• Journal of Environmental Science International
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• v.17 no.6
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• pp.611-621
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• 2008

This study intends to provide the necessary basic data needed for predicting the water quality and examining changes in water quality on the basis of the hydrological changes: an outflow or the character of a flow by investigating the interaction of the parameters through the estimation of optimal parameters need for predicting the water quality of the dam basin and the sensitivity among those estimated parameters. Im-Ha Dam in the upstream area of the Nakdong River was selected for analysis, and the water quality survey data necessary for parameter estimation was based on the monthly water quality data (water temperature, BOD, T-N and T-P) between December 1, $2005{\sim}$November 31, 2006. K1C(the saturated growth rate of plant plankton), K1RC (endogenous respiratory quotient of plankton), KDC(deoxidized ratio), K71C(minealized ratio of dissolved organic phosphorus), K83C(mineralized ratio of dissolved organic nitrogen) have been considered as the factors of the water quality performed in this water quality simulation, that is, the most effective parameters on BOD, T-N and T-P. In the result of the analysis of the sensitivity, KDC(deoxidized ratio) was the most sensitively reacted parameter on BOD and it was K71C(mineralized ratio of dissolved organic phosphorus) and K83C(mineralized ratio of dissolved organic nitrogen) on T-N and T-P. It is considered that it will be possible to apply the most optimal parameter to an analysis of the water quality simulation at Im-Ha Ho basin in the goal year by examining the interaction of the parameters through the parameters sampling which are able to applicable to prediction of the water quality and the analysis of the its sensitivity, in the future, also the analysis on the basis of the hydrological conditions: an outflow or the character of a flow will be needed.

• Asian-Australasian Journal of Animal Sciences
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• v.13 no.2
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• pp.149-154
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• 2000

The objectives of this study of Hanwoo (Korean Cattle) were 1) to estimate genetic parameters for direct and maternal genetic effects for birth weight, weaning weight, and six months weight which can be used for genetic evaluations and 2) to compare models with and without grandmatemal effects. Data were obtained from the National Livestock Research Institute in Rural Development Administration (RDA) of Korea and were used to estimate genetic parameters for birth weight (BW, n=10,889), weaning weight at 120-d (WW, n=8,637), and six month weight (W6, n=8,478) in Hanwoo. Total number of animals in pedigrees was 14,949. A single-trait animal model was initially used to obtain starting values for multiple-trait animal models. Estimates of genetic parameters were obtained with MTDFREML using animal models and derivative-free REML (Boldman et al., 1995). Estimates of direct heritability for BW, WW, and W6 analyzed as single-traits were 0.09, 0.03, and 0.02 from Model 3 which included direct and maternal genetic, maternal permanental environmental effects, and effects due to sire ${\times}$ region ${\times}$ year-season interaction, respectively. Ignoring sire ${\times}$ region ${\times}$ year-season interaction effect in the model (Model 2) resulted in larger estimates for direct heritability than for Model 3. Estimates of maternal heritability for BW, WW and W6 were 0.04, 0.05, and 0.07 from Model 3, respectively. The estimates of direct-maternal genetic correlation were positive for BW, WW, and W6 with Model 3 but were negative with Model 2 for WW and W6. Estimates of direct genetic correlations between BW and WW, BW and W6, and WW and W6 were large: 0.52, 0.45, and 0.90, respectively. Genetic correlations were also large and positive for maternal effects for BW with maternal effects for WW and W6 (0.69 and 0.74), and even larger for WW with W6 (0.97). The log likelihood values were the same for models including grandmatemal effects as for models including maternal effects for all traits. These results indicate that grandmatemal effects are not important for these traits for Hanwoo or that the data structure was not adequate for estimating parameters for a grandmatemal model.

• Toxicological Research
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• v.33 no.1
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• pp.25-30
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• 2017

Saccharin, the first artificial sweetener, was discovered in 1879 that do not have any calories and is approximately 200~700 times sweeter than sugar. Saccharin was the most common domestically produced sweetener in Korea in 2010, and it has been used as an alternative to sugar in many products. The interaction between artificial sweeteners and drugs may affect the drug metabolism in patients with diabetes, cancer, and liver damage, this interaction has not been clarified thus far. Here, we examined the effects of the potential saccharin-drug interaction on the activities of 5 cytochrome P450 (CYPs) in male ICR mice; further, we examined the effects of saccharin (4,000 mg/kg) on the pharmacokinetics of bupropion after pretreatment of mice with saccharin for 7 days and after concomitant administration of bupropion and saccharin. Our results showed saccharin did not have a significant effect on the 5 CYPs in the S9 fractions obtained from the liver of mice. In addition, we observed no differences in the pharmacokinetic parameters of bupropion between the control group and the groups pretreated with saccharin and that receiving concomitant administration of saccharin. Thus, our results showed that saccharin is safe and the risk of saccharin-drug interaction is very low.

