• The Korean Journal of Applied Statistics
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• v.33 no.1
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• pp.47-59
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• 2020

In this paper, we present the longitudinal Markov binary regression model with t-link function when its transition order is known or unknown. It is assumed that logit or probit models are considered in binary regression models. Here, t-link function can be used for more flexibility instead of the probit model since the t distribution approaches to normal distribution as the degree of freedom goes to infinity. A Markov regression model is considered because of the longitudinal data of each individual data set. We propose Bayesian method to determine the transition order of Markov regression model. In particular, we use the deviance information criterion (DIC) (Spiegelhalter et al., 2002) of possible models in order to determine the transition order of the Markov binary regression model if the transition order is known; however, we compute and compare their posterior probabilities if unknown. In order to overcome the complicated Bayesian computation, our proposed model is reconstructed by the ideas of Albert and Chib (1993), Kuo and Mallick (1998), and Erkanli et al. (2001). Our proposed method is applied to the simulated data and real data examined by Sommer et al. (1984). Markov chain Monte Carlo methods to determine the optimal model are used assuming that the transition order of the Markov regression model are known or unknown. Gelman and Rubin's method (1992) is also employed to check the convergence of the Metropolis Hastings algorithm.

• Journal of the Computational Structural Engineering Institute of Korea
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• v.29 no.4
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• pp.317-325
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• 2016

In this study, nonlinear earthquake responses of a soil-structure interaction(SSI) system which is subjected to a three-directional ground motion are examined. The structure and the near-field region of soil, where the geometry is irregular, the material properties are heterogeneous, and nonlinear dynamic responses are expected, are modeled by nonlinear finite elements. On the other hand, the infinite far-field region of soil, which has a regular geometry and homogeneous material properties and dynamic responses is assumed linearly elastic, is represented by three-dimensional perfectly matched discrete layers which can radiate elastic waves into infinity efficiently. Nonlinear earthquake responses of the system subjected to a three-directional ground motion are calculated with the numerical model. It is observed that the dynamic responses of a SSI system to a three-directional motion have a predominant direction according to the characteristics of the ground motion. The responses must be evaluated using precise analysis methods which can consider nonlinear behaviors of the system accurately. The the method employed in this study can be applied easily to boundary nonlinear problems as well as material nonlinear problems.

• Management & Information Systems Review
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• v.15
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• pp.109-145
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• 2004

Upcoming 21st century, Management circumstance for a small and medium enterprise have been rapidly changed by Knowledge management, Informationization, Hi-technology. Changing from an era of small concept to strong concept, It will be a severe innovation period and can not survive with life as the same as the past, It is the era of best which mean only the best can survive, None of the average faculty can survive. Due to rapid proceeding of innovation of Informationization, It stimulate acceleration of technology innovation, infinity competition regardless the nation boarder, result in proceeding to Informationization. A small and medium enterprise is defined as smaller size of business than big business as point of capital, employee, output. It is concept, which usually used against concept of big business. When define a small and medium enterprise, criteria to determine a small and medium enterprise is depends on country and a category of business. However, In every country, A small and medium enterprise is getting be bigger and importance factor in whole industry. A small and medium enterprise is well developed and also well balanced with a large enterprise in the developed country. All around in the world, Interest about a small and medium enterprise is becoming higher. It is actively researching into a small and medium enterprise as the mean to create new employment, new industry, as means to from integration of a all and medium enterprise,as source of high competitive power. The status quo of rapid changing into informationization have been realized at considerable level in Korea. Information society is defined as information technology is main key to determine individuals competitiveness, which can solve effectively the side effect result from industrialization. It cleary imply that information technology is the most promising and important industry in 21st century. Therefore, We should seek to foster independent a small and medium enterprise and develop them corresponding to new concept of a small and medium enterprise in 21st century. The main frame of policy should be new economic system, which can contribute establishment of a small and medium enterprise, management innovation. It also attribute a small and medium enterprise to reveal their creative. New economic paradigm in 21st will be expanded with organization, market, technology. So far, a small and medium enterprise has been acknowledge as economic weaker and the one should be protected. However, In 21st century a small and medium enterprise will be considered as active majority or a source of creative. Development of technology to produce a small quantity with variety product and acceleration of knowledge and informationization will result in comparative merits of a small and medium enterprise. Hereby, The role and relative importance of a small and medium enterprise in our economic will getting be larger and It will be developed as the main force to activate the economic. However, Only a small and medium enterprise, which overcome difficulty with active desire and effort to improve their lot can be developed as a competitive enterprise in 21st century in considering themselves to be developed as diversity, active, independent, business by an enterprise.

