mandibular molars after the occlusal planes and occlusal relationship were harmonized. The patient adapted well to altered vertical dimension without any specific problems including peri-implant marginal bone loss. Interdisciplinary approach resolve the complex orthodontic-prosthodontic problems and concluded in successful results.

• 보건교육건강증진학회지
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• 제7권1호
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• pp.1-9
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• 1990

This paper discusses a new perspective in health approach and the effect of health life on health status, and suggests some points to be improved in the establishment of health policies hereafter. Today's health problems changed from the acute epidemic diseases caused by simple factor to the multifactorial chronic diseases. Therefore, the health approach tries the holistic health approach, that is, the integrative approach by the interdisciplinary cooperation. With the advent of holistic health and holistic medicine in 1970's, the behavioral medicine was born in 1977, which is the interdisciplinary field concerned with the development and integration of behavioral and biomedical science knowledge and techniques relevent to prevention, diagnosis and treatment. As a means to the reducement of the unnecessary medical utilization and medical expense, the medical self care and self-help movement is well under way in the countries of America, England, and Canada, in which lay persons are encouraged to actively function for themselves to prevent, detect and treat common illnesses and to promote positive health habits through the health activation programs such as The Course for Activated Patients and The Health Activated Person. This study shows that the individual health life gives great positive effect to his health status with the reducement of medical expense. These above facts suggest that the preventive health programs such as health education should be developed and strengthened instead of medical care-oriented health policy.

• 정보과학회지
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• 제16권10호
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• pp.26-33
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• 1998