• Proceedings of the KSME Conference
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• 2008.11a
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• pp.1404-1408
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• 2008

The migration and proliferation of vascular endothelial cells (VEC), which play an important role in vascular remodeling, are known to be regulated by hemodynamic forces in the blood vessels. When shear stresses of 2, 6, 15 dynes/$cm^2$ are applied on mouse micro-VEC in vitro, cells surprisingly migrate against the flow direction at all conditions. While higher flow rate imposes more resistance against the cells, reducing their migration speed, the horizontal component of the velocity parallel to the flow increases with the flow rate, indicating the higher alignment of cells in the direction parallel to the flow at a higher shear stress. In addition, cells exhibit substrate stiffness and calcium dependent migration behavior, which can be explained by polarized remodeling in the mechanosensitive pathway under shear stress.

• The Korean Journal of Applied Statistics
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• v.33 no.4
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• pp.421-437
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• 2020

This paper implemented a method to predict the fertility rate, mortality rate, and international migration rate using the R program, which has been widely used in recent years, that calculates population projection by substituting the results into the Leslie matrix. In particular, the generalization log gamma model for the fertility rate by Kaneko (2003), LC-ER model for mortality rate by Li et al. (2013), and functional data model for international migration rates proposed by Ramsay and Silverman (2005) and Hyndman and Booth (2008), Hyndman et al. (2013) can be directly demonstrated with R programs. Demography and bayesPop have been introduced as a representative demographic package implemented in R; however, it can be analyzed only for data uploaded to Human Mortality Database (HMD) and Human Fertility Database (HFD) with data changes and modifications requiring application of other data. In particular, in Korea, there is a limitation in applying this package because it is provided only for short-term data in HMD. This paper introduces an R program that can reflect this situation and the different patterns of low fertility, aging, migration of domestic and foreigners in Korea, and derives a population projection for the year 2117.

• Proceedings of the Korean Institute of Building Construction Conference
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• 2017.05a
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• pp.246-247
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• 2017

In this study, it reviewed the effect of moisture migration in concrete with heating rate on concrete spalling. Concrete specimens with compressive strength 30MPa and 110MPa are used and its size is □100×100×h200mm. And, two kinds of heating rate are set such as IS0 834 and 1℃/min. As a result, in the concrete specimen exposed to ISO 834 standard heating condition, moisture could migrate through pore network and surface concrete pieces fall out by generating moisture clog near the surface in 110MPa concrete specimen. Meanwhile, In the case of concrete specimens exposed to 1℃/min. heating condition, it is appeared that moisture could not migrate because temperature is distributed uniformly. Therefore, surface spalling is not occurred with low heating rate. However, in the case of 110MPa concrete specimen is exploded even though it heated by low heating rate.

• Journal of the Korean Institute of Telematics and Electronics A
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• v.30A no.6
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• pp.1-7
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• 1993

After the 1%S-Al metal is deposited, a thin oxide is formed thereon. Then, a single charged Argon(Ar$^{+}$) is ion implanted into the oxide layer, thereby causing the metal grain in the upper surface of the metal layer to become amorphous. Consequently, the grain size will be reduced and the rough surface of the metal layer flattened. However, the remainder of the metal layer beneath the upper surface thereof will still exhibit large grain size and low resistance, because the Argon ion is only implanted to characterized by a dual-sized grain structure which served to reduce interlayer stress, thereby decreasing the rate of stress migration, and to lower the resistivity of the metal line, thereby enhancing the electromigration characteristic thereof. Experiments have shown that the metal line exhibits a metal migration rate which is approximately 700% less than the control group and a standard deviation which is approximately 200% less than these group.p.

• Journal of the Korean Geographical Society
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• v.46 no.2
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• pp.212-232
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• 2011

The main objective of this study is to establish a population projection method based on the biregional cohort-component method and to apply it to population projections for Busan. Some drawbacks of using the net migration cohort-component method in a regional or local level population projection are demonstrated. A biregional cohort-component method, a variant of the interregional cohort-component method, is established as an alternative where in-migration and out-migration are separately considered and then are combined to produce a projection for the migration component. Predicated on the established method, population projections for Busan are undertaken for the period of 2005~2030 under three different scenarios. Considerably different projection results are obtained between the net migration and biregional methods; among others, the trend of population decline is more severe in the former than in the latter. An investigation of the temporal trend of the projected population shows that the proposed method is highly reasonable. In conclusion, the proposed method based on the biregional cohort-component method seems not only to be theoretically more robust than the net migration cohort-component method but also to be very effective in the real world application.

• The Korean Journal of Community Living Science
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• v.18 no.3
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• pp.455-467
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• 2007

Recently, there has been a gradual growth of retired in-migrants in high-amenity, rural areas in Korea. However, little has known about that the retirement migration is a blessing or a blight for a local economy in Korea. Therefore, in this study, we intend to explore the relationship between retirement migration and economic development of rural communities in Korea. For this purpose, we used the 1995 and 2000 census data and annual regional statistics for 138 counties in Korea. Based on the previous empirical studies, economic development was measured by 3 indicators such as GRDP (Gross Regional Domestic Product), job creation in the wholesale and retail sector, and the increase of local tax. Also, cross-tab, scatter plot, and correlation were analyzed using the SPSS Windows Program. The finding are as follows: First, from 1995 to 2000, nearly 11 percent of rural counties showed 10 percent and over increase of in-migration rate among retirees. Second, correlation statistics showed a close relationship between retirement in-migrant flows and economic resurgence. In particular, retirement in-migration rates were significantly tied to the job creation of the wholesale and retail sector (r=.19, p<.05) as well as car ownership rate (r=.58, p<.001) resulting in the increase of local tax. However, there was non-significantly positive correlation between retirement in-migrant flows and GRDP change (r=.13). Knowledge of these relationships will be important to policy-makers and for understanding the role that retirement in-migration play in stimulating economic growth of rural communities in Korea.

