• 동의생리병리학회지
• /
• 제21권1호
• /
• pp.1-9
• /
• 2007

${\ulcorner}$Hamsansachon Dongyi Suse Bowon Gabogubon${\lrcorner}$ , discovered in 2000, can give very precious information in order to study the formation and development process of ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Dircourse on the Constitutional Symptoms and Disease${\lrcorner}$ . I examined, by comparison, changes in understanding pathology explained in ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Discourse on the Constitutional Symptoms and Disease${\lrcorner}$ of Gabobon and Sinchukbon, and consequently tried to define the concept of Dispositional Symptom(Dispositional disease) as below, in a point of view that ‘Dispositional Symptom(Dispositional disease)’ should be the key word in explaining the changes in understanding of pathology. Dispositional Symptom(dispositional disease) is a new concept that was first troduced in the Kyongjabon, not found in the Gabobon, and that played a key role in editing ${\ulcorner}$Dongyi Suse Bowon${\lrcorner}$ ${\ulcorner}$The Discourse on the Constitutional Symptom and Disease${\lrcorner}$ . Dispositional Symptom(dispositional disease) means an innate temperament or a pathological tendency, which is already constructed in the system of an individual, prior to expression of specific diseases and symptoms, and can be a primary basis to tell the susceptibility and developing pattern of a certain disease, to decide how to treat and forecast the prognosis. Sinchukbon inductively categorized symptoms of the dispositional symptom (dispositional disease) into the concept of ‘Eight principles’, or eight standards of diagnosis, such as superficies-interior, cold-heat, and weakness-strength.

• 동의생리병리학회지
• /
• 제38권1호
• /
• pp.1-9
• /
• 2024

Cognitive reserve (CR) is a concept that can explain the discrepancies between the pathologic burden of the disease and clinical manifestations. It refers to the individual susceptibility to age-related brain changes and pathologies related to Alzheimer's disease, thus recognized as a factor affecting the trajectories of the disease. The purpose of this study was to explore the current states of clinical studies on neural substrates of CR in Alzheimer's disease using functional magnetic resonance imaging. We searched for clinical studies on CR using fMRI in the Pubmed, Cochrane library, RISS, KISS and ScienceON on August 14, 2023. Once the online search was finished, studies were selected manually by the inclusion criteria. Finally, we analyzed the characteristics of selected articles and reviewed the neural substrates of CR. Total thirty-four studies were included in this study. As surrogate markers of CR, not only education and occupational complexity, but also composite score and questionnaire-based method, which cover various areas of life, were mainly used. The most utilized methods in resting-state fMRI were independent component analysis, seed-based analysis, and graph theory analysis. Through the analysis, we demonstrated that neuroimaging techniques could capture the neural substrates associated with cognitive reserve. Moreover, functional connectivity of brain regions centered on prefrontal and parietal cortex and network areas such as default mode network showed a significant correlation with CR, which indicated a significant association with cognitive performance. CR may induce differential effects according to the disease status. We hope that this perspective on cognitive reserve would be helpful when conducting clinical researches on the mechanisms of traditional Korean medicine for Alzheimer's disease in the future.

• 동의생리병리학회지
• /
• 제22권4호
• /
• pp.896-902
• /
• 2008

Yukmijihwang-tang(YM) is used in Oriental medicine for treatments of diverse systemic symptoms including neurological dosorders. The present study was performed to examine potential effects of YM on growth-promoting activity of injured sciatic nerve axons. YM treatment in the injured sciatic nerve induced enhanced distal elongation of injured axons when measured 3 and 7 days after injury. Retrograde tracing of sciatic nerve axons showed YM-mediated increases in the number of DiI-labeled dorsal root ganglion (DRG) sensory neurons and spinal cord motor neurons at 3 days after injury. Hoechst nuclear staining showed that non-neuronal cell population was largely elevated by YM treatment in distal nerve area undergoing axonal regeneration. Furthermore, phospho-Erk1/2 protein levels were upregulated by YM treatment in the injured nerve area. These data suggest that YM may play a role in facilitated axonal regeneration in injured peripheral nerves. Further investigations of individual herbal components would be useful to explore effective molecular components and develop therapeutic strategies.

