• Journal of Physiology & Pathology in Korean Medicine
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• v.30 no.5
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• pp.347-354
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• 2016

This study evaluated the effects of Fructus Corni Officinalis water extract (FCE) on congnitive impairment and Aβ clearance induced by beta amyloid Aβ (1-42) injection in the hippocampus of rat. Aβ (1-42) was injected into the hippocampus using a Hamilton syringe and micropump (5 ㎍/5 ㎕, 1 ㎕/min, each hippocampus bilaterally). FCE was administered orally once a day (100, 250, 500 mg/kg) for 4 weeks after the Aβ (1-42) injection. The acquisition of learning and retention of memory were tested using the Morris water maze. Aβ accumulation and Aβ clearance in the hippocampus were observed using immunostaining. Aβ (1-42) level in plasma was confirmed using enzyme-linked immunosorbent assay (ELISA). FCE significantly shortened the escape latencies during acquisition training trials. FCE significantly increased the number of target heading to the platform site and significantly shortened the time for the 1^sttargetheadingduringtheretentiontesttrial.FCEsignificantlyattenuatedtheAβ accumulation in the hippocampus produced by Aβ (1-42) injection. FCE significantly increased LRP-1 expression around vessels in the hippocampus and Aβ (1-42) levels in plasma. The results suggest that FCE improved cognitive impairment by ameliorate Aβ clearance and Aβ accumulation in the hippocampus. FCE may be a beneficial herbal formulation in treating cognitive impairment including Alzheimer's disease.

• Journal of Acupuncture Research
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• v.30 no.1
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• pp.13-22
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• 2013

Objectives : The aim of this study was to show the application to add the Dong-Qi therapy of the Dong-Si acupuncture to exercise therapy of the movement system impairment syndrome(MSIS) and to determine the best acupuncture point for the Dong-Qi therapy. Methods : We reviewed Diagnosis and Treatment of Movement Impairment Syndrome and Movement System Impairment Syndromes Of The Extremities, Cervical and Thoracic Spines written by Sahrmann SA. to show the exercise therapy of the sort of MSIS. We reviewed complete works of Yang Wei Jie to show the acupuncture points of the Dong-Si acupuncture and the Dong-Qi therapy. Results : We showed the acupuncture point of the Dong-Si acupuncture by each type of MSIS based on the reference book of MSIS, the Dong-Si acupuncture. Also, we selected and tabulated the best possible acupuncture point of the Dong-Si acupuncture which could minimize a side effect of acupuncture during the therapeutic exercise by each type of MSIS. Conclusion : A specific acupuncture point of the Dong-Si acupuncture could be chosen for a specific MSIS therapeutic exercise. The best possible acupuncture point could be chosen when selecting an acupuncture point of the Dong-Si acupuncture.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.345-351
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• 2016

Objective: This clinical study reports on the effectiveness of traditional Korean medicine on a patient with diplopia and eye-movement impairment caused by brain-stem infarction.Method: A patient with diplopia and eye-movement impairment caused by brain-stem infarction was treated with herbal medicine (Bogan-san), acupuncture, and moxibustion. We used the visual analogue scale (VAS) of diplopia and measured the patient's eye-movement range to evaluate the effectiveness of the treatment.Results: The diplopia VAS decreased and eye-movement range improved after treatment with traditional Korean medicine.Conclusion: This clinical study suggests that traditional Korean medicine could greatly contribute to the treatment of diplopia and eye-movement impairment caused by brain-stem infarction.

• Korean Journal of Occupational Health Nursing
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• v.32 no.3
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• pp.89-98
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• 2023

Purpose: This study proposes preventive strategies for factors affecting the work impairment of international medical tourism coordinators. Methods: Data for this study were collected via an online questionnaire survey involving 296 international medical tourism coordinators in South Korea, considering the impact coronavirus disease 2019. The survey was conducted from 25th April 2022 to 22nd July 2022 and data were analyzed SPSS/WINdows software version 22, including statistical, reliability, factor and regression analyses. Results: This study focused on occupational stress, health problems and job efficacy among international medical tourism coordinators in medical tourism research. The main objective was to examine the factors that influenced their work impairment. Conclusion: This study emphasizes the importance of factors such as occupational stress, health problems and job efficacy in influencing work impairment among international medical tourism coordinators. The identified factors account for 30% of explanation power. An intervention program tailored to the characteristics of domestic and international medical tourism coordinators is recommended.

• International journal of advanced smart convergence
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• v.7 no.3
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• pp.1-7
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• 2018

This study relates to a composition for improvement of memory or prevention and treatment of cognitive impairment using waste resources rich in beneficial substances. This study makes good effects to inhibit the activity of acetylcholinesterase in brain tissue and to improve the cognitive functions in a simulation model of cognitive impairment induced by scopolamine, so it can be available in the promotion of memory and the prevention and treatment of cognitive impairment. The composition uses the extract of fruit peels, which have long been used without causing toxicity in a wide range of food applications; therefore, it can be used safely without a risk of side effects, even in the case of a long-term administration for the preventive purpose. Furthermore, this research is a very beneficial invention in the environment-friendly aspect in association with the recycling of resources, as it is based on the novel efficacies of fruit peels, which have been conventionally disposed as a refuse of fruits due to their poor sensory qualities despite the content of beneficial substances.

