• Title/Summary/Keyword: independent life

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A Justification on the Evil of Death (죽음의 나쁨에 관한 정당화)

  • Kwon, Su-Hyeon
    • The Journal of the Convergence on Culture Technology
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    • v.3 no.4
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    • pp.27-33
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    • 2017
  • Epicurus and Lucretius expressed that death is neither evil to the living nor the dead. On the contrary, our everyday perception of death is that death is evil. Such everyday perception might seem in lack of introspection and blind but our living environment and form of life are strongly supporting this perception. This paper argues that there is reasonable cause for believing death is evil. In order to justify this argue, this paper critically supports Thomas Nagel's 'Deprivation Theory', which identifies the cause of death being in evil in the deprivation of life. This paper investigates the main substances of 'Deprivation Theory, suggests the related problems and therefore reconstitutes the main arguments of 'Deprivation Theory, resulting in the investigation of the following facts; that we cannot avoid the fate of death, but that our existence is headed towards the future, and that as independent individuals we have infinite possibilities of life. Death is natural to humanity as species, but as independent individuals death deprives us from possible life and future. Therefore, death we encounter in our living environment and form of life is evil. As species, we can agree with Epicurus and Lecretius' view, but as independent individuals we cannot share them.

A Study on the Linkage Model Between Institutions Related to Lifelong Education for People with Developmental Disabilities Based on the K-PACE Center of Daegu University: A Perspective on the Whole Life Cycle for People with Developmental Disabilities

  • Kim, Young-Jun;Kim, Wha-Soo;Rhee, Kun-Yong
    • International Journal of Advanced Culture Technology
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    • v.10 no.1
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    • pp.24-35
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    • 2022
  • The purpose of this study was to form a linked model in which local institutions related to lifelong education for the disabled can cooperate based on the Daegu University K-PACE Center. The contents of the study started with recognizing the problem that the adult-centered lifelong education support system does not effectively cope with these factors, even though the independent life of people with developmental disabilities is a major factor determining the quality of life. Regarding this problem recognition, this study primarily emphasized the view that educational support for independent life of people with developmental disabilities should establish the context of the school foundation. The context of the school foundation is established for lifelong education centered on adulthood for people with developmental disabilities because the curriculum is embodied through the standards of subject matter education. In this regard, the Daegu University K-PACE Center, which established a curriculum that supports the independent life of people with developmental disabilities in terms of linking higher and lifelong education, actually reflects the context of the school foundation. As a result, this study prepared a strategy that could be considered as a transition to advance the curriculum organized by the Daegu University K-PACE Center, and the strategy was secondarily reflected as a procedure that could be linked to local lifelong education-related institutions for the disabled. Finally, this study presented a form of transition in which people with developmental disabilities can access the curriculum of lifelong education through the connection of local lifelong education-related institutions for the disabled, centering on the entire life of adulthood.

CopA3 peptide from Copris tripartitus induces apoptosis in human leukemia cells via a caspase-independent pathway

  • Kang, Bo-Ram;Kim, Ho;Nam, Sung-Hee;Yun, Eun-Young;Kim, Seong-Ryul;Ahn, Mi-Young;Chang, Jong-Soo;Hwang, Jae-Sam
    • BMB Reports
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    • v.45 no.2
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    • pp.85-90
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    • 2012
  • Our previous study demonstrated that CopA3, a disulfide dimer of the coprisin peptide analogue (LLCIALRKK), has antibacterial activity. In this study, we assessed whether CopA3 caused cellular toxicity in various mammalian cell lines. CopA3 selectively caused a marked decrease in cell viability in Jurkat T, U937, and AML-2 cells (human leukemia cells), but was not cytotoxic to Caki or Hela cells. Fragmentation of DNA, a marker of apoptosis, was also confirmed in the leukemia cell lines, but not in the other cells. CopA3-induced apoptosis in leukemia cells was mediated by apoptosis inducing factor (AIF), indicating induction of a caspase-independent signaling pathway.

Factors Affecting Health Related Quality of Life in Korean Perimenopausal Women Using Hierarchical Regression Analysis

  • Jeong, Ae-Suk
    • International Journal of Contents
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    • v.13 no.3
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    • pp.65-74
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    • 2017
  • Women's menopause is a natural process that every woman must eventually experience, but changes in hormones before and after menopause can serve to produce life-threatening crises in some situations, with individual differences. Data for the study was elicited from 22,610 Korean women ranging in age from 45 to 55 years in the 2013 Korean Community Health Survey. Statistical analyses was performed using descriptive, t-test, ANOVA, and hierarchical regression analysis using SPSS IBM 20.0 version. Individual characteristics, lifestyle, history of chronic disease(s), psychological and environmental factors were included as independent and EQ5D weights of Koreans were used as dependent variables. The survey subjects consisted of a total 15,505(58.3%) in their 50s, 1,765 (66.5%) in middle and high school dropouts or graduates, 22,174 (83.3%) living in spouses and 10,534(39.6%) in wages. There was a significant difference in HRQOL among all independent variables except drinking and residential areas. Hierarchical regression analysis showed that age, smoking, obesity and other incidental disease factors (fall, angina, asthma, arthritis, osteoporosis, stroke) had a negative effect on HRQOL. The selected independent variables accounted for 22.7% of HRQOL. It is necessary to find a way to improve HRQOL of Korean perimenopausal women, focusing on the significant variables revealed by the study results.

