• International Journal of Oral Biology
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• v.41 no.4
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• pp.183-190
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• 2016

Anthricin (Deoxypodophyllotoxin), a naturally occurring flavolignan, has well known anti-cancer properties in several cancer cells, such as prostate cancer, cervical carcinoma and pancreatic cancer. However, the effects of Anthricin are currently unknown in oral cancer. We examined the anticancer effect and mechanism of action of Anthricin in human FaDu hypopharyngeal squamous carcinoma cells. Our data showed that Anthricin inhibits cell viability in a dose- and time-dependent manner ($IC_{50}$ 50 nM) in the MTT assay and Live & Dead assay. In addition, Anthricin treated FaDu cells showed marked apoptosis by DAPI stain and FACS. Furthermore, Anthricin activates anti-apoptotic factors such as caspase-3, -9 and poly (ADP-ribose) polymerase (PARP), suggesting that caspase-mediated pathways are involved in Anthricin- induced apoptosis. Anthricin treatment also leads to accumulation of the pro-apoptotic factor Bax, followed by inhibition of cell growth. Taken together, these results indicate that Anthricn-induced cell death of human FaDu hypopharyngeal squamous carcinoma cells is mediated by mitochondrial-dependent apoptotic pathway. In summary, our findings provide a framework for further exploration on Anthricin as a novel chemotherapeutic drug for human oral cancer.

• Proceedings of the Korean Institute of Information and Commucation Sciences Conference
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• 2000.05a
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• pp.93-97
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• 2000

In an era of very rapid technological change, standardization organizations have been confronted with the problem that they should develop more new and more complex standards as strategic tools for enforcement of competitive power in shorter time according to the reduction of Life Cycle of products and the increase in the number of standards and their complexity. To cope with this challenge, we introduce the functionalities and development directions for implementing standardization information system. Also this paper describes the architecture of the next generation system for standard information that enabling information sharing and exchanging using XML. Finally, we suggest implementation framework of Standardization Vortal Site for the One-stop service of integrated standards information which provide users with standards development roadmap and give brief introduction to SOL(Standards On-Line) site which is operated by ETRI/PEC.

• The Journal of Korean Institute for Practical Engineering Education
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• v.2 no.1
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• pp.8-16
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• 2010

Confronted with serious problems in nurturing IT engineers such as a mismatch in supply and demand of IT workers, shortage of globally competitive IT professionals, and insufficient education and training of university graduates, the Ministry of Information and Communication has decided to adopt a new approach in national IT engineering education, based on supply chain management (SCM) in manufacturing. SCM weighs improving competitiveness of the supply chain as a whole via a long-term commitment to supply chain relationships and a cooperative, integrated approach to business processes. These benefits of SCM are believed to provide useful insight into a more effective IT education and industry orientation. On the basis of the SCM literature, a framework for industry-oriented practical IT higher education is designed, and then applied in the field of computer-software engineering in Korea.

• Korean Chemical Engineering Research
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• v.52 no.2
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• pp.154-165
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• 2014

Development of unconventional natural resources such as shale gas, shale oil and coal bed methane, has been activated and improved the productivity due to the recent technology advance in horizontal drilling and hydraulic fracturing. However, the flowback water mixed with chemical additives, and the brine water containing oil, gas, high levels of salts and radioactive metals is produced during the gas production. Potential negative environmental impact due to large volumes of the produced wastewater is increasingly seen as the major obstacles to the unconventional natural resource development. In this study an integrated framework for the flowback and brine water treatment is proposed, and we reviewed the upcoming state of the art technology in water treatment. Basic separation processes which include not only membrane, evaporation, crystallization and desalination processes, but the potential water reuse and recycling techniques can be applied for the unconventional natural resource industry.

• Korean Journal of Health Education and Promotion
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• v.20 no.3
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• pp.145-170
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• 2003

The purpose of this study was to clarity the concept of health insensitivity using Hybrid model, which consists of three phases： theoretical, empirical, and analytic. In the theoretical phase, the definitions of health insensitivity were searched in korean dictionary and examples used in the websites because the concept of health insensitivity has never been studied before. Two dimensions of health insensitivity emerged out from this investigation were cognitive and behavioral. And then a working definition of health insensitivity was established. The sub-concepts and related factors of health insensitivity were identified through the extensive reviews of the literature focusing on two dimensions of cognitive and behavioral. In the empirical phase, in order to obtain description of health insensitivity, face-to-face in-depth interviews were conducted with nine persons who are not related to professional health care. Grounded theory approach was applied to analyze these qualitative data. In the final analytic phase, theoretical results and empirical results were analyzed in the integrated way and a theoretical framework of health insensitivity was established. A refined definition of health insensitivity was that decreased health risk perception in cognitive dimension and conduction of the unhealthy behaviors in behavioral dimension. Sub-concepts of decreased health risk perception were optimistic bias and decreased general fear. Sub-concepts of unhealthy behavior were doing health threatening behavior and not doing desirable health behavior. The contact of health information was a causal condition of health insensitivity. Optimistic disposition, health locus of control, and avoidance coping style were intervening conditions of health insensitivity. Three types of health insensitivity were identified： unconcern or ignorance type, optimistic bias type, and cognitive dissonance type. Finally, The implications of these findings for further research and nursing practice are discussed.

