• 대한조선학회지
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• 제27권1호
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• pp.24-34
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• 1990

본 연구에서는 축력과 굽힘모멘트의 조합하중(組合荷重)을 받는 손상원통부재의 최종강도(最終强度)를 해석하기위하여 간이유한요소해석이론을 정식화한다. 여기서, 굽힘 및 국부손상이 존재하는 원통부재(圓筒部材)를 보요소로 모델링하며, 각요소의 접선탄성강성행렬(接線彈性剛性行列)은 기하학적 비선형 효과를 고려하여 updated Lagrangian 기법에 의하여 도출한다. 이때, 국부손상부위의 강성이 외력에 대한 저항에 기여하는 정도는 비교적 작다고 생각되므로 요소의 강성평가시에 국부손상부위의 강성은 무시한다. 요소의 소성화는 국부손상부위의 영향을 고려한 전단면(全斷面) 소성강도(塑性强度) 상관관계식을 적용하여 요소의 각절점에서 판정하며, 접선(接線) 탄소성(彈塑性) 강성행렬(剛性行列)은 소성절점법(塑性節點法)에 의하여 계산한다. 마지막으로 본 연구에서 정식화한 해석법을 바탕으로 컴퓨터프로그램을 작성하고 실험 등에 의하여 얻어진 기존의 결과에 대해 재해석하여 본해석법의 정도와 유용성을 확인한다.

• Bulletin of the Korean Chemical Society
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• 제30권12호
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• pp.2962-2968
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• 2009

The photodissociation dynamics of 1,2-bromochloroethane ($C_2H_4BrCl$) was investigated near 234 nm. A two-dimensional photofragment ion-imaging technique coupled with a [2+1] resonance-enhanced multiphoton ionization scheme was utilized to obtain speed and angular distributions of the nascent Br($^2P_{3/2}$) and Br${\ast}($^2P_{1/2}$) atoms. The total translational energy distributions for the Br and Br${\ast}$ channels were well characterized by Gaussian functions with average translational energies of 100 and 84 kJ/mol, respectively. The recoil anisotropies for the Br and Br${\ast}$ channels were measured to be ${\beta}$ = 0.49 ${\pm}$ 0.05 for Br and 1.55 ${\pm}$ 0.05 for Br${\ast}$. The relative quantum yield for Br${\ast}$ was found to be ${\Phi}_{Br{\ast}}$ = 0.33 ${\pm}$ 0.03. The probability of nonadiabatic transition between A' states was estimated to be 0.46. The relevant nonadiabatic dynamics is discussed in terms of interaction between potential energy surfaces in Cs symmetry.

• 대한본초학회지
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• 제21권1호
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• pp.1-7
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• 2006

Objectives: To find out the effects GGT1, an antiobestic drug widely used clinics, has on the amount of feed intake, the amount of change in the body weight and the food efficiency ratio using the data from the hGHTg obese male rats. Also, to evaluate in terms of antiobestic effects, the difference between GGT1 and reductil (sibutramine), which has been approved by the FDA of the United States. Methods: We measured the change in body weight and the amount of feed intake for 8 weeks by categorizing the hGHTg obese male rats into three groups: the control group, the GGT1 group, and the reductil (RD) group. We also evaluated the antiobestic effect by calculating the food efficiency ratio, which is the increase of bodyweight divided by the amount of feed intake. Results: In case of body weight, moderate slope of the curve in the graph of GGT1 group could mean that the weight is decreasing as time flows. In case of food efficiency ratio, the p-value was 0.745 in a test for determining if an interaction exists between the group and the point of measurement, meaning that it does not exist; also, the p-value in a test for the effect of level of repetition in food efficiency ratio according to the point of measurement equaled 0.002. Conclusion: The drug-treated groups had a greater inhibitory effect in feed intake than the control group. The results showed the food efficiency ratio had a tendency to decrease. The GGT1 group in particular was under a greater effect than the RD group.

• 한국임상약학회지
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• 제20권1호
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• pp.25-29
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• 2010

The purpose of this study was to investigate the effect of atorvastatin on the pharmacokinetics of nifedipine (6 mg/kg) after oral administration of nifedipine with or without atorvastatin (0.5 and 2.0 mg/kg) in rats, and also was to evaluate to the effect of atorvastatin on the CYP3A4 activity. The 50% inhibiting concentration ($IC_{50}$) values of atorvastatin on CYP3A4 activity is 46.1 ${\mu}M$. Atorvastatin inhibited CYP3A4 enzyme activity in a concentration-dependent manner. Coadministration of atorvastatin increased significantly (p<0.05, 2.0 mg/kg) the plasma concentration-time curve (AUC) and the peak concentration ($C_{max}$) of nifedipine compared to the control group. The relative bioavailability (RB%) of nifedipine was increased from 1.15- to 1.37-fold. Coadministration of atorvastatin did not significantly change the terminal half-life ($T_{1/2}$) and the time to reach the peak concentration ($T_{max}$) of nifedipine. Based on these results, we can make a conclusion that the significant changes of these pharmacokinetic parameters might be due to atorvastatin, which possesses the potency to inhibit the metabolizing enzyme (CYP3A4) in the liver and intestinal mucosa, and also inhibit the P-glycoprotein (P-gp) efflux pump in the intestinal mucosa. It might be suggested that atorvastatin altered disposition of nifedipine by inhibition of both the first-pass metabolism and P-glycoprotein efflux pump in the small intestine of rats. In conclusion, the presence of atorvastatin significantly enhanced the oral bioavailability of nifedipine, suggesting that concurrent use of atorvastatin with nifedipine should require close monitoring for potential drug interation.

