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Helicobacter pylori Eradication Reduces the Metachronous Recurrence of Gastric Neoplasms by Attenuating the Precancerous Process

  • Jung, Da Hyun;Kim, Jie-Hyun;Lee, Yong Chan;Lee, Sang Kil;Shin, Sung Kwan;Park, Jun Chul;Chung, Hyun Soo;Kim, Hyunki;Kim, Hoguen;Kim, Yong Hoon;Park, Jae Jun;Youn, Young Hoon;Park, Hyojin
    • Journal of Gastric Cancer
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    • v.15 no.4
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    • pp.246-255
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    • 2015
  • Purpose: The importance of Helicobacter pylori eradication after endoscopic resection (ER) of gastric neoplasms remains controversial. In this study, we clarified the importance of H. pylori eradication for metachronous lesions after ER. Materials and Methods: This study included 3,882 patients with gastric neoplasms who underwent ER. We included patients infected with H. pylori who received eradication therapy. Among them, 34 patients with metachronous lesions after ER and 102 age- and sex-matched patients (nonmetachronous group) were enrolled. Background mucosal pathologies such as atrophy and intestinal metaplasia (IM) were evaluated endoscopically. The expression levels of CDX1, CDX2, Sonic hedgehog (SHH), and SOX2 were evaluated based on H. pylori eradication and the development of metachronous lesions. Results: The eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.036). Open-type atrophy (P=0.003) and moderate-to-severe IM (P=0.001) occurred more frequently in the metachronous group. In patients with an initial diagnosis of dysplasia, the eradication failure rate was higher in the metachronous group than in the nonmetachronous group (P=0.002). In addition, open-type atrophy was more frequent in the metachronous group (P=0.047). In patients with an initial diagnosis of carcinoma, moderate-to-severe IM occurred more frequently in the metachronous group (P=0.003); however, the eradication failure rate was not significantly different between the two groups. SHH and SOX2 expression was increased, and CDX2 expression was decreased in the nonmetachronous group after eradication (P<0.05). Conclusions: Open-type atrophy, moderate-to-severe IM, and H. pylori eradication failure were significantly associated with metachronous lesions. However, eradication failure was significantly associated with dysplasia, but not carcinoma, in the metachronous group. Thus, H. pylori eradication may play an important role in preventing metachronous lesions after ER for precancerous lesions before carcinomatous transformation.

Synthesis of Diglyceride Containing Caprylic acid by Immobilized Lipase Catalyzed Esterification of Monoglyceride in a Solvent Free System (모노글리세리드와 카프릴산으로부터 고정화 리파제를 사용한 디글리세리드 생산)

  • Lee, Jang-Woon;Kang, Sung-Tae
    • Microbiology and Biotechnology Letters
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    • v.37 no.4
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    • pp.365-370
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    • 2009
  • For the production of diglyceride (DG) containing medium chain fatty acid, which could be utilized as a substrate to structured lipid production, monoglyceride (MG) and caprylic acid were reacted in the presence of lipase. The reaction system was well mixed homogeneously without using any organic solvent. Among the lipases investigated, Lipozyme RM IM and Novozym 435 were selected on the basis of equilibrium DG yields from the medium chain fatty acid and MG. And reaction conditions such as addition of molecular sieve, water content of immobilized lipase, reaction temperature, and mole ratio of MG/caprylic acid are optimized to increase DG production by using Lipozyme RM IM. DG content of reaction mixture showed 8% increase by adding molecular sieve to reaction mixture. Removal of water from the immobilized lipase could affect seriously equilibrium content of DG. More than 2.8%(w/w) removal of water from the support could make 44% of DG. Optimum temperature was found to $60^{\circ}C$. Temperature shift from $60^{\circ}C$ to $25^{\circ}C$ resulted in increase of free fatty acid (FFA) content. The equilibrium DG yield was not seriously affected by on MG/caprylic acid molar ratio. However, at the stoichiometric ratio of 1:1 the highest DG yield was obtained. Increasing MG/caprylic acid ratio from 0.3 to 1.8 decreased FFA content from 34% to 13%, while MG content increased from 27% to 50%.

