• Proceedings of the PSK Conference
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• 2002.10a
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• pp.313.1-313.1
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• 2002

Nitric oxide (NO) production through the inducible nitric-oxide synthase (iNOS) pathway has been implicated in inflammatory diseases and cellular injury. Inhibition of various genes related to inflammation, including iNOS is one of the major roles of well-known anti-inflammatory drugs. In the present study, the effects of ceramide analogs on iNOS expression and NO production were evaluated to investigate how ceramide and its structurally related analogs modulate NO-mecliated cellular signals and inflammation. (omitted)

• 대한치주과학회:학술대회논문집
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• 2005.11a
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• pp.153-153
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• 2005

• 대한치주과학회:학술대회논문집
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• 2005.11a
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• pp.91-91
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• 2005

• 대한치주과학회:학술대회논문집
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• 2004.11a
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• pp.47-47
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• 2004

• 대한치주과학회:학술대회논문집
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• 2004.11a
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• pp.135-135
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• 2004

• 대한치주과학회:학술대회논문집
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• 2004.11a
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• pp.136-136
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• 2004

• 대한치주과학회:학술대회논문집
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• 2003.11a
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• pp.89-90
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• 2003

• Journal of Life Science
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• v.16 no.2 s.75
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• pp.192-198
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• 2006

Epidemiological studies have demonstrated an association between exposure to diesel exhaust particles (DEP) and adverse cardiopulmonary effects. Despite the epidemiological proof, the pathogenesis of DEP-related pulmonary diseases remain poorly understood. So, comprehensive in vivo and in vitro researches are required to know the effects of DEP on diverse lung diseases. Alveolar macrophages (AM) and airway epithelial cells are known as important cellular targets in DEP-induced lung diseases. Other studies have shown that nitric oxide (NO) is involved in particle matter induced lung injury. The present study was undertaken to determine whether DEP has an synergistic effects on lipopolysaccharide (LPS)-induced NO formation and inducible nitric oxide synthase (iNOS) with nitrotyrosilated-protein formation in cultured primary alveolar macrophages. The formation of NO was determined through the Griess reaction in the cultured medium and iNOS with nitrotyrosilated-proteins are analyzed by immunohistochemical staining and Western analysis. The results indicate that DEP exposure does not induce NO formation by itself, however DEP showed significant synergistic effects on LPS-induced NO formation. So, our results suggest that DEP inhalation could aggravate inflammatory lung disease through NO formation.

• Korean Journal of Food Science and Technology
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• v.43 no.1
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• pp.110-113
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• 2011

Egg allergies are the most prevalent food hypersensitivity in children. The major egg allergens are proteins, such as ovalbumin (OVA) and ovomucoid (OVM), which are mainly contained in egg whites. OVA is the major protein in egg white, comprising 54% of the total protein content. OVA has been widely used in experimental inhalant and dietary allergy animal models, but its mechanism has not been clearly identified. In this study, we showed that OVA induced nuclear factor-${\kappa}B$ activation. OVA also induced the expression of cyclooxygenase-2 and inducible nitric oxide synthase. These data suggest new approaches for developing efficient anti-allergic strategies.

• Journal of Physiology & Pathology in Korean Medicine
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• v.21 no.4
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• pp.961-966
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• 2007

Lesser yang person-Hyungbangpaedok-san (HBPDS) is a prescription originated in the