• Asian Pacific Journal of Cancer Prevention
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• 제14권1호
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• pp.81-85
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• 2013

Background: Early diagnosis of carcinoma of bladder remains a challenge. Survivin, a member of the inhibitor of apoptosis (IAP) protein family, is frequently activated in bladder carcinoma. The objective of this study was to investigate urinary survivin as a marker for diagnosis of urinary bladder. Materials and Methods: We examined urinary survivin concentration in 28 healthy individuals, 46 positive controls and 117 cases of histologically proven TCC prior to transurethral resection, using ELISA, and compared values with findings for urinary cytology. Results: Survivin was found to be significantly higher in the cancer group (P<0.05). A cut off value of 17.7 pg/ml was proposed, with an approximate sensitivity of 82.9% and specificity of 81.1% (P<0.0001), whereas urine cytology had a sensitivity of 66.7% and a specificity of 96.0%. Conclusions: Urinary survivin can be used as a non-invasive diagnostic biomarker for TCC bladder, both for primary and recurrent disease.

• 한국정보시스템학회지:정보시스템연구
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• 제27권3호
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• pp.141-160
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• 2018

Purpose The purpose of this study is to verify mobile game users' perceived utilities about real (price) and virtual (Ruby) currencies, which are the major factors of in-app purchase (IAP) widely used as a business model in a mobile game industry. Design/methodology/approach By using sales volume and sales frequency data for products sold in an 'S' mobile game from the 'D' mobile game company, we conducted a conjoint analysis according to the procedure recommended by Bicheno (2009). Findings The results of this study indicate that (1) mobile game users have greater utility for a virtual currency (Ruby) than for a real currency (price), (2) mobile game users' utility for virtual (Ruby) and real (price) currencies varies depending on sales volume and sales frequency, as well as (3) mobile markets (e.g., Google Play Store vs. Apple App Store), and (4) mobile game users have greater utility for a virtual currency (Ruby) which can be used readily than later.

• 천문학회보
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• 제37권1호
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• pp.40.1-40.1
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• 2012

In the hierarchical universe, galaxy merger is predicted to be frequent, and thus it is an important element for understanding galaxy evolution. In particular, star formation is greatly enhanced during the merger. The aim of this study is to understand the position and rate change of star formation caused by equal-mass edge-on mergers. We use the GADGET2- N-body/SPH code, and fully consider gas cooling, star formation, and supernova feedback. We show the star formation rate (SFR), and the magnitude and color evolution of the merger remnants for 18 different configurations varying orbit elements and inclinations of host galaxies against orbit planes. Then we construct the mock images of the remnants and investigate on how equal-mass galaxy merger affects the SFR and color/magnitude evolution while considering dust reddening. We conclude that over 90% mass of SF in equal-mass merger is in the central region. SF in tidal feature involves a small fraction of new stars and thus is difficult to detect unless deep imaging is performed. Around 55 ${\pm}$ 5 percent of gas turns into stars until the final coalescence which typically corresponds to 0.8, 1.2, and 2.5 Gyr for direct, parabolic, and elliptical orbit, respectively. This result is roughly consistent with Cox et al. 2000. We plan to implement this result into semi-analytic model of galaxy formation. Caveats and future work on merging conditions are discussed.

• Asian-Australasian Journal of Animal Sciences
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• 제13권5호
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• pp.698-701
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• 2000

To prevent surface and underground water pollution, wastewater treatment is essential. Four bench-scale activated sludge units (10 L operational volumes) were operated at 5, 10 and $20^{\circ}C$ for evaluation of treatment efficiencies with typical wastewater from swine housing. The units were set for a 24-hour cycle. As compared to the conventional process, high removal efficiencies for organic substances, nitrogen and phosphorus in swine wastewater were obtained simultaneously with an intermittent aeration process (lAP). The NOx-N produced during an aeration period was immediately reduced to nitrogen gas (e.g. $N_2$ or $N_2O$) in the subsequent non-aeration periods, and nitrification in aeration periods occurred smoothly. Under these conditions, phosphorus removal occurred with the release of phosphorus during the non-aeration periods followed by the excess uptake of phosphorus in the activated sludge during aeration periods. It was confirmed that the lAP had a better ability to remove pollutants under both low temperatures and high nitrogen loading conditions than the ordinary method did. In addition to that, the total emission of $N_2O$ from lAP was reduced to approximately 1/50 of the conventional process for the same loading. By adopting an adequate aeration programme for individual swine wastewater treatment, this system will provide a promising means for nitrogen and phosphorus control without pH control or addition of methanol.

