Korean Journal of Veterinary Research (대한수의학회지)

The Korean Society of Veterinary Science (대한수의학회)
권호 표지
DOI QR코드

DOI QR Code

Balance impairment caused by diazepam in 2 dogs with vestibular disease: case reports

  • Kim, Hyunseok (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University) ;
  • Son, Won-gyun (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University) ;
  • Lee, Inhyung (Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Seoul National University) ;
  • Jang, Min (Department of Veterinary Surgery, College of Veterinary Medicine, Kyungpook National University)
  • Received : 2021.08.04
  • Accepted : 2021.11.09
  • Published : 2021.12.31
Download PDF
⟨ Previous Next ⟩

Abstract

Following intravenous (IV) administration of diazepam as a preanesthetic agent, sudden balance impairment, such as falling, leaning, and rolling, was identified in 2 canine cases. The 2 dogs were anesthetized for brain magnetic resonance scan to diagnose about a history of head tilt. After end of the diagnostic procedures, during the anesthetic recovery period, balance impairment was also observed. However, the symptoms gradually ceased by IV administration of flumazenil. These 2 canine cases indicated that diazepam premedication was responsible for the acute balance impairment.

Keywords

Acknowledgement

This work was supported by the National Research Foundation of Korea (NRF) grant funded by the Korea government (Ministry of Science and ICT) (No. 2021R1G1A1013034).

References

  1. Thomas WB. Vestibular dysfunction. Vet Clin North Am Small Anim Pract 2000;30:227-249. https://doi.org/10.1016/S0195-5616(00)50011-4
  2. Rossmeisl JH Jr. Vestibular disease in dogs and cats. Vet Clin North Am Small Anim Pract 2010;40:81-100. https://doi.org/10.1016/j.cvsm.2009.09.007
  3. Rankin DC. Sedatives and Tranquilizers. In: Grimm KA, Lamont LA, Tranquilli WJ, Greene SA, Robertson SA, eds. Veterinary Anesthesia and Analgesia. 5th ed. pp. 196-206, Wiley-Blackwell, Ames, 2015.
  4. de Groot MH, van Campen JP, Moek MA, Tulner LR, Beijnen JH, Lamoth CJ. The effects of fall-risk-increasing drugs on postural control: a literature review. Drugs Aging 2013;30:901-920. https://doi.org/10.1007/s40266-013-0113-9
  5. Jang M, Mann FA, Bukoski A, Dodam JR, Lee I. Effect of midazolam on vestibular signs in two geriatric dogs with vestibular disease. J Am Anim Hosp Assoc 2020;56:e56402. https://doi.org/10.5326/JAAHA-MS-7014
  6. Jang M, Shin CW, Choi S, Won S, Lee I. Anesthesia case of the month. J Am Vet Med Assoc 2018;253:279-282. https://doi.org/10.2460/javma.253.3.279
  7. Cutson TM, Gray SL, Hughes MA, Carson SW, Hanlon JT. Effect of a single dose of diazepam on balance measures in older people. J Am Geriatr Soc 1997;45:435-440. https://doi.org/10.1111/j.1532-5415.1997.tb05167.x
  8. Padoan S, Korttila K, Magnusson M, Pyykko I, Schalen L. Effect of intravenous diazepam and thiopental on voluntary saccades and pursuit eye movements. Acta Otolaryngol 1992;112:579-588. https://doi.org/10.3109/00016489209137444
  9. Vouriot A, Gauchard GC, Chau N, Nadif R, Mur JM, Perrin PP. Chronic exposure to anesthetic gases affects balance control in operating room personnel. Neurotoxicology 2005;26:193-198. https://doi.org/10.1016/j.neuro.2004.11.002
  10. Matsuura N. Muscle power during intravenous sedation. Jpn Dent Sci Rev 2017;53:125-133. https://doi.org/10.1016/j.jdsr.2017.02.001
  11. Leece EA. Neurological disease. In: Duke-Novakowski T, de Vries M, Seymour CJ, eds. BSAVA Manual of Canine and Feline Anaesthesia and Analgesia. 3rd ed. pp. 392-408, BSAVA, Gloucester, 2016.
  12. Wendt-Hornickle E. Neurologic Disease. In: Snyder LBC, Johnson RA, eds. Canine and Feline Anesthesia and Co-existing Disease. 1st ed. pp. 71-81, Wiley-Blackwell, Ames, 2015.