• Molecules and Cells
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• v.38 no.1
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• pp.89-94
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• 2015

The shape and activity of mitochondria are tightly regulated by fusion and fission processes that are essential for maintaining normal cellular function. However, little is known about the involvement of mitochondrial dynamics in the development of the immune system. In this study, we demonstrate that mitochondrial dynamics play a role in the differentiation and migration of immature dendritic cells (imDCs). We show that mitochondrial elongation is induced during GM-CSF-stimulated differentiation of bone marrow progenitors to imDCs accompanied by upregulation of mitochondrial fusion proteins. These processes precede the changes in mitochondrial morphology and connectivity that occur during differentiation. Mfn2 and OPA1, but not Mfn1, are transcriptionally upregulated during differentiation; however, knockdown of Mfn2 and OPA1 does not induce any change in expression of CD11c, CDC80, or CD86. Notably, knockdown of Mfn2 or OPA1 by siRNA in imDCs significantly reduces CCR7 expression and CCL19-mediated migration. These results suggest that the mitochondrial fusion-related proteins Mfn2 and OPA1 are upregulated during bone marrow progenitor differentiation and promote the migration of imDCs by regulating the expression of CCR7.

• Proceedings of the KSR Conference
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• 2010.06a
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• pp.1383-1388
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• 2010

The latest generation of tram is low-floor design, various nations in europe and japan have developed battery driven hybrid trams that combine battery and wiring. Battery driven tram system is achieved by contactless power supply system, thus system is needed high efficiency, high power and low weight traction motor for maximization of energy efficiency. Research from abroad is still in induction motor(IM) application, and it is not meet the efficiency and the power per unit volume in IPMSM. In this paper, we design compare IM and IPMSM to apply battery driven tram, and then compare these motors. To design the motor, we estimate the loading condition at first. Loading condition includes rolling resistance, air-drag resistance, and slope resistance. Based on the loading condition by estimation, we determine the power and compute rated voltage and rated current. In this paper, voltage is limited by battery voltage level. As a result, volume about IM is 1.98 times bigger than IPMSM under same condition. Even though IPMSM is bigger than IM in power density per volume, we consider more factors for actual application because there are demagnetization of permanent magnet in IPMSM and so on by external environment conditions.

• Journal of Marine Bioscience and Biotechnology
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• v.1 no.4
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• pp.311-316
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• 2006

Enzymatic ethanolysis of fish oil with immobilized lipase was investigated for reducing the free fatty acid contents and enhancing the function of fish oil. Ethanolysis reactions were carried out in erlenmeyer flask (25ml) containing a mixture of squid viscera oil and 99.9% ethanol using 1% (based on w/w squid viscera oil) immobilized lipase. The reaction mixtures were incubated at $50^{\circ}C$ and shaken at 100rpm. Ethanol was added into the mixture by stepwise addition method of Shinmada[9]. Measurement of free fatty acid molar amounts was studied by Acid Value. Tendency of oil variation during transesterification was studied by TLC method. Enzymatic ethanolysis composed diglyceride, monoglyceride and fatty acid ethyl ester with reducing free fatty acid contents. Also, selective ethanolysis by Lipozyme TL-IM and Lipozyme RM-IM mostly did not react at the sn-2 position of squid viscera oil. Lipozyme RM-IM was more suitable enzyme to reduce the free fatty acid contents by ethanolysis than Lipozyme TL-IM. Squid viscera oil was transformed into suitable properties (5 in Acid Value) for functional fish oil production.

• Journal of Electrical Engineering and Technology
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• v.13 no.4
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• pp.1604-1613
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• 2018

The paper presents the equivalent circuit of an induction machine (IM) model which includes fundamental stray load and iron losses. The corresponding equivalent resistances are introduced and modeled as variable with respect to the stator frequency and flux. Their computation does not require any tests apart from those imposed by international standards, nor does it involve IM constructional details. In addition, by the convenient positioning of these resistances within the proposed equivalent circuit, the order of the conventional IM model is preserved, thus restraining the inevitable increase of the computational complexity. In this way, a compromise is achieved between the complexity of the analyzed phenomena on the one hand and the model's practicability on the other. The proposed model has been experimentally verified using four IMs of different efficiency class and rotor cage material, all rated 1.5 kW. Besides enabling a quantitative insight into the impact of the stray load and iron losses on the operation of mains-supplied and vector-controlled IMs, the proposed model offers an opportunity to develop advanced vector control algorithms since vector control is based on the fundamental harmonic component of IM variables.

