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http://dx.doi.org/10.15188/kjopp.2018.10.32.5.347

Clinical Study of Liver Function Tests (AST/ALT) of 121 HPV Disease Patients taking Herbal Medicine over 6 Months  

Lee, Eun (Roadledam Korean Medical Clinic)
Lee, Kyoung Yeob (Roadledam Korean Medical Clinic)
Yu, Byung Kook (Roadledam Korean Medical Clinic)
Publication Information
Journal of Physiology & Pathology in Korean Medicine / v.32, no.5, 2018 , pp. 347-353 More about this Journal
Abstract
There are some controversies about the safety of herbal medicine. In order to examine the safety of herbal medicine, this study investigated the level of liver function test(AST/ALT) in patients taking herbal medicine for more than 6 months We checked liver function in 121 patients who took herbal medicine for more than 6 months. AST/ALT were measured before treatment and every 3 months (from 3 month to 9 month). In 121 patients taking herbal medicine for more than 6 months, mean AST level after 6 months was lower than before treatment and mean ALT level after 6 months was lower than before treatment. In 20 patients with abnormal AST/ALT before herbal treatment, 18 patients's AST/ALT changed to normal after 6 month herbal treatment. 2 patients's AST/ALT was slightly higher than normal. One woman patient met the criteria for herb-induced liver injury(HILI) with RUCAM scores 4 after taking herbal medicine for 6 months. Although her RUCAM score decreased to zero after taking herbal medicine for 9 months. This study suggests that long-term herbal medicine for 6 months or longer is very unlikely to injury liver function. Individual-specific liver damage may occur, it can be recovered.
Keywords
LFT; Long-term herbal medicine; Herb-induced liver injury;
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1 Bagheri H, Michel F, Lapeyre-Mestre M Lagier E, Cambus JP, Valdiguie P, Montastruc JL. Detection and incidence of drug-induced liver injuries in hospital: a prospective analysis from laboratory signals. Br J Clin Pharmacol. 2000;50:479-84.
2 Reuben A, Koch DG, Lee WM. Drug-induced acute liver failure: results of a U.S. multicenter, prospective study. Hepatology. 2010;52(6):2065-76.   DOI
3 Chalasani N, Bonkovsky HL, Fontana R, Lee W, Stolz A, et al, Features and Outcomes of 889 Patients with Drug-induced Liver Injury: The DILIN Prospective Study, Gastroenterology. 2015;148(7):1340-52.   DOI
4 Han DJ, Park SM, Kang BG, Lee JW, Na RH, Bang CH, et al. Review on the changes of liver function parameters after administration of herbal medicine. Korean J Oriental Phygiology & Pathology. 2008;22(6);1390-6.
5 Kim DY. Interpretation of examinations common to physicians : liver function tests. Korean Academy of Internal Medicine Spring Academic Congress 2014;No:5-11. http://www.riss.kr/link?id=A100053540
6 Ko H, Kim KT, Shin SM. Prevalence of HBsAg positive and abnormal hepatic enzyme among college students by health examination in a Korean medicine hospital. J Int Korean Med. 2015;36(4):470-7.
7 Han CW, Kim SY, Min KS, Lee JH, Lee SH, Youn YS. Incidence of liver function test abnormality among patients hospitalized in an oriental hospital. J Korean Oriental Med 2010;31(2):109-13.
8 Ko H, Hong SK. Acute hepatitis after taking herbal medicine with Western drugs-1 case report. J. Internal Korean Med. 1999;20(2):711-8.
9 Jang IS, Yang CS, Lee SD, Han CH. A review of herbal medicinal products associated with toxic events in Korea. J Korean Oriental Med 2007;28(1):3-7.
10 The Harrison Institute of Internal Medicine. Harrison's Internal Medicine. Seoul: Jungdam; 1997, p. 80, 1585-9.
11 World Health Organization. Vaccines against human papillomavirus. World Health Organization 2010. Available from : URL:http://www.who.int/vaccines/en/hpvrd.shtml/shtml/shtml
12 Cardoso JC, Calonje E. Cutaneous manifestations of human papillomaviruses: A review. Acta Dermatovenerol APA. 2011;20(3):145-54.
13 Lee MW, Choi JH, Sung KJ, Moon KC, Koh JK. Treatment of Verruca Plana by Alexandrite Laser. Korean J dermatol. 2000;38(7):864-7.
14 Mario M, Fabiana G. Treatment of genital lesions with diode laser vaporization. BMC Urology. 2015;15:39-45.   DOI
15 Lee JH, Kim CW, Kim SS. Preliminary study of intralesional bleomycin injection for the treatment of genital warts. Ann Dermatol. 2015;27:239-41.   DOI
16 Lee KB, Lee E, Cho NK. Medicine Treatment for 326 patients with Genital Warts : Retrospective Chart Review Purpose : To observe effects of Korean Medic. J Korean Med Ophthalmol Otolaryngol Dermatol. 2015;28(4):196-207.   DOI
17 Lim JH, Kim YS, Lee YN, Kim SG, Jeong SW. Gastroenterology ; Clinical Characteristics and Pathological Findings in Patients with Toxic Hepatitis. Korean J Medicine. 2011;81(1):55-63.
18 Yun YJ, Shin BC, Lee MS, Cho SI, Park JH, Lee HJ. Systematic Review of the Cause of Drug-Induced Liver Injuries in Korean Literature. J Korean Oriental Med. 2009;30(2):30-45.
19 Pack YC, Park HM, Lee SD. Inducible mecanisms for hepatotoxicity caused by traditional korean medicines in a view of toxicology. J Korean Oriental Med 2011;32(4):55-63.
20 Kang SH, Kim JI, Jeong KH, Ko KH, Ko PG, Hwang SW, et al. Clinical characteristics of 159 cases of acute toxic hepatitis. Korean J Hepatol. 2008;14(4):483-92.   DOI
21 Yang JI, Lee KH, Kim YS, Shin MK, Yoo JH, Chang GT. A report on liver function tests of 82 psoriasis patients taking herbal medication over 3 months. J Korean Oriental Med. 2012;33(3):95-104.
22 Jeong TY, Park BK, Cho JH, Kim YI, Ahn YC. A prospective study on the safety of herbal medicines, used alone or with conventional medicines. J Ethnopharmacol. 2012;143(3):884-8.   DOI
23 Cho JH, Oh DS, Hong SH, Ko H, Lee NH, Park SE, et al. A nationwide study of the incidence rate of herb-induced liver injury in Korea. Arch Toxicol. 2017 Jun 2. doi:10.1007/s00204-017-2007-9.   DOI
24 Report of an International Consesnsus Meeting. Criteria of drug-induced liver disorders. J Hepatol. 1990;11:272-6.   DOI
25 Park YC, Park HM, Lee SD. Inducible Mechanisms for Hepatotoxicity caused by Traditional Korean Medecines in a View of Toxicology. J Korean Oriental Med. 2011;32(4):55-63.
26 WHO Traditional Medicine Stratege 2002-2005. World Health Organization; 2002.
27 Melchart D, Linde K, Hager S, Kaesmayr J, Shaw D, Bauer R, Weidenhammer W. Monitoring of liver enzymes in patients treated with traditional Chinese drugs. JAMA. 1999;282:28-9.   DOI
28 Meier Y, Cavallaro M, Roos M. Pauli-Magnus C, Folkers G, Meier PJ, et al. Incidence of drug-induced liver injury in medical inpatients. Eur J Clin Pharmacol. 2005;61:135-43.   DOI