• Knowledge Management Research
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• v.16 no.2
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• pp.249-278
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• 2015

Employees' knowledge integration capabilities and innovative behavior are still of crucial importance in the effective knowledge management. Recently researchers and practitioners are interested in both the potential benefits of unlearning and the negative aspects of learning inertia. The purpose of this study is to examine the relationships among learning inertia, unlearning, knowledge integration capabilities(knowledge exploitation and knowledge exploration) and innovative behavior. The results of analysis show that learning inertia is employees' psychological obstacle factor affecting knowledge integration capabilities and unlearning, that unlearning of employees is a key factor affecting knowledge integration capabilities, and that knowledge integration capabilities are driving forces leading to innovative behaviors of employees. For theoretical and practical implications, the research presents the grounds for arguments that knowledge integration capabilities are employees' dynamic capabilities from the knowledge management perspective, that unlearning is a driving force of employees' positive behaviors, and that organizations trying to perform the dynamic knowledge management need to identify the causes of employees' psychological resistance to learning. Limitations arisen in the course of the research and suggestions for future research directions are also discussed.

• International Journal of Stem Cells
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• v.16 no.3
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• pp.251-259
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• 2023

Mesenchymal stromal cells (MSCs) have attracted scientific and medical interest due to their self-renewing properties, pluripotency, and paracrine function. However, one of the main limitations to the clinical application of MSCs is their loss of efficacy after transplantation in vivo. Various bioengineering technologies to provide stem cell niche-like conditions have the potential to overcome this limitation. Here, focusing on the stem cell niche microenvironment, studies to maximize the immunomodulatory potential of MSCs by controlling biomechanical stimuli, including shear stress, hydrostatic pressure, stretch, and biophysical cues, such as extracellular matrix mimetic substrates, are discussed. The application of biomechanical forces or biophysical cues to the stem cell microenvironment will be beneficial for enhancing the immunomodulatory function of MSCs during cultivation and overcoming the current limitations of MSC therapy.

• BMB Reports
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• v.51 no.2
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• pp.85-91
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• 2018

Pluripotent stem cell (PSC) variations can cause significant differences in the efficiency of cardiac differentiation. This process is unpredictable, as there is not an adequate indicator at the undifferentiated stage of the PSCs. We compared global gene expression profiles of two PSCs showing significant differences in cardiac differentiation potential. We identified 12 up-regulated genes related to heart development, and we found that 4 genes interacted with multiple genes. Among these genes, Gata6 is the only gene that was significantly induced at the early stage of differentiation of PSCs to cardiomyocytes. Gata6 knock-down in PSCs decreased the efficiency of cardiomyocyte production. In addition, we analyzed 6 mESC lines and 3 iPSC lines and confirmed that a positive correlation exists between Gata6 levels and efficiency of differentiation into cardiomyocytes. In conclusion, Gata6 could be utilized as a biomarker to select the best PSC lines to produce PSC-derived cardiomyocytes for therapeutic purposes.

• Current Optics and Photonics
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• v.5 no.3
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• pp.311-321
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• 2021

Indocyanine green (ICG) is a dye approved for use in clinical diagnostics. ICG remains in the intravascular space following intravenous administration, due to its ability to rapidly bind to the plasma proteins, and its therapeutic potential has been studied in well-vascularized cutaneous tumors. Here we have evaluated the clinical response of a subconjunctival tumor to photothermal therapy (PTT) using an ICG-enhanced near-infrared diode laser and its adverse effects, in a rabbit. 22 male New Zealand white rabbits with subconjunctival tumors were enrolled (control group 6, laser-only group 8, laser-with-ICG group 8). Rabbits in the laser-with-ICG group received ICG (twice, 2 mg/kg each time, intravenously) directly followed by irradiation with a diode laser (λ = 810 nm). Rabbits in the laser-only group were irradiated with the diode laser. ICG angiography, ultrasonography, and pathologic examination were performed to evaluate PTT response at specific time points (0, 2, and 4 weeks after PTT). Two weeks after initial treatment, the eight rabbits treated by laser with ICG showed a 100% response rate. There was no clinical response in both laser-only and control groups. ICG-PTT is a potential and effective palliative therapeutic modality for subconjunctival tumors.

• Nuclear Engineering and Technology
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• v.48 no.1
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• pp.268-273
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• 2016

An innovative safety concept for a light water reactor has been developed at the Korea Atomic Energy Research Institute. It is a unique concept that adopts both a fast heat transfer mechanism for a small containment and a changing mechanism of the cooling geometry to take advantage of the potential, thermal, and dynamic energies of the cold water in the containment. It can bring about rapid cooling of the containment and long-term cooling of the decay heat. By virtue of this innovative concept, nuclear fuel damage events can be prevented. The ultimate heat transfer mechanism contributes to minimization of the heat exchanger size and containment volume. A small containment can ensure the underground construction, which can use river or seawater as an ultimate heat sink. The changing mechanism of the cooling geometry simplifies several safety systems and unifies diverse functions. Simplicity of the present safety system does not require any operator actions during events or accidents. Therefore, the unique safety concept of PX can realize both economic competitiveness and inherent safety.

