• 대한정형외과학회지
• /
• 제55권4호
• /
• pp.348-353
• /
• 2020

68세 남자 환자가 허리의 피부에서 고름을 동반한 욕창으로 내원하였다. 초진시 일반 방사선상 제4요추체의 광범위한 파괴 소견과 자기공명영상 촬영에서 제4요추 척추체의 결손 부위에 고인 조영 증강된 많은 양의 액체가 양측 요근 및 후관절까지 확장된 소견을 보였다. 신경병성 척추병증으로 일차 진단하였으나 농양을 동반한 감염성 척추염을 배제할 수 없어 정맥 항생제를 2주 투여하였다. 자기공명영상을 재촬영한 결과 농양의 크기는 줄어 들지 않아 수술적 치료로 진행하였다. 샤르코 척추 관절병증은 광범위한 척추체 파괴를 일으켜 감염성 척추염과 유사한 소견을 보일 수 있으며 특히 척추체 불안정으로 인한 경막 파열로 뇌척수액이 축적되면 감별이 어려울 수 있어 이 증례를 보고하는 바이다.

• IMMUNE NETWORK
• /
• 제15권4호
• /
• pp.167-176
• /
• 2015

Macrophages are the main effector cells of innate immunity and are involved in inflammatory and anti-infective processes. They also have an essential role in maintaining tissue homeostasis, supporting tissue development, and repairing tissue damage. Until few years ago, it was believed that tissue macrophages derived from circulating blood monocytes, which terminally differentiated in the tissue and unable to proliferate. Recent evidence in the biology of tissue macrophages has uncovered a series of immune and ontogenic features that had been neglected for long, despite old observations. These include origin, heterogeneity, proliferative potential (or self-renewal), polarization, and memory. In recent years, the number of publications on tissue resident macrophages has grown rapidly, highlighting the renewed interest of the immunologists for these key players of innate immunity. This minireview aims to summarizing the new current knowledge in macrophage immunobiology, in order to offer a clear and immediate overview of the field.

• 한국환경보건학회지
• /
• 제34권5호
• /
• pp.382-386
• /
• 2008

This study was designed to establish the time frame of viability and infectivity of Cryptosporidium, when the Cryptosporidium is discharged to the aquatic environment. Changes in viability and infectivity of Cryptosporidium in relation to temperature and pH were investigated during winter (Dec 05-Feb 06) using semipermeable cellulose tubes containing infective Cryptosporidium. Infectivity was maintained at 50% after 30 days and almost completely lost after 50 days. It was also established that viability was maintained at about 8% after 90 days.

• KSBB Journal
• /
• 제14권2호
• /
• pp.198-204
• /
• 1999

Asymbiotic bacterium with highly effective toxins was isolated from entomopathogenic nematode Steinernema glaseri which has been widely used against various soil-inhabiting pests. The symbiont of S. glaseri was identified as Xenorhabdus nematophilus sp. by using several biochemical and physiological tests. When this strain was released into the hemolymph of insect larva, it produced highly toxic substances and killed the larva within 2 days. Two colony forms that differed n some biochemical characteristics were observed when cultures in vitro. Phase l colonies were mucid and difficult to be dispersed in liquid. Phase II was not mucoid and was easily dispersed in liquid. It did not adsorb neutral red or bromothymol blue. Rod-shaped cell size was highly variable between two phases, ranging 2-10 ${\mu}{\textrm}{m}$. It was also found that only infective-stage nematodes can carry only primary-phase Xenorhabdus in their intestine.

• Clinical and Experimental Pediatrics
• /
• 제50권12호
• /
• pp.1257-1260
• /
• 2007

저자들은 출생 직후부터 심한 혈변과 구토 증상을 보인 신생아의 위액과 변에서 아메바를 확인하여 자궁 내에서 감염된 것으로 판단되는 신생아 아메바증을 경험하고 치료하였기에 문헌 고찰과 함께 보고하는 바이다.

