• Proceedings of the Earthquake Engineering Society of Korea Conference
• /
• 2001.04a
• /
• pp.120-127
• /
• 2001

Long term earthquake observations at different tunnel sites within a variety of alluvial soil deposits have demonstrated that a circular tunnel is liable to deform in such a way that its two diagonal diameters crossing each other expand and contract alternately. Based on this knowledge, the soil-tunnel interaction and isolation effect for this particular vibration mode is investigated. Interaction effect is considered with the condition of fixed tangential strain between the tunnel and the soil. Isolation effect embodied by covering up the tunnel with isolation materials is discussed as a possible measure for mitigating seismic damage to it. When Poisson`s ratio of isolation material decreases or the shear modulus ratios of the soil to isolation material become large, the isolation effect becomes bigger.

• Structural Engineering and Mechanics
• /
• v.45 no.5
• /
• pp.655-676
• /
• 2013

In this study, strength reduction factors and inelastic displacement ratios are investigated for SDOF systems with period range of 0.1-3.0 s considering soil structure interaction for earthquake motions recorded on soft soil. The effect of stiffness degradation on strength reduction factors and inelastic displacement ratios is investigated. The modified-Clough model is used to represent structures that exhibit significant stiffness degradation when subjected to reverse cyclic loading and the elastoplastic model is used to represent non-degrading structures. The effect of negative strain - hardening on the inelastic displacement and strength of structures is also investigated. Soil structure interacting systems are modeled and analyzed with effective period, effective damping and effective ductility values differing from fixed-base case. For inelastic time history analyses, Newmark method for step by step time integration was adapted in an in-house computer program. New equations are proposed for strength reduction factor and inelastic displacement ratio of interacting system as a function of structural period($\tilde{T}$, T) ductility (${\mu}$) and period lengthening ratio ($\tilde{T}$/T).

• Bulletin of the Korean Chemical Society
• /
• v.29 no.4
• /
• pp.736-740
• /
• 2008

The interaction of myelin basic protein (MBP) from bovine central nervous system with divalent calcium ion was studied by isothermal titration calorimetry at 27 ${^{\circ}C}$ in aqueous solution. The extended solvation model was used to reproduce the enthalpies of $Co^{2+}$-MBP interaction over the whole $Co^{2+}$ concentrations. The solvation parameters recovered from the solvation model were attributed to the structural change of MBP due to the metal ion interaction. It was found that there is a set of three identical and noninteracting binding sites for $Co^{2+}$ ions. The association equilibrium constant is 0.015 ${\mu}M^{-1}$. The molar enthalpy of binding is $\Delta$H = −14.60 kJ $mol^{-1}$.

• Journal of Information Science Theory and Practice
• /
• v.9 no.1
• /
• pp.79-89
• /
• 2021

This study explores Facebook use in Vietnamese academic libraries by analysing libraries' posts on their Facebook pages and library users' interaction with those posts. A total of 260 posts on four academic libraries' Facebook pages were examined using the content analysis method. The findings reveal that Facebook was mainly used to encourage reading and to transmit announcements. Most of the academic libraries published one post a week. The photo was the most frequent media type of libraries' posts and gained a higher level of interaction than other posts. According to the research results, the user engagement was low, and the user interaction with libraries' posts generally was in the form of reaction. The findings can help better understand Facebook use in Vietnamese academic libraries and may assist libraries in creating a plan for using Facebook more effectively.

• Korean Journal of Biological Psychiatry
• /
• v.6 no.1
• /
• pp.49-66
• /
• 1999

Polypharmacotherapy, both psychotropic and nonpsychotropic, is widespread in various situations including psychiatric hospitals and general hospitals. As the clinical practice of using more than one drug at a time increase, the clinician is faced with ever-increasing number of potential drug interactions. Although many interactions have little clinical significances, some may interfere with treatment or even be life-threatening. The objective of this review is evaluation for drug-drug interactions often encountered in psychiatric consultation. Drug interactions can be grouped into two principal subdivisions : pharmacokinetic and pharmacodynamic. These subgroups serve to focus attention on possible sites of interaction as a drug moves from the site of administration and absorption to its site of action. Pharmacokinetic processes are those that include transport to and from the receptor site and consist of absorption, distribution on body tissue, plasma protein binding, metabolism, and excretion. Pharmacodynamic interactions occur at biologically active sites. In psychiatric consultation, these two subdivisions of drug interactions between psychotropic drugs and other drugs are likely to happen. We gathered informations of the drugs used in physically ill patients who are consulted to psychiatric department in Korea University Hospital. And we reviewed the related literatures about the drug-drug interactions between psychotropic drugs and other drugs.

