• 한국수정란이식학회지
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• 제30권3호
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• pp.239-248
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• 2015

The nature of molecular mechanisms governing embryonic cell block is largely unknown, but recent reports have demonstrated that proper execution of programmed cell death is crucial for this process. The main objective of this study is to determine effects of programmed cell death on porcine oocytes development in vitro after parthenogenesis. Among the blastocysts matured in 3MA, MAP1LC3A and ATG5 RNA gene expression level increased in the order of Cyst < 3MA < RP. However, Casp-3 and TNF-r RNA gene expression level decreased in the order of RP < 3MA < Cyst. Expression of mTOR within the RP-cultured blastocyst was the most highly to the inner cell mass, while 3MA-cultured blastocyst showed very lowest expression in inner cell mass. The expression of mTOR showed a pattern opposite to that of MAP1LC3A. That is, its expression was the lowest in Cyst group. When the enzymatic activity of MMP-2 and MMP-9 was assessed in culture, the level of active MMP-9 was higher expression in the medium of each RP treatment group, with the level of another treatment group being relatively higher. Analyses of TIMP-2 and TIMP-3 revealed that their expression was higher in groups that did not receive RP treatment. More specifically, the level of TIMP-2 was not affected by Cyst treatment, while the level of TIMP-3 was higher in 3MA and RP treatment group. There was highly cell division activation efficiency of parthenogenesis on cultured system of RP supplement IVC medium. Therefore, these results suggest that embryo development was significantly increased in conditional culture medium with active autophagy as compared to common cultured condition. Further investigation of this distinction may enable the development of innovative improvements for the production of porcine somatic cell nuclear transfer.

• 한국산학기술학회논문지
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• 제19권3호
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• pp.553-556
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• 2018

본 연구는 실제 산업현장에서 활용 가능한 'NCS를 활용한 사업 내 자격 신설 정비 매뉴얼'을 개발하여, 기업특수 숙련기술에 대한 육성 평가를 담당하는 사업 내 자격 운영을 체계화 시킬 수 있는 기준 마련이 필요하고 사업체별 특수 직무를 다루고 있는 사업 내 자격이 기업의 숙련요구를 정확히 반영함과 동시에 각 사업 내 자격의 기준과 절차를 표준화할 수 있는 매뉴얼 개발을 통한 신뢰성 및 객관성 제고하고자 하는데 그 목적이 있다. 연구의 목적을 달성하기 위하여 일본의 사업 내 자격을 운영하고 있는 기업 및 협회 등을 방문하여 해외사례분석을 하여 구체적인 현행제도 및 사례분석을 통한 개선방향과 사업 내 자격을 인정받고 현재 검정을 시행하고 있는 기관 실무자들을 대상으로 온라인 및 1:1 면접조사를 통하여 설문을 실시했으며, 사업 내 자격의 체계 및 내용에 대한 현황분석을 통하여 NCS와 사업 내 자격의 체계 분석 및 자격 신설 정비 모형을 도출하여 NCS를 활용한 사업 내 자격 신설 정비 표준매뉴얼을 개발하여 이 표준매뉴얼의 사용 촉진을 위하여 현행제도 및 사례분석을 통한 개선방향 제시하였다. 이러한 결과를 토대로 NCS 기반 사업 내 자격 신설 매뉴얼과 NCS 기반 사업 내 자격 정비 매뉴얼을 제시하였다.

• 한국콘텐츠학회논문지
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• 제9권11호
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• pp.192-200
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• 2009

21세기 디자인 역역은 인간과 환경, 친환경 영역으로 확산되고 새로운 제품 시장 역시 서비스와 마케팅 전략이 새롭게 도입되고 있다. 새로운 국제경쟁력 시대에서 세계시장을 주도하기 위해서는 새로운 디자인 방법이 핵심적인 요소로 받아들여져야 하고 성공적인 디자인 프로젝트 운영에 의존하기 때문에 디자인 전략 역시 더욱 중요한 이슈가 될 것으로 보인다. 우리나라의 장례문화 역시 새로운 디자인 방법이 도입되어 어려운 시장 환경에서 효과적으로 전문적인 성과를 얻기 위하여 창조적인 디자인 방법과 디자인 경영 전략을 보여 줄 수 있어야 할 것이다. 본 연구는 새로운 디자인 방법과 제작기법의 도입으로 장례문화 기업에 지속적인 이익과 창조적인 가치를 부여할 수 있도록 새로운 디자인 방법을 도입하여 새로운 장례문화 발전에 기여 할 수 있도록 본 연구의 목적을 가지고 논하고자 한다.

