• Molecules and Cells
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• v.44 no.7
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• pp.433-443
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• 2021

Multi-omics approaches are novel frameworks that integrate multiple omics datasets generated from the same patients to better understand the molecular and clinical features of cancers. A wide range of emerging omics and multi-view clustering algorithms now provide unprecedented opportunities to further classify cancers into subtypes, improve the survival prediction and therapeutic outcome of these subtypes, and understand key pathophysiological processes through different molecular layers. In this review, we overview the concept and rationale of multi-omics approaches in cancer research. We also introduce recent advances in the development of multi-omics algorithms and integration methods for multiple-layered datasets from cancer patients. Finally, we summarize the latest findings from large-scale multi-omics studies of various cancers and their implications for patient subtyping and drug development.

• Transactions of the Korean Society of Mechanical Engineers A
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• v.21 no.9
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• pp.1373-1384
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• 1997

There have been a number of expert systems which are concerned with the design of machine elements such as gear, shaft, bearing and so on. However the design of more complicated systems such as gear dreives are still difficult. Thus, in consideration of the integrative nature of the system, we develop a design support system for gear drives which is composed of various machine elements-gear, shaft, bearing, key and so on. Design systems for each machine element are developed and integrated through object-oriented approach. Databases essential for data reference and/or data control in the design process are built up independently and interface to the main program. Expert systems are also developed and integrated for intelligent support to the designer, in those of the determination of gear specification and the selection of bearing types. Through the integration of design environment for each machine element, it is expected to increase the convenience in the design process and the stability of the design solution. And also the system management, including addition of various design/analysis modules and expansion to the gear drives of other types, can be conveniently achieved since the system has developed under due consideration of its efficiency and expandability through object-oriented programming approach.

• Journal of Pharmacopuncture
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• v.16 no.1
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• pp.12-20
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• 2013

Objective: Standard cancer therapy prolongs survival, but can be detrimental to the quality of life, compromise the immune system, and leave residual disease that can cause recurrence years or decades in the future. Tumor dormancy therapy is a novel therapeutic approach that may improve these shortcomings, promote quality of life, and prolong survival. The aim of this study was to analyze studies on dormancy therapy, especially studies using traditional Oriental herbal medicine, so as to evaluate the efficacy of dormancy therapy with traditional oriental herbal medicine. Methods: We conducted a systematic literature review using Scientific and Technical Information Integration Services (NDSL), PubMed, and RISS. We searched for clinical reports, papers, and books related to tumor metastasis, recurrence, immunotherapy, tumor dormancy, and traditional oriental herbal medicine with anticancer effects. Seventy-nine (79) experimental and clinical articles in both Korean and English were reviewed. This study was conducted from March 1, 2012 to May 31, 2012. Results: This approach, Tumor dormancy therapy, rather than seeking to remove the tumor, includes combination of low-dose chemotherapy, immunotherapy, immunosurveillance, and other methods to stabilize tumor growth and to enhance the host is immunity against disseminated tumor cells and thus to manage cancer as a chronic disease while maintaining quality of life. In particular, integrative use of Oriental herbal medicine has been shown to induce or maintain tumor dormancy, increase the effectiveness of conventional chemotherapy, improve quality of life, and prolong survival. Conclusion: Tumor dormancy therapy is a promising novel therapeutic approach that may be especially effective with Oriental herbal medicine. Further research is needed to determine its potential mechanisms and therapeutic applications.

• Journal of Global Scholars of Marketing Science
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• v.15 no.3
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• pp.93-116
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• 2005

This study explored factors affecting consumer's external information search effort on online shopping malls through three approaches(cost-benefit approach, psychological motivation approach, and web-site theory approach) respectively, and designed the integrative model through searching the relationships among them. In this study search motivation are designed to be explained by search benefit and search cost that are explained by factors related to the web site and search efforts are designed to be explained by search benefit, search cost and search motivation. The results from our empirical research showed that search motivation, search benefits and prior knowledge on online shopping malls have a direct effect on consumer external information search effort. On the other hand, it was verified that the search motivation was affected by search benefits and purchase involvement, and the search benefits are directly influenced by purchase involvement, constructive simplicity, search convenience and trust. In addition, purchase involvement, time press, constructive simplicity and search convenience had direct effects on the search cost.

