• Journal of Life Science
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• 제11권1호
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• pp.39-41
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• 2001

Cytohesin family has been thought to participate in inside-outside signaling linking growth factor receptor stimulation of PI 3-kinase to cell adhesion and stimulate nucleotide exchange of ARF through its Sec7 domain. The genomic structure of the cytohesin family was analyzed by BLAST search using cDNA and genomic DNA sequences from the GeneBank database. The cytohesin-2 was encoded by 12 exons. while the cytohesin-4 was encoded by 13 exons. The Sec7 and PH domains were not encoded by separate exons. In an analysis of retroviral integration, those two families did not contain any retroviral elements in introns or exons. The phylogenetic tree calculated by the neighbor-joining method suggests that the cytohesin-1 family was closely related to cytohesin-3 (ARNO3) family. These date could be of great use in further studies for resolving the exact function and evolution of the cytohesin family.

• 한국정보통신학회논문지
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• 제16권6호
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• pp.1204-1208
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• 2012

휴대폰 및 카메라 산업의 급속한 발전에 따라 모든 전자 제품이 소형화, 고성능화, 다양화 추세에 따라 PCB도 고집적화, 다층화, 고사양화가 급속히 이루어지고 있다. 현재 계속해서 진화하고 발전하는 디지털 카메라 그 중에서도 DSLR카메라 이외에 소형, 경량화 하는 고객 요구로 부터 탄생한 미러리스 카메라와 하이브리드 디지털 카메라의 시장이 계속해서 증가하고 있다. 그에 고사양, 저전력, 고성능 부품에 따라 PCB설계 난이도가 점차 증가하고 설계 L/T이 오래 걸리고 있다. 본 논문에서는 디지털 카메라 개발기간 및 제조기간 축소에 적용되는 PCB설계 L/T 단축에 대한 방법을 제안한다.

• Asian Pacific Journal of Cancer Prevention
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• 제13권6호
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• pp.2735-2738
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• 2012

Background: Our objective was to clarify the clinical and biological characteristics of basal-like breast cancer (BLBC) and non-basal-like breast cancer (TN3BKE) in Heilongjiang. Methods: We examined, by immunohistochemistry, expression of biological markers cytokeratin (CK) 5/6 and epidermal growth factor receptor (EGFR) and B cell specific moloney murine leukemia virus integration site 1( Bmi-1) in triple-negative breast cancer (TNBC). We studied the correlation between BLBC and several factors related to tumor progression, along with its prognostic value. Results: In the 229 cases of operable TNBC, BLBC was detected in 178 (77.7%) and TN3BKE- in 51 (22.2%). There was no significant difference in clinicopathological factors between them, However, BLBC was significantly associated with Bmi-1 expression (P=0.000) and shorter disease-free survival (DFS) (P = 0.045) and overall survival (OS) (P = 0.041). Conclusions: Compared with the non-basal group, patients with BLBC have a high expression of Bmi-1 and a poor prognosis.

• Journal of Microbiology and Biotechnology
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• 제19권9호
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• pp.881-887
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• 2009

Forty-four eicosapentaenoic acid (EPA)-producing microbial strains were isolated from the intestines of marine fishes. Among them, one strain showing a maximum level of EPA (4.78% of total fatty acids) was identified as Shewanella sp. BR-2 on the basis of its 168 rRNA sequence. The EPA content reached a maximum level during the mid-exponential phase of cell growth, and gradually decreased with further growth of the cells. A cosmid DNA including the EPA biosynthesis gene cluster consisting of pfaA-E was isolated from a cosmid library of genomic DNA of Shewanella sp. BR-2, named pCosEPA-BR2. An E. coli clone harboring pCosEPA-BR2 produced EPA at a maximum level of 7.5% of total fatty acids, confirming the EPA biosynthesis activity of the cloned gene cluster.

• 한국통신학회논문지
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• 제19권6호
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• pp.1046-1055
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• 1994

본 논문에서는 영상 신호처리에 적합한 고속 1 line VRAM을 ASIC화 설계하기 위하여 엑세스 시간특성 및 집적도가 우수한 3-TR dual-port 다이나믹 셀을 채용하여 메모리 코어를 설계하였다. 고속 파이프라인 동작을 위하여 서브어레이 1로부터 첫 행을 분리하였고, TM기 비트 라인에 데이터 래치 구조를 채용하여 한 번지의 동시 입.출력이 가능하도록 설계하였다. 주변 회로로 번지 선택기, 1/2V 전압 발생기를 각각 설계하여 개선된 동작특성을 확인한 후 1.5[ m] CMOS 설계규칙을 이용하여 ASIC화 설계하였다.

