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An Elimination of False-Positive I-131 Sites in Esophagus for Thyroid Carcinoma; Using Water with Vitamin C Dissolved (갑상선암의 방사성옥소 치료 후 전신 스캔에서 비타민C 용액을 이용한 식도의 위양성 병소 제거에 대한 고찰)

  • Lee, Seung-Jae;Park, Hoon-Hee;Ahn, Sa-Ron;Cho, Seok-Won;Choi, Young-Sook;Cho, Arther;Kim, Jae-Sam;Lee, Chang-Ho
    • The Korean Journal of Nuclear Medicine Technology
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    • v.12 no.1
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    • pp.49-56
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    • 2008
  • Purpose: Whole body imaging with radioiodine can detect functioning metastases. Non-physiologic I-131 uptake detected on images usually is interpreted as suggesting functioning thyroid metastases. However, extra-thyroidal I-131 accumulation does not always imply thyroid cancer metastases and has been reported in many circumstances. In order to avoid unnecessary therapeutic interventions it is important to distinguish false-positive sites of I-131 localization. We study here to remove false-positive sites around esophagus region on I-131 whole body imaging in patients who were administrated thyroidectomy. Materials and Methods: From April to August in 2007, we had the patients who had visited our department after they received thyroidectomy due to thyroid cancer. They were given I-131, and performed radioiodine body scan after 41 to 50 hours. Patients were whole-body-scanned for the speed of 8 cm per minute. After that, we took anterior and posterior static images around the patients' neck measured by 300 thousand counts per image. We selected 44 patients who had hot spots around neck region, we divided the patients into two groups. One group was given 0.5 L of water and the other group was given 0.5 L of water with 1 g of Vitamin C dissolved. The patients were asked to drink the fluid for one minute in sitting position and after that, we measured 300 kilo counts per image again. We compared prior anterior, posterior static images with anterior, posterior images after the patients had water or water that Vitamin C resolved. Results: In using water, both observer 1 and 2 interpreted 6 patients were washed out. In the water with Vitamin C resolved, observer 1 and 2 interpreted 9 and 8 patients were washed out. Observer 1 and 2 interpreted 6 and 5 patients had 'indeterminate' when they used water. Both observer 1 and 2 interpreted 6 patients had 'indeterminate' when they used water with Vitamin C resolved. When they used water, observer 1 interpreted 10 patients had 'unchanged' and observer 2 interpreted 11 patients had 'unchanged'. Differently, when they used water with vitamin C resolved, observer1 had 8 patients having 'unchanged'and observer 2 had 9. Conclusion: As a result, by making patients drink 0.5 liter of water which has vitamin C resolved helped getting rid of false-positive sites in esophagus. Therefore, based on this study, we believe that drinking water with vitamin C dissolved is very in terms of reducing false-positive hot spot around the esophagus for the iodine-131 whole body scan.

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Agronomic Characteristics of Adzuki bean (Vigna angularis W.F. Wight) Germplasm in Korea (팥 유전자원의 작물학적 형질 특성)

  • Yoon, Seong-Tak;Qin, Yufeng;Kim, Tae-Ho;Choi, Seong-Hoon;Nam, Jung-Chang;Lee, Jun-Soo
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.57 no.1
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    • pp.7-15
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    • 2012
  • Agronomic characteristics of 150 adzuki bean ($Vigna$ $angularis$ W.F. Wight) germplasm collected in Korea were investigated in order to establish basic data for the improvement of crop breeding. Growth types were classified as 3 types of indeterminate type, determinate type, and semideterminate type, of which indeterminate type was the highest percentage of 96.6%. Seed color were classified as 8 colors of which dark brown took 66.5% in 150 adzuki bean germplasm. Days from seeding to maturity showed the range from 89 to 142 days with 115 days in the average and the highest frequency proportion was 37.2% of the group from 131 to 140 days, and the next was 27.3% of the group from 121 to 130 days among 150 germplasm. Pod length showed the range from 5.9 to 10.1 cm with 7.8 cm in the average and the highest frequency distribution of it was the group from 7.1 to 8.0 cm with the proportion of 45.1% and the next was the group from 8.1 to 9.0 cm with the proportion of 32.2%. Number of pods per plant showed the range from 5.0 to 132.5 pods with 28.5 pods in the average and the highest frequency distribution of it was the group from 11.0 to 20.0 pods with the proportion of 30.8% and the next was the group from 21.0 to 30.0 pods with the proportion of 28.6%. Number of seeds per pod showed the range from 5.3 to 11.3 seeds with 8.2 seeds in the average and the highest frequency proportion of it was the group from 7.1 to 8.0 seeds, which occupied 32.2% among 150 germplasm. 89.3% of 150 germplasm showed the resistance to shattering of grains at harvest period. 100 grain weight showed the range from 5.7 to 23.0 g with 12.9 g in the average and the highest frequency proportion of it was the group from 9.01 to 13.0 g, which occupied 43.3% and the next was the group from 13.01 to 17.00 g with the proportion of 28.5% of 150 germplasm.