Clinical features of Epstein-Barr Virus-associated Infectious Mononucleosis According to Age Group in Children

  • Lee, Soram;Chung, Ju-Young;Park, Jung Je;Seo, Ji-Hyun;Kim, Jae Young;Yeom, Jung Sook;Park, Eun-Sil;Lim, Jae-Young;Woo, Hyang-Ok;Youn, Hee-Shang
    • Kosin Medical Journal
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    • v.33 no.3
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    • pp.347-357
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    • 2018
  • Objectives: Few studies of pediatric Epstein-Barr virus (EBV)-associated infectious mononucleosis (IM) have been conducted in Korea. We evaluated the clinical features of children with IM to define differences according to age. Methods: We conducted retrospective chart reviews of 68 children aged 0 to 15 years who were diagnosed by EBV-associated IM with EBV-Viral Capsid Antigen(VCA) IgM at laboratory test and were admitted between 2010 and 2014. The children were classified into four age groups: aged 0-3, 4-6, 7-9, and 10-15 years. Results: The age distribution of patients was as follows: 19 (27.9%) 0-3, 25 (36.8%) 4-6, 13 (19.1%) 7-9, and 11 (16.2%) 10-15. Fever was the most common presentation regardless of age. It was more common in the 0-3 group than the 4-6 group (P = 0.018). Pharyngitis was more common in the 7-9 group than the 0-3 group (P = 0.048), and myalgia was more common in the 10-15 group than the 0-3 group (P = 0.007). Pharyngitis was accompanied by lymphadenopathy, protracted fever, and rash. In the 0-3 age group, the prevalence of rash was higher while the percentage of atypical lymphocytes was lower, but there was no statistical support for this tendency. There were no differences in the frequency of hepatosplenomegaly or laboratory findings between age groups. Conclusions: IM is not uncommon in young children and its clinical presentation varies with age. Therefore, IM should be suspected in young febrile children with pharyngitis and rash despite low percentages of atypical lymphocytes.

Prediction-based Dynamic Thread Pool System for Massively Multi-player Online Game Server

  • Ju, Woo-Suk;Im, Choong-Jae
    • Journal of Korea Multimedia Society
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    • v.12 no.6
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    • pp.876-881
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    • 2009
  • Online game servers usually has been using the static thread pool system. But this system is not fit for huge online game server because the overhead is always up-and-down. Therefore, in this paper, we suggest the new algorithm for huge online game server. This algorithm is based on the prediction-based dynamic thread pool system. But it was developed for web servers and every 0.1 seconds the system prediction the needed numbers of threads and determine the thread pool size. Some experimental results show that the check time of 0.4 seconds is the best one for online game server and if the number of worker threads do not excess or lack to the given threshold then we do not predict and keep the current state. Otherwise we apply the prediction algorithm and change the number of threads. Some experimental results shows that this proposed algorithm reduce the overhead massively and make the performance of huge online game server improved in comparison to the static thread pool system.

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Advancement in Powder Metallurgy of Aluminum Alloys

  • Takeda, Yoshinobu
    • Journal of Powder Materials
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    • v.5 no.4
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    • pp.340-344
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    • 1998
  • Along with the growth of conventional ferrous powder metallurgy (PM), PM of aluminum alloys has been intensively investigated in Japan. Although rapidly solidified aluminum alloy powder was first used in the USA,/sup 1)/ commercialization for consumer market was first realized in Japan./sup 2)/ In order to achieve the viable cost-performance including Near Net Shape (NNS) formability, we developed three processes, powder extrusion, powder forging and sintering. The new powder extrusion process does not use either capsulation or vacuum degassing. The new powder forging does not need lateral flow. The new sintering process does not use liquid phase. The performance achieved by the processes is outstanding mechanical or physical properties that has potential to substitute cast iron, steel, titanium Metal Matrix Composite (MMC) or Ingot Metallurgy (IM) aluminum alloys. Cooperation with customers, powder suppliers and research associations contributed to the advancement of PM aluminum alloys in Japan.

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Nonlinear Compression Characteristics of Highly Plastic Clays and Silts (고소성점토 및 실트의 비선형 압밀특성)

  • Han, Dae-Hee;Im, Jong-Chul;Kwon, Jung-Keun
    • Proceedings of the Korean Geotechical Society Conference
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    • 2008.10a
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    • pp.1081-1089
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    • 2008
  • Highly plastic clays in their normally consolidated state are not linear but are concave upwards. Thus their compression index deceases with the increase in consolidation pressure. Likeness the e - log ${\sigma}\;_{\upsilon}\;'$ curves of the silts are not linear but are convex upwards. In this paper, conducted consolidation test with four undisturbed field soil and found that their e - log ${\sigma}\;_{\upsilon}\;'$ plots are not linear. And analyzed difference of settlement between computed value with compression index($C_c$) and computed value with improved compression index($\mathbb{C}$).