• 대한인간공학회지
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• 제32권1호
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• pp.9-16
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• 2013

Objective: The aim of this study is to investigate a trend of human error types observed in a series of verification and validation experiments for an Advanced Control Room(ACR) equipped with Lager Display Panel(LDP), Work Station Flat Panel Display(WS FPD), list type Alarm System(AS), Soft Control(SC) and Computerized Procedure System(CPS). Background: Operator behaviors in a fully computerized control room are quite different from those in a traditional hard-wired control room. Operators in an ACR all together monitor plant status and variables through their own interface system such as LDP and WS FPD, are notified of abnormal plant status through their own list type AS, control the plant through their own SC, and follow the structured procedure through their own CPS whereas operators in a traditional control room only separately do their duty directed by their supervisor. Especially the secondary task such as manipulating the user interface of ACR can be an extra burden to all the operators including the supervisor. Method: The Reason's human error classification method was applied to operators' behavioral data collected from a series of verification and validation experiments where operators showed their plant operational behaviors under a couple of harsh scenarios using the ACR simulator. Results: As operators accustomed to the new ACR system, knowledge or rule based mistakes appearing frequently in the early series of experiments decreased drastically in the latest stage of the series. Slip and lapse types of errors were observed throughout the series of experiments. Conclusion: Education and training can be one of the most important factors for the operators accustomed to the traditional control room to be adapted to the new system and to run the ACR successfully. Application: The results of this study implied that knowledge or rule based mistakes can be reduced by training and education but that lapse type errors might be reduced only through innovative improvement in human-system interface design or teamwork culture design including a new leadership style suitable for ACR.

• Archives of Plastic Surgery
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• 제43권5호
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• pp.451-456
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• 2016

Background Comprehensive aesthetic surgery training continues to be a challenge for residency programs. Our residency program developed a rhinoplasty-based objective structured clinical examination (OSCE) based upon validated methods as part of the residency education curriculum. We report our experience with the rhinoplasty-based OSCE and offer guidance to its incorporation within residency programs. Methods The encounter involved resident evaluation and operative planning for a standardized patient desiring a rhinoplasty procedure. Validated OSCE methods currently used at our medical school were implemented. Residents were evaluated on appropriate history taking, physical examination, and explanation to the patient of treatment options. Examination results were evaluated using analysis of variance (statistical significance P<0.05). Results Twelve residents completed the rhinoplasty OSCE. Medical knowledge assessment showed increasing performance with clinical year, 50% versus 84% for postgraduate year 3 and 6, respectively (P<0.005). Systems-based practice scores showed that all residents incorrectly submitted forms for billing and operative scheduling. All residents confirmed that the OSCE realistically represents an actual patient encounter. All faculty confirmed the utility of evaluating resident performance during the OSCE as a useful assessment tool for determining the Next Accreditation System Milestone level. Conclusions Aesthetic surgery training for residents will require innovative methods for education. Our examination showed a program-educational weakness in billing/coding, an area that will be improved upon by topic-specific lectures. A thoroughly developed OSCE can provide a realistic educational opportunity to improve residents' performance on the nonoperative aspects of rhinoplasty and should be considered as an adjunct to resident education.

• 농촌계획
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• 제17권1호
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• pp.89-98
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• 2011

Recently, the food industry has evolved into a new and innovative trend according to its globalization and change of food consumption patterns. However, it is hard for the traditional food industry in Korea to meet the changing consumers' needs because of its poorer quality control and lower industrialization technology than other advanced industries. Also the knowledges acquired through a lot of time and efforts would be lost after the human resources with tacit knowledges leave by their too much aging. Especially, the 21st century would be called as knowledge based society which means that knowledge be the important contributing factor in the economic growth. In this regard, this study aimed at proposing the knowledge based system for systematically managing or preserving knowledges of Mosisongpyun industry in Yeonggwang County to seek for the sustainable development of the traditional food industry in Korea. The knowledge based system of Mosisongpyun industry in Yeonggwang County is finally proposed as follows; First, hardware is composed with the necessary unit facilities such as interpretive center, learning and experience room, library, etc. And the integrating facilities such as Mosisongpyun theme park, traditional village, and knowledge industrialization support center are proposed. Second, software is composed with the necessary unit softwares such as the preservation manual of traditional knowledge and skill, web-site administrator, development of graded textbooks, development database software, etc. And the integrating softwares such as development of innovation and management ability in Mosisongpyun industry are proposed. Third, humanware is composed with the necessary unit programs such as exhibition, own training program, incubator support system, etc. And the integrating programs such as the farm association corporation, the testing and research institute, the institution of learning and training are proposed.

