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Comparison of hemostatic efficacy and cytotoxicity of three ferric subsulfate- and chitosan-based styptics in different formulations using a rat tail bleeding model

  • Byun, Jae-Young;Lee, Soojung;Lee, Jeong Ik;Yoon, Hun-Young
    • Korean Journal of Veterinary Research
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    • v.58 no.3
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    • pp.119-124
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    • 2018
  • This study was conducted to compare the hemostatic efficacy of three ferric subsulfate- and chitosan-based styptics as a powder and a gel containing ferric subsulfate and chitosan (FSC-PO and FSC-G, respectively) and a soaked pad containing ferric subsulfate and lidocaine (FSL-SP) using a rat tail bleeding model. The cytotoxicity of the styptics against L-929 mouse fibroblasts was also evaluated using a cell counting kit-8 assay. Four groups of 10 rats each were assigned to the three different styptics and a non-treated control groups. Rat tail tips were transected, after which styptics were applied with pressure. The wounds were observed for hemostasis for 3 min, then irrigated with saline to check for recurrent hemorrhage. L-929 mouse fibroblasts were exposed to extracts of the styptics (100 mg/mL) and their dilutions (1:10, 1:100, and 1:1,000). FSC-PO and FSC-G more effectively controlled initial hemorrhage than FSL-SP (p = 0.033). Additionally, FSC-PO and FSC-G more effectively maintained hemostasis than the control group (p = 0.02 and p < 0.01, respectively). However, all styptics showed enhanced cytotoxicity against L-929 cells in a dose-dependent manner. Therefore, although FSC-PO and FSC-G would be recommended to control hemorrhage, the benefits of styptics must be balanced against the clinical significance of their cytotoxicity.

Application of the Method of Caustics into Anisotropic Materials (이방성재료에 대한 코스틱스법의 적용)

  • 백명철;최선호;황재석;김원현
    • Transactions of the Korean Society of Mechanical Engineers
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    • v.16 no.12
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    • pp.2226-2240
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    • 1992
  • This paper studies the applicability of the method of caustics into anisotropic materials under mode I and mixed static loading conditions and introduces the procedure to obtain stress intensity factors(S.I.F.) in anisotropic materials by the method of caustics. The mapping equations for initial and caustic curves in anisotropic materials were introduced and their computer graphical images were compared to the experimental ones to check the validity of the mapping equations proposed in this paper. The agreement between them was found to satisfactory. Two kinds of method to determine S.I.F. in anisotropic materials by the method of caustics were proposed in this paper and applied into the orthotropic materials under various loading conditions. In the case of mode I loading condition, the S.I.F.'s obtained by this paper's methods were found to be quite similar to the results by other method, boundary element method(B.E.M) and in the case of mixed loading condtion, the S.I.F's by this paper and B.E.M. showed a little differences(2.2-24.4%) with respect to the slanted angle of crack.

Solar Array Deployment Analysis of a Satellite (인공위성 태양전지판 전개해석)

  • Kim, Kyung-Won;Kim, Sun-Won;Lim, Jae-Hyuk;Rhee, Ju-Hun;Hwang, Do-Soon;Jin, Ik-Min;Kim, Hak-Jung;Song, Woon-Hyung;Choi, Hang-Suk
    • Journal of Satellite, Information and Communications
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    • v.3 no.1
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    • pp.29-34
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    • 2008
  • After spacecraft is separated from the launch vehicle, first of all spacecraft deploy the solar array. Solar array deployment is one of the key factors deciding the success of the spacecraft mission. Therefore, It is necessary to predict the solar array deployment motion and check the safety through calculating the load on the tape hinges of solar array using the deployment analysis in the initial design phase. In this paper, solar array deployment analysis is performed by multi-body dynamics simulation program. From the analysis results, assessment on the safety also is carried out. In addition, hinge characteristic test is fulfilled to find out hinge characteristic, and is applied to the deployment analysis.