• The Journal of Information Technology
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• v.2 no.2
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• pp.69-88
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• 1999

Only service organizations providing service quality above customers' anticipations have survived and developed in hyper competitive environment. These organizations are more dependent on their customer-contact service employees than those providing tangible products, because of the characteristics of service, intangibility, inseparability, heterogeneity, and perishability. But few researches focused on the efficient managements or controls of service organizations in this context. Therefore, author aimed at understanding of the determinants of service organizations' control system(i.e., characteristics of service), service employees' reaction on control types(i.e., service employees' role stress), and their performance(perceived service quality by customers). First the concepts of service quality and control systems are described. Specially, author explained the differences between service quality and service satisfaction or service attitude, and the control system types and their fundamental ideologies. Second, some propositions are provided according to integrated framework developed in this paper: (1)control types according to the characteristics of service, (2)influences of control systems on employees' reactions and (3)perceives service quality by the customers, and (4)relationships between the reactions and the service quality. This paper concludes with a summary, a discussion of theoretical and managerial implications, and several suggestions for future directions.

• Journal of the Institute of Electronics Engineers of Korea TC
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• v.43 no.9 s.351
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• pp.14-24
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• 2006

The terrestrial-DMB (T-DMB) provides one-way broadcasting service in intial phase and two-way interactive data services through a return channel of mobile communications network are commercialized recently. The possible evolution of the T-DMB will be fully convergence between the T-DMB and other communication services such as telematics, RFID and so on. From this evolution point of view, a framework should be defined for supporting telematics and RFID applications on T-BMB platform. In this paper, we propose an integrated service model that could support RFID application services on the interactive T-DMB. To realize the model, we design a service scenario, a network reference model, functionalities of each entity, a data transmission mechanism messages, and coding rules. The service model could allow users to support the identical RFID application services over the T-DMB network even if T-DMB terminal doesn't have RFID reader capability. In addition, in the case for providing the interactive TTI(Traffic and Travel Information)service, users could utilize the current location based RFID application service using by the TPEG-Location application that forms the basis of user location referencing. The messages structure is designed by following TPEG standardization

• Journal of the Korean Institute of Telematics and Electronics C
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• v.36C no.12
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• pp.36-46
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• 1999

As the requirements of embedded systems increase, the design complexity of the system becomes higher. The formal design methodology is required which supports well-balanced specification for control and dataflow to design a complex system. In this paper, control modules and function modules are separately described with FSMs and dataflow graphs respectively, and integrated into a system specification via inter-model communications. In previous approaches, the system could not be verified until control modules and dataflow modules are combined at the final design stage. However our approach enables us to design each part as the proper model of computation at early stage, and to verify the compositions and to co-synthesize the system effectively in the same framework. Especially this paper focuses on the communication protocols between control and dataflow models. Preliminary experiments show practicality of the proposed technique.

• The Journal of Bigdata
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• v.4 no.1
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• pp.39-51
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• 2019

With the advent of the fourth industrial revolution characterized by hyperconnectivity and superintelligence and the emerging cyber physical systems, enormous volumes of data are being generated in the cyberspace every day ranging from the records about human life and activities to the communication records of computers, information and communication devices, and the Internet of things. Big data represented by 3Vs (volume, velocity, and variety) are actively used in the defence field as well. This paper proposes a big data governance model to support effective military operations in the cyberspace. Cyberspace operation missions and big data types that can be collected in the cyberspace are classified and integrated with big data governance issues to build a big data governance framework model. Then the effectiveness of the constructed model is verified through examples. The result of this study will be able to assist big data utilization planning in the defence sector.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.36 no.11
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• pp.1112-1120
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• 2008

The real-time distributed simulation at the present age concentrates on the construction of a system development environment in order to accomplish a synthetic battlefield environment connected with Live-Virtual-Constructive simulation and to realize the Simulation Based Acquisition which supports the life cycle of weapon system. Accordingly this paper describes the development environment of the UML modeling and simulation which integrates the system analysis and design methods performed during the conceptual design phase of the reconnaissance UAV system development. An integrated framework linked with the UML simulation and X-plane visualization is suggested to efficiently perform the system analysis and design, and finally the implementation contents, the analysis of experiment results and concluding remarks are described.