• The Journal of Internal Korean Medicine
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• v.19 no.1
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• pp.3-21
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• 1998

This study was to investigate the effects of Gibangganbang on the liver injury induced dimethylnitrosamine, CCl4, ethanol and partial hepatectomy. Hydroxyproline, hepatic fibrosis, hepatic inflammatory cell infiltration, fatty value, lipidoperoxide levels, glutathione levels, mitotic index, contents of protein in the serum and liver tissues were measured and observed. The results obtained were as follows. 1. The increasing level of hydroxyproline volume induced by dimethylnitrosamine in mice was decreased by the oral administration of Gibangganbang. 2. The degree of hitological fibrosis and hepatic inflammatory cell infiltration induced by $CCl_4$ was decreased by the oral administration of Gibangganbang. 3. The degree of fatty value and the increasing level of lipidoperoxide in liver tissues was decreased by the oral administration of Gibangganbang. 4. The level of glutathione in liver tissues was increasing by the oral administration of Gibangganbang. 5. The increasing level of microsomal lipidoperoxide in vitro assay was decreasing by the oral administration of Gibangganbang. 6. The increasing level of the mitotic index, weight of liver, contents of protein, RNA and DNA synthesis of the liver tissues after partial hepatectomy was activated by the oral administration of Gibangganbang. These results suggest that Gibangganbang not only inhibits liver cirrhotic change and ethanol-induced fatty change but also activates antioxidant enzymes and regeneration ability ocf liver.

• Biomedical Science Letters
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• v.10 no.4
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• pp.353-360
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• 2004

Eosinophils play an essential role in allergy reaction after parasite infection. To examine the immune reaction induced by eosinophils, we investigated the allergy reaction in BALB/c mice infected with Echinostoma hortense's metacercariae, as well as the effect of ketotifen, an anti-allergy drug, on eosinophil immune reaction in the villi of host intestine. The worm recovery rate was higher in ketotifen-treated mice than in untreated mice and the worms in ketotifen-treated mice survived longer than those in untreated mice. The antibody titer in the serum of ketotifen-treated mice was very low. Especially, Echinostoma hortense infection strongly increased serum IgE level and eosinophil infiltration into the villi of the mouse intestine. Ketotifen treatment suppressed eosinophil infiltration into the infected areas and inhibited IL-4 production. The reduced IL-4 production may be related with the reduction of IgE, IgG1 and IgG2 production. In conclusion, ketotifen inhibited eosinophil infiltration functioning in the allergy reaction induced by parasite infection and the expression of immunoglobulins and cytokines.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.33 no.2
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• pp.559-571
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• 2013

Recently, due to increase of the impervious layer, the storage of surface layer has been reduced. Otherwise the peak runoff and the total surface runoff have been raised. Because of larger amount of the peak runoff and the rapid time of concentration, the flood damage of the urban watershed was increased. The groundwater level is descended by reducing the amount of rainfall that infiltrated into the soil. Thereby the hydrologic cycle is degenerated by the dry stream. Therefore, in this study, the evaluation and the quantitative analysis of the percolation effect were performed through the infiltration experiment of permeable pavement, which is one of the ways that can reduce the problem of the dry stream. Also the SWMM model is used to analyze the effect of the hydrologic cycle for permeable pavement in Changwon stream and Nam stream watersheds, with the coefficient of permeability from the infiltration experiments.

• Journal of the Korea Institute of Building Construction
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• v.22 no.1
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• pp.1-10
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• 2022

Recently, due to the frequent occurrence of localized torrential rains and heat waves caused by abnormal climates. For this reason, it is necessary to develop an economical and eco-friendly rainwater detention facility that can secure the groundwater level through rainwater detention as well as flood prevention against concentrated rainfall by simultaneously implementing rainwater permeation and storage. In this study, the structural safety of an eco-friendly rainwater infiltration type detention facility made using eco-friendly inorganic binders including red clay was examined. Static analysis considering the constant load and additional vertical load and dynamic analysis considering the seismic spectrum were performed. As a result, it was found that the eco-friendly prefabricated rainwater infiltration type detention facility developed in this study has a maximum stress of about 68.1% to 75.4% and a maximum displacement of about 0.9% to 9.6% under the same load and seismic conditions compared to the existing PE block rainwater detention facility. It was confirmed that the eco-friendly prefabricated rainwater infiltration type detention facility secured excellent structural stability.

• Journal of Ginseng Research
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• v.47 no.5
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• pp.672-680
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• 2023

Background: Korean Red Ginseng (KRG), the steamed root of Panax ginseng, has pharmacological activities for immunological and neurodegenerative disorders. But, the role of KRGE in multiple sclerosis (MS) remains unclear. Purpose: To determine whether KRG extract (KRGE) could inhibit demyelination in corpus callosum (CC) of cuprizone (CPZ)-induced murine model of MS Methods: Male adult mice were fed with a standard chow diet or a chow diet supplemented with 0.2% (w/w) CPZ ad libitum for six weeks to induce demyelination while were simultaneously administered with distilled water (DW) alone or KRGE-DW (0.004%, 0.02 and 0.1% of KRGE) by drinking. Results: Administration with KRGE-DW alleviated demyelination and oligodendrocyte degeneration associated with inhibition of infiltration and activation of resident microglia and monocyte-derived macrophages as well as downregulation of proinflammatory mediators in the CC of CPZ-fed mice. KRGE-DW also attenuated the level of infiltration of Th1 and Th17) cells, in line with inhibited Mrna expression of IFN-γ and IL-17, respectively, in the CC. These positive effects of KRGE-DW mitigated behavioral dysfunction based on elevated plus maze and the rotarod tests. Conclusion: The results strongly suggest that KRGE-DW may inhibit CPZ-induced demyelination due to its oligodendroglial protective and anti-inflammatory activities by inhibiting infiltration/activation of immune cells. Thus, KRGE might have potential in therapeutic intervention for MS.