• The Journal of Korean Medical History
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• v.36 no.1
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• pp.51-72
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• 2023

IM Won-jun(任元濬, 1423~1500) was an Confucianism Doctor in the former period of Joseon Dynasty. Through IM Won-jun's historical trace we could know the range of Uiseoseubdoggwan(Medical Learning Officer)'s duty not limited to study medical books at that time but extended to medical treat, educate, recommend medical policy, personnel manage, carry out administrative work, carry out all the works concerned with medical books, make new medicines at different official period. Among these after learning duties the Royal Family of the Joseon Dynasty awarded high grades to medical treatment for king and king's mother, but from the viewpoint of advancement of medicine controling the top of medical policy as a chief of Jeonuigam had important meaning. The system of Uiseoseubdoggwan(Medical Learning Officer) in the Joseon Dynasty played the role of cultivating widely the man of ability who leaded medical development by sharing the man of ability between medicine and confucianism which was dominant learning at that time, so the knowledge and professional skill of medicine, Yin-Yang and the Five Elements theory, the spirit of relief of the world were spreaded across to national administration, education, publication culture, putting philosophy of filial piety into practice in the Joseon Dynasty.

• (The)Study of the Eastern Classic
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• no.63
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• pp.43-82
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• 2016

The purpose of this paper is to study the image of the 16th Century Honam Chinese poetry. for that, Park Sang, Im Eokryeong, Ko Gyeongmyeong in this study. This paper identified the characteristics of Ho Nam poetry is two things. First of all, is "literary talent does not acknowledge" consciousness and image of army. Park Sang, Im Eokryeong, Ko Gyeongmyeong was advanced to the center politics with excellent literary talent to the talents our 16th century Honam. However, at that time, the ruling layer was time to lead the politics. Therefore, the three people to frustration. Yet three people were criticizing the reality. And they thought that they were unhappy. It is unfortunate that they did because of their literary talent to be recognized. Three people were very sensitive to not be recognized literary talent. This is because they were subject to the management by the literary ability. It does not recognize the literary consciousness appears as sword, spear, admiral image. Second, The HwaIbulryu consciousness and image of integrity. Park Sang, Im Eokryeong, Ko Gyeongmyeong thought it not right politics. Yet continued to politics. This is not behavior that is typical scholar. What they did so because we follow a man named Yuhahye. A man named yuhahye pursue life, be it a dirty political reality was to continue the crest. But that never lose their integrity. Three people who will follow the life of this Yuhahye. This is a life attitude graft Japanese apricot flower, oriole, rock of pillar, appears as an image.

• IMMUNE NETWORK
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• v.11 no.6
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• pp.412-415
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• 2011

Hypocrellin A has gained much attention in recent years due to its light-induced antitumor, antifungal and antiviral activities. Here we report that hypocrellin A exerts immunomodulatory effects on MHC-restricted presentation of antigen. Hypocrellin A inhibited class II-MHC restricted presentation of exogenous antigen, but not class I MHC-restricted presentation of exogenous antigen, in dendritic cells. Hypocrellin A also inhibited the cytosolic pathway of endogenous antigen presentation. However, hypocrellin A did not inhibit the expression of class I and class II MHC molecules on dendritic cells (DCs), the phagocytic activity of DCs, or the $H-2K^b$-restricted presentation of a synthetic peptide, SIINFEKL. These results show that hypocrellin A differentially modulates the MHC-restricted antigen presentation pathways.

