• 한국지능시스템학회논문지
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• 제11권7호
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• pp.591-597
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• 2001

In this paper, we propose a method of cooperative control (T-cell modeling) and selection of group behavior strategy (B-cell modeling) based on immune system in distributed autonomous robotic system (DARS). Immune system is living body's self-protection and self-maintenance system. These features can be applied to decision making of optimal swarm behavior in dynamically changing environment. For applying immune system to DARS, a robot is regarded as a B-cell, each environmental condition as an antigen, a behavior strategy as an antibody and control parameter as a T-cell respectively. The executing process of proposed method is as follows. When the environmental condition changes, a robot selects an appropriate behavior strategy. And its behavior strategy is stimulated and suppressed by other robot using communication. Finally much stimulated strategy is adopted as a swarm behavior strategy. This control school is based on clonal selection and idiotopic network hypothesis. And it is used for decision making of optimal swarm strategy. By T-cell modeling, adaptation ability of robot is enhanced in dynamic environments.

• 대한전기학회논문지:전력기술부문A
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• 제49권9호
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• pp.433-445
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• 2000

In this paper, optimal tuning problem of power system stabilizer(PSS) using Immune Algorithm(IA) is investigated to improve power system dynamic stability. In proposed method, objective function is represented as antigens. An affinity calculation is embedded within the algorithm for determining the promotion or suppression of antibody. An antibody that most fits the antigen is considered as the solution to PSS tuning problem. The computaton performance by the proposed method is compared with Genetic Algorithm(GA). The porposed PSS using IA has been applied for two sample system, single-machine infinite bus system and multi-machine power system. The performance of the proposed PSS is compared with that of conventional PSS. It is shown that the proposed PSS tuned using immune algorithm is more robust than conventional PSS.

• 한국지능시스템학회:학술대회논문집
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• 한국퍼지및지능시스템학회 2003년도 춘계 학술대회 학술발표 논문집
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• pp.325-329
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• 2003

This paper discuss the method of the system's efficient control using a Intelligent hybrid algorithm in nonlinear dynamics systems. Existing neural network and genetic algorithm for the control of non-linear systems work well in static states. but it be not particularly good in changeable states and must re-learn for the control of the system in the changed state. This time spend a lot of time. For the solution of this problem we suggest the intelligent hybrid self-tuning controller. it includes neural network, genetic algorithm and immune system. it is based on neural network, and immune system and genetic algorithm are added against a changed factor. We will call a change factor an antigen. When an antigen broke out, immune system come into action and genetic algorithm search an antibody. So the system is controled more stably and rapidly. Moreover, The Genetic algorithm use the memory address of the immune bank as a genetic factor. So it brings an advantage which the realization of a hardware easy.

• IMMUNE NETWORK
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• 제12권5호
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• pp.165-175
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• 2012

Vaccination is one of the most effective methods available to prevent infectious diseases. Mucosa, which are exposed to heavy loads of commensal and pathogenic microorganisms, are one of the first areas where infections are established, and therefore have frontline status in immunity, making mucosa ideal sites for vaccine application. Moreover, vaccination through the mucosal immune system could induce effective systemic immune responses together with mucosal immunity in contrast to parenteral vaccination, which is a poor inducer of effective immunity at mucosal surfaces. Among mucosal vaccines, oral mucosal vaccines have the advantages of ease and low cost of vaccine administration. The oral mucosal immune system, however, is generally recognized as poorly immunogenic due to the frequent induction of tolerance against orally-introduced antigens. Consequently, a prerequisite for successful mucosal vaccination is that the orally introduced antigen should be transported across the mucosal surface into the mucosa-associated lymphoid tissue (MALT). In particular, M cells are responsible for antigen up-take into MALT, and the rapid and effective transcytotic activity of M cells makes them an attractive target for mucosal vaccine delivery, although simple transport of the antigen into M cells does not guarantee the induction of specific immune responses. Consequently, development of mucosal vaccine adjuvants based on an understanding of the biology of M cells has attracted much research interest. Here, we review the characteristics of the oral mucosal immune system and delineate strategies to design effective oral mucosal vaccines with an emphasis on mucosal vaccine adjuvants.

• 대한한방내과학회지
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• 제39권4호
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• pp.822-830
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• 2018

Objective: This case report describes the treatment of hemoptysis in a bronchiectasis patient with Hyunggaeyungyo-tang plus Gamijihwang-tang. Methods: The hemoptysis in this patient was suspected to result from bronchiectasis, which was diagnosed with a chest CT at another hospital. She was treated with a herbal medicine, Hyunggaeyungyo-tang, plus Gamijihwang-tang. The effectiveness of the treatment was evaluated by measuring the amount of hemoptysis and by a visual analogue scale (VAS) to determine the patient's quality of life. Results: After administration of Hyunggaeyungyo-tang plus Gamijihwang-tang, the severity of hemoptysis decreased, based on the amount of hemoptysis and the VAS scores. Conclusions: Hyunggaeyungyo-tang plus Gamijihwang-tang is a potent therapeutic agent for the treatment of hemoptysis.