Application of Vision-based Measurement System for Estimation of Dynamic Characteristics on Hanger Cables (행어케이블의 동특성 추정을 위한 영상계측시스템 적용)

  • Kim, Sung-Wan;Kim, Nam-Sik
    • KSCE Journal of Civil and Environmental Engineering Research
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    • v.32 no.1A
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    • pp.1-10
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    • 2012
  • Along with the development of coasts, islands and mountains, the demand of long-span bridges increases which, in turn, brings forth the construction of cable-supported bridges like suspension and cable-stayed bridges. There are various types of statically indeterminate structures widely applied that supported the main girder with stay cables, main cables, hanger cables with aesthetic structural appearance. As to the cable-supported bridges, the health monitoring of a bridge can be identified by measuring tension force on cable repeatedly. The tension force on cable is measured either by direct measurement of stress of cable using load cell or hydraulic jack, or by vibration method estimating tension force using cable shape and measured dynamic characteristics. In this study, a method to estimate dynamic characteristics of hanger cables by using a digital image processing is suggested. Digital images are acquired by a portable digital camcorder, which is the sensor to remotely measure dynamic responses considering convenient and economical aspects for use. A digital image correlation(DIC) technique is applied for digital image processing, and an image transform function(ITF) to correct the geometric distortion induced from the deformed images is used to estimate subpixel. And, the correction of motion of vision-based measurement system using a fixed object in an image without installing additional sensor can be enhanced the resolution of dynamic responses and modal frequencies of hanger cables.

Genetic Analysis of Quantitative Trait for Flowering Habits by Diallel Crosses in Sesame (참깨의 이면교잡에 의한 유한형 양적형질 유전분석)

  • Mun Sik Shin
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.48 no.6
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    • pp.442-446
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    • 2003
  • The Gene action for eight quantitative characters related to the plant type was estimated using diallel cross among three different plant types of sesame (Sesamum indicum L.) in 2001. The parental varieties used for diallel cross were Ahnnam and Yangbaeck as indeterminate type, ksan22 as semi-determinate type, and dt-45 and Suwon131 as determinate type. In variance and covariance analysis (Wr-Vr) for eight characters the mean square of array except for capsule length, 1,000 seed weight were significant, which suggest that varieties involved in diallel set cross may have epitasis. Complete dominance was observed in the flowering periods, and ratio of matured grains while partial dominance was observed in the plant height, no. of capsules per plant, and no. of branch per plant. Broad sense heritability for flowering periods, plant height, no. of capsules per plant, and no. of branch per plant ranged from 0.91 to 0.99. Narrow sense heritability for flowering periods, capsule length, ratio of matured grain, 1,000 seed eight were 0.18 to 0.34, and plant height, no. of capsules per plant and no. of branch per plant were ranged 0.77 to 0.81.

Sensitivity of Whole-Blood Interferon-Gamma Release Assay According to the Severity and the Location of Disease in Patients with Active Tuberculosis (활동성 결핵의 중증도 및 병변 부위에 따른 전혈 인터페론 감마 분비능 측정의 민감도)

  • Kim, Yi-Young;Lee, Jae-Hee;Lee, Yoon-Jee;Lee, So-Yeon;Lee, Yong-Hun;Choi, Keum-Ju;HwangBo, Yup;Cha, Seung-Ick;Park, Jae-Yong;Jung, Tae-Hoon;Park, Jun-Sik;Kim, Chang-Ho
    • Tuberculosis and Respiratory Diseases
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    • v.70 no.2
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    • pp.125-131
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    • 2011
  • Background: The clinical manifestation of $M.$ $tuberculosis$ infection ranges from asymptomatic latent infection, to focal forms with minimal symptoms and low bacterial burdens, and finally to advanced tuberculosis (TB) with severe symptoms and high bacillary loads. We investigated the diagnostic sensitivity of the whole-blood interferon-${\gamma}$ release assay according to the wide spectrum of clinical phenotypes. Methods: In patients diagnosed with active TB that underwent $QuantiFERON^{(R)}$ (QFT) testing, the QFT results were compared with patients known to be infected with pulmonary tuberculosis (P-TB) and extra-pulmonary TB (EP-TB). In addition, the results of the QFT test were further analyzed according to the radiographic extent of disease in patients with P-TB and the location of disease in patients with EP-TB. Results: There were no statistical differences in the overall distribution of QFT results between 177 patients with P-TB and 84 patients with EP-TB; the positive results of QFT test in patients with P-TB and EP-TB were 70.1% and 64.3%, respectively. Among patients with P-TB, patients with mild extents of disease showed higher frequency of positive results of QFT test than that of patients with severe form (75.2% vs. 57.1%, respectively; p=0.043) mainly due to an increase of indeterminate results in severe P-TB. Patients with TB pleurisy showed lower sensitivity by the QFT test than those with tuberculous lymphadenitis (48.8% vs. 78.8%, respectively; p=0.019). Conclusion: Although QFT test showed similar results between overall patients with P-TB and EP-TB, individual sensitivity was different according to the radiographic extent of disease in P-TB and the location of disease in EP-TB.

