Proceedings of the PSK Conference (대한약학회:학술대회논문집)
- 2002.10a
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- Pages.313.1-313.1
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- 2002
Ceramide analogs inhibit inducible nitric oxide synthase expression and nitric oxide production in interferon-gamma and lipopolysaccharide-stimulated RAW 264.7 macrophages.
- Park, Sung-Sik (College of Pharmacy, Chungang University) ;
- Kim, Hae-Jong (College of Pharmacy, Chungang University) ;
- Yim , Chul-Bu (College of Pharmacy, Chungang University) ;
- Kim, Mie-Young (College of Pharmacy, Chungang University) ;
- Chun, Young-Jin (College of Pharmacy, Chungang University)
- Published : 2002.10.01
Abstract
Nitric oxide (NO) production through the inducible nitric-oxide synthase (iNOS) pathway has been implicated in inflammatory diseases and cellular injury. Inhibition of various genes related to inflammation, including iNOS is one of the major roles of well-known anti-inflammatory drugs. In the present study, the effects of ceramide analogs on iNOS expression and NO production were evaluated to investigate how ceramide and its structurally related analogs modulate NO-mecliated cellular signals and inflammation. (omitted)
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