• Journal of Genetic Medicine
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• v.18 no.1
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• pp.55-59
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• 2021

West syndrome (WS) presenting with infantile spasms, developmental delay, and hypsarrhythmia has genetic etiology in some patients. Movement disorders or visual impairment that share genetic underpinnings with infantile spasms can provide diagnostic clues for specific genetic mutations. Mutations of the GRIN1 gene encoding the glutamate receptor inotropic N-methyl-D-aspartate subunit can result in WS with hyperkinetic movements, cortical visual impairment, autistic features, and bilateral polymicrogyria. An 11-month-old boy with WS showed hyperkinetic movements and visual impairment. Brain magnetic resonance imaging and metabolic investigations revealed no abnormalities. Whole-exome sequencing revealed a novel likely pathogenic variant (c.1561_1563del; p.Asn521del) of GRIN1 (NM_007327.3). The proband was treated with vigabatrin and became seizure-free within one week. Notably, the cortical blindness improved within 3 months and the hyperkinetic movements resolved one year after the proband became seizure-free. To the best of our knowledge, this is the first report of GRIN1 encephalopathy in Koreans.

• Korean Journal of Veterinary Research
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• v.61 no.4
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• pp.35.1-35.4
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• 2021

Following intravenous (IV) administration of diazepam as a preanesthetic agent, sudden balance impairment, such as falling, leaning, and rolling, was identified in 2 canine cases. The 2 dogs were anesthetized for brain magnetic resonance scan to diagnose about a history of head tilt. After end of the diagnostic procedures, during the anesthetic recovery period, balance impairment was also observed. However, the symptoms gradually ceased by IV administration of flumazenil. These 2 canine cases indicated that diazepam premedication was responsible for the acute balance impairment.

• Korean Journal of Radiology
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• v.25 no.2
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• pp.212-213
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• 2024

• The Journal of Internal Korean Medicine
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• v.33 no.4
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• pp.599-608
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• 2012

Objectives : To report three cases of eye movement impairment: internuclear ophthalmoplegia (INO) due to pontine infarction, traumatic abducens nerve palsy, and abducens nerve involvement in Miller-Fisher syndrome. Cases Summary : There were three cases. First, a 64-year-old woman, who was given a diagnosis of INO due to pontine infarction, had left gaze palsy of her right eye while the convergence was intact. Second, a 34-year-old man had abduction impairment of his right eye after a traffic accident. Third, a 66-year-old man, who was diagnosed with Miller-Fisher syndrome, had left gaze palsy of his left eye. Their symptoms improved substantially and their anxieties were relieved after treatment with herbal medicine and acupuncture. Conclusions : There has been no certain cure for eye movement impairment yet. In this report, we present three successful cases of patients with eye movement impairment and show that Korean medical treatment could be a solution for this incurable disease.

• Journal of Korean Academy of Nursing Administration
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• v.4 no.2
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• pp.351-361
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• 1998

The purpose of this study was to explore whether there is a point within the range of physical impairment after which the cost of home care exceeds the cost of nursing home care among the elderly who require long-term care. The provision of long-term care for the elderly is a major health policy issue, in part due to the aging of the American population and dramatic increase in health care costs. The framework for this study was guided by Pollak's(1973)model of costs of alternative care settings for the elderly. This study used a retrospective, descriptive correlational design. Physical impairment was measured by the modified Index of Activities of Daily Living(Katz et al. 1963). Cost of care was measured by the average cost per patient per day. The sample for this study included 67 patients receiving long-term care at home from the Long-term Home Health Care Programs (LTHHCPs) and 67 patients receiving long-term care in nursing homes. Data were collected on patient characteristics. including activities of daily living and cognitive impairment. and on the number of physician visits. emergency room visits. and hospitalization from the patient records. For each patient. Medicaid cost data for home care services/or nursing home services were collected from the financial department of each home care agency or nursing home. The living costs and informal care costs were estimated for home care patients. The results indicated that the home care sample and the nursing home sample were similar in terms of gender. ethnic background. and marital status. The elderly patients in the home care sample were: however. younger and less physically impaired than those in the nursing home sample. The hypotheses of this study were supported: For elderly persons with physical impairment scores below 12(possible range of 0 to 14), cost of care was lower in home care than in the nursing home care setting. However, for elderly persons with physical impairment scores above 12. the cost of care was higher in home care than in the nursing home care setting. Thus. in this sample for elderly patients with extreme physical impairment, the cost of home care exceeded the cost of nursing home care.