• Biomolecules & Therapeutics
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• v.10 no.1
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• pp.1-6
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• 2002

The particle size of medicinal materials is an Important physical property that affects the phar-maceutical behaviors such as dissolution, chemical stability, and bioavailability of solid dosage forms. The size reduction of raw medicinal powder is needed to formulate insoluble drugs or slightly soluble medicines and to improve the pharmaceutical properties such as the solubility, the pharmaceutical mixing, and the dispersion. The objective of the present study is to evaluate physiological activity of amorphous and nano-particle prep-arations of insoluble drug, ursodeoxycholic acid (UDCA), which were made by three types of fine grinding mills. The change of physical properties of ground UDCA was conformed by Mastersiger microplus and X-ray diffraction. We have investigated hepatoprotective effects of the nano-particle preparations of UDCA by plan-etary mill, vibration rod mill and jet mill in $CCI_4$-induced oxidatively injured mouse liver. The results showed that nano-particle preparations of UDCA all decreased reactive oxygen sepecies generation and lipid peroxi-dation in $CCI_4$-induced oxidative stress mice. Among them, nano-particle preparations by vibration rod mill and jet mill showed more significantly hepatoprotective effects compared to intact UDCA and planetary mill-ground UDCA. These results suggest that ground UDCA with vibration rod mill and jet mill shows a high amorphous state and the improved dissolution.

• Journal of Korea Water Resources Association
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• v.32 no.3
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• pp.301-310
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• 1999

In this paper a numerical model and two analytical models in the hydraulically connected stream-aquifer system were analyzed to compare the induced infiltration rate curves derived from each model. And we also examined the effects of anisotropy of hydraulic conductivity and the direction of the ambient ground water flow on the quantification of the induced infiltration rate. The induced infiltration rate curve determined by models is very simple and useful for estimating the induced infiltration rate since it contains only four physical variables such as the induced infiltration rate, the pumping rate, the distance between the pumping well and the stream, and the ambient ground water flow rate. Under the conditions tested in this paper the induced infiltration rate curves resulted from the Wilson's analytical model and FEWA numerical model were in good agreement, and the anisotropic ratio of hydraulic conductivity was evaluated as a physical factor which influences the behaviour of the induced infiltration rate curve. The methods and results of the paper might Icad to improve the understanding of the induced infiltration phenomenon and can be applied to the planning and disign of pumping well and the optimal determination of the induced infiltration rate and pumping rate for water quality management of the water supply wells.

• Proceedings of the KIEE Conference
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• 2008.07a
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• pp.181-182
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• 2008

Gaspipe buried close to power lines can be subjected to hazardous induction effects, especially during single line to ground faults. Accordingly, it is necessary to take into consideration for analysis of induced voltage on a gaspipeline in transmission lines. This paper analyses the induced voltage on the gaspipeline due to single line to ground faults of the transmission lines using EMTP (Electro-Magnetic Transients Program).

• Proceedings of the Korean Society for Noise and Vibration Engineering Conference
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• 2006.05a
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• pp.875-878
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• 2006

In the case of a vibration sensitive equipment, it require a vibration free environment to provide its proper function, therefore, it is very important to predict precisely vibration environment of microelectronics production facility due to adjacent blast work. However, it is not easy to evaluate a quantitative vibration response of structure due blast because it can be determined by the characteristics of vibration sources, propagation through rock and soil and dynamic properties of building. In this paper, vibration influence evaluation of micro-electronic Production building induced from adjacent blast activity was performed by real measurement data obtained on ground and structure at same time. And blast vibration allowable limit on ground was supposed by measurement data analysis in order to avoid operation error of precision equipments

• Structural Engineering and Mechanics
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• v.54 no.3
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• pp.545-560
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• 2015

In this paper, blast-induced vibration effects on buildings located in rural areas were investigated. Damages to reinforced concrete, adobe and masonry buildings were evaluated in Çatakk$\ddot{o}pr\ddot{u}$ and Susuz villages in Silvan district of Diyarbakir, Turkey. Blasting of stiff rocks to construct highway at vicinity of the villages damaged the buildings seriously. The most important reason of the damages is lack of engineering services and improper constructed buildings according to the current building design codes. Also, it is determined that, inappropriate blast method and soft soil class increased the damages to the buildings. The study focuses on four points: Blast effect on buildings, soil conditions in villages, building damages and evaluation of damage reasons according to the current Turkish Earthquake Code (TEC).