• 한국통신학회논문지
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• 제35권5B호
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• pp.741-752
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• 2010

The ability to seamlessly switch between the macro networks and femtocell networks is a key driver for femtocell network deployment. The handover procedures for the integrated femtocell/macrocell networks differ from the existing handovers. Some modifications of existing network and protocol architecture for the integration of femtocell networks with the existing macrocell networks are also essential. These modifications change the signal flow for handover procedures due to different 2-tier cell (macrocell and femtocell) environment. The handover between two networks should be performed with minimum signaling. A frequent and unnecessary handover is another problem for hierarchical femtocell/macrocell network environment that must be minimized. This work studies the details mobility management schemes for small and medium scale femtocell network deployment. To do that, firstly we present two different network architectures for small scale and medium scale WCDMA femtocell deployment. The details handover call flow for these two network architectures and CAC scheme to minimize the unnecessary handovers are proposed for the integrated femtocell/macrocell networks. The numerical analysis for the proposed M/M/N/N queuing scheme and the simulation results of the proposed CAC scheme demonstrate the handover call control performances for femtocell environment.

• 미생물학회지
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• 제43권4호
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• pp.237-242
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• 2007

레트로바이러스(Retrovirus; RV)의 독특한 특징 중 하나는 프로바이러스의 상태로 숙주세포의 염색체에 삽입되어 숙주세포 유전자의 일부분으로서 다른 숙주세포 유전자들과 함께 다음세대로 유전된다는 것이다. 이러한 독특한 형태의 RV를 내인성 RV (endogenous RV; ERV)라고 하는데, 여러 종류의 내 외적신호에 의해 그자신의 유전자뿐만 아니라 인근한 숙주유전자의 발현에 변화가 일어난다. 사람과 쥐에서는 각각 HERV (Human ERV)와 MuERV (Murine ERV)가 세포 속에 존재하여 이들의 발현 변화가 숙주 생물체에 주로 해롭게 작용하여 질병을 일으키게 된다. 이들 ERV는 생체분자, 세포물질들이 관여하는 기작을 통해 암과 자가면역 반응과 같은 질병을 일으키는데, 이에 수반하여 많은 병리생리적 변화를 가져온다. HERV와 관련된 질병을 앓고 있는 환자들을 위해서는 이러한 질병을 이해하고, 이를 바탕으로 치료요법을 개발하기 위해 여러 단계의 대책들이 고려되어야 한다.

• KIEAE Journal
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• 제4권3호
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• pp.113-119
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• 2004

As Building Integrated Photovoltaic(BIPV) system replaces the conventional building finishing materials with PV modules, two function of electricity generation and building envelope can be expected. Therefore BIPV can be a good alternative technology for the 21 century environment-friendly buildings. The objective of this paper is to develope BIPV modules for a commercial buildings of which structure is mainly light-weight, curtain wall system. Two types of module are developed for a opaque part and a transparent part of building envelope. Current technology level and market status of Korea determines the configuration of developed BIPV modules. Architectural considerations for the integration of PV module to building envelope such as building structure, construction type, safety, regulation, maintenance etc. have been carefully reflected from the early stage of BIPV module design. Especially the survey result of current building envelope materials determines the size of unit BIPV modules and a unique cladding method for PV module installation is developed. Trial product of BIPV modules and cladding hardwares are manufactured and sample construction details for a demonstration building are proposed.

• JSTS:Journal of Semiconductor Technology and Science
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• 제2권3호
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• pp.213-225
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• 2002

Metal-Ferroelectric- Insulator- Silicon (MFIS) structured field effect transistor (FET) device was fabricated and characterized. Important issues to realize ferroelectric gate field effect transistor device were summarized in three sections. The choice of interlayer dielectric was made in the consideration of device functionality and chemical reaction between ferroelectric materials and silicon surface during fabrication process. Also, various ferroelectric thin film materials were taken into account to meet desired memory window and process compatibility. Finally, MFIS structured FET device was fabricated and important characteristics were discussed. For feasible integration of current device as random access memory array cell address schemes were also suggested.

• JSTS:Journal of Semiconductor Technology and Science
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• 제13권4호
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• pp.402-409
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• 2013

An innovative application of voltage-contrast (VC) inspection allowed inline detection of NMOS leakage in dense SRAM cells is presented. Cell sizes of SRAM are continual to do the shrinkage with bit density promotion as semiconductor technology advanced, but the resulting challenges include not only development of smaller-scale devices, but also intra-devices isolation. The NMOS leakage caused by the underneath n+/P-well shorted to the adjacent PMOS/N-well was inspected by the proposed electron-beam (e-beam) scan in which VC images were compared during the in-line process step of post contact tungsten (W) CMP (Chemical Mechanical Planarization) instead of end-of-line electrical test, which has a long response time. A series of experiments based on the mechanism for improving the intra-well isolation was performed and verified by the inline VC inspection. An optimal process-integration condition involved to the tradeoff between the implant dosage and photo CD was carried out.