• Proceedings of the Zoological Society Korea Conference
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• 2001.10a
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• pp.255.2-255
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• 2001

No Abstract, See Full Text

• Journal of Contemporary Eastern Asia
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• v.12 no.1
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• pp.49-63
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• 2013

This work identifies the key factors influencing the success of multidisciplinary, interdisciplinary, and trans-disciplinary R&D projects in transition economies by integrating knowledge management, organizational, inter/intra-collaboration (open-innovation), and leadership perspectives, while also addressing the perspective of the science of team science, which is an integrative approach to R&D. This is followed by providing the major sub-constructs of team science and policy implications to better facilitate multidisciplinary, interdisciplinary, and transdisciplinary R&D projects in knowledge-based transition economies.

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2012.04a
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• pp.439-440
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• 2012

New analysis methods complement classical approaches in the vehicle NVH development by reducing and accelerating iteration steps to obtain a target sound. Therefore, tools are required that allow an integrative approach of sound engineering and structural analysis and enable a precise simulation and modification based on measured data. The Response Modification Analysis (RMA) is such a hybrid solution, which provides indications of relevant transfer paths taking into account the sensitivity of response channels to modifications of reference channels.

• BMB Reports
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• v.44 no.4
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• pp.250-255
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• 2011

In multicellular organisms, including humans, understanding expression specificity at the tissue level is essential for interpreting protein function, such as tissue differentiation. We developed a prediction approach via generated sequence features from overrepresented patterns in housekeeping (HK) and tissue-specific (TS) genes to classify TS expression in humans. Using TS domains and transcriptional factor binding sites (TFBSs), sequence characteristics were used as indices of expressed tissues in a Random Forest algorithm by scoring exclusive patterns considering the biological intuition; TFBSs regulate gene expression, and the domains reflect the functional specificity of a TS gene. Our proposed approach displayed better performance than previous attempts and was validated using computational and experimental methods.

• Journal of the Korean BIBLIA Society for library and Information Science
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• v.21 no.1
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• pp.89-103
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• 2010

Study on users which was done centering information approach, acquisition and interoperability between users and information systems need to be studied in the perspective of information behavior including information acquisition and sharing behavior in the changing information environment. In order to analyze users' information acquisition and sharing behavior's demands, motives and processes in libraries and internet environments, integrated approach of both qualitative and quantitative study were tried by applying Wilson's information behavior concept. Plans for the improvement of information services were suggested on the basis of integrative analysis.

• BMB Reports
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• v.37 no.1
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• pp.53-58
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• 2004

With advances in determining the entire DNA sequence of the human genome, it is now critical to systematically identify the function of a number of genes in the human genome. These biological challenges, especially those in human diseases, should be addressed in human cells in which conventional (e.g. genetic) approaches have been extremely difficult to implement. To overcome this, several approaches have been initiated. This review will focus on the development of a novel 'chemical genetic/genomic approach' that uses small molecules to 'probe and identify' the function of genes in specific biological processes or pathways in human cells. Due to the close relationship of small molecules with drugs, these systematic and integrative studies will lead to the 'medicinal systems biology approach' which is critical to 'formulate and modulate' complex biological (disease) networks by small molecules (drugs) in human bio-systems.

• Korean Journal of Biological Psychiatry
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• v.9 no.2
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• pp.79-94
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• 2002

Polarisation of biological and psychosocial aspects of psychiatry is nowadays main stream. Current knowledges of the interaction between biology and psychology make it possible to consider a truly integrative approach of the two aspects. Research findings suggest that the neuronal plasticity is the key mechanism to answer how the mental function work to an environmental stimuli and how the psychotherapeutic approach work on the brain. Advances in neuroscience research have led to a more sophisticated understanding of how psychotherapy may affect brain function. Even though there have been a tremendous efforts to find out the neurobiological mechanism of mental function, the answer is at best premature. In this article, research findings about of neuronal plasticity, implicit memory, animal studies which were associated with psychotherapy and psychological aspects were reviewed.

• Journal of Korea Society of Digital Industry and Information Management
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• v.10 no.1
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• pp.29-38
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• 2014

EDMS systems have been a main alternative for enterprise content management (ECM), which provide valuable functions for the effective control and management of organization-level digital contents. However, it has not been effective frequently for the purpose of integrative control of overall contents in an organization. One of reasons for this problem is that individuals usually create and store files with their own personal computers and do not move them to the central storage and control device, EDMS. Many occasions show that this situation can cause undesirable results for better management of enterprise contents. This paper introduced an approach of virtual folder which can directly connect individual computers and EDMS storage device without users' inconvenience. Adding the capacity of restricting usage of individual computer, users unavoidably and conveniently store and retrieve digital contents using EDMS server system. Several modules and implementing architecture for the virtual folder system are shown and the results of utilizing the system are explained with a case of application.

• Journal of Power Electronics
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• v.2 no.4
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• pp.231-239
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• 2002

This paper describes the restructuring of power electronics and electric drives courses, sponsored by NSF, EPRI, NASA and the local utilities, which has significantly increased student enthusiasm, and the undergraduate enrollment in these courses at the University of Minnesota has tripled since 1997. The developed leaching approaches have been the subject of NSF-sponsored faculty workshops in 1994, 1997, 1998,2002, and 2003. In power electronics, the power-pole based building-block approach unifies analysis and control aspects of all converters. PSpice-based simulations aid in analysis and design, supported by a hardware laboratory. For electric drives, an integrative approach addressing all three aspects of electric drives - machines, power converters and control is being. used. Space vectors, introduced on a physical basis rather than purely mathematical ions, are used fur analysis of ac machines. This leads to a more physical understanding of machine operation and also makes it easier to address control aspects in the advanced course. The lecture materials are supported by a DSP-based laboratory.

• Microbiology and Biotechnology Letters
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• v.51 no.1
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• pp.109-123
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• 2023

Preterm birth (PTB) is defined as giving birth prior to the 37th week of pregnancy and is a major cause of infant mortality. Studies have indicated that the vaginal microbiota's composition and its dysbiosis, particularly during pregnancy, may play a major role in PTB. While previous research work concentrated on well-studied microorganisms such as Lactobacillus, Prevotella, Gardnerella, various other microbes, and their significance in the vaginal microbiota's stability remain unknown. Moreover, current studies have focused primarily on the relative abundances of the microbes found, without considering their interactions with other members of the vaginal microbiota. In this work, we developed a novel computational approach and performed taxonomic classification of vaginal microbiota samples stratified longitudinally (Term/PTB) to observe compositional disparities and find underexamined microbes that may be contributing to PTB. Furthermore, we carried out a correlational analysis to build a microbial co-interaction network and investigated the functional implications of the genes present in both Term and PTB samples. The co-occurrence network revealed that Lactobacillus acts in solidarity to maintain the stability of the vaginal microbiota and did not have strong co-interactions with any of the other microbes. Similarly, microbes with strong interactions with Atopobium, a well-known marker microbe of PTB, were also observed. Additionally, several genes such as PTXA, FANCM, GPX, and DUSP were found to be playing an important role in the occurrence of PTB. This study provides a novel conceptual framework revealing distinct vaginal microbiota signatures that could be potential therapeutic targets for the prevention of PTB.