• 유체기계공업학회:학술대회논문집
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• 2001.11a
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• pp.243-249
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• 2001

Steady state flow calculations are executed for turbo-pump inducers of modem design to validate the performance of Tascflow code. Hydrodynamic performance is evaluated and structure of the passage flow and leading edge recirculation are also investigated. Calculated results show good coincidence with experimental data of static pressure performance and velocity profiles over the leading edge. Upstream recirculation, tip leakage and vortex flow at the blade tip and near leading edge are main source of pressure loss. Amount of pressure loss from the upstream to the leading edge corresponds to that of pressure loss through the whole blade. The total viscous loss is considerably large due to the strong secondary flow.

• Microbiology and Biotechnology Letters
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• v.20 no.2
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• pp.207-212
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• 1992

An anti-inflammatory agent, serratiopeptidase, was produced from the culture of the Serratia marcescens. The effects of carbon sources, nitrogen sources and inducers on the production were investigated. Citrate was found to be inhibitory in the production of serratiopeptidase. The enzyme was synthesized in the synthetic medium without inducers, albeit low level of synthesis. But the synthesis was increased by the addition of proteinaceous substrate and leucine. Induction of extracellular proteinase by its end-product was discovered, which is not common in the proteinase synthesis in the bacteria. By the glucose fed-batch culture, we found the possible catabolite repression on the production of serratiopeptidase.

• The KSFM Journal of Fluid Machinery
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• v.5 no.2 s.15
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• pp.22-28
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• 2002

Steady state flow calculations are conducted for the newly-designed turbo-pump inducers to validate the performance of Tascflow code. Hydrodynamic performance is evaluated, and structures of the passage flow and leading edge recirculation are also investigated. The calculated results show good coincidence with the experimental data of the static pressure performance and velocity profiles near the leading edge. Upstream recirculation, tip leakage and vortex flow at the blade tip and near leading edge are main sources of pressure losses. Amount of pressure losses from the upstream to the leading edge corresponds to that of pressure losses through the whole blade. The total viscous losses are considerably large due to the strong secondary flow.

• Proceedings of the Korean Society of Propulsion Engineers Conference
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• 2010.05a
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• pp.264-267
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• 2010

This research focuses on the development of numerical code to deal with compressible two phase flow around three dimensional objects combined with cavitation model suggested by Weishyy et al. with k-e turbulent model. The cryogenic cavitation is carried out by considering the thermodynamic effect on physical properties of cryogenic fluids in physical point of view and implementing the temperature sensitivity in the energy equation of the government equations in numerical point of view, respectively. The formulation has been extensively validated for both liquid nitrogen and liquid hydrogen by simulating the experiments of Hord on hydrofoils. Then, simulations of cavitating turbopump inducers at their design flow rate are presented. Results over a broad range of Nss numbers extending from single-phase flow conditions through the critical head break down point are discussed. In particular, thermal depression effects arising from cavitation in cryogenic fluids are identified and their impact on the suction performance of the inducer quantified.

• The KSFM Journal of Fluid Machinery
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• v.12 no.2
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• pp.52-57
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• 2009

The effects of number of blades on the hydraulic performance of the inducer were studied using a computational method. Inducers with number of blades from 2 to 4 were used for computations and the hydraulic performances of the inducers were compared. The computational results showed that the hydraulic performance decreased due to the increase of the skin friction loss at blade passages as the blade number increased. The results also showed that the strength of the backflow became weak because of the decrease of unfavorable pressure gradient as the blade number increased.

• Archives of Pharmacal Research
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• v.24 no.6
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• pp.597-600
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• 2001

Based on the potential cancer chemoprebentive activity of resveratrol, a trihydroxystilbene with the induction of quinone reductase activeity this study was designed to determine if stilbene-related compounds were inducers of phase ll detoxifying metabolic enzyme quinone reductase (QR) in the mouse hepatoma Hepa 1c1c7 cells. Among the thirteen compounds tested, several compounds including 3,4,5,3',5'-pentamethoxy-trans-stibene were found to potentially induce QR activity in this cell line. In addition, substitution with 3-thiofurane ring instead of phenyl ring in the stilbene skeleton also exhibited potential induction of QR activity. This result will give primary information to design the potential inducers of QR activity in the stilbene analogs.

• Bulletin of the Korean Chemical Society
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• v.18 no.1
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• pp.18-23
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• 1997

Data from structure/activity studies in vir gene induction system have led to evaluate the working hypothesis of interaction between phenolic inducers and phenol binding proteins. The primary specificity in the association of a phenolic inducer with its receptor in our system is hypothesized to be the hydrogen bonding interactions through the ortho methoxy substituents as well as the proton transfer between the inducer and the binding protein. In this paper the proposed working model for phenol-mediating signal transduction was evaluated in several ways. The importance of the general acid-base catalysis was first addressed by the presence of an acidic residue and a basic residue in the phenol binding protein. Series of compounds were tested for vir gene expression activity to confirm the generation of a strong nucleophile by an acidic residue and an involvement of a basic residue as a proton acceptor. An attempt was made to correlate the pKa values of the phenolic compounds with vir gene induction activities as inducers to further support the proposed proton transfer mechanism. Finally, it was also observed that the regioselectively attached methoxy group on phenol compounds is required as the proper hydrogen bond acceptor.