• Journal of Soil and Groundwater Environment
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• v.23 no.1
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• pp.1-13
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• 2018

A series of experiments using transparent micromodels with an artificial pore network etched on glass plates was performed to investigate the effects of flow rate on the migration and distribution of resident wetting porewater (deionized water) and injecting non-wetting fluid (n-hexane). Multicolored images transformed from real RGB images were used to distinguish n-hexane from porewater and pore structure. Hexane flooding followed by immiscible displacement with porewater, migration through capillary fingering, preferential flow and bypassing were observed during injection experiments. The areal displacement efficiency increases as the injection of n-hexane continues until the equilibrium reaches. Experimental results showed that the areal displacement efficiency at equilibrium increases as the flow rate increases. Close observation reveals that preferential flowpaths through larger pore bodies and throats and clusters of entrapped porewater were frequently created at lower flow rate. At higher flow rate, randomly oriented forward and lateral flowpaths of n-hexane displaces more porewater at an efficiency close to stable displacement. It may resulted from that the pore pressure of n-hexane, at higher flow rate, increases fast enough to overcome capillary pressure acting on smaller pore throats as well larger ones. Experimental results in this study may provide fundamental information on migration and distribution of immiscible fluids in subsurface porous media.

• Journal of the Korea Academia-Industrial cooperation Society
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• v.17 no.9
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• pp.737-744
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• 2016

Seoul Metropolitan Area has been changed by fierce internal migration during the last several decades. To determine the regional structure, we analyzed the in-and-out migration pattern and main factors affecting the intense of mobility. The migration within metropolitan city and province shows that in Seoul, Songpa and Dobong Gu gained a large population, in Incheon, Namdong Gu experienced a huge population influx, and in Gyeonggi Province, Hwasung, Yongin and Paju city gained a great population. In Seongnam, Suwon city lost a lot of population. These population gains and losses came from mainly residential redevelopment projects in the metropolitan city and new land development projects in Gyeonggi Province. The main factors affecting the intense of mobility diverse from city characters. In central type cities, house price gets the more population influx. In job-housing balanced cities, total income growth rate, housing supply rate and roads cause in-migration. In bed-town type cities, the increase of housing supply rate and parks increase the population. In suburban type cities, business density, housing supply rate, housing, subway station number and educational facilities increase population from outside the city. So, we have to prepare more detailed urban and housing policy responses.

• Proceedings of the Korean Vacuum Society Conference
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• 2013.02a
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• pp.526-526
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• 2013

Plasma technology isbeing developed for a range of medical applications including wound healing. However, the effect of plasma on many cells and tissues is unclear. Cell migration and cell proliferation are very important biological processes which are affected by plasma exposure and might be a potential target for plasma therapy during wound healing treatment. In this study, we confirmed the plasma exposure time and incubation time after plasma treatment in skin fibroblast (L-929 cells) to evaluate the optimal conditions forplasma exposure to the cell in-vitro. In addition, we used a scratch method to generate artificial wound for evaluating the cell migration by plasma treatment. Where, the cells were treated with plasma and migration rate was observed by live-cell imaging device. To find the cell proliferation, cell viability assay was executed. The results of this study indicate the increased cell proliferation and migration on mild plasma treatment. The mechanisms for cell migration and cell proliferation after plasma treatment for future studies will be discussed.

• Tissue Engineering and Regenerative Medicine
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• v.15 no.6
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• pp.721-733
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• 2018

BACKGROUND: Because three-dimensional (3D) models more closely mimic native tissues, one of the goals of 3D in vitro tissue models is to aid in the development and toxicity screening of new drug therapies. In this study, a 3D skin wound healing model comprising of a collagen type I construct with fibrin-filled defects was developed. METHODS: Optical imaging was used to measure keratinocyte migration in the presence of fibroblasts over 7 days onto the fibrin-filled defects. Additionally, cell viability and growth of fibroblasts and keratinocytes was measured using the $alamarBlue^{(R)}$ assay and changes in the mechanical stiffness of the 3D construct was monitored using compressive indentation testing. RESULTS: Keratinocyte migration rate was significantly increased in the presence of fibroblasts with the cells reaching the center of the defect as early as day 3 in the co-culture constructs compared to day 7 for the control keratinocyte monoculture constructs. Additionally, constructs with the greatest rate of keratinocyte migration had reduced cell growth. When fibroblasts were cultured alone in the wound healing construct, there was a 1.3 to 3.4-fold increase in cell growth and a 1.2 to 1.4-fold increase in cell growth for keratinocyte monocultures. However, co-culture constructs exhibited no significant growth over 7 days. Finally, mechanical testing showed that fibroblasts and keratinocytes had varying effects on matrix stiffness with fibroblasts degrading the constructs while keratinocytes increased the construct's stiffness. CONCLUSION: This 3D in vitro wound healing model is a step towards developing a mimetic construct that recapitulates the complex microenvironment of healing wounds and could aid in the early studies of novel therapeutics that promote migration and proliferation of epithelial cells.