• Journal of Life Science
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• v.33 no.8
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• pp.663-679
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• 2023

This review analyzes research trends related to new drug development using artificial intelligence from 2010 to 2022. This analysis organized the abstracts of 2,421 studies into a corpus, and words with high frequency and high connection centrality were extracted through preprocessing. The analysis revealed a similar word frequency trend between 2010 and 2019 to that between 2020 and 2022. In terms of the research method, many studies using machine learning were conducted from 2010 to 2020, and since 2021, research using deep learning has been increasing. Through these studies, we investigated the trends in research on artificial intelligence utilization by field and the strengths, problems, and challenges of related research. We found that since 2021, the application of artificial intelligence has been expanding, such as research using artificial intelligence for drug rearrangement, using computers to develop anticancer drugs, and applying artificial intelligence to clinical trials. This article briefly presents the prospects of new drug development research using artificial intelligence. If the reliability and safety of bio and medical data are ensured, and the development of the above artificial intelligence technology continues, it is judged that the direction of new drug development using artificial intelligence will proceed to personalized medicine and precision medicine, so we encourage efforts in that field.

• Journal of Internet Computing and Services
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• v.24 no.4
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• pp.117-125
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• 2023

Flipped learning is an instructional approach that reverses the traditional order of in-class and after-class activities. It entails students studying course materials before attending class, and then utilizing class time for completing homework tasks. Due to collaborative support available from teachers and peers, flipped learning has gained extensive adoption in computer science and engineering courses, enabling students to effectively engage in homework assignments. Nevertheless, students are responsible for studying class materials independently, which can limit their understanding of advanced topics. We propose an approach that combines both flipped learning and the traditional method, allowing them to mutually enhance each other. In the proposed approach, students acquire foundational concepts prior to attending class, and subsequently delve into advanced topics during classroom sessions through lectures and guidance provided by the teacher. Afterward, students collaborate with their peers to solve problems that involve the application of the concepts they have learned, and exchange a variety of solutions and perspectives. We implemented the proposed approach in four computer science and engineering classes, spanning one to four semesters and observed an enhancement in students' comprehension and satisfaction levels. We anticipate implementation of the proposed approach across various computer science and engineering courses, while enhancing their overall quality.

• Land and Housing Review
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• v.14 no.3
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• pp.145-155
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• 2023

Recently, with the widespread adoption of Building Information Modeling (BIM) technology in the construction industry, various object detection algorithms have been used to verify errors between 3D models and actual construction elements. Since the characteristics of objects vary depending on the type of construction facility, such as buildings, bridges, and tunnels, appropriate methods for object detection technology need to be employed. Additionally, for object detection, initial object images are required, and to obtain these, various methods, such as drones and smartphones, can be used for image acquisition. The study uses a 360° camera optimized for internal tunnel imaging to capture initial images of the tunnel structures of railway and road facilities. Various object detection methodologies including the YOLO, SSD, and R-CNN algorithms are applied to detect actual objects from the captured images. And the Faster R-CNN algorithm had a higher recognition rate and mAP value than the SSD and YOLO v5 algorithms, and the difference between the minimum and maximum values of the recognition rates was small, showing equal detection ability. Considering the increasing adoption of BIM in current railway and road construction projects, this research highlights the potential utilization of 360° cameras and object detection methodologies for tunnel facility sections, aiming to expand their application in maintenance.

• Journal of recreation and landscape
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• v.8 no.4
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• pp.43-51
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• 2014

This research is based on a rural village reconstruction business that is a priority under the national support act for rural village vitalization. Allowing for an analysis of the regional and annual classification of business contents as part of the master district implementation plan, this research presents amenity resource applications for the purpose of understanding the business contents and resource status reports. To analyze the utilization of amenity resources in the rural villages' overall development business, a content analysis of the business characteristics and resources of 299 districts was conducted for a seven-year period (2005-2011). Information that included district names, enterprise types, and specifications of a particular business, were coded in Excel, through exhaustive research of the 299 districts. Using this process, a more detailed categorization of seven years of business data, periodic, and regional business contents were defined. As a result of this research, it is apparent that the overall district's facility resources are optimized for the most, and that the environmental management of resources, including animal and plant resources, as well as water resources, is continuously decreasing, as was shown in the annual amenity resource usage transition. The annual amenity resource usage transition data denotes the highest rates in Jun-Ra-Buk-Do and Kyung-Sang-Buk-Do. In summary, this analysis verified the urgent need for diverse amenity resource utilization, research on practical alternatives, and the resource optimization of environmental controls for sustainable development in rural areas.