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Changes in Prevalence of Obesity for 10 Years (1997~2007) and Its Related Factors in Health Checkup Examinees (건강검진 수검자의 최근 10년(1997~2007)간 비만 유병률의 변화양상 및 관련요인)

  • Bae, Nam-Kyou;Kim, Kwang-Hwan;Kwon, In-Sun;Cho, Young-Chae
    • Journal of the Korea Academia-Industrial cooperation Society
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    • v.10 no.5
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    • pp.1091-1099
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    • 2009
  • The purpose of this study was to estimate the change of prevalence rate of obesity, also to know the relevant factors for 10 years in korean adults, which targets on the 5,420(4,556 men and 864 women) people who had undergone one biennial medical health check-up through the National Health Insurance Corporation from 1997 to 2007. As a results, the prevalence rate of obesity increased 11.0% point from 20.9% in the initial year(1997) to 31.9% in the final year(2007) for the recent decades and this is related to the socio-demographic characteristics, health-related, and eating habits.

Maxillary expansion with the memory screw: a preliminary investigation

  • Halicioglu, Koray;Kiki, Ali;Yavuz, Ibrahim
    • The korean journal of orthodontics
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    • v.42 no.2
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    • pp.73-79
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    • 2012
  • Objective: The purpose of this study was to investigate the effects of a newly developed rapid maxillary expansion screw-the memory screw-over 6 months. Methods: Five subjects, aged between 11.7 and 13.75 years, were enrolled in this study. All subjects underwent placement of a maxillary expansion appliance containing superelastic nickel-titanium open-coil springs in its screw bed. The parents of the patients and/or the patients themselves were instructed to activate the expansion screw by 2 quarter-turns 3 times a day (morning, midday, and evening; 6 quarter-turns a day). The mean expansion period was $7.52{\pm}1.04$ days. Dentoskeletal effects of the procedure, including dentoalveolar inclination, were evaluated. Measurements of all the parameters were repeated after 6 months of retention in order to check for relapse. Results: Sella-Nasion-A point (SNA) and Sella-Nasion/Gonion-Menton angles increased, and Sella-Nasion-B point (SNB) angle decreased in all the subjects during the expansion phase. However, they approximated to the initial values at the end of 6 months. On the other hand, the increments in maxillary apical base (Mxr-Mxl) and intermolar widths was quite stable. As expected, some amount of dentoalveolar tipping was observed. Conclusions: The newly developed memory expansion screw offers advantages of both rapid and slow expansion procedures. It widens the midpalatal suture and expands the maxilla with relatively lighter forces and within a short time. In addition, the resultant increments in the maxillary apical base and intermolar width remained quite stable even aft er 6 months of retention.

ART1 Algorithm by Using Enhanced Similarity Test and Dynamical Vigilance Threshold (개선된 유사성 측정 방법과 동적인 경계 변수를 이용한 ART1 알고리즘)

  • 문정욱;김광백
    • Journal of the Korea Institute of Information and Communication Engineering
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    • v.7 no.6
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    • pp.1318-1324
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    • 2003
  • There are two problems in the conventional ART1 algorithm. One is in similarity testing method of the conventional ART1 between input patterns and stored patterns. The other is that vigilance threshold of conventional ART1 influences the number of clusters and the rate of recognition. In this paper, new similarity testing method and dynamical vigilance threshold method are proposed to solve these problems. The former is similarity test method using the rate of norm of exclusive-NOR between input patterns and stored patterns and the rate of nodes have equivalence value, and the latter method dynamically controls vigilance threshold to similarity using fuzzy operations and the sum operation of Yager. To check the performance of new methods, we used 26 alphabet characters and nosed characters. In experiment results, the proposed methods are better than the conventional methods in ART1, because the proposed methods are less sensitive than the conventional methods for initial vigilance and the recognition rate of the proposed methods is higher than that of the conventional methods.

