• The Korea Journal of Herbology
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• v.23 no.4
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• pp.113-120
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• 2008

Objectives: This study was evaluated to elucidate the inhibitory potential of Imyosan(IMS) and its components, Phellodendri Cortex(PC: Phellodendron amurense Rupr., Hwangbaek in Korean) and Atractylodis Rhizoma(AR: Atratylodes lancea D.C., Changchool in Korean), on human aortic smooth muscle cells(HASMC) migration and production of matrix metalloproteinase (MMP)-2 and MMP-9 by TNF-${\alpha}$ treatment. Methods: Cytotoxic activity of IMS and its components on HASMC was using 5-(3-caroboxy meth-oxyphenyl)-2H-tetra-zolium inner salt(MTS) assay. Effect of IMS, PC and AR on TNF-${\alpha}$-induced HASMC migration underside of matrigel filter was stained with hematoxylin-eosin. And total number of cells that migrated to the underside of the filter was counted. MMP-2 and MMP-9 activity was evaluated by gelatin zymography assay. Results: The matrigel migration assay showed that IMS effectively inhibited the TNF-${\alpha}$-induced migration of HASMC. Moreover, IMS significantly inhibited MMP-9 activity. Our present study demonstrates that IMS and its components inhibit TNF-${\alpha}$-induced HASMC migration and MMP-9 activity. The inhibitory effect of IMS extract is more potent than that of its component herb extracts. Conclusions: These results provide evidence that IMS has multiple effects in the inhibition of HASMC migration and may offer a therapeutic approach to block HASMC migration.

• Journal of Convergence Society for SMB
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• v.2 no.2
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• pp.7-12
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• 2012

The objectivity of this study is to analyze why revocation of certification of Information Management System(IMS) increase in small and medium-sized enterprises. In this study, the main causes of revocation is the correlation between customers and enterprises. In other words, the decreases of request of customer to IMS bring about the decreases of interest of enterprises. As a result, enterprises don't feel the need of IMS, which cause revocation of IMS. This study will be helpful in improving IMS for small and medium-sized enterprises to avail themselves of the system.

• Herbal Formula Science
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• v.14 no.2
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• pp.21-32
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• 2006

The purpose of this study was to investigate the effect of Imyosan on apoptosis in human colorectal cancer HCT116 cells. Phellodendron amurense Rupr. and Atratylodes lancea D.C. compose Imyosan. First of all, to study the cytotoxic effect of methanol extract of Imyosan (IMS-MeOH) on HCT116 cells, the cells were treated with various concentrations of IMS-MeOH and then cell viability was determined by XTT reduction method. IMS-MeOH reduced viability of HCT116 cells in a dose and time-dependent manner. To confirm the induction of apoptosis, the c1eavage of poly ADP-ribose polymerase (PARP), a substrate for caspase-3 and a typical sign of apoptosis, and the activation of caspase-3, procaspase-8 and procaspase-9 were examined by western blot analysis. IMS-MeOH decreased procaspase-3, procaspase-8 and procaspase-9 levels in a dose-dependent manner and induced the clevage of PARP. IMS-MeOH triggered the mitochondrial apoptotic signaling by increasing the release of cytochrome c from mitochondria to cytosol. Furthermore, IMS-MeOH also downregulated the anti-apoptotic Bcl-2 and upregulated the pro-apoptotic-Bax. Therefore, these results suggest that IMS-MeOH induced HCT1l6 cell death through the mitochondrial pathway. To explore whether the activities of caspases was required for induction of apoptosis by IMS-MeOH, caspase-3, -8, -9 activity measured by using substrates, respectively. IMS-MeOH increased caspase-3, -8, -9 activity. Co-treatment with inhibitors of caspase-3, -8, -9 and IMS-MeOH significantly blocked IMS-MeOH-triggered apoptosis in HCT1l6 cells. These results suggest that IMS-MeOH induces caspases-mediated apoptosis.

• Proceedings of the IEEK Conference
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• 2007.07a
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• pp.145-146
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• 2007

HSPA의 기술이 발전되어 오면서 WCDMA 망을 활용한 PS 기반의 서비스는 계속적으로 발전되어 오고 있다. 그러나 다양한 IP-CAN 과의 연동을 고려한 서비스 구조에 대해서는 더욱 연구가 되어야한다. 따라서, 본 논문에서는 IMS 기반의 서비스 개발에 있어서 고려되어야 하는 IMS 서비스 구조에 대해서 연구한다.

• Asian-Australasian Journal of Animal Sciences
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• v.30 no.10
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• pp.1478-1485
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• 2017