• Structural Engineering and Mechanics
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• v.58 no.6
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• pp.1045-1075
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• 2016

Shallow footings are one of the most common types of foundations used to support mid-rise buildings in high risk seismic zones. Recent findings have revealed that the dynamic interaction between the soil, foundation, and the superstructure can influence the seismic response of the building during earthquakes. Accordingly, the properties of a foundation can alter the dynamic characteristics (natural frequency and damping) of the soil-foundation-structure system. In this paper the influence that shallow foundations have on the seismic response of a mid-rise moment resisting building is investigated. For this purpose, a fifteen storey moment resisting frame sitting on shallow footings with different sizes was simulated numerically using ABAQUS software. By adopting a direct calculation method, the numerical model can perform a fully nonlinear time history dynamic analysis to realistically simulate the dynamic behaviour of soil, foundation, and structure under seismic excitations. This three-dimensional numerical model accounts for the nonlinear behaviour of the soil medium and structural elements. Infinite boundary conditions were assigned to the numerical model to simulate free field boundaries, and appropriate contact elements capable of modelling sliding and separation between the foundation and soil elements are also considered. The influence of foundation size on the natural frequency of the system and structural response spectrum was also studied. The numerical results for cases of soil-foundation-structure systems with different sized foundations and fixed base conditions (excluding soil-foundation-structure interaction) in terms of lateral deformations, inter-storey drifts, rocking, and shear force distribution of the structure were then compared. Due to natural period lengthening, there was a significant reduction in the base shears when the size of the foundation was reduced. It was concluded that the size of a shallow foundation influences the dynamic characteristics and the seismic response of the building due to interaction between the soil, foundation, and structure, and therefore design engineer should carefully consider these parameters in order to ensure a safe and cost effective seismic design.

• Coupled systems mechanics
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• v.3 no.3
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• pp.305-318
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• 2014

The study deals with the physical modeling of a typical building frame resting on pile foundation and embedded in cohesive soil mass using complete three-dimensional finite element analysis. Two different pile groups comprising four piles ($2{\times}2$) and nine piles ($3{\times}3$) are considered. Further, three different pile diameters along with the various pile spacings are considered. The elements of the superstructure frame and those of the pile foundation are descretized using twenty-node isoparametric continuum elements. The interface between the pile and pile and soil is idealized using sixteen-node isoparametric surface elements. The current study is an improved version of finite element modeling for the soil elements compared to the one reported in the literature (Chore and Ingle 2008). The soil elements are discretized using eight-, nine- and twelve-node continuum elements. Both the elements of superstructure and substructure (i.e., foundation) including soil are assumed to remain in the elastic state at all the time. The interaction analysis is carried out using sub-structure approach in the parametric study. The total stress analysis is carried out considering the immediate behaviour of the soil. The effect of various parameters of the pile foundation such as spacing in a group and number piles in a group, along with pile diameter, is evaluated on the response of superstructure. The response includes the displacement at the top of the frame and bending moment in columns. The soil-structure interaction effect is found to increase displacement in the range of 58 -152% and increase the absolute maximum positive and negative moments in the column in the range of 14-15% and 26-28%, respectively. The effect of the soil- structure interaction is observed to be significant for the configuration of the pile groups and the soil considered in the present study.

• Journal of the Korean GEO-environmental Society
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• v.10 no.6
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• pp.135-141
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• 2009

Fracturing technique using fluid injection into the borehole is widely used technology in the industry for the geothermal heat, oil, and gas extraction. Dealing with fluid-driven natural fractures such as dike and vein indirectly, design technology would be improved by adapting their principles. In this paper, mechanical interaction between the segments is evaluated by modeling highly segmented and closely spaced fluid-driven natural fractures. The number of segments is 71 with 3,339 measured apertures in which the interaction is considerably predicted. To evaluate mechanical interaction, boundary collocation method is used and the net pressure is calculated by using least square method to fit measured apertures. As a result, in case that mechanical interaction is considered, two pressures as fitting parameters are sufficient to capture measured apertures.

