• 제목/요약/키워드: influx

검색결과 1,032건 처리시간 0.035초

Vibrio vulnificus cytolysin의 흰쥐 혈소판 응집 기전 (Mechanism of Vibrio vulnificus Cytolysin on Rat Platelet Aggregation)

  • 김현철;채수완;이병창;은재순
    • 약학회지
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    • 제43권6호
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    • pp.802-808
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    • 1999
  • Vibrio vulnificus cytolysin has been incriminated as one of the important virulence determinants in V. vulnificus infection. In the present study, the effects of Vibrio vulnificus cytolysin on platelets were examined. Vibrio vulnificus cytolysin induced platelet aggregation and increased intracellular calcium concentration ($[Ca^{2+}]_i$) of rat platelets. These effects were abolished in $Ca^{2+}-free$ buffer (2 mM EGTA). Cytolysin also potentiated ADP-and collagen-induced platelet aggregation. Lanthanum (2 mM) inhibited cytolysin-diduced platelet aggregation. However, another $Ca^{2+}$ channel blockers, verapamil ($20{\;}{\mu}M$) or mefenamic acid ($20{\;}{\mu}M$) did not block cytolysin-induced platelet aggregation. Osmotic protectants, sucrose (50 mM) and raffinose (50 nM) suppressed platelet aggregation by 35.9% and 63.4%, respectively. V. vulnificus cytolysin increased membrane conductances of platelet membranes. These results suggest that cytolysin-induced platelet aggregation is mediated via lanthanum sensitive-calcium influx which resulted from the pore formation by V. vulnificus cytolysin.

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오존에 대한 식물 기공 반응고찰 (Stomatal Response by Ozone)

  • 이준상;김병우
    • The Korean Journal of Ecology
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    • 제20권2호
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    • pp.83-94
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    • 1997
  • Stomatal closing by ozone and water stress could reduce further ozone injury by inhibition of ozone influx to the tissue. Direct effect of ozone on stomata can be explained from two aspects which are a stimulation of stomatal closing and an inhibition of stomatal opening. An increase of $Ca^{2+}$ influx into cytoplasm by ozone could stimulate potassium efflux ion channel and inhibits inward potassium ion channels. By this mechanism ozone could induce stomatal closing. On the other hand, ozone could inhibit stomatal opening by affecting the activity of $H^{+}$ dependent ATPase of the membrane in guard cells. This would inhibit proton efflux which precede stomatal opening. It is also possible that ozone could reduce the activity of photosynthesis in guard cells which lead to affect the production of osmotically active sugars and energy. Indirect effect of ozone to stomata is through the effect of $CO_2$ elevation as a result of damage of the photozynthetic machinery. This indirect effect is slower than the direct effect.

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농촌생활형 펜션의 입지환경에 관한 연구 - 금산지역을 중심으로 - (A Study on the Locational Condition of Rural Life Style Pensions - Focused on the Geumsan Area -)

  • 도용호
    • 한국농촌건축학회논문집
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    • 제10권1호
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    • pp.11-18
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    • 2008
  • The Geumsan is contiguous to Daejeon and population is decreasing every year. Consequently, the population influx, and securing source of revenue dimensional geographic and environmental benefits of the establishment of a pensions plan for the rural life style pensions research. The result is that Geumsan has a convenient traffic circumstance geographically and is a clean area as the high-level area of solid water system. Also, Geumsan forms the mountainous area whose sea-level elevation reaches to 2.5 times of the Chungcheongnam-do. Consequently, Geumsan has a suitable environment for locating many kinds of pensions like the riverside village style, the mountain village style and the villa style, the country style, the cafe style, experience style, theme style etc. So, Geumsan is found to be a suitable area to host 'rural life style' pensions, because it has wide area, small population and nice environmental conditions.

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공극 자속밀도의 공간 고조파 유입 방법을 통한 IPM type BLDC Motor의 성능 개선 (Performance Improvement of IPM-type BLDC Motor Using the Influx Method of Spatial Harmonic in Air-gap Flux Density)

  • 이광현;류진욱;허진
    • 전기학회논문지
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    • 제60권4호
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    • pp.739-745
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    • 2011
  • This paper proposes a method for reducing the negative spatial harmonics of the radial flux density of an interior-type permanent magnet (IPM) motor. The reliability of the motor is increased by minimizing its vibrations under dynamic eccentricity (DE) state and normal state due to reduction of a negative spatial harmonics component through the influx of a zero spatial harmonics component in the radial flux density. To minimize the vibrations, optimal notches corresponding to the distribution shape of the magnetic field are designed on the rotor pole face. The variations of vibration computation by finite element method (FEM) and the validity of the analysis and rotor shape design are confirmed by vibration and performance experiments.