• 대한한방내과학회지
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• 제41권5호
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• pp.856-867
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• 2020

Objectives: The purpose of this case study was to report the effect of Korean Medicine treatment on a patient diagnosed with nontuberculous mycobacterial lung disease. Methods: A 61-year-old female patient with nontuberculous mycobacterial lung disease was admitted to the clinic from October 15th, 2018 to November 7th, 2018. The patient was treated using Korean medical treatments of Jinhae-tang-gami, Ssanghwa-tang-gami, Haeyeol-tang, Jinhae-tang plus Ssanghwa-tang-gami, and Jinhae-tang plus Bojungikgi-tang-gami. We evaluated the improvement of symptoms by a numeric rating scale (NRS) score, C-reactive protein (CRP) levels, erythrocyte sedimentation rate (ESR), and body temperature. Results: After Korean medicine treatment, the patient's cough and sputum amounts were decreased as measured by the NRS score. CRP levels and ESR were also decreased and fever was relieved. Conclusion: This study suggested that Korean medicine treatment might be effective in treating patients diagnosed with nontuberculous mycobacterial lung disease.

• 동의생리병리학회지
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• 제27권5호
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• pp.660-666
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• 2013

The purpose of this study was to investigate the clinical effects of herbal steam therapy on cough. Twenty-eight patients with cough who had treated with herbal steam therapy(chungsang, chungpae) between 3rd of January and 30th of April, 2013 were analyzed. The effects were evaluated the severity and frequency of cough as the modified questionnaire, severity of discomfort using visual analogue scale(VAS), and the patients' subjective satisfaction. Eighteen patients who had been treated herbal steam therapy over 3 times were analyzed improvements before and after therapy. Chungsang and Chungpae steam therapies significantly decreased the severity and frequency of cough. VAS scores also decreased from $7.78{\pm}0.878$ to $4.39{\pm}2.033$. Patients were satisfied with herbal steam therapy. Chungsang and Chungpae steam therapies seem to be effective in the treatment of cough. Further studies with a large number of cases will be needed in the future.

• 대한한방내과학회지
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• 제39권3호
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• pp.443-449
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• 2018

Objective: This case reports the management of a patient with bronchiectasis treated with Sikyungbanha-tang, an herbal extract covered by national health insurance. Methods: Twice a year, the patient was treated for a 30-day period with the herbal extract Sikyungbanha-tang. History-taking and a chest X-ray (CXR) were used to evaluate the effects. Results: Following treatment with herbal medicine, the patient's complaints of symptoms decreased, and improvement was shown on CXR. Conclusions: Sikyungbanha-tang in herbal extract form in insured herbal extracts has effects on the management of bronchiectasis patients.

• 대한한방내과학회지
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• 제40권5호
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• pp.752-759
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• 2019

Objective: The purpose of this case study was to report the effect of Korean medicine treatment on a patient diagnosed with a nasal polyp. Methods: A 62-year-old female patient with a nasal polyp visited the clinic sixteen times from September 11th, 2018 to December 18th, 2018. The patient was treated with Eunhwayeongyo-tang, Haeyeol-tang, Hongsamkyungok-go extract, and acupuncture during the treatment period. We evaluated the improvement of symptoms by nasoendoscopy. Results: After the Korean medicine treatment, the nasal polyp was completely eradicated. Hyperemia of the nasal mucous membrane and rhinorrhea were also relieved. Conclusion: The study findings suggested that Korean medicine treatment (Eunhwayeongyo-tang, Haeyeol-tang, and Hongsamkyungok-go extract, and acupuncture) might be effective for treatment of patients diagnosed with nasal polyps.

• 대한한방내과학회지
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• 제43권3호
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• pp.327-343
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• 2022

Objective: The purpose of this study was to develop a standard tool for identifying idiopathic pulmonary fibrosis patterns. Methods: Textbooks, published literature, and references with comments on patterns were reviewed. Using the Delphi method, we determined pattern identification based on the advice of a committee consisting of 11 Korean respiratory internal medicine professors. Results: Four pattern identifications were selected by the Delphi method: qi difficiency (氣虛), yin difficiency (陰虛), phlegm dampness (痰飮), blood stasis (瘀血). The tool was developed in a question-and-answer format containing 38 questions. Conclusions: An IPF pattern identification tool that can analyze IPF patterns for standardized diagnostics was developed with the consent of experts. Further research is needed on its reliability.