• 동의생리병리학회지
• /
• 제32권3호
• /
• pp.165-170
• /
• 2018

The aim of this study was to investigate the predictive validity of the five organ pattern identification questionnaire(FOPIQ). Data collection was conducted from 190 people who were randomly selected from the general population living in D city from October 2016 to June 2017, and the collected data were analyzed by SPSS 23.0 Statistics Program. Pearson correlation coefficient was used to know the relation between the expert's score and FOPIQ's one. The cut-off value, sensitivity and specificity were analyzed through ROC-curve. Significant p was <.05. The pearson correlation coefficient was .735, .756, .762, .736, and .513 between individual score of FOPIQ and that of the experts in liver, heart, spleen, lung, and kidney, respectively. The cut-off value of the FOPIQ was 46.209, 47.276, 45.336, 48.823, and 42.508 in liver, heart, spleen, lung, and kidney respectively. The AUC derived from the cut-off value of the FOPIQ was .907, .854, .888, .902, and .781 respectively. This study suggests that the FOPIQ could be valid to apply for general population in clinics as well as health checkups.

• 동의생리병리학회지
• /
• 제32권5호
• /
• pp.347-353
• /
• 2018

There are some controversies about the safety of herbal medicine. In order to examine the safety of herbal medicine, this study investigated the level of liver function test(AST/ALT) in patients taking herbal medicine for more than 6 months We checked liver function in 121 patients who took herbal medicine for more than 6 months. AST/ALT were measured before treatment and every 3 months (from 3 month to 9 month). In 121 patients taking herbal medicine for more than 6 months, mean AST level after 6 months was lower than before treatment and mean ALT level after 6 months was lower than before treatment. In 20 patients with abnormal AST/ALT before herbal treatment, 18 patients's AST/ALT changed to normal after 6 month herbal treatment. 2 patients's AST/ALT was slightly higher than normal. One woman patient met the criteria for herb-induced liver injury(HILI) with RUCAM scores 4 after taking herbal medicine for 6 months. Although her RUCAM score decreased to zero after taking herbal medicine for 9 months. This study suggests that long-term herbal medicine for 6 months or longer is very unlikely to injury liver function. Individual-specific liver damage may occur, it can be recovered.

• 동의생리병리학회지
• /
• 제29권5호
• /
• pp.386-393
• /
• 2015

Bian-zheng(辨證) of Korean Medicine(KM) is based on four examinations(四診) of Korean medical doctor. The interrogation or questioning(問診) provides the most information of four examinations. The symptom obtained from the interrogation or questioning is the main basis of the Bian-zheng. KM is understood in the whole state of the body of a specified time without seeing the disease exist. So the observable symptom is disease itself. Symptom in KM is used as an important basis for the diagnosis. But if the interview when memories are not sure of the correct answer does not get much easier to find exactly the symptoms. So when recording original symptom(素證) and daily subjective symptom can be helpful for care. In this paper, we propose daily living symptom record system as a method that can be applied to the health care according to the importance of collecting the symptom in the KM. Daily living symptom record system can record the symptom in the individual to awaken daily. The system stores the symptom in structure and provides an open shared services. So it can be used as a symptom of other systems, such as PHR, EMR, CDSS. In addition, Doctor may be able to help in the treatment determined by reference to shared symptom.

• 동의생리병리학회지
• /
• 제25권4호
• /
• pp.683-690
• /
• 2011

The object of this study was to observe the effects of Hwanggeum-tang (HGT) aqueous extracts on Streptozotocin-induced rat's diabetes and related complications. Three different dosages of HGT extracts were orally administered oncea day for 28 days from 3 weeks after Streptozotocin treatment (60 mg/kg, single intraperitoneally administered). All the rats were checked at 3 weeks after Streptozotocin treatment as follows. Changes on the body weight, blood glucose level, kidney weight, serum BUN and creatinine level, liver weight, serum AST and ALT level, serum LDL, HDL, triglyceride and total cholesterol level were observed with changes on the pancreatic MDA content and GSH content. The results were compared with a potent antioxidant silymarin 100 mg/kg in which the effects on Streptozotocin-induced diabetes and related complications were already confirmed. As results of Streptozotocin-injected diabetes and related complications, dramatical decreases on the body weight, increase of the kidney and liver weight, increase of serum BUN, creatinine, AST, ALT, LDL, triglyceride, total cholesterol level and decreases of serum HDL level were detected in streptozotocin control as compared with intact control. In addition, marked increases of pancreatic MDA content and decreases of GSH content were also detected in streptozotocin control as compared with intact control. However, these diabetes and related complications, and inhibition of antioxidant effects induced by Streptozotocin were inhibited by 28 days continuous treatment of 50, 100 and 200 mg/kg of HGT extracts in the present study. HGT have favorable effects on the diabetes and various diabetic complications. Therefore, more detail mechanism studies should be conducedin future with the efficacy tests of individual herbal composition of HGT and the screening of the biological active compounds in herbs.

