• Proceedings of the Korean Society for Bioinformatics Conference
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• 2004.11a
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• pp.265-271
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• 2004

The interaction network of protein -protein plays an important role to understand the various biological functions of cells. Currently, the high -throughput experimental techniques (two -dimensional gel electrophoresis, mass spectroscopy, yeast two -hybrid assay) provide us with the vast amount of data for protein-protein interaction at the proteome scale. In order to recognize the role of each protein in their network, the efficient bioinformatical and computational analysis methods are required. We propose a systematic and mathematical method which can analyze the protein -protein interaction network rigorously and enable us to capture the biological and physical essence of a topological character and stability of protein -protein network, and sensitivity of each protein along the biological pathway of their network. We set up a Laplacian matrix of spectral graph theory based on the protein-protein network of yeast proteome, and perform an eigenvalue analysis and apply a perturbation method on a Laplacian matrix, which result in recognizing the center of protein cluster, the identity of hub proteins around it and their relative sensitivities. Identifying the topology of protein -protein network via a Laplacian matrix, we can recognize the important relation between the biological pathway of yeast proteome and the formalism of master equation. The results of our systematic and mathematical analysis agree well with the experimental findings of yeast proteome. The biological function and meaning of each protein cluster can be explained easily. Our rigorous analysis method is robust for understanding various kinds of networks whether they are biological, social, economical...etc

• Korean Journal of Computational Design and Engineering
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• v.20 no.4
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• pp.337-347
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• 2015

This paper presents a dynamic association and natural interaction method for multi-displays composed of smart devices. Users can intuitively associate relations among smart devices by shake gestures, flexibly modify the layout of the display by tilt gestures, and naturally interact with the multi-display by multi-touch interactions. First of all, users shake their smart devices to create and bind a group for a multi-display with a matrix configuration in an ad-hoc and collaborative situation. After the creation of the group, if needed, their display layout can be flexibly changed by tilt gestures that move the tilted device to the nearest vacant cell in the matrix configuration. During the tilt gestures, the system automatically modifies the relation, view, and configuration of the multi-display. Finally, users can interact with the multi-display through multi-touch interactions just as they interact with a single large display. Furthermore, depending on the context or role, synchronous or asynchronous mode is available to them for providing a split view or another UI. We will show the effectiveness and advantages of the proposed approach by demonstrating implementation results and evaluating the method by the usability study.

• Structural Engineering and Mechanics
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• v.30 no.2
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• pp.165-176
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• 2008

In this paper, a new iterative method for solving vehicle-bridge interaction problems is proposed. Iterative methods have advantages over the non-iterative methods in that it is not necessary to update the system matrix for a given wheel location, and the method can be applied for a new type of car or bridge with few or no modifications. In the proposed method, the necessity of system matrices update is eliminated using the equivalent interaction force acting on the bridge, which is obtained iteratively. Ballast stiffness is included in the interaction forces and the geometric compatibility at the contact points are used as convergence criteria. The bridge is considered as an elastic Bernoulli-Euler beam with surface irregularity and ballast stiffness. The moving vehicle is modeled as a multi-axle mass-spring-damper system having many degrees of freedom depending on the number of axles. The pitching effect, which is the interaction effect between the rear and front wheels when a vehicle begins to enter or leave the bridge, is also considered in the formulation including extended ground boundaries having surface irregularity and ballast stiffness. The applicability of the proposed method is illustrated in the numerical studies.

• Interaction and multiscale mechanics
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• v.5 no.4
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• pp.385-397
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• 2012

In this paper the dynamic stiffness matrix method was used for the free vibration analysis of axially moving micro beam with constant velocity. The extended Hamilton's principle was employed to derive the governing differential equation of the problem using the modified couple stress theory. The dynamic stiffness matrix of the moving micro beam was evaluated using appropriate expressions of the shear force and bending moment according to the Euler-Bernoulli beam theory. The effects of the beam size and axial velocity on the dynamic characteristic of the moving beam were investigated. The natural frequencies and critical velocity of the axially moving micro beam were also computed for two different end conditions.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2005.11a
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• pp.301-305
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• 2005

This paper introduces a novel technique to detect and isolate the failures of multiple actuators connected to a system. Failure of actuator considered in this study could be any type of erroneous input that is different from commanded one. The interaction matrix technique allows the development of input-output equations that are only influenced by one target input. These input-output equations serve as an effective toot to monitor the integrity of each actuator regardless of the status of the other actuators. The method is capable of real-time actuator failure detection and isolation under any type of input excitation. The laboratory experiment using 8-bay NASA truss structure verifies the feasibility of the proposed method.