• Journal of Acupuncture Research
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• 제26권3호
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• pp.49-58
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• 2009

목적 : 본 연구는 봉약침의 주요성분인 멜리틴이 전립선 암세포주인 DU-145 세포성장에 어떤 영향을 미치는지를 알아보기 위하여 시행하였다. 방법 : 멜리틴이 DU-145의 성장에 미치는 영향을 알아보기 위한 cell viability 측정으로는 WST-1 assay를, 세포자멸사의 관찰에는 DAPI(4,6-diamidino-2-phenylindole)와 TUNEL staining assay를 시행하였으며, 세포자멸사 조절단백질(calpain, Bax, caspase-3, -9, cleaved caspase-3, cleavaged PARP, cleaved caspase-9, Bcl-2, XIAP, cIAP2, Akt, p-Akt, MMP-2, MMP-13)의 관찰을 위하여 western blot analysis를 시행하였다. 결과 : 1. DU-145 세포에서 멜리틴을 처리한 후 세포자멸사가 유도되어 세포성장이 억제되었다. 2. 세포자멸사 관련 단백질 중 분리된 caspase-3, caspase-9은 유의한 증가를, Bcl-2, p-Akt, XIAP, cXIAP는 유의한 감소를 나타내었다. 결론 : 이상의 결과는 멜리틴이 인간 전립선암세포주인 DU-145의 세포자멸사를 유발함으로써 증식억제 효과가 있음을 나타낸 것으로, 전립선암의 예방과 치료에 대한 효과적인 치료제 개발에 도움이 될 것으로 기대된다.

• 한국대기환경학회지
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• 제11권2호
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• pp.137-144
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• 1995

The I.A.P.(Index of Atmospheric Purity) by the distribution of Bryophtes on the bark of various latifoliate tree trunks was investigated at four sites(Daeheung, Songkwang, Jeungsim, and Heunggook Temple) from April, 1991 to April, 1993. The IAP was in inverse proportion to the degree of air pollution. The I.A.P at four sites were estimated 78.2 at Daeheung temple, 61.0 at Songkwang temple, 28.3 at Jeungsim temple, and 10.3 at Heunggook temple, respectively. The distribution degree of Bryophytes in Heunggook temple progressed during the last ten years. It represents the bettrment of air quality. Bioassay by means of lichens seems to have great potential for better and less expensive ways of measuring pollution levels instead of the high cost of buying and maintaining air pollution monitoring equipment.

• 대한한방내과학회지
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• 제29권1호
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• pp.42-66
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• 2008

Aconiti Tuber is a traditional medicinal plant generally used in Oriental medicine therapy. In this study, we investigated the biochemical mechanisms of anti-proliferative effects by the methanol extract of Aconiti tuber (MEBJ) in Caki-1 human renal cell carcinoma cells. It was found that MEBJ could inhibit, in a dose-dependent manner, cell growth which was associated with apoptotic cell death such as formation of apoptotic bodies, DNA fragmentation and increased populations of apoptotic-sub G1 phase. Apoptosis of Caki-1 cells by MEBJ was associated with an up-regulation of pro-apoptotic Bax expression, and a down-regulation of anti-apoptotic Bcl-2 in a dose-dependent manner; however, the levels of IAP family were not affected. MEBJ treatment also induced the proteolytic activation of caspase-3 and -8, and a inhibition of poly(ADP-ribose) polymerase (PARP) and $PLC{\gamma}1$ protein. Furthermore, MEBJ treatment caused a dose-dependent inhibition of iNOS and cyclooxygenase-2 (Cox-2). Though further studies will be needed to identify the active compounds that confer the anti-cancer activity of MEBJ, the present findings provide important new insights into the possible molecular mechanisms of the apoptotic activity of MEBJ in cancer cells.

