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Insulin-like and Insulin Sensitizing Effects of Modified Anti-diabetic Remedies in 3T3-L1 Fibroblasts  

Park Sun Min (Food and Nutrition, Hoseo University)
Choi Mi Kyung (Food and Nutrition, Hoseo University)
Jun Dong Wha (School of Medicine, Konkuk University)
Choi Soo Bong (School of Medicine, Konkuk University)
Park Seong Kyu (College of Oriental Medicine, Kyunghee University)
Lee Mi Young (Korea Institute of Oriental Medicine)
Kim Ho Kyoung (Korea Institute of Oriental Medicine)
Hwang Young Hee (Korea Institute of Oriental Medicine)
Ko Byoung-Seob (Korea Institute of Oriental Medicine)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.18, no.2, 2004 , pp. 451-456 More about this Journal
Abstract
Based on the data from our previous studies, four new diabetic remedies were composed with the addition of Coicis Semen into Okchun-san (OCH), Commelinae Herba into Gangsim-tang (GST) , Scrophulariae Radix into Sunki-san (SKS), and Erythrinae Cortex into Yukmijihuang-hwan (YMG). The water extracts of these new remedies were treated in 3T3-L1 fibroblasts and adipocytes in order to investigate insulin-like substances and insulin sensitizers, respectively. With and without differentiation inducers, unmodified SKS (SKS-O) treatment induced 3T3-L1 fibroblasts into adipocytes more than the control. However, without inducers, YMG treatment, but not SKS, induced the differentiation more than the control among modified remedies. Without inducers, SKS, OCH as well as YMG increased the induction of differentiation from 3T3-L1 fibroblasts into adipocytes, compared to the control. The treatment of OCH and YMG with 1 ng/mL insulin increased glucose uptake much more than only insulin 1 ng/mL treatment. Thus, OCH and YMG contained increased insulin actions. In conclusions, the modified remedies, OCH and YMG, contained insulin-like substances and insulin sensitizers, and they can be improved the hypoglycemic effects.
Keywords
3T3-L1 fibroblasts; insulin-like; insulin sensitizers; hypoglycemic effects;
Citations & Related Records
Times Cited By KSCI : 1  (Citation Analysis)
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[ Yajnik CS ] / Curr. Diab. Rep.   DOI   ScienceOn
3 Contributions of insulin-resistance and insulin- secretory defects to the pathogenesis of type 2 diabetes mellitus /
[ Gerich JE ] / Mayo Clin. Proc   DOI   ScienceOn
4 Isolation of Insulin like substance from Ephedra sinica STAPF /
[ Takaku T; Jiang M; Okuda H; Maeda N ] / J. Traditional Med.
5 Insulin like action of trans-10-hydroxy-2-decanoic acid and its related substance /
[ Kameda K; Chikaki M; Morimoto C; Jiang M; Okuda H ] / J. Traditional Med.
6 /
[ 許浚 ] / 東醫寶鑑
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8 Troglitazone enhances differentiation, basal glucose uptake, and GLUT1 protein levels in 3T3-L1 adipocytes /
[ Tafuri SR ] / Endocrinology   DOI   ScienceOn
9 Dual action of isoprenols from herbal medicines on both PPAR and PPAR in 3T3-L1 adipocytes and HepG2 hepatocytes. /
[ Takahashi N; Kawada T; Goto T; Yamamoto T; Taimatsu A; Matsui N; Saito M; Hosokawa M; Fushiki T ] / FEBS Letters   DOI
10 A novel small molecule that directly sensitizes the insulin receptor in vitro and in vivo /
[ Manchem VP; Goldfine ID; Kohanski RA; Cristobal CP; Lum RT; Schow SR; Shi S; Spevak WR; Laborde E; Toavs DK; Villar HO; Wick MM; Kozlowski MR ] / Diabetes   DOI   ScienceOn
11 A selective peroxisome proliferator-activated receptor-gamma (PPARgamma) modulator blocks adipocyte differentiation but stimulates glucose uptake in 3T3-L1 adipocytes /
[ Mukherjee R; Hoener PA; Jow L; Bilakovics J; Klausing K; Mais DE; Faulkner A; Croston GE; Paterniti JR Jr ] / Mol. Endocrinol.   DOI   ScienceOn
12 Isolation of Insulin like substance from Ephedra sinica STAPF /
[ Takaku T; Jiang M; Okuda H; Maeda N ] / J. Traditional Med.
13 Insulin-reasing and Insulin-like activity of the Traditional antidiabetic plant Coriandurm sativum (coriander). /
[ Gray AM; Flatt PR ] / Br. J. Nutr.   DOI
14 2'-benzyloxychalcone derivatives stimulate glucose uptake in 3T3-L1 adipocytes /
[ Kamei R; Kadokura M; Kitagawa Y; Hazeki O; Oikawa S ] / Life Sci   DOI   ScienceOn
15 /
[ Mudaliar S; Chang AR; Henry RR ] /