• Journal of Korea Water Resources Association
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• v.45 no.7
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• pp.643-656
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• 2012

There has been an increase for the landslide areas and restoration expenses due, in large part, to the increased locally heavy rains caused by recent climate change as well as the reckless development. This study carried out a slope stability analysis by the application of distributed wetness index, using the GIS-based infinite slope stability model, which took the root cohesion effect into consideration, for part of Mt. Umyeon in Seoul, where landslide occurred in July 2011, in order to compensate the defects of existing analysis method, and subsequently compared its result with the case on the exploitation of lumped wetness index. In addition, this study estimated the distributed wetness index by methodology, applying three methods of specific catchment area calculation: single flow direction (SFD), multiple flow direction (MFD), and infinity flow direction (IFD), for catchment area, one of the variables of distributed wetness indices, and finally implemented a series of comparative analysis for slope stability by methodology. The simulation results showed that most unstable areas within the study site were dominantly located in cutting-area surroundings along with the residential area and the mountaintop and unstable areas of IFD and lumped wetness index method were similar while SFD and MFD provided smaller unstable areas than the two former methods.

• Korean Journal of Clinical Pharmacy
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• v.12 no.2
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• pp.91-95
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• 2002

The pharmacokinetics of intravenous paclitaxel (1 mg/kg) were investigated in rabbits with renal failure induced by folic acid. The area under the plasma concentration-time curve from time zero to time infinity (AUC) of paclitaxel was significantly (p<0.05) greater in rabbits with severe renal failure induced by folic acid $(1030\pm382)$ compared to that in rabbits with in moderate renal failure induced by folic acid $(780\pm209\;ng/ml{\cdot}hr)$. The apparent volume of distribution (Vd) $(0.008\pm0.002\;L/kg)$ and the elimination rate constant $(\beta)\;(0.09\pm0.025\;hr^{-1})$ of paclitaxel in rabbits with severe renal failure were significantly (p<0.05) smaller and slower respectively than those of control rabbits $(0.016\pm0.004\;L/kg,\;0.12\pm0.03\;hr^{-1})$, but not significantly different compared with that in rabbits with moderate renal failure $(0.010\pm0.003\;L/kg,\;0.10\pm0.026\;hr^{-1})$. total body clearance (CL) of paclitaxel in rabbits with severe renal failure $(0.97\pm0.183\;L/hr/kg)$ was significantly (p<0.05) slower than that in control rabbits $(1.68\pm0.440\;L/hr/kg)$, but not significantly different compared with that in rabbits with in moderate renal failure $(1.28\pm0.311\;L/hr/kg)$. The terminal half-life ($t_{1/2}$) of paclitaxel in rabbits with severe renal failure $(7.46\pm2.16\;hr)$ was significantly (p<0.05) longer than that in control rabbits $(5.75\pm1.44\;hr)$, but not significantly different compared to that in rabbits with moderate renal failure rabbits $(6.67\pm1.76\;hr)$. The above data could be at least partly decrease in due to paclitaxel excretion in rabbits with renal failure, since $7-15\%$ of interavenous paclitaxel was excreted via kidney as unchanged forms plus its metablites.