• Iberoamérica
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• v.21 no.1
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• pp.57-105
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• 2019

This paper deals with the regional asymmetries of MERCOSUR and regional development cooperation for its solution. Through the formation of a common market, the countries of Southern Cone expected to grow evenly. However MERCOSUR had structural asymmetry from the beginning and exposed policy asymmetry over time. It is basically due to the overwhelming influences of Brazil on MERCOSUR. With regard to asymmetries, Paraguay calls for special and differential treatment. Uruguay wants equitable application of market liberalization. Argentine emphasizes production integration based on the development of value chains. In the issue of asymmetries, while Paraguay, Uruguay and Argentine act as petitioners, Brazil is capable of selecting the initiatives. Under these circumstances MERCOSUR has established FOCEM as regional redistribution mechanism. FOCEM has achieved some results as seen in Paraguay, but there are still problems such as financial limitations and lack of enforcement. In oder to activate the redistributive mechanism for regional integration and to coordinate the policies to resolve regional disparities, transnational governance is essential but all member countries are reluctant to it. To date, regional asymmetries or development gaps have persisted and disparities in individual countries remains a problem.

• Journal of Practical Agriculture & Fisheries Research
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• v.12 no.1
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• pp.137-150
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• 2010

Traditionally, like many people in mountain region of the Himalaya, the Lwang communities depend on mix of subsistence agriculture, animal husbandry, and seasonal migrant labor for their livelihoods. These traditional systems are characterized by low productivity, diverse use of available natural resources (largely for home consumption), limited markets, and some aversion for innovation. The potential to generate wealth through commerce has largely been untapped by these mountain residents and thus is undervalued in local and national economies. Introduction of organic tea farming is a part of Lwang community's several initiatives to break the vicious poverty cycle Annapurna Conservation Area Project (ACAP) played facilitating roles in all their efforts since beginning. In five years, the tea plantation emerged as a new means for secured a livelihood. This study aims to analyze the current practices in tea farming both in terms of farm management and soil nutrient status(technical) and the prosperity of the tea farmers (social). The technical aspect covers the soil and tea leaf analysis of various nutrients contents in the soil and tea leaf. Originally, the technical aspect of the study was not planned but later during the consultation with the advisor it was taken into consideration which added value to the research study. The sample were collected from different locations and analyzed on the field itself. The other part of the study i.e. the social aspect was done through questionnaire survey and focus group discussion. the tea farming provided them not only a new opportunity but also earned an identity in the region. This initiative was undertaken as a piloting measure. Now that the tea is in production with processing unit established locally, more serious consideration has to be given for better yield and economic prosperity. This research finding will help the community to analyze their efforts and make correction measures in tea garden management and application of fertilizer. It is also expected to fill up the gaps of knowledge and information required to reduce economic stresses and enhance capacity of farmers to make the tea farming a sustainable and beneficial business. The findings are expected to Sustainability of organic tea farming has direct impacts on biodiversity conservation compared to the other traditional farming practices that are more resource intensive. The study will also contribute to identify key action points required for reducing poverty while conserving environment and enhancing livelihoods

• Economic Analysis
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• v.27 no.2
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• pp.71-123
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• 2021