• BMB Reports
• /
• v.50 no.4
• /
• pp.226-231
• /
• 2017

At the post-transcriptional and translational levels, microRNA (miRNA) represses protein-coding genes via seed pairing to the 3' untranslated regions (UTRs) of mRNA. Although working models of miRNA-mediated gene silencing are successfully established using miRNA transfections and knockouts, the regulatory interaction between miRNA and long non-coding RNA (lncRNA) remain unknown. In particular, how the mRNA-resembling lncRNAs with 5' cap, 3' poly(A)-tail, or coding features, are regulated by miRNA is yet to be examined. We therefore investigated the functional interaction between miRNAs and lncRNAs with/without those features, in miRNA-transfected early zebrafish embryos. We observed that the greatest determinants of the miRNA-mediated silencing of lncRNAs were the 5' cap and 3' poly(A)-tails in lncRNAs, at both the post-transcriptional and translational levels. The lncRNAs confirmed to contain 5' cap, 3' poly(A)-tail, and the canonical miRNA target sites, were observed to be repressed in the level of both RNA and ribosome-protected fragment, while those with the miRNA target sites and without 5' cap and 3' poly(A)-tail, were not robustly repressed by miRNA introduction, thus suggesting a role as a miRNA-decoy.

• Journal of Korean Port Research
• /
• v.7 no.1
• /
• pp.13-24
• /
• 1993

The rapid progress of the intermodal freight transportation in recent years has induced fierce competition among the adjacent hub ports for container transport. This brings increased attention to the evaluation of the port competitive ability. But it is not easy to evaluate the port competitive ability because this belongs to ill-defined system which is composed of ambiguous interacting attributes. Paying attention to this point, this paper deals the competitive ability of container port in Far-East Asia by fuzzy integral evaluation which is adequate to interacting ambiguous attribute problem. For this, the proposed fuzzy evaluation algorithm is applied to the real problem, based on the factors such as cargo volumes, costs, services, infrastructure and geographical sites These are extracted from the precedent study of port competitive ability, etc. The results show that the port evaluation factors come in following order ; services, costs, infrastructure, geographical sites and cargo volumes. There are some interactions(interaction coefficient, ${\lambda}=-0.664$ between evaluation attributes. The port competitive ability comes in following order : Singapore, Hongkong, Kobe, Kaoshiung and Busan. According to the sensitivity analysis, the rank between Busan and Kaoshiung changes when ${\lambda}=0.7$. From the analysis of the results, we confirmed that the proposed fuzzy evaluation algorithm is very effective in the complex-fuzzy problem which is composed of hierarchical structure with interacting attributes.

• Transactions on Electrical and Electronic Materials
• /
• v.11 no.1
• /
• pp.11-14
• /
• 2010

The interaction of -$Al(CH_3)_2$ with -OH on a fully OH-terminated Si (001) surface was studied using density functional theory. Two sites for $Al(CH_3)_3$ to react with the -OH on the surface were identified. The $-Al(CH_3)_2$ product energetically favored the dimer-row site rather than the inter-row site because the Al atom of $-Al(CH_3)_2$ at the dimer-row site was attracted by the lone pair electrons of the O atom in the neighboring -OH. The energy barrier for the transfer of the $-Al(CH_3)_2$ between the two sites was 0.11 eV, and therefore, the $-Al(CH_3)_2$ at the inter-row site can easily transfer to the dimer-row site at room temperature.

• Nuclear Engineering and Technology
• /
• v.54 no.8
• /
• pp.2974-2988
• /
• 2022

Implementation of component isolation in nuclear industry is challenging due to gaps in research and the lack of specific guidelines. In this study, parameters affecting component-level isolation of advanced reactor vessels are identified based on a representative numerical model with explicit consideration of nonlinear soil-structure interaction (SSI). The objective of this study is to evaluate the effectiveness of, and to identify potential limitations of using conventional friction pendulum bearings to seismically isolate vessels. It is found that slender vessels or components are particularly vulnerable to rotational accelerations at the isolation interface, which are caused by rotation of the sub-structure and by excitation of higher modes in the horizontal direction of the seismically isolated system. Component isolation is found to be more effective for relatively stiffer vessels and at sites with stiff soil. Considering that conventional isolators are deficient in resisting axial tension, it is observed that the optimum location for supporting a component to achieve seismic isolation, is at a cross-sectional plane passing through the center of mass of the vessel. These findings are corroborated by numerous simulations of the response of seismically isolated reactor vessels at different nuclear power plant sites subject to a variety of ground motions.

• International Journal of Contents
• /
• v.18 no.3
• /
• pp.21-33
• /
• 2022

Previous research has provided inconsistent findings as to whether socially (in)competent individuals benefit from social networking sites (SNSs) use. Based on the rich-get-richer model, some studies have shown that socially competent individuals expand their existing networks even further via SNSs use. Based on the poor-get-richer model, other studies have shown that those with poor social skills can achieve beneficiary outcomes from SNSs use by overcoming their deficient social resources of offline environments. The present study is devised to add evidence regarding how and why social skills are related to SNSs use. To this end, we tested the relationships between social competence and three types of Facebook communication activities: interaction, self-presentation, and passive observation. Further, drawing on the social cognitive theory, the mediating role of outcome expectancy in the relationship between social competence and Facebook communication activities was examined. Using an online survey in South Korea (N = 708), it was found that individuals with higher social competence were more likely than those with lower social competence to engage in interaction, self-presentation, passive observation on Facebook. Moreover, these relationships were mediated by outcome expectancy that the desired social outcomes could be achieved as a result of Facebook use.