Objective: The effects of vaccinating 18-day-old chicken embryos with the combination of recombinant Eimeria profilin plus Clostridium perfringens (C. perfringens) NetB proteins mixed in the Montanide IMS adjuvant on the chicken immune response to necrotic enteritis (NE) were investigated using an Eimeria maxima (E. maxima)/C. perfringens co-infection NE disease model that we previously developed. Methods: Eighteen-day-old broiler embryos were injected with $100{\mu}L$ of phosphate-buffered saline, profilin, profilin plus necrotic enteritis B-like (NetB), profilin plus NetB/Montanide adjuvant (IMS 106), and profilin plus Net-B/Montanide adjuvant (IMS 101). After post-hatch birds were challenged with our NE experimental disease model, body weights, intestinal lesions, serum antibody levels to NetB, and proinflammatory cytokine and chemokine mRNA levels in intestinal intraepithelial lymphocytes were measured. Results: Chickens in ovo vaccinated with recombinant profilin plus NetB proteins/IMS106 and recombinant profilin plus NetB proteins/IMS101 showed significantly increased body weight gains and reduced gut damages compared with the profilin-only group, respectively. Greater antibody response to NetB toxin were observed in the profilin plus NetB/IMS 106, and profilin plus NetB/IMS 101 groups compared with the other three vaccine/adjuvant groups. Finally, diminished levels of transcripts encoding for proinflammatory cytokines such as lipopolysaccharide-induced tumor necrosis $factor-{\alpha}$ factor, tumor necrosis factor superfamily 15, and interleukin-8 were observed in the intestinal lymphocytes of chickens in ovo injected with profilin plus NetB toxin in combination with IMS 106, and profilin plus NetB toxin in combination with IMS 101 compared with profilin protein alone bird. Conclusion: These results suggest that the Montanide IMS adjuvants potentiate host immunity to experimentally-induced avian NE when administered in ovo in conjunction with the profilin and NetB proteins, and may reduce disease pathology by attenuating the expression of proinflammatory cytokines and chemokines implicated in disease pathogenesis.

• Journal of the Korean Society for information Management
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• v.23 no.1 s.59
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• pp.139-158
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• 2006

University library in university organization needs more to innovating with through information management systems. In this paper introduced IMS to university library in Korea. In this paper investigated difference of recognition between college and university about IMS. The samples (n=67) were composed of those who had already engaged in university library and college. The results of this study were as follows; Most participants who was considerate no more important to mind for IMS introduction. Then, the results of ANOVA analysis was recognized employee's about IMS that among of the best problems was negative(-) effect to introduction necessary and introduction timeless of IMS was insignified with F=0.469(p=0.497), sig=0.05. and F=2.410(p=0.125), sig=0.05. By the way, education necessary of IMS was signified with F=7.470(p=0.008), sig=0.01. Finally, in this paper provided the fundamental data for the standardization and transparency related to policy establish of university library for introducing of IMS.

• The Journal of the Institute of Internet, Broadcasting and Communication
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• v.14 no.5
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• pp.209-214
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• 2014

IMS(IP Multi-Media Subsystem) is in the limelight as the Integrated wire and wireless Systems because of a sudden increase of smart mobile devices and growth of multimedia additional services such as IPTV. The structure of IMS is designed as a session control layer to provide various multimedia summative service using SIP based on IP communication network in order to carry out set-up, change and release by NGN of course, the existing voice services. But now It is broadly substituting in the IPTV, wire phone company and it is substituted in internet platform base on the soft-switch in currently. Especially, in currently, 4G LTE in a mobile communication company is rapidly growing in market. Therefore, in this study, we had designed and developed to the main prosser that can admit to 1000 user over and SIP gateway which can link the IMS Core that can link SIP Device which adopt the standard protocol on the SIP and to provide variable multimedia services.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.45 no.5
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• pp.117-124
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• 2008

In this paper, the call setup performance of the CSCF(Call Session Control function) that manages the session control in providing the IMS(IP Multimedia subsystem)-based multimedia service in the BcN(Broadband convergence Network) is analyzed. While the performance related with the call/session of the SIP-Based voice service is analysed, the study for the call recessing performance of the IMS-based multimedia service is insufficient. In this paper, as, the processing capacity and subscriber number of CSCF were changed, the call setup delay time according to the session setup procedure of IMS was measured using the M/M/1 queuing model and OPNET simulation. The experimental results show that the sudden increased delay showed up in case the session establishment requirement ratio of total users over 13% of the CSCF processing capacity. Therefore, the user number and capacity of CSCF suitable for the session establishment delay threshold can be calculated or estimated.

• Journal of IKEEE
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• v.19 no.2
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• pp.133-141
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• 2015

The IMS is an architectural control framework for delivering IP multimedia services such as voice, video, audio and data, the IMS supports not only the mobile communication system but also the existing wired and wireless network based on IP. The network that is integrated by the IMS needs policy-based network management protocol for managing the limited network resources to provide efficient multimedia service. The IMS use additional device called PDF for efficient resource management, but the PDF only uses diameter which is one of the network management protocol such as SNMP and COPS. Many devices use various protocol to manage the limited network resources. There is an algorithm using a variety of protocols such as Diameter, COPS and SNMP to handle the resources management efficiently. We also analyze the performance using the proposed algorithm in the implemented IMS environment.

• Management Science and Financial Engineering
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• v.16 no.2
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• pp.67-80
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• 2010

This study is focused on instant messaging service (IMS) providers' efforts to maintain a steadfast group of consumers who are willing to continuously use one service without switching to another. Various factors, carefully selected to reflect the unique features of instant messaging, were tested to verify their relationship with consumer loyalty. The results suggest that consumer loyalty of IMS users is most significantly affected by trust and perceived reputation a consumer has on the provider of IMS. Network externality, or the size and proximity of relationships formed through an IMS, also proves to have effect on consumer loyalty. Consumer loyalty in IMS users of different age or different internet usage is affected differently by each factor.