장기인구성장에 따른 교육개발 (Educational Development Plan for the Future Popultion Growth)

  • 박덕규
    • 한국인구학
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    • 제8권1호
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    • pp.20-46
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    • 1985
  • The increase of the population has an effect on the increase of students. The high birthrate, which means the extension of enrollments in the future, requires preparation of enough facilities and equipment for education. However, the educational conditions of Korea are not yet developed, and in such a situation the increase of enrollments makes the improvement of educational conditions difficult. Besides, the influx of students into the large cities has made complex educational problems such as a decrease of students in the rural area and a change for the worse of the educational conditions in the urban area. For the development of education in such a situation, an emphasis should be put not only on security of a stable educational finance but also on activation of family planning project and curb of population influx into large cities in the realm of population policy. In addition, population education for the youth should be strengthened in order that they can have sound view of family life, married life, children, and sex moral. For the way the young married live has relationship with the number and quality of children in the future of our nation.

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건설기능인력 양성을 위한 특성화 고등학교 건설교육 개선방안 (Improvement Measures on the Construction Education of Specialized High Schools for Training Construction Skilled Workers)

  • 한경민;조병욱;손창백
    • 한국건축시공학회:학술대회논문집
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    • 한국건축시공학회 2019년도 추계 학술논문 발표대회
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    • pp.46-47
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    • 2019
  • The construction industry has a higher dependency on manpower than other industries, requiring a supply of high quality skilled workers. But negative perceptions regarding the construction industry have continued to reduce the inflow of young workers into the industry, and the existing skilled workforce is aging. In response, as a solution for training young construction skilled manpower, training programs for young construction skilled workers have been implemented by specialized high schools. But the current status of career paths chosen by the graduates of these specialized high schools did not show a substantial influx of workers into the construction industry. In this regard, with the purpose of promoting an influx of young construction skilled manpower into the industry, this study analyzed the goals and problems of construction education in specialized high schools in South Korea, and suggested a method for improvement.

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Effects of (lR,9S)-($\beta$)-Hydrastine on Intracellular Calcium Concentration in PC12 Cells

  • Kim, Yu-Mi;Lee, Jae-Joon;Jin, Chun-Mei;Yang, Yoo-Jung;Yin, Shou-Yu;Kang, Min-Hee;Lee, Myung-Koo
    • 대한약학회:학술대회논문집
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    • 대한약학회 2003년도 Proceedings of the Convention of the Pharmaceutical Society of Korea Vol.2-2
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    • pp.97.2-97.2
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    • 2003
  • (1R,9S)-(${\beta}$)-Hydrastine (HS) at 10-50 ${\mu}$M has been proven to have an inhibitory effect on dopamine biosynthesis in PC12 cells by the inhibition of tyrosine hydroxylase (TH) activity and TH gene expression. In the present study, therefore, the effects of HS on the basal and K$\^$+/-induced dopamine release, and Ca$\^$2+/ influx induced by high K$\^$+/ and caffeine in PC12 cells were investigated. The dopamine release by high K$\^$+/ (56 mM) was inhibited by co-incubation of 20 ${\mu}$M HS. Application of HS also significantly reduced the magnitude of the maintained Ca$\^$2+/ influx induced by K$\^$+/ depolarization. (omitted)

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슈퍼컴퓨터 5호기 사용자의 작업별 IO 통계정보 획득 방안에 대한 연구 (A study on the method of acquiring IO statistical information for each user task of the KISTI-5 supercomputer)

  • 권민우;윤준원;홍태영
    • 한국정보처리학회:학술대회논문집
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    • 한국정보처리학회 2021년도 추계학술발표대회
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    • pp.6-8
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    • 2021
  • 슈퍼컴퓨터 5호기 누리온은 8,437대의 계산노드와 33.88PB 규모의 병렬스토리지가 100Gbps의 Omni-Path(OPA) 인터커넥트로 연결되어 있는 초대형 클러스터 시스템이다. 누리온의 계산자원은 PBS 작업스케줄러를 통해 관리되고 있고 병렬 스토리지는 DDN사의 Exascaler Monitoring System(ESMON)을 통해 influxDB에 read/write IO 통계 데이터를 수집하고 있다. 본 논문에서는 PBS의 과금 데이터와 ESMON influxDB의 IO 통계 데이터를 활용하여 사용자의 작업별 IO 통계 정보를 생성하는 방안에 대하여 소개한다.