• Animal cells and systems
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• v.16 no.4
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• pp.329-336
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• 2012

This study evaluated ecological health, using various biomarkers and bioindicators, of pale chub (Zacco platypus) as a sentinel species, in Daejeon Stream, South Korea, during AprilMay 2011. The biomarkers and bioindicators were compared among three sites of control: Reference ($C_z$), transition ($T_z$), and the urban zones ($U_z$); and the 7-Ethoxyresorufin-O-deethylase (EROD) activity, DNA damage, acetylcholinesterase (AChE) activity, and vitellogenin (VTG) concentrations were more significantly increased in the $U_z$ than in the $C_z$. Also, physiological markers such as condition factor, liver somatic index, visceral somatic index, and gonad somatic index were significantly increased in the $U_z$ than in the $C_z$. For the health assessments, three categorized parameters of blood chemistry, molecular biomarkers, and physiological bioindicators were standardized and calculated as a star-plot, representing values of Integrated Health Response (IHR). Values of IHR had more significant (P<0.05) increases in the $U_z$ than any other zones, indicating an impairment of ecological health by organic matter, nutrients (N, P), and toxic chemicals. This study is based on low levels of biological organization approach of molecular and physiological biomarkers and bioindicators, so further study of high-levels of biological organization approach such as community and population is required for overall range of health assessments. The approach of IHR values, however, may be useful in providing early warning of future impacts on ecological health.

• Journal of Ginseng Research
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• v.44 no.3
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• pp.453-460
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• 2020

Background: BIOGF1K, a fraction of Panax ginseng, has desirable antimelanogenic, anti-inflammatory, and antiphotoaging properties that could be useful for treating skin conditions. Because its potential positive effects on allergic reactions in skin have not yet been described in detail, this study's main objective was to determine its efficacy in the treatment of atopic dermatitis (AD). Methods: High-performance liquid chromatography was used to verify the compounds in BIOGF1K, and we used the (3-4-5-dimethylthiazol-2-yl)-2-5-diphenyltetrazolium bromide method to determine its cytotoxicity in RBL-2H3 and HMC-1 cell lines. RBL-2H3 cells were induced using both anti-DNP-IgE/DNP-BSA and calcium ionophore (A2187) treatments, whereas HMC-1 cells were induced using A2187 alone. To measure mast cell degranulation, we performed histamine (enzyme-linked immunosorbent assay) and β-hexosaminidase assays. To quantify interleukin (IL)-4, IL-5, and IL-13 levels in RBL-2H3 cells, we performed quantitative polymerase chain reaction (PCR); to quantify expression levels of IL-4 and IL-13 in HMC-1 cells, we used semiquantitative reverse transcription polymerase chain reaction (RT-PCR). Finally, we detected the total and phosphorylated forms of extracellular signal-regulated kinase, p-38, and c-Jun N-terminal kinase proteins by immunoblotting. Results: BIOGF1K decreased the AD response by reducing both histamine and β-hexosaminidase release as well as reducing the secretion levels of IL-4, IL-5, and IL-13 in RBL-2H3 cells and IL-4 and IL-13 in HMC-1 cells. In addition, BIOGF1K decreased MAPK pathway activation in RBL-2H3 and HMC-1 cells. Conclusions: BIOGF1K attenuated the AD response, hence supporting its use as a promising and natural approach for treating AD.

• Journal of The Korean Society of Integrative Medicine
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• v.2 no.2
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• pp.89-96
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• 2014

Purpose : In this study, we selected three research subjects to attempt to clear learning motivation of college students is what impact the stress coping style and stress test. First, age, gender, the future career after graduation, the presence or absence of part-time job is, its impact on learning motivation. Second, learning motivation is what effect the stress of the test. Third, based on the motivation of learning, how deal pursuing efforts form the social support, the center of the problem-solving approach, seeking to avoid the reaction to stress how different form. Methods : K University occupational therapy and one, two, three grade 100 students (male 22 people, female 78) to target age, sex, and after graduation, part-time status, motivation, stress, stress coping style questionnaire for distribution and was written. Results : First of all, women's social support form graduation course, more robust than pursue blank after the synchronization uncertainty and stress, and graduated from the trading center and avoid the use of career, more form. Second, motivation and stress test, a difference between the notice could not see. Third, the higher the motivation of learning, problem-solving, Action form to the center to use as many as you, but avoid using too much in the center form is addressed. Conclusion : As a result of the study that came out of the course after graduating from ensure that learning motivation is high, the more the uncertainty, the more to cope with stress in the center of the form to avoid form address was used. Because of this, the student careers after graduation, to make sure that can help you to compare efforts over is believed to be necessary.