• Journal of Pharmaceutical Investigation
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• v.37 no.6
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• pp.397-402
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• 2007

To evaluate the bioequivalence of two venlafaxine formulations, a standard 2-way randomized cross-over study was conducted in twenty-four healthy male Korean volunteers. A single oral dose of 75 mg of test formulation Venfaxine $OR^{(R)}$ (tablet) or reference formulation Efexor $XR^{(R)}$ (capsule) was administered with one-week washout period. Plasma concentrations of venlafaxine were assayed for over a period of 72 hours with a well validated method using liquid chromatography coupled to tandem mass spectrometry (LC-MS-MS). The $mean{\pm}S.D$. of maximum concentration $(C_{max})$ and elimination half-life $(t_{1/2})$ were $64.7{\pm}28.5$ ng/mL, $9.2{\pm}3.0$ h, and $67.2{\pm}30.2$ ng/mL, $9.9{\pm}3.5$ h for test and reference formulations, respectively. Time to reach maximum concentration $(T_{max})$ expressed in median value (range), for the test and the reference, were 10 h (6-14) and 8h (4-12), respectively. Similarly, area under the plasma concentration-time curve, from time zero to last sampling time $(AUC_t)$ and from time zero to time infinity $(AUC_{inf})$, for test and reference formulations were $1185{\pm}755$, $1326{\pm}896$ and $1124{\pm}737$, $1185{\pm}755$ $ng{\cdot}h/mL$, respectively. The parametric 90% confidence intervals on the mean of the differences between the two formulations (test-reference) of the log transformed values of $AUC_t$, and $C_{max}$ were 0.9630 to 1.1383 and 0.8650 to 1.0446, respectively. The overall results indicate that the two formulations are bioequivalent and can be prescribe interchangeably.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.16 no.9
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• pp.6227-6235
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• 2015

The HUD has recently been downsized due to the development of micro display and LED technology as a see through information display device, gradually expands the application areas. In this paper, using a DLP micro display device designed a compact head-up display(HUD) optical system for biocular observation of the image exhibition area 5 inches. It was analyzed for each design element of the optical system in order to design a compacted HUD. DLP, projection optical system and concave image combiner were discussed the design approach and the characteristics. Through a connection structure analysis of each optical system, detailed design specifications were set up and designed the optical system in detail. Put a folded configuration in the form of a white diffuse reflector between the projection lens and concave image combiner was designed to be independent, respectively. Distance of the projected image is adjustable up to approximately 2m ~ infinity and observation distance is 1m. Resolution could be recognized by 1 ~ 2pixels in HD($1,280{\times}720pixels$) class, various characters and symbols could be read. In addition, color navigation map, daytime video camera and thermal imaging cameras can be displayed.

• International journal of advanced smart convergence
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• v.10 no.4
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• pp.241-255
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• 2021

The human auricle is the first part to receive sound from the outside. In this part, the frequency range of human recognizable form is divided and organized. In this study, we propose modeling by applying a single sound source to the surface of the human auricle. This means that when the sound pressure of a low frequency (low frequency) sound enters the pinna, the impedance felt at the tip of a part of the non-linear surface of the pinna is mainly due to the tensile force at the end of the part of the non-linear surface of the pinna. By expressing the situation of moving at a very small speed, the characteristic impedance of the pinna was confirmed to be negative infinity, and it was also confirmed that the speed at the tip of a part of the non-linear surface of the pinna was 0 in the anti-resonance state. It was found that the wave propagation phenomenon that determines the characteristics of the filter is determined by how large the wavelength, kL, is compared to the length of the tip of a part of the non-straight surface of the pinna. Humans first receive sounds from outside through their ears. The auricle is non-linear and has a curved shape, and it is known that it analyzes frequencies while receiving external sounds. The human ear has an audible frequency range of 20Hz - 20,000Hz. Through the study, we applied the characteristics of the notch filter to hypothesize that the human audible frequency range is separated from the auricle, and applied filter theory to analyze it, and as a result, meaningful results were obtained. The curved part and the inner part of the auricle function as a trumpet, collecting sounds, and at the same time amplifying the weak sound of a specific band. The point was found and the shape of the envelope detected in the auricle was found. Selectivity for selecting sounds coming from the outside is the formula of the pinna that implements the function of Q. The function of distinguishing human-recognizable sound from the pinna from low to high through frequency analysis is performed in the pinna, and the 2-3kHz area, where human hearing threshold is the most sensitive, is also the acoustic impedance of the most recessed area of the pinna. It can be seen that starting from.