The Effects of Parental Support, Control and School Life Adjustment on Suicidal Ideation of Adolescents: Mediating Effects of Depression (부모의 지지와 통제 및 학교생활 적응이 남녀 청소년의 자살생각에 미치는 영향: 우울의 매개효과를 중심으로)

  • Lee, Ah Young;Park, Bu Jin;Kim, Se Young
    • Korean Journal of Child Studies
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    • v.37 no.1
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    • pp.61-71
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    • 2016
  • Objective: The purpose of this study was to confirm if there are gender differences in influences of parental support, control, and school life adjustment on suicidal ideation of adolescents and to examine the mediating effect of depression on the influences of independent variables on their suicidal ideation. Methods: This study comprised a total of 671 students in seventh and eighth grades in Seoul and Gyeonggi-do. The data were analyzed for frequency, average, and standard deviation, using the t-test, Pearson's correlation analysis, stepwise regression analysis, hierarchical multiple regression analysis, and the Sobel test. Results and Conclusion: First, significant differences among adolescents' gender were shown in fathers' psychological control, mothers' behavior control, and suicidal ideation. Second, in the case of male adolescents, all independent variables were found to have a full mediating effect on their suicidal ideation. Meanwhile, in the case of female adolescents, independent variables except for mothers' psychological control were found to have a full mediating effect on their suicidal ideation. Mothers' psychological control was found to have a partial mediating effect on suicidal ideation of adolescents for both genders.

Examining the Quality of Life Related to Fall Experience in Chronic Stroke Patients

  • Lee, Ju-Hwan;Park, Shin-Jun
    • Journal of the Korean Society of Physical Medicine
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    • v.11 no.3
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    • pp.73-80
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    • 2016
  • PURPOSE: The purpose of this study was to investigate the quality of life related to fall experiences in chronic stroke patients. METHODS: This cross-sectional study included 117 patients with stroke from 3 hospitals in D metropolitan city. General characteristics, including fall experiences and quality of life, were assessed through a face-to-face interviews conducted in a quiet place using a questionnaire. Measurement of quality of life in stroke patients was conducted using the Korean Stroke Specific Quality of Life Scale (SS-QOL). To identify the SS-QOL items related to fall experiences, the items of the SS-QOL were considered as independent variables, and the variables that were significantly different according to fall experiences were identified using a univariate analysis. A binary logistic regression was then performed using fall experiences as the independent variable. RESULTS: According to the univariate analysis, self help activities, social role, and upper extremity function were significantly lower in the fall group than that in the non-fall group (p<.05). The findings of the binary logistic regression confirmed that social roles and upper extremity function were the SS-QOL items that were related to fall experience in chronic stroke patients. CONCLUSION: These findings suggest that social roles and upper extremity function may be risk factors for fall experience in patients with chronic stroke.

A Study on Social Integration of Person With Disabilities based on Independent Living Paradigm : Life Span (자립생활 패러다임에 따른 장애인의 사회통합에 관한 연구 : 생애주기를 중심으로)

  • Park, Soo-Kyung
    • Korean Journal of Social Welfare
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    • v.58 no.1
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    • pp.237-264
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    • 2006
  • The purpose of this study is to examine the level of social integration of the person with physical disabilities based on independent living paradigm according to life span and to find factors affecting social integration and therefore to make policy implications for a better rehabilitation system. The data was obtained through telephone interviews with physically disabled residing in the city of Seoul and the suburb area of the city. The final sample consists of 591 respondents. The data was analyzed through frequency, oneway anova, pearson's correlation analysis, and multiple regression. In this study, social integration based on independent living paradigm was divided into separate but related dimensions: autonomy of activity daily living, accessibility, economic level, degree of social support satisfaction, consumer control, psychological empowerment. The major findings of this study were as follows: First, the levels of six dimensions of social integration based on independent living paradigm were very different and especially the level of dimensions such as degree of social support satisfaction and consumer control were lower than other dimensions of social integration. Second, each level of social integration by life span was very different. Finally, the factors affecting social integration were socio-psychological traits such as social support, rehabilitation services, self esteem and acceptance of disability as well as the attribution to disability. The current findings suggest that improving nay only ADL or accessibility but also consumer control or social support should be considered by professional and policy makers. And differentiated intervention and policy according to life span necessary to policy makers and field practitioners.

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Construction and Characterization of Transformed Insect Cells Expressing Baculovirus Very Late Factor in an Infection-Independent Manner

  • Park, Hye-Jin;Lee, Kwang-Sik;Cho, Eun-Sook;Yun, Eun-Young;Kang, Seok-Woo;Kim, Keun-Young;Sohn, Hung-Dae;Jin, Byung-Rae
    • International Journal of Industrial Entomology and Biomaterials
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    • v.2 no.1
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    • pp.19-26
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    • 2001
  • Transformed Spodoptera frugiperda (Sf9) cells expressing baculovirus very late factor (VLF-1) were constructed by using Autograha nuclear polyhedrosis virus (AcNPV) immediate earthy gene (ie1). Neomycin-resistance gene as a selectable marker was introduced under the control of AcNPV ie1 promoter, and Bombyx mori nuclear polyhedrosis (BmNPV-K1) vlf-1 gene was introduced under the control of the Drosophila heat shock protein gene (hspr70) promoter to yield dual expression plasmid with two independent transcription units. It was transfected into Sf9 cells and cell clones expressing vlf-1 were selected by G4l8 treatment. Genomic DNA from transformed cells was isolated and integration of AcNPV iel harboring vlf-1 was confirmed by PCR using AcNPV iel-specific primers and Southern blot analysis. The transformed cells expressing VLF-1 in an infection-independent manner expressed foreign gene product of recombinant baculovirus in the earlier stage of infection compared with control Sf9 cells. These results suggest the possible to develop highly efficient transformed insect cells for baculovirus expression vector system.

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