• Journal of The Korean Society of Integrative Medicine
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• v.7 no.4
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• pp.171-180
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• 2019

Purpose : The purpose of this study is to understand the experiences of nursing students in clinical practice at a public health center through their self- reflections. Subjects : The 110 students in the 3rd year, practice at two public health centers in city P and city K. From the110, 53 male and female university students who practice in city K were selected to participate : 11males (20.8 %) and 42 females (79.2 %). Methods : The data analyzed were the self-reflections regarding the clinical practice. Results : These data indicate that : most of the participants now believe that public health centers provide many more services to the community than they previously knew about. They rate the public health center's programs highly, and want to be community health nurses. For the first time, they realize that the work of public health nurses is very important. In particular they note that their emotions while at the public health center differ significantly from when they work at the other. The environment in the public health center makes them feel more comfortable and less stressed. Generally, they are satisfied with their practice at the public health center. Conclusion : On the basis of these findings, the following recommendations can be made. Experience at public health centers is an important part of nursing students' education. I suggest that research on nursing students' experiences while practicing at the public health center should expand to include research methods other than the analysis of their reflection journals, In addition a follow-up study of experiences while practicing at the public health center should be attempted of self-reflections.

• Journal of Korean Academy of Nursing
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• v.47 no.5
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• pp.577-588
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• 2017

Purpose: This study was intended to integrate the evidence of home care service intervention for mothers and children in vulnerable groups through an integrative literature review. Methods: We searched the MEDLINE (PubMED), EMBASE, Cochrane Central Register of Controlled Trials, CINAHL, DBpia databases. The quality of the articles was assessed by one doctoral researcher and verified by one professor of community health nursing who had participated in the systematic review of literature. A framework was developed to identify the intervention patterns in the selected papers and categorize various elements. The extracted intervention elements were grouped into potential themes, which were verified by assessors on whether they clearly reflected the interventions in the papers. Results: Among 878 searched papers, we selected 16 papers after excluding literature that does not satisfy the selection criteria and quality evaluation. The intervention elements of 16 selected papers were categorized into six themes. The extracted intervention elements were divided into the themes of Patient-specific/Situation-specific care planning and intervention, Emphasis on self care competency, Intense home visit by developmental milestone, Reinforcing and modeling mother-child attachment, Communication and interaction across the intervention, Linkage with community resource and multidisciplinary approach. Conclusion: As a result of the analysis of proper interventions of home care services for mothers and children in vulnerable groups, it was found that it is necessary to consider indispensable intervention elements that can standardize the quality of home care services, and conduct studies on developing intervention programs based on the elements.

• Journal of The Korean Society of Integrative Medicine
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• v.9 no.4
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• pp.85-89
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• 2021

Background : Klippel-Trenaunay-Weber syndrome (KTS) is a rare congenital medical condition characterized by complex vascular malformation. KTS consists of a classic triad of capillary malformation (hemangioma), venous malformations and bone or soft tissue hypertrophy causing limb asymmetry. The aim of this report is to describe management for gait disturbance and foot pain in a Patient with KTS using custom-made total contact insole. Case presentation : A 32-year-old man with KTS presented with a 3-year history of gait disturbance on hard surface due to right first toe pain and Achilles tendon tightness. The patient had soft tissue hypertrophy, varicose veins and port-wine stains over the right lower limb associated with KTS. True leg length discrepancy was 2 cm. We prescribed custom-made total contact insole to protect his deformed foot and correct leg length discrepancy. The insole of right side included wedge shaped heel lift and the insole of left side included full length lift to add extra support on unaffected side. Also, we provided compression stocking and physiotherapy including manual lymphatic drainage for lymphedema and stretching exercise for tightness in right lower extremity. At 3 years follow-up, postural alignment including pelvic obliquity was improved using a custom-made total contact insole. The degree of scoliosis and foot pain were also reduced. Conclusion : An individualized and multidisciplinary approach is essential regarding the complexity of comorbidities in patients with KTS. For patients with KTS, orthotic management should be considered to prevent and correct deformities related to KTS. Active orthotic management, compression stocking and physiotherapy can enhance the quality of life and function in patients.