The Research on Aluminum and Silcon Nanoparticles as Anode Materials for Lithium Ion Batteries (알루미늄 실리콘 나노분말을 이용한 리튬이온전지 음극재료에 관한 연구)

  • Kim, Hyeong-Jo;Tulugan, Kelimu;Kim, Hyung-Jin;Park, Won-Jo
    • Journal of Power System Engineering
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    • v.17 no.1
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    • pp.110-115
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    • 2013
  • The electrochemical performance and microstructure of Al-Si, Al-Si/C was investigated as anode for lithium ion battery. The Al-Si nano composite with 5 : 1 at% ratio was prepared by arc-discharge nano powder process. However, some of problem is occurred, when Al nano composite was synthesized by this manufacturing. The oxidation film is generated around Al-Si particles for passivating processing in the manufacture. The oxidation film interrupts electrical chemistry reaction during lithium ion insertion/extraction for charge and discharge. Because of the existence the oxidation film, Al-Si first cycle capacity is very lower than other examples. Therefore, carbon synthsized by glucose ($C_6H_{12}O_6$) was conducted to remove the oxidation film covered on the composite. The results showed that the first discharge cycle capacity of Al-Si/C is improved to 113mAh/g comparing with Al-Si (18.6mAh/g). Furthermore, XRD data and TEM images indicate that $Al_4C_3$ crystalline exist in Al-Si/C composite. In addition the Si-Al anode material, in which silicon is more contained was tested by same method as above, it was investigated to check the anode capacity and morphology properties in accordance with changing content of silicon, Si-Al anode has much higher initial discharge capacity(about 500mAh/g) than anode materials based on Aluminum as well as the morphology properties is also very different with the anode based Aluminum.

Estimation about Local Strength using FE-Analysis for Steel Yacht (유한요소해석을 이용한 강선요트의 국부강도 평가)

  • Park Joo-Shin;Ko Jae-Yong
    • Journal of the Korean Society of Marine Environment & Safety
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    • v.11 no.2 s.23
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    • pp.77-82
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    • 2005
  • Previously sailing yachts or leisure yachts were mainly made from FRP(Fiber glass reinforced plastic) in the small shipbuilding, but recently there is a trend to replace it for steel or aluminum to substitute FRP for environmental friendly materials. Although It have to need a many checked item in case of hull girder strength and transverse strength normally evaluate base on calculation of class guideline so called direct calculation method. Otherwise. this method of initial structural design considered enough for safety margin on the structure. But, case of small craft must consider for evaluating local strength through rational method. In this paper, check the bow structure members for satisfying results base on allowable stress criterion of damaged bow structure by dynamic load due to slamming and bottom impact load due to pitching motion through finite element analysis. and investigate engine bed structure considering engine weight load and transverse wave load.

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A Development of Measurement and Comparison Technique for Large Curved Hull Pieces (대형 곡면 부재의 계측 및 비교기술 개발)

  • Jong-Moo Lee;Jong-Gye Shin
    • Journal of the Society of Naval Architects of Korea
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    • v.39 no.2
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    • pp.28-33
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    • 2002
  • The characteristics of hull-pieces are large quantity, comparatively large piece-size, and different each shape. For the more, in the forming process(including Line-Heating Process) of curved hull pieces, shape checking processes including initial shape measurement and forming shape measurement of the each pieces are needed to achieve a given accuracy. So, the forming process of large curved hull pieces needs efficient measurement and comparison technique to check the shape and ensure the forming-accuracy In this paper, we try to construct integrated S/W, H/W system for efficient measurement and comparison of large curved hull pieces, which can apply to above forming environment.

Development of the Design System for the Lifting Lug Structure (탑재용 러그 구조의 설계 시스템 개발)

  • Juh-Hyeok Ham
    • Journal of the Society of Naval Architects of Korea
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    • v.38 no.1
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    • pp.86-98
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    • 2001
  • Due to the rapid growth of ship building industry and the increment of ship construction in Korea, several hundred thousand of lifting lugs per year, have been installed at the lifting positions of ship block and removed after finishing their function, therefore. appropriate design system for the strength check or the optimal design of each lug structure has been required in order to increase the capability of efficient design. In this study, the design system of D-type lifting lug structure which is most popular and useful in shipyards, was developed for the purpose of initial design of lug structure. Developed system layout and graphic user interface for this design system based on the $C^{++}$ language were explained step by step. Through the illustration of one example of D-type lug designs, the efficiency of this design system was proved. Therefore, more efficient performance of practical lug structural design will be expected on the windows of personal computer using this design system.

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