• 한국축산식품학회지
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• 제26권3호
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• pp.394-401
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• 2006

Forty Clostridium perfringens isolates were obtained from twelve animal products, following the examination of eighty six beef, pork, broiler chicken and salami meat products, and eleven milk powder products. There were 21 isolates from salami stored at $25^{\circ}C$, 3 isolates from pork, 4 isolates from beef, 9 isolates from broiler chicken, and 3 isolates from milk powder. Only the cpa gene encoding a toxin among the 5 toxin genes tested (cpa, cpb, etx, iap, and cpe) was detected in all forty isolates, suggesting contamination with C. perfringens type A. DNA fingerprinting analysis using PCR of the tRNA intergenic spacer (tDNA-PCR) and the 16S-23S internal transcribed spacer (ITS-PCR), and randomly amplified polymorphic DNA (RAPD) analysis were attempted to differentiate the isolates. RAPD analysis was the most discriminating method among the three PCR analyses. Isolates from the same products tended to show similar RAPD patterns. Antimicrobial susceptibility tests showed that some isolates from broiler chickens had the same antibiogram with multiple resistance to streptomycin, colistin, and ciprofloxacin. Antibiograms were similar between isolates from the same livestock products, but differed considerably between the products.

• 천문학논총
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• 제30권2호
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• pp.535-537
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• 2015

Interpreting ultraviolet-to-infrared (UV-to-IR) observations of galaxies in terms of constraints on physical parameters-such as stellar mass ($M_{\ast}$) and star formation rate (SFR)-requires spectral synthesis modelling. We investigate how increasing the level of sophistication of the standard simplifying assumptions of such models can improve estimates of galaxy physical parameters. To achieve this, we compile a sample of 1048 galaxies at redshifts 0.7 < z < 2.8 with accurate photometry at rest-frame UV to near-IR wavelengths from the 3D-HST Survey. We compare the spectral energy distributions of these galaxies with those from different model spectral libraries to derive estimates of the physical parameters. We find that spectral libraries including sophisticated descriptions of galaxy star formation histories (SFHs) and prescriptions for attenuation by dust and nebular emission provide a much better representation of the observations than 'classical' spectral libraries, in which galaxy SFHs are assumed to be exponentially declining functions of time, associated with a simple prescription for dust attenuation free of nebular emission. As a result, for the galaxies in our sample, $M_{\ast}$ derived using classical spectral libraries tends to be systematically overestimated and SFRs systematically underestimated relative to the values derived adopting a more realistic spectral library. We conclude that the sophisticated approach considered here is required to reliably interpret fundamental diagnostics of galaxy evolution.

• 천문학회보
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• 제46권1호
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• pp.47.2-47.2
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• 2021

Focusing on both small separations and baryonic acoustic oscillation scales, the cosmic evolution of the clustering properties of peak, void, wall, and filament-type critical points is measured using two-point correlation functions in ΛCDM dark matter simulations as a function of their relative rarity. A qualitative comparison to the corresponding theory for Gaussian random fields allows us to understand the following observed features: (i) the appearance of an exclusion zone at small separation, whose size depends both on rarity and signature (i.e. the number of negative eigenvalues) of the critical points involved; (ii) the amplification of the baryonic acoustic oscillation bump with rarity and its reversal for cross-correlations involving negatively biased critical points; (iii) the orientation-dependent small-separation divergence of the cross-correlations of peaks and filaments (respectively voids and walls) that reflects the relative loci of such points in the filament's (respectively wall's) eigenframe. The (cross-) correlations involving the most non-linear critical points (peaks, voids) display significant variation with redshift, while those involving less non-linear critical points seem mostly insensitive to redshift evolution, which should prove advantageous to model. The ratios of distances to the maxima of the peak-to-wall and peak-to-void over that of the peak-to-filament cross-correlation are ~2-√~2 and ~3-√~3WJ, respectively, which could be interpreted as the cosmic crystal being on average close to a cubic lattice. The insensitivity to redshift evolution suggests that the absolute and relative clustering of critical points could become a topologically robust alternative to standard clustering techniques when analysing upcoming surveys such as Euclid or Large Synoptic Survey Telescope (LSST).