• Asian Pacific Journal of Cancer Prevention
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• 제13권1호
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• pp.329-337
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• 2012

Considerable attention has been given to the accuracy of HER-2 testing and the correlation between the results of different testing methods. This interest reflects the growing importance of HER-2 status in the management of patients with breast cancer. In this study the detection of HER-2 gene and centromere 17 status was evaluated using dual-colour primed in situ labelling (PRINS) in comparison with fluorescence in situ hybridization (FISH). These two methods were evaluated on a series of 27 formalin fixed paraffin embedded breast carcinoma tumours, previously tested for protein overexpression by HercepTest (grouped into Hercep 1+/0, 2+ and 3+). HER-2 gene amplification (ratio${\geq}2.2$) by PRINS was found in 3:3, 6:21 and 0:3 in IHC 3+, 2+ and 1+/0 cases, respectively. Comparing FISH and IHC (immunohistochemistry), showed the same results as for PRINS and IHC. Chromosome 17 aneusomy was found in 10 of 21 IHC 2+ cases (47.6%), of which 1 (10%) showed hypodisomy (chromosome 17 copy number per cell${\leq}1.75$), 7 (70%) showed low polysomy (chromosome 17 copy number per cell=2.26 - 3.75) and 2 (20%) showed high polysomy (chromosome 17 copy number per cell ${\geq}3.76$). The overall concordance of detection of HER-2 gene amplification by FISH and PRINS was 100% (27:27). Furthermore, both the level of HER-2 amplification and copy number of CEN17 analysis results correlated well between the two methods. In conclusion, PRINS is a reliable, reproducible technique and in our opinion can be used as an additional test to determine HER-2 status in breast tumours.

• 한국도로학회논문집
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• 제13권1호
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• pp.33-40
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• 2011

국내에서 일반적으로 보조기층재료로 사용되고 있는 보조기층 다짐재료의 역학적 특성을 반영한 실내 회복탄성계수는 역학적-경험적 포장설계법에서 적용하는 설계 인자이다. 따라서, 역학적-경험적 포장설계법의 보조기층 현장에서 실시하여야 하는 다짐관리는 다짐 후 측정된 현장 탄성계수가 설계에 적용된 실내 회복탄성계수를 만족하는지 여부를 확인하여야 할 것이다. 이를 위하여 본 연구에서는 기존 다짐관리 시험인 들밀도 시험과 평판재하시험(PBT)의 시험결과와 현장탄성계수와의 상관성을 분석하였고, 현장에서 탄성계수를 측정할 수 있는 소형 충격 재하시험(LFWD)을 통한 현장탄성계수와 실내 회복탄성계수와의 상관관계식과 시험간격을 제안하였다. 또한 제안된 상관관계를 이용하여 현장시험을 통한 보조기층의 다짐관리방안을 제안하였다.

• 비파괴검사학회지
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• 제23권5호
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• pp.409-417
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• 2003

열경화성 수지 복합재료의 제조과정에서 제품의 품질과 생산성 향상에 필수적인 경화 모니터링 기술을 개발하였다 경화도를 분석하기 위해, 동일한 경화조건에서 유전기법에 의한 소산계수 측정결과와 시차 주사 열분석 방법에 의한 발열량 계측 결과를 비교하였으며, 계측 감도의 향상을 위해 센서부분과 계측선의 영향을 적절히 분리하는 방법을 사용하였다. 유리섬유/폴리에스터 복합재료와 유리섬유/에폭시 복합재료에 대하여 경화과정에서의 경화도 분석을 위한 새로운 경화 모니터링 방법으로 소산계수와 온도를 동시에 고려하였다. 이 때, 소산계수의 변화 경향은 수지 점도의 변화 양상과 비교하여 분석하였다 개발된 경화 모니터링 방법은 다양한 종류의 열경화성 복합재료 경화 모니터링에 사용될 수 있다.

• Nuclear Engineering and Technology
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• 제52권7호
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• pp.1481-1485
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• 2020

The creep behavior of Ni-Cr-W alloy at 950 ℃ has been investigated by a novel creep testing system which is capable of in-situ measurement of strain. Tubular specimens were pressurized with argon gas for effective stresses up to 32 MPa. Experimental results show that the thermal fatigue reduces the creep life of the tubular specimens and with the introduction of thermal cycling fatigue the primary stage disappears and the creep rate higher than the pure thermal creep (without thermal fatigue). Also the creep behavior of Ni-Cr-W alloy doesn't consist in the secondary stage. A new creep equation has been derived and implemented into finite element method. The results from the finite element analyses are in good agreement with the creep experiment.