• 한국미생물·생명공학회지
• /
• 제32권1호
• /
• pp.1-10
• /
• 2004

Many bacteria monitor their population density and control the expression of specialized gene sets in response to bacterial cell density based on a mechanism referred to as quorum sensing. In all cases, quorum sensing involves the production and detection of extracellular signaling molecules, auto inducers, as which Gram-negative and Gram-positive bacteria use most prevalently acylated homoserine lactones and processed oligo-peptides, respectively. Through quorum-sensing communication circuits, bacteria regulate a diverse array of physiological functions, including virulence, symbiosis, competence, conjugation, antibiotic production, motility, sporulation, and biofilm formation. Many pathogens have evolved quorum-sensing mechanisms to mount population-density-dependent attacks to over-whelm the defense responses of plants, animals, and humans. Since these AHL-mediated signaling mechanisms are widespread and highly conserved in many pathogenic bacteria, the disruption of quorum-sensing system might be an attractive target for novel anti-infective therapy. To control AHL-mediated pathogenicity, several promising strategies to disrupt bacterial quorum sensing have been reported, and several chemicals and enzymes have been also investigated for years. These studies indicate that anti-quorum sensing strategies could be developed as possible alternatives of antibiotics.

• 대한수학회보
• /
• 제47권6호
• /
• pp.1131-1138
• /
• 2010

In the present paper, we evaluate an analytic formula as a solution of Susceptible Infective (SI) model problem for communicable disease in which the daily contact rate (C(N)) is supposed to be varied linearly with population size N(t) that is large so that it is considered as a continuous variable of time t. Again, we introduce some Lie group of operators to make an extension of above analytic formula of the determin-istic epidemics model problem. Finally, we discuss some of its particular cases.

• Journal of Korean Neurosurgical Society
• /
• 제37권4호
• /
• pp.303-306
• /
• 2005

In cases of brain or other organ abscess, the causative etiology or disease are not always definable. We report a case of brain, renal, and possibly lung abscesses in a middle aged woman. After close, stepwise surveillance of possible etiologic factors, we covered out a small solitary pulmonary arteriovenous fistula without any pulmonary symptoms and successfully occluded the fistula via endovascular approach. The congenital pulmonary arteriovenous fistula should be bear in mind as a cause of repeated, multiple systemic infective source spray and be pursued despite of negative initial baseline studies.

• 혜화의학회지
• /
• 제8권2호
• /
• pp.153-170
• /
• 2000

This paper presents a study for a development of the oriental medical treatment on the gastric disease caused by Helicobacter Pylori. Helicobacter Pylori is observed in stomach mucosa and it is caused gastric disease via various routes. Helicobacter Pylori is spread generally mouth to mouth by men. So it is related to personal health condition or life style. The treatment of Helicobacter Pylori is an antibiotic combination therapies, but it caused a problem of side effect and drug resistant. In the oriental medical treatment, an immunopotentiation reduces an infective rate of Helicobacter Pylori and prevents a progressive gastric disease.

• KSBB Journal
• /
• 제13권1호
• /
• pp.31-37
• /
• 1998

A simple method for the in vivo production of third-stage infective juveniles(IJs) of Steinernema glaseri was developed. Using Galleria mellonella larvae, only IJs can be rapidly generated inadequate quantities for field application. The nematode inoculation concentration and incubation temperature were critically important. The most effective temperature for infectivity of Steinernema glaseri IJs to Galleria mellonella larvae was 33$^\circ C$. However, the total number of menatodes harvested at 25$^\circ C$ about 66,000 IJs per larva was significantly greater than those at other temperatures. The optimal inoculation number of nematodes was 60 to 80 nematodes per host larva. The higher nematode inoculation concentration of 100 IJs per larva caused a rapid decrease in the total number of IJs harvested. As the inoculation medium pH increased, the number of IJs harvested increased and reached about 110,000 IJs per larva at pH 9.0. The pathogenicity of IJs decreased y increasing the salt concentration in the medium.