• Proceedings of the KIEE Conference
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• 2002.07d
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• pp.2824-2826
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• 2002

Immune system is an evolutionary biological system to protect innumerable foreign materials such as virus, germ cell, and etcetera. Immune algorithm is the modeling of this systems response that has adaptation and reliability when disturbance occur. In this paper, immune algorithm is proposed to control four wheels steering AGV(Automated Guided Vehicle) in container yard. The adaptive immune system is applied to the PID controller. For design the PID controller using immune algorithm, we tune PID parameters by off-line manner, in order to avoid the damage from abrupt control force. Repeatedly, the PID parameters are adjusted to be accurate by on-line fine tuner of immune algorithm. And then the computer simulation result from the viewpoint of yaw rate and lateral displacement are analyzed and compared with result of conventional PID controller.

• 제어로봇시스템학회:학술대회논문집
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• 1997.10a
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• pp.124-127
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• 1997

In this paper, we propose a method of cooperative control based on immune system in distributed autonomous robotic system(DARS). Immune system is living body's self-protection and self-maintenance system. Thus these features can be applied to decision making of optimal swarm behavior in dynamically changing environment. For the purpose of applying immune system to DARS, a robot is regarded as a B lymphocyte(B cell), each environmental condition as an antigen, and a behavior strategy as an antibody respectively. The executing process of proposed method is as follows. When the environmental condition changes, a robot selects an appropriate behavior strategy. And its behavior strategy is simulated and suppressed by other robot using communication. Finally much simulated strategy is adopted as a swarm behavior strategy. This control scheme is based on clonal selection and idiotopic network hypothesis. And it is used for decision making of optimal swarm strategy.

• The Journal of Internal Korean Medicine
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• v.38 no.1
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• pp.32-47
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• 2017

Objective: The purpose of this study was to develop a standard tool for pattern identification of radiation pneumonitis. Methods: Textbooks, published studies, and references with comments about patterns were reviewed. Through the Delphi method, we determined pattern identifications based on advice from a committee of experts composed of 13 Korean respiratory internal medicine professors. Results: Using the Delphi method, four pattern identifications were chosen: Qi Deficiency (氣虛), Yin Deficiency (陰虛), Heat Toxin (熱毒), and Phlegm Dampness (痰濕). The tool was developed in a question-and-answer format with 35 questions. Conclusions: A pattern identification tool that can discriminate the patterns of radiation pneumonitis for standardized diagnosis was developed through expert consultation. Further study of its validity and reliability is necessary.

• The Journal of Internal Korean Medicine
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• v.37 no.2
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• pp.352-360
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• 2016

Objective: This study reports on traditional Korean medicine therapy used for pneumonia among elderly patients.Method: Two patients diagnosed with pneumonia were treated with herbal medicine and acupuncture, as well as cupping along the back. We checked chest X-rays, coughing and sputum on the visual analogue scale (VAS), and lab evaluations in order to evaluate the effectiveness of the treatment.Results: Following treatment with traditional Korean medicine therapy, VAS scores for coughing and sputum decreased and the chest X-rays and inflammation markers improved.Conclusion: Traditional Korean medicine therapy treatment appears to be effective for treating pneumonia in elderly patients.

• Journal of the Korean Institute of Intelligent Systems
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• v.8 no.6
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• pp.12-20
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• 1998

As an approach to develope a control system with high robustness in changing control environment conditions, this paper will propose a robust control system, using multilayer neural network and biological immune system. The proposed control system adjusts weights of the multilayer neural network(MNN) with the immune algorithm. This algorithm is made up of two major divisions, the innate immune algorithm as a first line of defence and the adaptive immune algorithm as a barrier of self-adjustment. Using the proposed control system based on immune algorithm, we will work out a design for the controller of a robot manipulator. And we will demonstrate the effectiveness of the control system of robot manipulator with computer simulations.