• Journal of The Korean Society of Agricultural Engineers
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• v.54 no.3
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• pp.11-17
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• 2012

In this study, an experiment with large-scale model was performed according to raising embankment in order to investigate the cause of collapse by a change in water level of reservoir. Also, the settlement and pore water pressure by high water level and a rapid drawdown were compared and analyzed. After raising embankment for inclined core, there was no infiltration by leakage. For the vertical core, the pore water pressure showed a largely change by faster infiltration of pore water than in the inclined core. In a rapid drawdown, inclined core was remained stable but vertical core showed a largely change in pore water pressure. A settlement after a raising embankment showed a larger measure of settlement than before the raising embankment. The leakage quantity before a raising embankment and an inclined extension showed no leakage. Leakage in vertical extension was measured 160 $l$. From the result, a instrument system that can accurately estimate a change of pore water pressure shall be established for a rational maintenance and stabilization of raising embankment for agricultural reservoir.

• KIEAE Journal
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• v.13 no.2
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• pp.13-20
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• 2013

Today, the world energy consumption in buildings occupies more than 30%. In our country, the energy consumption in buildings also occupies 25% of the entire national energy consumption. With the increasing demand of energy saving in architectural fields, there is a more interest in low-energy construction. For these low-energy housings, our country is planning to apply the energy-saving design standards at the level of passive houses in 2017. However, there is still a limitation in energy saving only with the standards on the performance of envelope in buildings. This means that unless a building is airtight even though it was well-insulated, cooling and heating energy consumption will increase due to the infiltration and leakage. Therefore, this study aims to make a comparative analysis of airtight performance by conducting a blower door test on the housings applied with passive designs, analyze the reasons why most houses fall short of the airtightness standards, and complement the airtightness problems in the inadequate parts of the buildings in order to save building energy.

• Journal of Korea Water Resources Association
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• v.48 no.12
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• pp.1023-1035
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• 2015

This study applies 3-D N-S solver based on PBM (Porous Body Model), LED-WASS-3D ver 2.0 to directly analyze non-linear interaction of seawater-freshwater-coastal aquifer in order to simulate the seawater infiltration into coastal aquifer. This numerical simulation is the first trial in Korea, as well as unusual and new numerical analysis abroad. Firstly, to validate the applied numerical model, the validity and effectiveness was verified for the numerical model by comparing and considering it with the result of laboratory experiment for seawater-freshwater interface in coastal aquifer. And then it simulated the seawater infiltration into coastal aquifer considering the changed levels of seawater and groundwater in order to analyze the distribution characteristics of flow field and seawater-freshwater interface of coastal aquifer as the level difference between seawater and groundwater and rate of seawater level (${\Delta}h/h$) increased. In addition, the characteristics of seawater infiltration were analyzed from the vertical salinity in the coastal aquifer by ${\Delta}h/h$, which cannot be obtained from existing non-diffusion numerical models. Finally, it analyzed the effect of ${\Delta}h/h$ on the seawater infiltration distance in coastal aquifer, which was indexed.

• The Journal of Engineering Geology
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• v.29 no.2
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• pp.123-136
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• 2019

This study examines the effect of collector well installed to reduce groundwater level in the regions with the occurrence of landcreep, a soil mass movement triggered by instability on slopes. Slopes are prone to failure as a result of instability caused by its internal, topographic and geological properties as well as due to external factors such as rainfall and earthquake. In Korea during the rain season, rainfall infiltration affects the groundwater level in soil, building up porewater pressure and load, and finally drives slopes to collapse. Slope failure caused by rainfall infiltration has been leading to a drastic forest degradation. The studied slope is located adjacent to a valley, its terrain corresponds to piedmont gentle slope, while the upper part of the failure surface is steep. After reinforcing the terrain where landcreep had occurred and installing collector well on the slope, we measured the changes in the groundwater level. In order to analyze the relationship between the well and the slope, we calculated the ratio of groundwater level to rainfall before and after the installation of the collector well. As a result, it is confirmed that the ratio increases after the installation of the well, which in turn reduces the groundwater level. Analysis of the change in groundwater level after 3, 7, 15 days antecedent rainfall showed that the higher the overall groundwater level, the less the value ($r_p$) of groundwater level-rainfall ratio is, while the value becomes relatively greater when the groundwater level is low. In particular, if a slope has a large catchment basin as is in the case of the studied site, antecedent rainfall affects groundwater level in the order of 3 < 7 < 15 days.

• KSCE Journal of Civil and Environmental Engineering Research
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• v.5 no.1
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• pp.31-42
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• 1985

The most important and difficult part in the problem of unsteady seepage is, how to analyze a position and variation of free water level. Therefore, this paper found the relation between the rising water level and infiltration in the embankment by analyzing established equations and extrapolated the empirical equations from experimental data (For the seepage velocity; $V_S=Ki=k\frac{H-d_1}{d}$, For the rising velocity level; $V_R=\frac{dH}{dt}$) With the aid of these data, the necessary equations were compared with the experimental analyses.