• 동의생리병리학회지
• /
• 제24권6호
• /
• pp.1077-1081
• /
• 2010

In this work, we report the diagnostic relations among some primary pulse conditions such as the floating/sunken, deficient/forceful, large/fine, and the long/short pulses. For this purpose, we carried out a clinical test, in which 11 Oriental medical doctors had participated to diagnose the pulses for 1566 healthy subjects. The subjects were divided into 11 subgroups and each subgroup was allocated to an individual doctor. It resulted in that, for 847 subjects (54%), two or more than two pulse conditions were felt simultaneously, for which we counted the frequency of the pairs of the pulse conditions. For the statistical analysis, we used a Chi-square test. As a result, at high frequency, the forceful, large, and the long pulses were diagnosed in pairs or in their triplet, and a similar close relation was found between the deficient, fine, and the short pulses. The pairwise diagnoses of the pulse conditions between the forceful, large, and the long pulses, and between the deficient, fine, and the short pulses imply their close relatedness in clinics. This result is supported by the theory of deficiency/excess syndromes. Moreover, we show that the close relatedness among the pulse conditions can be understood in terms of the geometric features of the radial artery near the prominent bone. This is the first work which reports the relatedness between the primary pulses by an objective clinical test.

• 동의생리병리학회지
• /
• 제20권6호
• /
• pp.1418-1430
• /
• 2006

In the 18th century, Joseon and Japan corresponded politically and culturally through the Joseon Missionary. During this time, the people in Japan who received the Joseon Missionary left many records of their visits and among them were numerous accounts related to medicine, In the years 2003 and 2004, the Korea Institute of Oriental Medicine gathered records that were dispersed throughout japan, and in 20005, it organized the information and put it up on the web along with the original text. This research is an overall report on the documentary records. It analyzes individual documents and looks into what the mainly interested the joseon and Japanese medical worlds at that time. The documents located up till now are 21 medical dialogue records from the 18th century. Through the process of these medical dialogues, the Joseon medical circle discovered a different side of japanese medicine, and the japanese medical world had a chance to directly receive advanced medical skills. Through these medical dialogues, the two countries also exchanged bountiful information about clinical patients. The japanese scholars showed deep interest in Joseon's ginseng, and asked many questions about practical usages of the contents in the medical documents. It is thought that these medical dialogue records will greatly assist studies on the medical history of this time, because it reveals new research data on Korean medical history and Japanese medical history in the latter half of the Joseon Dynasty that has never been reported in the academia before.

• 동의생리병리학회지
• /
• 제25권2호
• /
• pp.326-333
• /
• 2011

This study was to develop an issue-centered small-group competing-debate program for the Introduction to Traditional Korean Medicine curriculum in School of Korean Medicine, Pusan National University. This debate program has student-, process- and depth-focused characteristics with critical-thinking perspectives. We employed random assignment of the position, submission of the presentation data prior to the debate, and individual result report to assess debate quality and participation of the students. This program was effective educational program for the understanding of traditional Korean medicine-related subjects. 56.7% of the students showed "Yes (>7 out of 10)" to the achievements of the program objectives, and 62.2% reported "much helpful (>7 out of 10)" to the usefulness of this program. We also found that this debate program would be specifically useful for critical reviewing of subjects which students have known superficially. This study will contribute to the development and improvement of efficacious educational curriculum for Korean Medicine by providing practical reference and template with self-directed group debate program.