• Structural Engineering and Mechanics
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• v.59 no.2
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• pp.277-290
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• 2016

This paper investigates the ground vibration induced by high-speed trains moving on multi-span continuous bridges. The dynamic impact factor of multi-span continuous bridges under trainloads was first determined in the parametric study, which shows that the dynamic impact factor will be large when the first bridge vertical natural frequency is equal to the trainload dominant frequencies, nV/D, where n is a positive integer, V is the train speed, and D is the train carriage interval. In addition, more continuous spans will produce smaller dynamic impact factors at this resonance condition. Based on the results of three-dimensional finite element analyses using the soil-structure interaction for realistic high-speed railway bridges, we suggest that the bridge span be set at 1.4 to 1.5 times the carriage interval for simply supported bridges. If not, the use of four or more-than-four-span continuous bridges is suggested to reduce the train-induced vibration. This study also indicates that the vibration in the train is major generated from the rail irregularities and that from the bridge deformation is not dominant.

• Proceedings of the Korean Geotechical Society Conference
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• 2010.03a
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• pp.213-220
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• 2010

This study presents a numerical simulation model of vertical ground heat exchangers, considering unsaturated hydro static ground conditions induced by the ground water table fluctuation. Heat transfer in ground and grout is modeled by a 3-D FEM transient conductive heat transfer model, where heat transfer between circulating fluid and heat exchanging pipe is treated as 1-D quasi steady state forced convective elements. To take into account the unsaturated ground condition, soil thermal conductivity and heat capacity which are dependent on the matric suction are applied to ground elements. Parametric studies considering various ground water table conditions are conducted to investigate the influence of unsaturated hydro static ground condition on the mean heat exchange rate of ground heat exchanger. Simulation results considering water table fluctuation show 60~100% of mean heat exchange rate for a saturated soil condition and 125~208% of that for a dry soil condition. Thus consideration of unsaturated soil condition is substantially recommended for more accurate design and performance evaluation for ground heat exchangers.

• 한국정보통신설비학회:학술대회논문집
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• 2007.08a
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• pp.215-218
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• 2007

In this paper, we have analyzed the effects from the change of separation distance between grounding equipment at end of telecommunication line and the inducting facilities in power inducting situation. In the result of measurement, we can see that as the separation distance between grounding equipment ant end of telecommunication line and the inducting facility become longer, the induced noise level and PIF level is decreased. From the another experiment results about the effect of changing the impedance size in both ends of telecommunication line, however, we already knew that as the ground impedance at either end of the telecommunication line become grower, the noise level is increased, and as the ground impedance at either end of the telecommunication line become smaller, the noise level is decreased. Hence we can not define the relationship exactly between separation distance from inducting facility to inducted facility and the induced noise level because when the grounding equipment is moved, its impedance size is changed too. In conclusion, changing the separation distance between grounding equipment at end of telecommunication line and the inducting facilities have not influence on the induced noise level.

• Journal of the Korean Society for Aeronautical & Space Sciences
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• v.42 no.4
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• pp.298-304
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• 2014

The lifting-line method based on Weissinger's method is extended to be able to analyze the ground effect. The method is applied to predict the variation of aerodynamic performance due to ground effect for the elliptic wing with aspect ratio of 10 and the wing of human powered aircraft. While the vortex strength of the wing increases slightly, the downwash decreases significantly as the wing approaches to the ground. For the wing of human powered aircraft, the increment of lift at the height of 2m is 5% than the lift outside the influence of ground effect. The decrease of induced drag at the height of wing span is 10% and at the height of 2m is 55% than that out of ground effect.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.1
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• pp.284-289
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• 2016

In recent years, the earthquake sequence in Christchurch, New Zealand (NZ) was unprecedented in terms of repeated earthquake shocks with substantial levels of ground motion affecting modern infrastructure, and in particular, broad and precise reports for liquefaction-induced permanent ground deformation (PGD) and repairs of wastewater (WW) pipelines were collected. In this study, a geographical information system (GIS) and linear regression analysis were performed using data for the length and repair points of earthenware (EW) and concrete (CONC) wastewater pipelines acquired after the MW 6.2 February 22, 2011 earthquake. The repair rates (repairs/km) for the EW and CONC wastewater pipelines were evaluated inside the areas of PGD, and both angular distortion of ground and lateral ground strain were calculated from the high resolution LiDAR data acquired before and after the seismic event. The research results showed that both pipelines have similar trends of damage but the CONC wastewater pipeline with higher stiffness showed less damage. The results of linear regression analyses can be used to predict the repair rates for EW and CONC wastewater pipelines inside the areas of PGD induced by future earthquakes.