In this study, we present a methodology and model to estimate land prices and the value of land assets in North Korea in the absence of any data about land characteristics from North Korean authorities. Using this framework, we experimentally make market price-based estimates for land assets across the entire urban area of North Korea. First, we estimate the determinants of land prices in South Korea using data on market prices of land from the late 1970s, when it was estimated that the income level gap between South Korea and North Korea wasn't relatively large, and from the early 1980s, when urbanization levels in both of them were similar. Second, we calculate land prices and their relative ratios for each city and urban area in North Korea around 2015 by substituting proxy variables of determinants of land prices derived through a geographic information analysis of North Korea into the function of land prices that we have already estimated. Finally, we estimate the value of land assets in urban areas across North Korea by combining the ratio of housing transaction prices surveyed in several cities in North Korea with the relative prices estimated in this research. As a result, land prices in urban areas in North Korea, looking at the relative ratio of price by city, are estimated to be the highest, at 100.00, in Tongdaewon district of Pyongyang, and to be the lowest, at 1.70, in Phungso county, Ryanggang Province. Meanwhile, the value of land assets in urbanized areas was estimated at $21.6 billion in 2015, which was 1.2 to 1.3 times the GDP of North Korea that year. This ratio is similar to South Korea's in the 1978-1980 period, when the South Korean economy grew at an average rate of 6%. Considering North Korea's growth rate of about 1% in the 2013-2014 period, its ratio of land assets to GDP appears very high.

• Journal of the Korean Geotechnical Society
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• v.23 no.8
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• pp.17-33
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• 2007

Downhole seismic method is widely used for obtaining shear wave velocity profile of a site because it is simple and economical. Determining accurate travel time of shear wave is very important to obtain reliable result in downhole seismic method. In this paper, comparison study of various travel time determination methods was performed. Numerical study and model chamber test were performed for effective comparison study. Signal traces were acquired by performing downhole test at each numerical simulation and soil box test. Travel time data for each signal traces were determined by using six different methods and Vs profiles were evaluated. Comparing travel time data and Vs profiles with the reference value, the first arrival picking method proved to be ambiguous and unreliable. Other methods also did not always provide accurate results and the magnitude of error was dependent on the signal to noise ratio. Cross-correlation method proved to be the most adequate method for the field application and it was verified additionally with field data.

• KOREAN JOURNAL OF PACKAGING SCIENCE & TECHNOLOGY
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• v.29 no.1
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• pp.27-33
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• 2023

An optimized design of the transportation insulated box must be considered to control the thermal damage in order to maintain the fresh condition for temperature-sensitive medicine and frozen food safety. The inside temperature of the insulated box is a natural convection enclosure state, thermal stratification naturally occurs as time passes in case of with outside heat load. The latent heat material (LHM) placement inside the box maintains the target temperature of the product for temperature fluctuations during transport, and LHM application is a common and efficient method. In this work, inside temperature stratification in an insulated box depending on the LHM pack position is numerically simulated and experimented. The insulated box is made up of vacuum insulation panel (VIP), and LHM modules are placed over six faces inside the box, with the same weight. The temperature curves for 72 hrs as experiment results clearly show the temperature stratification in the upper, middle, and lower at the LHM melting time region. However, the temperature stratification state is uniformly changed in accordance with the condition of the upper and lower placement weight of the LHM pack. And also, the temperature uniformity by changed placement weight of LHM has an effect on maintaining time for target air temperature inside the box. These results provide information on the optimized design of the insulated box with LHM.

• Journal of the Korean Geotechnical Society
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• v.22 no.8
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• pp.43-54
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• 2006

The scope of this paper covers the applications of bender element tests in consolidation, tomography, and liquefaction. Loading and unloading time during consolidation are evaluated based on shear wave velocity. As S-wave velocity is dependent on effective stress, the loading step may be determined. However, cautions are required due to the different mechanism between the settlement and effective stress criteria. The stress history may be evaluated because the S-wave shows the cement controlled regime and stress controlled regimes. A fixed frame complemented with bender elements permits S-wave tomography The tomography system is tested at low confinement within a true triaxial cell. Results show that shear wave velocity tomography permits monitoring changes in the velocity field which is related to the average effective stress. To monitor the liquefaction phenomenon, S-wave trans-illumination is implemented with a high repetition rate to provide detailed information on the evolution of shear stiffness during liquefaction. The evolution of shear wave propagation velocity and attenuation parallel the time-history of excess pore pressure during liquefaction. Applications discussed in this paper show that bender elements can be a very effective tool for the detection of shear waves in the laboratory.