• Steel and Composite Structures
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• 제34권6호
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• pp.891-907
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• 2020

Many studies reveal that during destructive earthquakes, most of the structures enter the inelastic phase. The amount of hysteretic energy in a structure is considered as an important criterion in structure design and an important indicator for the degree of its damage or vulnerability. The hysteretic energy value wasted after the structure yields is the most important component of the energy equation that affects the structures system damage thereof. Controlling this value of energy leads to controlling the structure behavior. Here, for the first time, the hysteretic behavior and energy dissipation capacity are assessed at presence of elliptical braced resisting frames (ELBRFs), through an experimental study and numerical analysis of FEM. The ELBRFs are of lateral load systems, when located in the middle bay of the frame and connected properly to the beams and columns, in addition to improving the structural behavior, do not have the problem of architectural space in the bracing systems. The energy dissipation capacity is assessed in four frames of small single-story single-bay ELBRFs at ½ scale with different accessories, and compared with SMRF and X-bracing systems. The frames are analyzed through a nonlinear FEM and a quasi-static cyclic loading. The performance features here consist of hysteresis behavior, plasticity factor, energy dissipation, resistance and stiffness variation, shear strength and Von-Mises stress distribution. The test results indicate that the good behavior of the elliptical bracing resisting frame improves strength, stiffness, ductility and dissipated energy capacity in a significant manner.

• 한국컴퓨터정보학회논문지
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• 제13권1호
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• pp.273-281
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• 2008

지식 정보화 시대가 도래하게 되면서 IT산업의 효율적인 관리 방안 및 이에 따른 정보 가치의 중요성과 상호 운영의 중요성이 과거 어느 때보다 높아지고 있다. 따라서 정보 기술을 체계적으로 계획하고 관리하는 ITA/EA가 2005년 법률로 제정 공포 시행되어 새로운 IT관리 방법론으로 인지되고 있으나 ITA와 EA의 새로운 표준화에 대한 논의는 미비한 게 현실이다. 이에 본 연구에서는 EA/ITA가 정보기술에 성공적으로 적용 활용될 수 있는 요인을 찾는 것이 가장 시급한 문제라고 판단하여 그에 대한 연구를 진행하였다. 그 결과 '용어 및 업무의 표준화', '인력양성의 표준화'를 통해 전문 인력 양성 시스템의 체계화 및 자격 제도신설의 필요성을 강조하고, ITA와 EA의 개념이 혼용되어 발생하는 이중적 구조를 제거해야 하는 당위성을 역설하였다. 그럼으로써 ITA/EA는 IT공학으로 인정하고 전문공학 인들로 하여금 학술적 분야로 수용할 수 있도록 국내 표준화를 위한 새로운 모델을 제시하였다. 종합적으로, ITH/EA를 통해 정보 관리의 효율성을 높일 수 있는 요인들에 대해 제언하고자 했다.

• 디지털융복합연구
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• 제20권5호
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• pp.897-908
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• 2022

본 연구의 목적은 개인의 학습 자기효능과 기업의 혁신적 지식전달과 같은 학습전이풍토가 디자이너의 특성을 고려한 디자인 역량강화교육과 개인성과와의 관계에서 매개역할을 할 것이라는 가설을 증명하는 것에 있다. 이는 단순히 교육의 만족도를 조사하는 기존의 연구와는 달리 디자이너의 특성에 근거한 학습 자기효능감과 디자이너가 조직의 문화에 영향을 주는 학습전이 풍토에 대한 정량적 분석을 하여 디자인 교육훈련의 의미를 확장하는데 의의가 있다. 구체적으로 본 연구에서는 7개의 가설을 설정하였고, 그 결과 디자이너 대상 디자인 역량강화 교육과 학습 자기효능감, 기업의 학습전이풍토는 개인성과에 유의한 영향을 미치는 것으로 나타났다.

• Korean Journal of Radiology
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• 제24권11호
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• pp.1061-1080
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• 2023

Artificial intelligence (AI) in radiology is a rapidly developing field with several prospective clinical studies demonstrating its benefits in clinical practice. In 2022, the Korean Society of Radiology held a forum to discuss the challenges and drawbacks in AI development and implementation. Various barriers hinder the successful application and widespread adoption of AI in radiology, such as limited annotated data, data privacy and security, data heterogeneity, imbalanced data, model interpretability, overfitting, and integration with clinical workflows. In this review, some of the various possible solutions to these challenges are presented and discussed; these include training with longitudinal and multimodal datasets, dense training with multitask learning and multimodal learning, self-supervised contrastive learning, various image modifications and syntheses using generative models, explainable AI, causal learning, federated learning with large data models, and digital twins.