• 한국관개배수논문집
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• 제2권1호
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• pp.57-64
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• 1995

현장 투수시험 방법 중에서 Borehole type의 Boutwell Permeameter와 Constant head bore-hole permeameter, 그리고 Porous probe type의 cone shaped porous probe(BAT Permeameter)에 대한 내용을 간단히 소개하였고, 각 측정법의 특징을 비교분석한 내용을 요약하면 (표-1)과 같으며, 기회가 있으면 Infiltrometer type와 Underdrain type에

• Smart Structures and Systems
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• 제26권1호
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• pp.1-10
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• 2020

Turkey is a transcontinental country located partly in Asia and partly in Europe, and hosted by diverse civilizations including Hittite, Urartu, Lydia, Phrygia, Pontius, Byzantine, Seljuk's and Ottomans. At various times, these built many historic monuments representing the most significant characteristics of their civilizations. Today, these monuments contribute enormously to the esthetic beauty of environment and important to many cities of Turkey in attracting tourism. The survival of these monuments depends on the investigation of structural behavior and implementation of needed repairing and/or strengthening applications. Hence, many countries have made deeper investigations and regulations to assess their monuments' structural behavior. This paper presents the dynamic behavior investigation of a monumental masonry mosque, the "İskenderpaşa Mosque" in Trabzon (Turkey), by performing an experimental examination with non-destructive testing. The dynamic behavior investigation was carried out by determining the dynamic characteristic called as natural frequencies, mode shapes and damping ratios. The experimental dynamic characteristics were extracted by Operational Modal Analysis (OMA). In addition, Finite Element (FE) model of masonry mosque was constructed in ANSYS software and the numerical dynamic characteristics such as natural frequencies and mode shapes were also obtained and compared to experimental ones. The paper aims at presenting the non-destructive testing procedure of a masonry mosque as well as the comparison of experimental and numerical dynamic characteristics obtained from the mosque.

• 한국세라믹학회지
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• 제45권12호
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• pp.788-795
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• 2008

An electrolyte supported SOFC cell was tested at $800^{\circ}C$ in air for 3600 h with an applied current density of $200\;mA/cm^2$ to examine possible cathode degradation issues. A scandium- stabilized zirconia (ScSZ) with additional manganese doping (ScSZ: Mn) was used as electrolyte. A strontium and copper-doped lanthanum ferrite (LaSrCuFe) and platinum were used as cathode and quasi-anode material, respectively. The DC resistance was logged over the complete testing period. Additionally, impedance spectroscopy was used from time to time to track changes of the cell in-situ. Post-test analysis of the cell using methods like scanning electron microscopy imaging and other electrochemical testing methods allow the identification of different degradation sources. The results indicate a promising combination of electrolyte and cathode material in terms of chemical compatibility and electrical performance.

• Structural Engineering and Mechanics
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• 제6권3호
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• pp.259-274
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• 1998

The test results from non-destructive and destructive field testing of a three-span deteriorated reinforced concrete slab bridge are used as a vehicle to examine the reliability of available tools for finite-element analysis of in-situ structures. Issues related to geometric modeling of members and connections, material models, and failure criteria are discussed. The results indicate that current material models and failure criteria are adequate, although lack of inelastic out-of-plane shear response in most nonlinear shell elements is a major shortcoming that needs to be resolved. With proper geometric modeling, it is possible to adequately correlate the measured global, regional, and local responses at all limit states. However, modeling of less understood mechanisms, such as slab-abutment connections, may need to be finalized through a system identification technique. In absence of the experimental data necessary for this purpose, upper and lower bounds of only global responses can be computed reliably. The studies reaffirm that success of finite-element models has to be assessed collectively with reference to all responses and not just a few global measurements.

• 대한기계학회논문집A
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• 제35권11호
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• pp.1377-1382
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• 2011

최근, 화석연료의 고갈과 환경오염의 문제로 인해 차세대 신재생 에너지에 대한 관심이 증대되고 있다. 그 중 수소연료는 친환경, 저장의 용이, 손쉬운 제조 등과 같은 장점에 반해 가연범위가 넓고, 폭발의 위험성이 단점으로 대두되고 있다. 본 연구에서는 간편한 SP 시험법을 이용하여 고압수소가스 분위기 하에서 in-situ 수소취화거동을 평가할 수 있는 시험기법을 확립하고자 한다. 그 적용성을 평가하기 위해서 수소저장용기 재료로 사용되는 스테인리스강(SUS316L)을 사용하여 대기압, 고압 헬륨 및 수소가스 분위기에서 시험하였다. 실험결과, 고압 수소가스 분위기에서는 수소 침투로 인해, 대기압 및 헬륨가스 분위기하에서와 달리, 시험편 표면에 미세균열 발생과 하중-변위 선도상 소성불안정 변형 영역에서 연신율 감소를 가져왔고, 파면관찰 결과 수소취화 균열이 관찰되어 SP시험법의 유효성을 나타내었다.

• 한국지반공학회:학술대회논문집
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• 한국지반공학회 2005년도 춘계 학술발표회 논문집
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• pp.431-438
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• 2005

In this paper, the characteristics of excessive horizontal stress components in Korea were studied using the in-situ hydraulic fracturing stress measurement data over five hundred in 110 individual test boreholes. Based on the in-situ testing data, the magnitude and orientation of the horizontal stress component and variation of stress ratio (K) with depth were investigated. And also horizontal stress magnitude versus depth relationships and distribution limits of stress ratio components were suggested. For the subsurface space above 310 m depth in the entire territory, the stress ratio has a tendency to diminish and be stabilized with depth, but for some areas, it was revealed that the excessive horizontal stress fields with stress ratio close to 3.0 below 200 m in depth have formed. The result of investigation for excessive horizontal stress regions indicates that there exist several regions above 300 m in depth where localized excessive horizontal stresses enough to induce potentially brittle failure around future openings have formed.