• Title/Summary/Keyword: integrative korean medicine

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Canavalia gladiata regulates the immune responses of macrophages differently depending on the extraction method

  • Lee, Ha-Nul;Kim, Young-Min;Jang, Ah-Ra;Kim, Young Ran;Park, Jong-Hwan
    • Korean Journal of Food Science and Technology
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    • v.52 no.6
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    • pp.622-626
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    • 2020

  • Recent studies have suggested that Canavalia gladiate, a dietary food and traditional folk medicine, has promising pharmaceutical potential, but the effects have mostly been demonstrated using its organo-soluble extract. To date, its immunomodulatory effect depending on the extraction method is unclear. Here, the immune responses of macrophages to C. gladiate and the underlying mechanisms were studied. C. gladiate hot water extract (CGW) induced cytokine production in bone marrow-derived macrophages (BMDMs) in a dose-dependent manner, whereas its ethanolic extract (CGE) did not. Immunoblotting analysis also showed that CGW activated nuclear factor (NF)-κB and mitogen-activated protein kinases (MAPKs). Moreover, an inhibitor assay revealed the involvement of NF-κB, p38, and JNK, but not ERK, in CGW-induced cytokine production. CGE inhibited lipopolysaccharide-stimulated production of pro-inflammatory cytokines and activation of NF-κB and MAPKs in BMDMs. The results suggest that C. gladiate regulates the immune responses of macrophages differently depending on the extraction method.

  • https://doi.org/10.9721/KJFST.2020.52.6.622 인용 PDF KSCI

Multi-Phasic Mental Health Characteristics according to Harm-Avoidance and Self-Directedness Profile of Cloninger's Biopsychosocial Model (클로닌저의 생리심리사회 모델에서 위험회피-자율성 프로파일에 따른 다면적 정신건강 특성)

  • Chae, Han;Lee, Soo Jin
    • Journal of Oriental Neuropsychiatry
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    • v.33 no.3
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    • pp.259-266
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    • 2022

  • Objectives: The combination of Harm-Avoidance (HA) and Self-Directedness (SD) of Temperament and Character Inventory (TCI) has been reported pivotal for mental health; however its clinical usefulness in integrative medicine has not sufficiently reported. The purpose of this study was to illustrate multi-phasic mental health of subjective satisfaction with life, emotional well-being, and psychopathology, following the HA-SD profile groups. Methods: A total of 527 Korean university students reported HA and SD scores as to render their HA-SD profile, and multi-phasic mental health characteristics using Satisfaction with Life Scale (SWLS), Positive Affect and Negative Affect Schedule (PANAS), and Beck Depression Inventory (BDI) with composite well-being scales of SC (Sum of Self-Directedness and Cooperativeness score) and HI (Happiness Index, subtraction of Negative Affect (NA) score from Positive Affect (PA) score) as standardized. Pearson's correlation was used to report correlation coefficient, and the ANCOVA with age and sex as covariates, to show significant differences in mental health and well-being between the HA-SD profile groups. Results: The HA-SD profile groups showed distinctive multi-phasic mental health characteristics; health related scores of SWLS, PA, SC and HI decreased following the order of hS (low HA and high SD), HS (high HA and high SD), hs (low HA and low SD) and Hs (high HA and low SD) profile groups; however the non-health related scores of NA and BDI showed contrasting order. Conclusions: The HA-SD profile was found to be clinically useful for examining multi-phasic mental health and well-being status, and the TCI may be an imperative personality inventory for integrative medicine.

  • https://doi.org/10.7231/jon.2022.33.3.259 인용 PDF KSCI KPUBS