• 한국전기전자재료학회논문지
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• 제21권9호
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• pp.835-843
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• 2008

We have fabricated the source-drain electrodes for OTFTs by screen printing method and manufactured Ag pastes as conductive paste. To obtain excellent conductivity and screen-printability of Ag pastes, the dispersion characteristics of Ag pastes prepared from two types of acryl resins with different molecular structures and Ag powder treated with caprylic acid, triethanol amine and dodecane thiol as surfactant respectively were investigated. The Ag pastes containing Ag powder treated with dodecane thiol having thiol as anchor group or AA4123 with carboxyl group(COOH) of hydrophilic group as binder resin exhibited excellent dispersity. But, Ag pastes(CA-41, TA-41, DT-41) prepared from AA4123 fabricated the insulating layer since the strong interaction between surface of Ag powder and carboxyl group(COOH) of AA4123 interfered with the formation of conduction path among Ag powders. The viscosity behavior of Ag pastes exhibited shear-thinning flow in the high shear rate range and the pastes with bad dispersion characteristic demonstrated higher shear-thinning index than those with good dispersity due to the weak flocculated network structure. The output curve of OTFT device with a channel length of 107 ${\mu}m$ using screen-printed S-D electrodes from DT-30 showed good saturation behavior and no significant contact resistance. And this device exhibited a saturation mobility of $4.0{\times}10^{-3}$ $cm^2/Vs$, on/off current ratio of about $10^5$ and a threshold voltage of about 0.7 V.

• Journal of Pharmaceutical Investigation
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• 제34권4호
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• pp.283-288
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• 2004

The pharmacokinetics of nifedipine was studied after oral coadministration of nifedipine (5 mg/kg) with quercetin (1.5, 7.5, 15 and 30 mg/kg, respectively) and 0.5 h or 3days pretreatment with quercetin (1.5 and 7.5mg/kg) in rabbits. Pretreatment of quercetin significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) increased the plasma concentration of nifedipine, but not significant in coadministraiton. The area under the plasma concentration-time curve (AUC) and the peak concentration $(C_{max})$ of nifedipine pretreated with quercetin were increased significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) compared to the control. By coadministration of quercetin, only 7.5 mg/kg of quercetin increased plasma AUC and $C_{max}$ of nifedipine significantly (p<0.05) compared to the control. Plasma AUC of intravenous nifedipine (1 mg/kg) is $4235\;{\pm}\;1192\;ng/ml{\cdot}hr$. Pretreatment of quercetin significantly (p<0.05, at 0.5 h; p<0.01, at 3 days) increased the absolute bioavailability (AB%) of nifedipine to 23.9-29.2% compared to the control (17.8%). Coadministration of quercetin showed no significant effect on the AB% of nifedipine except for 7.5 mg/kg. It is suggested that quercetin alters disposition of nifedipine by inhibition of P-glycoprotein efflux pump and its first-pass metabolism. The dosage of nifedipine should be adjusted when it is administered chronically with quercetin in a clinical situation.

• Clinical and Experimental Pediatrics
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• 제64권2호
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• pp.80-85
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• 2021

Background: Although identifying cases in large administrative databases may aid future research studies, previous reports demonstrated that the use of the International Classification of Diseases, Tenth Revision (ICD-10) code alone for diagnosis leads to disease misclassification. Purpose: We aimed to assess the value of the ICD-10 diagnostic code for identifying potential children with biliary atresia. Methods: Patients aged <18 years assigned the ICD-10 code of biliary atresia (Q44.2) between January 1996 and December 2016 at a quaternary care teaching hospital were identified. We also reviewed patients with other diagnoses of code-defined cirrhosis to identify more potential cases of biliary atresia. A proposed diagnostic algorithm was used to define ICD-10 code accuracy, sensitivity, and specificity. Results: We reviewed the medical records of 155 patients with ICD-10 code Q44.2 and 69 patients with other codes for biliary cirrhosis (K74.4, K74.5, K74.6). The accuracy for identifying definite/probable/possible biliary atresia cases was 80%, while the sensitivity was 88% (95% confidence interval [CI], 82%-93%). Three independent predictors were associated with algorithm-defined definite/probable/possible cases of biliary atresia: ICD-10 code Q44.2 (odds ratio [OR], 2.90; 95% CI, 1.09-7.71), history of pale stool (OR, 2.78; 95% CI, 1.18-6.60), and a presumed diagnosis of biliary atresia prior to referral to our hospital (OR, 17.49; 95% CI, 7.01-43.64). A significant interaction was noted between ICD-10 code Q44.2 and a history of pale stool (P<0.05). The area under the curve was 0.87 (95% CI, 0.84-0.89). Conclusion: ICD-10 code Q44.2 has an acceptable value for diagnosing biliary atresia. Incorporating clinical data improves the case identification. The use of this proposed diagnostic algorithm to examine data from administrative databases may facilitate appropriate health care allocation and aid future research investigations.