• Proceedings of the Korean Society of Developmental Biology Conference
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• 2003.10a
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• pp.24-25
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• 2003

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification of the roles of specific genes and signaling pathways in development. I will talk about positional cloning of two developmental mutants in zebrafish. The first mutant is headless: The vertebrate organizer can induce a complete body axis when transplanted to the ventral side of a host embryo by virtue of its distinct head and trunk inducing properties. Wingless/Wntantagonists secreted by the organizer have been identified as head inducers. Their ectopic expression can promote head formation, whereas ectopic activation of Wnt signalling during early gastrulation blocks head formation. These observations suggest that the ability of head inducers to inhibit Wntsignalling during formation of anterior structures is what distinguishes them from trunk inducers that permit the operation of posteriorizing Wnt signals. I describe the zebrafish headless (hdl) mutant and show that its severe head defects are due to a mutation in T-cell factor-3 (Tcf3), a member of the Tcf/Lef family. Loss of Tcf3 function in the hdl mutant reveals that hdl represses Wnt target genes. I provide genetic evidence that a component of the Wntsignalling pathway is essential in vertebrate head formation and patterning. Second mutant is mind bomb: Lateral inhibition, mediated by Notch signaling, leads to the selection of cells that are permitted to become neurons within domains defined by proneuralgene expression. Reduced lateral inhibition in zebrafish mib mutant embryos permits too many neural progenitors to differentiate as neurons. Positional cloning of mib revealed that it is a gene in the Notch pathway that encodes a RING ubiquitin ligase. Mib interacts with the intracellular domain of Delta to promote its ubiquitylation and internalization. Cell transplantation studies suggest that mib function is essential in the signaling cell for efficient activation of Notch in neighboring cells. (중략)

• Journal of Physiology & Pathology in Korean Medicine
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• v.18 no.2
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• pp.451-456
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• 2004

Based on the data from our previous studies, four new diabetic remedies were composed with the addition of Coicis Semen into Okchun-san (OCH), Commelinae Herba into Gangsim-tang (GST) , Scrophulariae Radix into Sunki-san (SKS), and Erythrinae Cortex into Yukmijihuang-hwan (YMG). The water extracts of these new remedies were treated in 3T3-L1 fibroblasts and adipocytes in order to investigate insulin-like substances and insulin sensitizers, respectively. With and without differentiation inducers, unmodified SKS (SKS-O) treatment induced 3T3-L1 fibroblasts into adipocytes more than the control. However, without inducers, YMG treatment, but not SKS, induced the differentiation more than the control among modified remedies. Without inducers, SKS, OCH as well as YMG increased the induction of differentiation from 3T3-L1 fibroblasts into adipocytes, compared to the control. The treatment of OCH and YMG with 1 ng/mL insulin increased glucose uptake much more than only insulin 1 ng/mL treatment. Thus, OCH and YMG contained increased insulin actions. In conclusions, the modified remedies, OCH and YMG, contained insulin-like substances and insulin sensitizers, and they can be improved the hypoglycemic effects.

• International Journal of Fluid Machinery and Systems
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• v.1 no.1
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• pp.64-75
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• 2008

During an experimental investigation on a 3-bladed and a 4-bladed axial inducer, a severe surge instability was observed in a range of cavitation number where the blade passage is choked and the inducer head is decreased from noncavitating value. The surge was stronger for the 4-bladed inducer as compared with a 3-bladed inducer with the same inlet and outlet blade angles. For the 4-bladed inducer, the head decreases suddenly as the cavitation number is decreased. The surge was observed after the sudden drop of head. This head drop was found to be associated with a rapid extension of tip cavity into the blade passage. The cause of surge is attributed to the decrease of the negative slope of the head-flow rate performance curve due to choke. Assuming that the difference between the 3 and 4-bladed inducers is caused by the difference of the blockage effects of the blade, a test was carried out by thickening the blades of the 3-bladed inducer. However, opposite to the expectations, the head drop became smoother and the instability disappeared on the thickened blade inducer. Examination of the pressure distribution on both inducers could not explain the difference. It was pointed out that two-dimensional cavitating flow analyses predict smaller breakdown cavitation number at higher flow rates, if the incidence angle is smaller than half of the blade angle. This causes the positive slope of the performance curve and suggests that the choked surge as observed in the present study might occur in more general cases.