• The Journal of the Convergence on Culture Technology
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• v.5 no.3
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• pp.209-214
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• 2019

The study is a hypothetical one about how to cut out a single emotion and activate it positively. The study could be used to treat literary therapy through AI. In this study, Hwang Jin-yi's Sijo "Long and Long Night of Winter Solstice Month" was studied. Because this work is very appropriate for the study of emotional cutting and interlinking. This counting method of treatment was used in this Sijo. Hwang Jin-yi's work cuts out "Long and Long Night of Winter Solstice Month" from the beginning. And they dream of regenerating their emotions by putting the time of their cut-off under the 'blanket of the spring breeze.' And in the end, the time of yearning unfolds to infinity, very finely. The extended hours of longing were added to the 'blanket of the spring breeze.' Spread out the times of yearning, it dreams of eternal love, the yearning for everlasting love. These literary acts are expected to lead to many changes in the human nervous system. This is the method of love that dreams of healing emotions in literature. Lover was left but not sent, lover's love amplifies feelings of joy. This method of emotional counting is believed to be very useful in the upcoming literary treatment by AI.

• Journal of Radiation Industry
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• v.17 no.4
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• pp.397-403
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• 2023

The purpose of this study is to obtain brain MRI images through Heavenly T₂ FLAIR and DWI techniques to find out strengths and weaknesses of each image. Data were analyzed on 13 normal people and 17 brain tumor patients. Philips Ingenia 3.0TCX was used as the equipment used for the inspection, and 32 Channel Head Coil was used to acquire data. Using Image J and Infinity PACS Data, 3mm² of gray matter, white matter, cerebellum, basal ganglia, and tumor areas were set and measured. Quantitative analysis measured SNR and CNR as an analysis method, and qualitative analysis evaluated overall image quality, lesion conspicuity, image distortion, susceptibility artifact and ghost artifact on a 5-point scale. The statistical significance of data analysis was that Wilcox-on Signed Rank Test and Paired t-test were executed, and the statistical program used was SPSS ver.22.0 and the p value was less than 0.05. In quantitative analysis, the SNR of gray matter, white matter, cerebellum, basal ganglia, and tumor of Heavily T₂ FLAIR is 41.45±0.13, 40.52±0.45, 41.44±0.51, 40.96±0.09, 35.28±0.46 and the CNR is 15.24±0.13, 16.75±0.23, 16.28±0.41, 15.83±0.17, 16.63±0.51. In DWI, SNR is 32.58±0.22, 36.75±0.17, 30.21±0.19, 35.83±0.11, 43.29±0.08, and CNR is 13.14±0.63, 14.21±0.31, 12.95±0.32, 11.73±0.09, 17.56±0.52. In normal tissues, Heavenly T₂ FLAIR obtained high results, but in disease evaluation, high results were obtained at DWI, b=1000 (p<0.05). In addition, in the qualitative analysis, overall image quality, lesion conspicuity, image distortion, susceptibility artifact and ghost artifact aspects of the Heavily T₂ FLAIR were evaluated, and 3.75±0.28, 2.29±0.24, 3.86±0.23, 4.08±0.21, 3.79±0.22 values were found, respectively, and 2.53±0.39, 4.13±0.29, 1.90±0.20, 1.81±0.21, 1.52±0.45 in DWI. As a result of qualitative analysis, overall image quality, image distortion, susceptibility artifact and ghost artifact were rated higher than DWI. However, DWI was evaluated higher in lesion conspicuity (p<0.05). In normal tissues, the level of Heavenly T₂ FLAIR was higher, but the DWI technique was higher in the evaluation of the disease (tumor). The two results were necessary techniques depending on the normal site and the location of the disease. In conclusion, statistically significant results were obtained from the two techniques. In quantitative and qualitative analysis, the two techniques had advantages and disadvantages, and in normal and disease evaluation, the two techniques produced useful results. These results are believed to be educational data for clinical basic evaluation and MRI in the future.