• Steel and Composite Structures
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• 제30권5호
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• pp.443-456
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• 2019

Although numerous researchers demonstrated the significant difference in performance between the various beam-to-column connection types, most of the previous studies in the area of infilled steel frames focused on the behaviour of frames with welded connections. Therefore, there is a need for conducting studies on infilled steel frames with other common connection types (extended endplate with and without rib stiffeners, flush endplate and shear connections). In this paper, firstly, a two-dimensional finite-element model simulating the cyclic response of infilled steel frames was presented. The infill-frame interaction, as well as the interactions between connections' components, were properly modelled. Using the previously-validated model, a parametric study on infilled steel frames with five different beam-to-column connection types, under cyclic loading, was carried out. Several parameters, including infill material, fracture energy of masonry and infill thickness, were investigated. The results showed that the infilled frames with welded connections had the highest initial stiffness and load-carrying capacity. However, the infilled frames with extended endplate connections (without rib stiffeners) showed the greatest energy dissipation capacity and about 96% of the load-carrying capacity of frames with welded connections which indicates that this type of connection could have the best performance among the studied connection types. Finally, a simplified analytical model for estimating the stiffness and strength of infilled steel frames (with different beam-to-column connection types) subjected to lateral cyclic loading, was suggested.

• 천문학회보
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• 제44권1호
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• pp.84.2-84.2
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• 2019

We present the absolute properties of the double-lined eclipsing binary KIC 6206751 exhibiting multiperiodic pulsations. The Kepler light curve of this system was simultaneously solved with the previously published radial-velocity data. The results indicate that the binary star is a short-period semi-detached system with fundamental parameters of $M_1=1.66{\pm}0.04M_{\odot}$, $M_2=0.215{\pm}0.006M_{\odot}$, $R_1=1.53{\pm}0.02R_{\odot}$, $R_2=1.33{\pm}0.02R_{\odot}$, $L_1=5.0{\pm}0.6L_{\odot}$, and $L_2=0.96{\pm}0.09L_{\odot}$. We applied multiple frequency analyses to the eclipse-subtracted light residuals and detected the 42 frequencies below $2.5days^{-1}$. Among these, three independent frequencies of $f_2$, $f_3$, and $f_4$ can be identified as high-order ($38{\leq}n{\leq}40$) low-degree (l=2) gravity-mode oscillations, whereas the other frequencies may be orbital harmonics and combination terms. The ratios between the orbital frequency and the pulsation frequencies are $f_{orb}:f_{2-4}{\simeq}2:3$, which implies that the ${\gamma}$ Dor pulsations of the detached primary star may be excited by the tidal interaction of the secondary companion. The short orbital period, and the low mass ratio and $M_2$ demonstrate that KIC 6206751 is an R CMa-type star, which is most likely evolving into an EL CVn star. Of seven well-studied R CMa-type stars, our program target is the only eclipsing binary with a ${\gamma}$ Dor pulsating component.

• 대한수의학회지
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• 제60권4호
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• pp.209-213
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• 2020

This study examined the residue of dl-methylephedrine hydrochloride (MEP) on the muscle of pigs administered orally with MEP 12 g/ton feed for seven consecutive days. Twenty healthy cross swine were administered MEP. Four treated animals were selected arbitrarily to be sacrificed at 1, 2, 3, 4, and 5 days after treatment. MEP residue concentrations in the muscle were determined by liquid chromatography coupled with tandem mass spectrometry. The drug was extracted from muscle samples using 10 mM ammonium formate in acetonitrile followed by clean-up with n-hexane. The analyte was separated on an XBridgeTM hydrophilic interaction liquid chromatography column using 10 mM ammonium formate in deionized distilled water and acetonitrile. The correlation coefficient (R2) of the calibration curve was 0.9974, and the limits of detection and quantification were 0.05 and 0.15 ㎍/kg, respectively. The recoveries at three spiking levels were 94.5-101.2%, and the relative Standard Deviations was less than 4.06%. In the MEP-treated group, MEP residues on one day post-treatment were below the maximum residue limit in the muscle. The developed method is sensitive and reliable for the detection of MEP in porcine muscle tissues. Furthermore, it exhibits low quantification limits for animal-derived food products destined for human consumption.