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Characteristic Analysis of a BLOC Motor which do not Have Rotor Core Using Finite Element Method (유한요소법을 이용한 회전자 철심을 가지지 않는 BLDC 모터의 특성해석)

  • Jung, I.S.;Im, T.B.;Chang, H.S.;Baek, S.H.
    • Proceedings of the KIEE Conference
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    • 2000.07b
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    • pp.614-616
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    • 2000
  • A ferrite bonded magnet type brushless DC (BLDC) motor which do not have rotor core is analyzed by using finite element method (FEM). The magnetization distribution of the magnet does not have only parallel or radial direction. So, the direction and intensity are taken into account by the analysis of the magnetization procedure. The validity of the analysis method is verified by comparing the analyzed results with measured ones.

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Study on Direct Dipolar Effect of Neighboring Protons in Proton Coupled $^{13}C$ Relaxation Experiment

  • NamGung, Hyeon;Lee, Im Pyo;Lee, Jo Ung
    • Bulletin of the Korean Chemical Society
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    • v.21 no.11
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    • pp.1077-1084
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    • 2000
  • The dipolar effect of neighboring protons that are not directly bonded to the carbon of interest on coupled carbon-13 relaxation in a simple organic molecule has been studied by comparing the relaxation behaviors of labeled carbon-13 in $Br13CH_2COOH$ with those in $BrCH_213COOH.$ Various pulse sequences, such as coupled inversion recovery pulse sequence, J-negative and J-positive pulse sequence, and nonselective and selective proton ${\pi}pulse$ sequence, were employed to perform the required coupled spin relaxation experiments. To gain information on various spectral densities, including that of dipolar-CSA cross correlation, the experiments were performed on two different spectrometers, operating, respectively, at 50.31 and 125.51MHz for 13C. The magnitude of CH dipolar spectral densities for $BrCH_213COOH$ was found to be about 8% of those for $Br13CH_2COOH$, which means the effect due to the protons not directly bonded to the carbon of interest is small but not completely negligible.

중국 루이스전환점 논쟁의 성과와 문제

  • Im, Ban-Seok
    • 중국학논총
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    • no.66
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    • pp.161-188
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    • 2020
  • The purpose of this paper is to analyze the debate on the Lewisian turning point in China. Despite the heated debate and accumulating research results both inside and outside China, the results showed a very complex spectrum. Different results were presented depending on which criteria the researcher selected, which analytical tools were used, and which data were utilized. Territory of China is vast, and the differences in economic basement and development stages between regions are not only severe, but also the economic gap among areas in a region is big. Therefore, it is difficult to have a significant meaning in analyzing the Lewisian Turning Point China as a whole. In addition, China's industrial production and labor force structure remain very unbalanced. This can be said to be due to the fact that the allocation and relocation of labor force according to the stage of economic development has not been achieved reasonably, and so it confuses the task of determining whether the Lewis Turning Point has arrived of not.

가능보어에 대한 고찰 - 현행 중국어 회화 교재 8종을 중심으로 -

  • Im, Ji-Yeong
    • 중국학논총
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    • no.72
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    • pp.25-45
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    • 2021
  • This study aims to select eight books to see if "potential complement" is sufficiently acquired and properly used in Chinese conversation textbooks, explore the reasons and problems of learners' errors through analysis, and briefly suggest textbook compilation and teaching. Twelve criteria were established and analyzed, including the concept and format of "potential complement", layout order, location of objects, three types of forms, distinction from auxiliary verb "能" and distinction between "能+V+結果補語". Some of the results of the study are simply as follows. All eight textbooks focus only on "possibility," missing an important part of "the impact of objective conditions" that the term "potential complement" does not contain. This is certainly enough to cause confusion for learners. A poor understanding of the concept of "potential complement" results in identifying it with the possible auxiliary verb "能", and incorrect mixing because it does not know exactly what the difference is. Most of the textbooks compiled in China place a high importance on "potential complement". This means that Chinese people often use "potential complement" in real life. on the other hand relatively Korean textbooks do not deal with "potential complement" relatively importantly.