• Proceedings of the Computational Structural Engineering Institute Conference
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• 1989.04a
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• pp.17-21
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• 1989

SSI2D/3D is a computer program to calculate dynamic stiffness matrix of the foundation for soil-structure-interaction problem in frequency demain. It is written in FORTRAN 77 and applicable to two or three dimensional situations. In this paper the program structure is summarized. Two examples aye shown to demonstrate the possibilities of the Boundary Element Method applied to dynamic problems in infinite domains.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.29 no.1A
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• pp.31-43
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• 2009

In this study, the numerical method is presented, which can consider the various train types and can solve the equations of motion for a vehicle-bridge interaction analysis by non-iteration procedure through formulating the coupled equations of motion. The coupled equations of motion for the vehicle-bridge interaction are solved by the Newmark ${\beta}$ of a direct integration method, and by composing the effective stiffness matrix and the effective force vector according to a analysis step, those can be solved with the same manner of the solving procedure of equilibrium equations in static analysis. Also, the effective stiffness matrix is reconstructed by the Skyline method for increasing the analysis effectiveness. The Cholesky's matrix decomposition scheme is applied to the analysis procedure for minimizing the numerical errors that can be generated in directly calculating the inverse matrix. The equations of motion for the conventional trains are derived, and the numerical models of the conventional trains are idealized by a set of linear springs and dashpots with 16 degrees of freedom. The bridge models are simplified by the 3 dimensional space frame element which is based on the Euler-Bernoulli theory. The rail irregularities of vertical and lateral directions are generated by the PSD functions of the Federal Railroad Administration (FRA). The results of the vehicle-bridge interaction analysis are verified by the experimental results for the railway plate girder bridges of a span length with 12 m, 18 m, and the experimental and analytical data are applied to the low pass filtering scheme, and the basis frequency of the filtering is a 2 times of the 1st fundamental frequency of a bridge bending.

• Journal of Korean Society of Steel Construction
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• v.10 no.3 s.36
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• pp.437-449
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• 1998

In order that the steel girder and the concrete slab act as a composite structure, the connectors must have adequate strength and stiffness. If there are no horizontal or vertical separations at the interface, the connectors are described as rigid, and complete interaction can be said to exist under these idealized circumstances. However, all connectors are flexible to some extent, and therefore incomplete interaction always exists. This paper presents a practical structural analysis of composite girders with incomplete interaction by three methods. One is the stiffness matrix method derived from the general solutions of differential equation, another is the finite element analysis that alternate method of solution treats the structure as a frame and defines the spring as an additional member, and the other is the finite element analysis using principle of virtual work. The deflection characteristic of composite girder is investigated using these three methods. Also, this paper propose a simplified procedure of estimating a degree of imperfection for a composite girder with incomplete interaction using the sectional properties of girder and spring constants of shear connectors.

• Steel and Composite Structures
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• v.21 no.1
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• pp.195-216
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• 2016

The dynamic characteristics of continuous steel-concrete composite beams considering the effect of interlayer slip were investigated based on Euler Bernoulli's beam theory. A simplified calculation model was presented, in which the Mode Stiffness Matrix (MSM) was developed. The natural frequencies and modes of partial-interaction composite continuous beams can be calculated accurately and easily by the use of MSM. Proceeding from the present method, the natural frequencies of two-span steel-concrete composite continuous beams with different span-ratios (0.53, 0.73, 0.85, 1) and different shear connection stiffnesses on the interface are calculated. The influence pattern of interfacial stiffness on bending vibration frequency was found. With the decrease of shear connection stiffness on the interface, the flexural vibration frequencies decrease obviously. And the influence on low order modes is more obvious while the reduction degree of high order is more sizeable. The real natural frequencies of partial-interaction continuous beams commonly used could have a 20% to 40% reduction compared with the fully-interaction ones. Furthermore, the reduction-ratios of natural frequencies for different span-ratios two-span composite beams with uniform shear connection stiffnesses are totally the same. The span-ratio mainly impacts on the mode shape. Four kinds of shear connection stiffnesses of steel-concrete composite continuous beams are calculated and compared with the experimental data and the FEM results. The calculated results using the proposed method agree well with the experimental and FEM ones on the low order modes which mainly determine the vibration properties.

• Analytical Science and Technology
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• v.11 no.6
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• pp.495-498
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• 1998

The effect of high concentration ion matrix on the analysis of low anion concentration in the suppressed ion chromatography was studied. The anions studied were $Br^-$, $NO_3{^-}$, $HPO_4^{2-}$, $SO_4^{2-}$, and $C_2O_4^{2-}$ in the presence of excess NaCl and $CaCl_2$. In this study we suggested that the erroneous results in the suppressed ion chromatographic determination of small concentration of anions were not caused by the interaction of large amount of cation in the suppressor, but by the interaction of cation with concerned anion in the original solution. The error in the analysis of such anion can not be eliminated just by dilution. Therefore, we suggested that standard addition method might be adequate for analyses of those samples.