• Korean journal of aerospace and environmental medicine
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• v.31 no.3
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• pp.73-76
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• 2021

Changes the gravity has a significant affect on the immune system. Astronauts experience the gravity changing during spaceflight, especially when launching and landing they experience hypergravity, and during spaceflight they feel microgravity. Both hypergravity and microgravity has an impact to the immune system, but not the same effect. These impacts have been investigated extensively during spaceflight in astronauts and in model experiments conducted on Earth as well. Astronauts during spaceflight feel the hypergravity, psychological stress, fear, high doses of radiation and microgravity. All these factors and changes may affect immune system directly or indirectly.

• Advances in Traditional Medicine
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• v.7 no.5
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• pp.518-526
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• 2008

Recently a major goal in asthma therapy is to reduce or prevent the inflammatory response of airway. Eosinophilic accumulation in the tissue is a prominent feature of allergic diseases including asthma. Production of chemokines by bronchial epithelial cells may contribute to the allergic inflammation by recruiting eosinophils. In this study we evaluated the inhibitory effect of Gamichungsangbohatang (GMCSBHT), used traditionally in treating asthma, on secretion of chemokines for eosinophils in human A549 epithelial cells. Chemokines such as eotaxin, RANTES, IL-8 were inhibited in a dose-dependent manner, but IL-16 showed no inhibition by GMCSBHT. These findings indicate that GMCSBHT might be a therapeutic value in treating asthma by suppression of chemokines secretion associated with local accumulation of eosinophils.

• KSBB Journal
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• v.25 no.6
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• pp.497-506
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• 2010

Vaccine is a protective clinical measure capable of persuading immune system against infectious agents. Vaccine can be categorized as live attenuated and inactivated. Live attenuated vaccines activate immunity similar to natural infection by replicating living organisms whereas inactivated vaccines are either whole cell vaccines, eliciting immune response by killed organisms,or subunit vaccines, stimulating immunity by non-replicating sub cellular parts. The components of vaccine play a critical role in deciding the immune response mediated by the vaccine. The innate immune responds against the antigen component. Adjuvants represent an importantcomponent of vaccine for enhancing the immunogenicity of the antigens. Subunit vaccines with isolated fractions of killed and recombinant antigens are mostly co-administered with adjuvants. The delivery system of the vaccine is another essential component to ensurethat vaccine is delivered to the right target with right dosage form. Furthermore, vaccine delivery system ensures that the desired immune response is achieved by manipulating the optimal interaction of vaccine and adjuvantwith the immune cell. The aforementioned components along with routes of administration of vaccine are the key elements of a successful vaccination procedure. Vaccines can be administered either orally or by parenteral routes. Many groups had made remarkable efforts for the development of new vaccine and delivery system. The emergence of new vaccine delivery system may lead to pursue the immunization goals with better clinical practices.

• Childhood Kidney Diseases
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• v.12 no.1
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• pp.23-29
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• 2008

Kidney allograft transplantation is the most effective method of renal replacement for end stage renal disease patients. Still, it is another kind of 'disease', requiring immunosuppression to keep the allograft from rejection(allograft immune reaction). Immune system of the allograft recipient recognizes the graft as a 'pathogen (foreign or danger)', and the allograft-recognizing commanderin-chief of adaptive immune system, T cell, recruits all the components of immune system for attacking the graft. Proper activation and proliferation of T cell require signals from recognizing proper epitope(processed antigen by antigen presenting cell) via T cell receptor, costimulatory stimuli, and cytokines(IL-2). Thus, most of the immunosuppressive agents suppress the process of T cell activation and proliferation.

• East Asian mathematical journal
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• v.32 no.1
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• pp.139-152
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• 2016

Inflammatory Bowel Disease(IBD) is chronic, relapsing, immune mediated disorder. The exact cause of IBD is still unknown. The immune system is known to play important role in the dynamics of IBD. We focus on relation between T cells and cytokines in immune system that leads to IBD. In this paper, we propose a mathematical model describing IBD under considering immune mediated disorder by using ordinary differential equations. The existence and stability of the model are established, where an applicable basin of attraction are calculated and examined. Some numerical simulations are presented to verify the proposed results and as changing parameter values given by sensitivity analysis, we show how to change dynamic behaviors of the model.