• Structural Engineering and Mechanics
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• v.66 no.3
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• pp.399-409
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• 2018

This paper demonstrates the potential application of machine learning algorithms for approximate prediction of the load and deflection capacities of the novel type of Laced Steel Concrete-Composite (LSCC) beams proposed by Anandavalli et al. (Engineering Structures 2012). Initially, global and local responses measured on LSCC beam specimen in an experiment are used to validate nonlinear FE model of the LSCC beams. The data for the machine learning algorithms is then generated using validated FE model for a range of values of the identified sensitive parameters. The performance of four well-known machine learning algorithms, viz., Support Vector Regression (SVR), Minimax Probability Machine Regression (MPMR), Relevance Vector Machine (RVM) and Multigene Genetic Programing (MGGP) for the approximate estimation of the load and deflection capacities are compared in terms of well-defined error indices. Through relative comparison of the estimated values, it is demonstrated that the algorithms explored in the present study provide a good alternative to expensive experimental testing and sophisticated numerical simulation of the response of LSCC beams. The load carrying and displacement capacity of the LSCC was predicted well by MGGP and MPMR, respectively.

• Journal of the Optical Society of Korea
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• v.19 no.2
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• pp.175-181
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• 2015

Optical coherence tomography (OCT) is a noninvasive technique for microscopic investigation of tissue. We thought that the OCT method could be a potential tool for monitoring the healing process of a tendon. In this study we used two rat models, denervated and non-denervated groups, to observe a variety of healing phases of Achilles tendon (AT) injury. We made samples of AT injury lesions, to take OCT images and to make histopathological samples of serial sectional tissue. In an OCT image the denervated rat showed no specific finding, but the non-denervated rat showed a large defect lesion that was scaffolding tissue. OCT findings combined with pathologic findings showed advantages in visualization of tendon microstructure over other imaging modalities such as MRI and US, and OCT is beneficial to making a treatment plan, especially the timing and intensity of rehabilitation. Therefore a multimodal platform using OCT for evaluation of tendon injury may be potentially useful for many applications.

• Journal of the Korea Society of Computer and Information
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• v.21 no.9
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• pp.113-119
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• 2016

In this paper, a research model is proved empirically which includes factors related on the purchase intention of smart car as high innovative product in advance of commercialization. As one of relating to consumer's expectation benefit factors, individual attribute factor includes product knowledge, individual innovativeness, and sociality. Consumer's expectation benefit factor includes perceived ease-of-use, usefulness, and enjoyment. As of switching cost variables, there are financial, uncertainty, relational and psychological switching costs factors. Analysis were performed using data from the 257 respondents as random sampling among potential consumers. Purchase intention were affected by individual innovativeness mediated by perceived enjoyment, and individual sociality by perceived ease-of-use and enjoyment also. Relational switching costs factor was only a significant control variable between purchase intention with consumer's expectation benefit factor. This result presents some implications for making the new smart car's detail concept and marketing strategy related to targeting the consumer as high innovative product and technology firms including smart car makers.

• International Journal of Computer Science & Network Security
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• v.21 no.12spc
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• pp.503-512
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• 2021

The article proposes a methodical approach to assessing the innovative capacity of agri-food enterprises. This approach is based on the calculation of personnel, investment, technical and technological, information components of the ability of agri-food enterprises to innovate. The algorithm of search of production, intellectual, financial, information resources reserves, which are necessary for functioning of the enterprises of agro-food sphere, is defined. The approach developed by the authors, in contrast to the existing ones in the scientific world, allows the tools of mathematical modeling to identify shortcomings in the development of agri-food enterprises, to forecast the development of these enterprises and on this basis to form different models of market stakeholders. The method proposed by the authors to assess the innovative capacity of agri-food enterprises allows market participants to assess the current state of agri-food enterprises and form the necessary management levers to influence its activities to eliminate market failures and pitfalls.

• Journal of Radiation Industry
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• v.3 no.1
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• pp.13-18
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• 2009

In earlier investigations, seeds of Perilla frutescens(L.) Britt. cv. Chookyoupjaso were irradiated with 200 Gy gamma ray to generate mutagenesis. The aim of this study is to investigate the effects of a hexane extract from Perilla frutescens (L.) Britt. cv. Chookyoupjaso mutant 45 on the actions of anti-inflammatory activity on inducible nitric oxide synthase, and an identification of the major active compound. The hexane extract from P. frutescens exhibited activity of inhibition of a NO production ($IC_{50}$, $295.1{\mu}g\;ml^{-1}$). The hexane extract was further divided into subfractions by silica-gel chromatogarphy. Inhibition of the NO production by various fractions was assayed in LPS-stimulated RAW 264.7 cells. Among the seven fractions, the 5th fraction was the most effective ($IC_{50}$, $19.5{\mu}g\;ml^{-1}$). The 5th fraction suppressed the expression of protein of iNOS in LPS-induced RAW 264.7 cells, and GC/MS analyses showed that isoegomaketone is a major bio-active compound in the 5th fraction. The result indicated that isoegomaketone has a good potential to be developed as an anti-inflammation agent.