Yield Response and light Utilization to Planting Density in Soybean Cultivars for Bean Sprouting and for Cooking with Rice (나물콩 및 밥밑콩 품종들의 재식밀도에 따른 광이용 수량반응)

  • 이호진;김홍식;이홍석
    • KOREAN JOURNAL OF CROP SCIENCE
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    • v.36 no.2
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    • pp.177-184
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    • 1991
  • Soybean cultivars for bean sprouting, and for cooking with rice are related closely with Korean dietary tradition, but their yields have been kept in low level. The yielding responses of Danyup, a cultivar for bean sprouting and Gumjung, a cultivar for cooking with rice were compared with Paldal as standard cultivar in planting density within 10 to 80 plants per ㎡. Yield of Paldal increased as planting density increased from 10 plants up to 80 plant/㎡. But, Danyup reached at threshold as planting density reached up to 40 plants/㎡. Gumjung did not have significant difference in yield within planting density. Danyup had the highest yield, 445 kg/l0a at 80 plants/㎡. The highest yield of Paldal was 406kg/10a at 40 plants /㎡ while Gumjung had 373kg/ l0a at 40 plants. The yield responses of cultivars were influenced by canopy structure and light utilization. Paldal had short and straight canopy with determinate growth habit responded well at the heavy density, and had 6.2 in critical LA!. But Gumjung, tall and dense canopy with indeterminate growth habit had limited utilization of light within canopy with 5.4 in critical LAI and high rate of lodging. Gumjung was concluded as a low yielding cultivar, since it did not have good response to increasing source size and sink number.

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Electron microscopic studies on Flavobacterium branchiophila in experimentally induced gill disease of rainbow trout (세균성(細菌性) 아가미병(病)에 실험적(實驗的)으로 감염(感染)된 무지개송어에 있어서 Flavobacterium branchiophila에 대한 전자현미경학적(電子顯微鏡學的) 연구(硏究))

  • Heo, Gang-joon
    • Korean Journal of Veterinary Research
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    • v.32 no.3
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    • pp.381-387
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    • 1992
  • Gill epithelia of normal rainbow trout fingerlings and abnormal ones suffering bacterial gill disease by experimental infection were examined by transmitting electron microscopy (TEM) and scanning electron microscopy (SEM). TEM observations revealed that Flavobacterium branchiophila consisted of slender rods measuring 0.5 by 5 to $8{\mu}m$, and they had which were long, thin, flexible filaments measuring approximately 4 nm by $1{\mu}m$, and packed together to organize into bundles. Morphological alterations of the diseased epithelia started at hypertrophy of the lamellar epithelium. F branchiophila attached to the gill surface of infected fish through pili with a regular distance, and did not invade into gill tissue. In SEM observations, normal surface ultrastructure of epithelial cell in the outermost layer were characterized by a typical labyrinth-like structure branching and anastomosing microridges on the cell surface. Hyperplastic lesions in experimentally infected gill were most serious at near the tips. Each filament exhibited a club-like, and fusion between the filaments was sometimes observed at their tips. On the surface of gill filaments, thread-like bacterial cells attached and were entangled. The bacterial cells almost covered the surface. After immersion in 5 % NaCl, the cell of F branchiophila, however, appeared to be indeterminate shape.

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PNA-Mediated PCR Clamping for the Detection of EGFR Mutations in Non-Small Cell Lung Cancer (비소세포폐암에서 PNA-Mediated PCR Clamping을 이용한 EGFR 돌연변이 분석법)