• Journal of the Society of Naval Architects of Korea
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• v.38 no.4
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• pp.11-22
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• 2001

The interaction between forward mounted propeller and wing in ground effect, and its aerodynamic performance are analyzed by potential flow approximation. A Vortex Lattice Method(VLM) for the propeller analysis and a potential based panel method for the WIG are used together with an image method by assuming the free surface as a rigid wall. The interaction of propeller and wing in the proximity of the ground is taken into account by an iterative procedure where the boundary conditions are satisfied with the given convergence criteria. The program developed is first checked by comparing its numerical results with the experimental data and other numerical results for the propeller MP101-rudder MR21 system. Then, the propeller-WIG interaction and its performance versus ground clearance are investigated by changing parameters such as propeller position, diameter and speed of revolution. It is shown that the forward mounted propeller increases the lift forces of the wing and also enhances the height stability, depending on the design parameter. Therefore, the appropriate selection of the design parameter such as propeller diameter, revolution, the longitudinal and vertical position of propeller is necessary.

• Journal of Microbiology and Biotechnology
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• v.23 no.1
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• pp.7-14
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• 2013

In the Bacillus amyloliquefaciens ${\alpha}$-amylase (BAA), the loop (residues 176-185; region I) that is the part of the calcium-binding site (CaI, II) has two more amino acid residues than the ${\alpha}$-amylase from Bacillus licheniformis (BLA). Arg176 in this region makes an ionic interaction with Glu126 from region II (residues 118-130), but this interaction is lost in BLA owing to substitution of R176Q and E126V. The goal of the present work was to quantitatively estimate the effect of ionic interaction on the overall stability of the enzyme. To clarify the functional and structural significance of the corresponding salt bridge, Glu126 was deleted (${\Delta}$E126) and converted to Val (E126V), Asp (E126D), and Lys (E126K) by site-directed mutagenesis. Kinetic constants, thermodynamic parameters, and structural changes were examined for the wild-type and mutated forms using UV-visible, atomic absoption, and fluorescence emission spectroscopy. Wild-type exhibited higher $k_{cat}$ and $K_m$ but lower catalytic efficiency than the mutant enzymes. A decreased thermostability and an increased flexibility were also found in all of the mutant enzymes when compared with the wild-type. Additionally, the calcium content of the wild-type was more than ${\Delta}E126$. Thus, it may be suggested that ionic interaction could decrease the mobility of the discussed region, prevent the diffusion of cations, and improve the thermostability of the whole enzyme. Based on these observations, the contribution of loop destabilization may be compensated by the formation of a salt bridge that has been used as an evolutionary mechanism or structural adaptation by the mesophilic enzyme.

• Membrane Journal
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• v.31 no.2
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• pp.145-152
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• 2021

While there are increasing demands on biomolecules separation, resin chromatography lacks in terms of throughput and membrane chromatography is an alternative with high binding capacity and enhanced mass transfer properties. Unlike typical membrane processing, where the performance can only be empirically assessed, understanding how mechanisms work in membrane chromatography is decisive to design biospecific processing. This short review covers three separation mechanisms, including affinity interaction modes for selectively capturing bulk molecules using biospecific sites, ion exchange modes for binding biomolecules using net charges and hydrophobic interaction modes for binding targeted, hydrophobic species. The parameters in designing membrane chromatography that should be considered operation-wise or material-wise, are also further detailed in this paper.

• Journal of the Earthquake Engineering Society of Korea
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• v.17 no.6
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• pp.257-269
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• 2013

In this study, the capability of an existing analysis method for the fluid-structure-soil interaction of an offshore wind turbine is expanded to account for the geometric nonlinearity and sea water drag force. The geometric stiffness is derived to take care of the large displacement due to the deformation of the tower structure and the rotation of the footing foundation utilizing linearized stability analysis theory. Linearizing the term in Morison's equation concerning the drag force, its effects are considered. The developed analysis method is applied to the earthquake response analysis of a 5 MW offshore wind turbine. Parameters which can influence dynamic behaviors of the system are identified and their significance are examined.