• Health Policy and Management
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• v.2 no.1
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• pp.42-65
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• 1992

To survey the specialties or sujects of practice displayed by the private practitioners the authors visited 691 clinics in Taegu from April 1 to May 18, 1991, At the same time, a mail questionnaire was administered to ask the number of displayed subjects of practice, and the reasons for displaying the subjects, reasons for not displaying in case of no specialty was displayed, composition of patients, and role as a specialist. The questionnaire was returned by 308(44.6%) practitioners. The distributions of private practitioners by specialty were 13.9% for internal medicine (IM), 11.7% for pediatrics(Ped), 13.0% for obstetrics '||'&'||' gynecology(OBGY), 11.1% for general surgery(GS), 10.0% for family practice(FP), and 5.3% for general practitioner(GP). Ninety percent of the specialists have displayed their specialty in their offices. Among all the private practitioners, 61.9% of them have displayed their subjects of practice and 23.7% have shown telephone number. Among private practitioners who displayed the subjects of practice, 80.6% have signs of 'subjects of practice'. Mean number of the displayed subjects of practice for the all private practitioners is 1.20, and 1.93 for the private practitioners who displayed subjects of practice. FP and GS have displayed their subjects of practice in 91.2% and 87.0% respectively and OBGY have displayed in 32.2%, the lowest percentage among all the soecuaktues. IM specialists displays pediatrics as a major subject of practice in 72.1% the pediatricians display IM in 88.9% the OBGYs display pediatrics in 77.8%, and the GSs display IM in 51.9%. Most commonly displayed subjects of practice are Ped and IM. Sixty-five percent of the private practitioners answered that they don't display their specialties because their clinics are "primary health care facility". The reasons for displaying the subjects of practice and its relevance with their own specialty(45.6%), and the difficulty in clinic management only with the patients for their own specialty(36.9%). The proportion of clinics whose patients of other specialty are than their own specialty accounted less than 10% was 52.8% and that accounted more than 51% was 16.0%. Specially, 51.4% of GS specialists cared more than 51% of patients of other specialty area than their own specialty. Most of the patients of IM, Ped, and OBGY specialists are the patients of their own specialty. However, 56.8% of GS care more of IM patients and only 24.3% of them care mostly GS patients, The respondents to the mail questionnaire who stated that they can not play the role of specialist well are 30.5% and especially 72.9% of the GS specialists state so. The proportion of respondents who do not suffort the private practice of specialists is 71.1%. Among the surgical specialists, 82.7% of them rarely perform operation. The reasons for not performing operation are insufficient insurance fee (76.9%), and risk of operation(58.0%), so as the OBGY specialists. Above finidngs suggest that most of the specialists, especially surgeons, in the private practice can not play their role as a specialist. It is necessary to develop a policy that facilitates the production of practice and the retention of the specialists in the hospitals.s.

• Bulletin of the Korean Chemical Society
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• v.21 no.1
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• pp.35-36
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• 2000

• The Journal of Korean Academy of Sensory Integration
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• v.16 no.1
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• pp.14-24
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• 2018

Objective : The purpose of this study was to identify the effect of Interactive Metronome (IM) training on postural control and hand writing performance of children with Attention Deficit Hyperactivity Disorder (ADHD). Methods : Participant was a third grade elementary school student diagnosed with ADHD. ABA design was used and a total of 30 sessions were held for 3 sessions every week for a total of 10 weeks. In the intervention period, IM training was conducted for 40~50 minutes before intervention for writing, and the writing task was carried out. We evaluated the handwriting legibility and speed. Before baseline A and within a month after A' phase, Clinical Observation of Motor and Postural Skills (COMPS) was evaluated to examine the changes in postural control of the student. Results : After the IM intervention, the postural control of the student improved in the score of slow movement, finger-nose touching, and asymmetrical tonic neck reflex. The handwriting legibility and speed has also tended to increase during the intervention period, but it has not significantly changed. Conclusion : This study could be used as an evidence that the IM training aimed at postural control and handwriting ability could enhance the ability to improve postural control and thereby provide fundamental knowledge for future studies.