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Facilitated Axonal Regeneration of Injured Sciatic Nerves by Yukmijihwang-tang Treatment  

Kim, Jung-Hyun (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Seol, In-Chan (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Ryu, Ho-Ryong (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Jo, Hyun-Kyung (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
An, Joung-Jo (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Namgung, Uk (Department of Neurophysiology, College of Oriental Medicine, Daejeon University)
Kim, Yoon-Sik (Department of Internal Medicine, College of Oriental Medicine, Daejeon University)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.22, no.4, 2008 , pp. 896-902 More about this Journal
Abstract
Yukmijihwang-tang(YM) is used in Oriental medicine for treatments of diverse systemic symptoms including neurological dosorders. The present study was performed to examine potential effects of YM on growth-promoting activity of injured sciatic nerve axons. YM treatment in the injured sciatic nerve induced enhanced distal elongation of injured axons when measured 3 and 7 days after injury. Retrograde tracing of sciatic nerve axons showed YM-mediated increases in the number of DiI-labeled dorsal root ganglion (DRG) sensory neurons and spinal cord motor neurons at 3 days after injury. Hoechst nuclear staining showed that non-neuronal cell population was largely elevated by YM treatment in distal nerve area undergoing axonal regeneration. Furthermore, phospho-Erk1/2 protein levels were upregulated by YM treatment in the injured nerve area. These data suggest that YM may play a role in facilitated axonal regeneration in injured peripheral nerves. Further investigations of individual herbal components would be useful to explore effective molecular components and develop therapeutic strategies.
Keywords
Yukmijihwang-tang(YM); axonal regeneration; sciatic nerve; Erk1/2;
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