  • Lee, Kye-Young;Kim, Hee-Joung;Kim, Sun-Jong;Yoo, Gwang-Ha;Kim, Won-Dong;Oh, Seo-Young;Kim, Wan-Seop
    • Tuberculosis and Respiratory Diseases
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    • v.69 no.4
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    • pp.271-278
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    • 2010
  • Background: Recent studies have demonstrated that the epidermal growth factor receptor (EGFR) genotype is the most important predictive marker to EGFR-tyrosine kinase inhibitors (TKIs) and first-line gefitinib treatment will be approved in the near future for use in non-small cell lung cancer (NSCLC) patients with the EGFR mutation. Direct sequencing is known to be the standard for detecting EGFR mutations; however, it has limited sensitivity. Peptide nucleic acids (PNA)-mediated PCR clamping method is a newly introduced method for analyzing EGFR mutations with increased sensitivity and stability. Methods: A total of 71 NSCLC patients were analyzed for EGFR mutations using the PNA-mediated PCR clamping technique. Sixty-nine patients were analyzed for clinicopathologic correlation with EGFR genotype; 2 patients with indeterminate results were excluded. In order to determine EGFR-TKI drug response, 57 patients (42 gefitinib, 15 erlotinib) were included in the analysis. Results: The EGFR mutation rate was 47.8%. Being female, a non-smoker, and having adenocarcinoma were favorable clinicopathologic factors, as expected. However, more than a few smokers (33.3%), male (28.1%), and patients with non-adenocarcinoma (28.6%) had the EGFR mutation. Having a combination of favorable clinicopathologic factors did not increase the EGFR mutation rate significantly. Drug response to EGFR-TKIs showed significant differences depending on the EGFR genotype; ORR was 14.3% for wild type vs 69.0% for mutant type; DCR is 28.6% for wild type vs 96.6% for mutant type. The median EGFR-TKI treatment duration is 7.6 months for mutant type group and 1.4 months for wild type group. Conclusion: EGFR genotype determined using the PNA-mediated PCR clamping method is significantly correlated with the clinical EGFR-TKI responses and PNA-mediated PCR.

An Empirical Study on Information system for Performance of Phisical Distribution - by Agricaltural Products - (물류정보화 수준이 물류성과에 미치는 영향에 관한 연구 - 농산물을 중심으로 -)

  • Kwon, Oh-cheol;Kim, Sang-cheol
    • Journal of Distribution Science
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    • v.5 no.1
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    • pp.57-73
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    • 2007
  • There are more problems in distributing agricultural and special products than industrial products because they have such restrictions as seasonal fluctuation in the quantity, indeterminate and diverse shapes, many farm households, a small amount of shipment, and mandatory guide and maintenance. However, with social atmosphere called well-being, there are increasing concerns about inorganic agricultural products and direct trade with farmers. It is therefore urgent to stabilize the price of agricultural and special products and to correctly grasp and improve logistics activities for those dealing with agricultural and special products in order to supply fresh ones. This study aimed at examining logistics activities and the information technology level for agricultural and special products, determining how these factors affect logistics performance, and eventually suggesting a scheme to improve the logistics achievements for agricultural and special products. For this purpose, it selected information technology and logistics activity levels as independent variables and logistics performance as a dependent variable. The information technology level was measured for utility, holding level, and concern, respectively, and the logistics activity level was tested for the level of using the logistics information system in those companies concerned. From the above-mentioned findings, it is urgent to enhance distribution technology and its level immediately since distribution of agricultural and special products is poor in Korea and good distribution can contribute to a reduction of logistics costs or improvement of customer service.

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Effects of Liming and Inoculation on Growth and Yield of Soybean in Paddy-Upland Rotational Cropping (답전윤환답(沓田輪換沓)의 콩 생육(生育) 및 수량(水量)에 미치는 토양산도(土壤酸度) 보정(補整)과 근류균(根瘤菌) 접종효과(接種效果))

  • Cho, Seang-Ho;Hwang, Young-Hyun;Lee, Sang-Chull
    • Current Research on Agriculture and Life Sciences
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    • v.15
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    • pp.7-16
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    • 1997
  • The effects of liming and inoculation of nodule bacteria on the growth and yield of soybeans in the 1st and 3rd year paddy-upland rotated paddy fields was investigated. Compared with the 1st rotated field, the degree of nodulation was much higher in the 3rd rotated one with greater difference at flowering stage than at the early stage of soybean growth. At the same time, greater difference in the degree of nodulation was also recognized between soybean varieties. In the 3rd year rotated field, a great deal of nodulation effect was recognized in the no-limed field but not in the limed one. The growth of soybean was not much affected by liming and nodulation at early stage but it was much increased by liming at flowering stage, especially in Williams 79, indeterminate type variety. Most of yield components and yield of soybean at maturity was much increased by liming with greater in Williams 79 than in Namhaekong. Nodulation effect on the yield components and yield was great in the no-limed filed but not in the limed one for both varieties. The yield and yield components of soybean, without no relation with liming and nodulation, was much great in the 3rd year rotated paddy fields than in the 1st year one, which was inferred that the more rotated fields the more yield and better growth of soybeans could be possible in the paddy-upland rotatonal soybean croppings.

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