• Journal of Internet Computing and Services
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• v.6 no.3
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• pp.159-170
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• 2005

OC-SVM(One Class Support Vector Machine) avoids solving a full density estimation problem, and instead focuses on a simpler task, estimating quantiles of a data distribution, i.e. its support. OC-SVM seeks to estimate regions where most of data resides and represents the regions as a function of the support vectors, Although OC-SVM is powerful method for data description, it is difficult to incorporate human subjective importance into its estimation process, In order to integrate the importance of each point into the OC-SVM process, we propose a fuzzy version of OC-SVM. In FOC-SVM (Fuzzy One-Class Support Vector Machine), we do not equally treat data points and instead weight data points according to the importance measure of the corresponding objects. That is, we scale the kernel feature vector according to the importance measure of the object so that a kernel feature vector of a less important object should contribute less to the detection process of OC-SVM. We demonstrate the performance of our algorithm on several synthesized data sets, Experimental results showed the promising results.

• The Journal of the Korea Contents Association
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• v.9 no.12
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• pp.592-599
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• 2009

In this paper, I explain the design and implementation of an automated drawing system by communicating with a user. I made a system providing an UI for virtual environmental actual robot to interwork with environment to make a drawing that I was able to read work, and to help convenience of a user in computers. The UI of a system was used the AWT(Abstract Window Toolkit) in NetBean tools. To draw images, I got image information from SVG vector files. This system can make images according to the demand of users by using real-time communication. Also this kind of drawing process can be an artists performance, not only the final image as a result of the work. So I suggest that this real-time drawing process which is operated by user’s command can be considered as an artists performance.

• Biomolecules & Therapeutics
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• v.5 no.1
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• pp.53-58
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• 1997

$[Lys^7$]dermorphin, abbreviated K7DA, which has structural features similar to a metabolically stable $\mu$-opioid peptide agonist $[D-Arg^2, Lys^4$]dermorphin analogue (DALDA), but is intrinsically more potent with respect to binding to the $\mu$-opioid peptide receptor. The present studies report on attempts to enhance brain uptake of systemically administered K7DA by conjugation to a complex of streptavidin (SA) and the OX26 murine monoclonal antibody to the rat transferrin receptor, which undergoes receptor-mediated transcytosis through the blood-brain barrier (BBB). SA-OX26 conjugate mediates BBB transport of biotinylated therapeutics. The K7DA is monobiotinylated at the $\varepsilon$-amino group of the $[Lys^7$] residue with cleavable linker using NHS-SS-biotin. The brain uptake of $^{125}I$ labeled biotinylated K7DA ($^{125}I$-bio-SSa-K7DA) was very small and rapidly metabolized after intravenous injection. The brain uptake, expressed as percent of injected dose delivered per gram of brain, of the $^{125}I$-bio-55-K7DA bound to the SA-OX26 conjugate $^{125}I$-bio-SS-K7DA/SA-OX26) was 0.14$\pm$0.01, a level that is 2-fold greater than the brain uptake of morphine. The cleavability of the disulfide linker in vivo in rat plasma and brain was assessed with gel filtration HPLC and intravenous injection of labeled opioid chimeric peptides. The disulfide linker is stable in plasma in vivo but is cleaved in rat brain in vivo. In conclusion, these studies show that delivery of these potential opioid peptides to the brain may be improved by coupling them to vector-mediated BBB drug delivery system.

• Journal of the Institute of Electronics Engineers of Korea CI
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• v.49 no.1
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• pp.1-7
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• 2012

In general, currently developed ECG(electrocardiogram) based biometrics approaches are not suitable for real market applications since they require high cost ECG monitoring device and their measurement methods showed poor usability. In this paper, we developed lead I signal based biometrics system using special purpose ECG measurement hardware. To guarantee signal quality for biometrics from various signal measurement environment in our ordinary life, several filters are applied. In addition, to enhance usability, only two skin on electrodes without reference point are used for measurement. Lead I signals of seventeen candidates are measured from developed hardware and features are extracted. Extracted features are applied to support vector machine (SVM) pattern classifier for biometrics, and the experimental results showed 98.59% of sensitivity (SN) and 97.21% of accuracy (ACC). Compare to conventional ECG biometrics approaches, proposed system showed enhanced usability with low-cost measurement hardware.

• Parasites, Hosts and Diseases
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• v.53 no.6
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• pp.777-783
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• 2015

The nitric oxide (NO) formation and intrinsic nitrosation may be involved in the possible mechanisms of liver fluke-associated carcinogenesis. We still do not know much about the responses of inducible NO synthase (iNOS) induced by Clonorchis sinensis infection. This study was conducted to explore the pathological lesions and iNOS expressions in the liver of mice with different infection intensity levels of C. sinensis. Extensive periductal inflammatory cell infiltration, bile duct hyperplasia, and fibrosis were commonly observed during the infection. The different pathological responses in liver tissues strongly correlated with the infection intensity of C. sinensis. Massive acute spotty necrosis occurred in the liver parenchyma after a severe infection. The iNOS activity in liver tissues increased, and iNOS-expressing cells with morphological differences were observed after a moderate or severe infection. The iNOS-expressing cells in liver tissues had multiple origins.

• Journal of Microbiology and Biotechnology
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• v.24 no.4
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• pp.431-439
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• 2014

We report the construction of two Bacillus subtilis expression vectors, pBNS1/pBNS2. Both vectors are based on the strong promoter P43 and the ampicillin resistance gene expression cassette. Additionally, a fragment with the Shine-Dalgarno sequence and a multiple cloning site (BamHI, SalI, SacI, XhoI, PstI, SphI) were inserted. The coding region for the amyQ (encoding an amylase) signal peptide was fused to the promoter P43 of pBNS1 to construct the secreted expression vector pBNS2. The applicability of vectors was tested by first generating the expression vectors pBNS1-GFP/pBNS2-GFP and then detecting for green fluorescent protein gene expression. Next, the mannanase gene from B. pumilus Nsic-2 was fused to vector pBNS2 and we measured the mannanase activity in the supernatant. The mannanase total enzyme activity was 8.65 U/ml, which was 6 times higher than that of the parent strain. Our work provides a feasible way to achieve an effective transformation system for gene expression in B. subtilis and is the first report to achieve B. pumilus mannanase secretory expression in B. subtilis.

• Journal of the Chungcheong Mathematical Society
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• v.31 no.4
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• pp.397-409
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• 2018

In this paper, we investigate the generalized Hyers-Ulam stability of the functional equation $$f\({\sum\limits_{i=1}^{n}}x_i\)+{\sum\limits_{1{\leq}i<j{\leq}n}}f(x_i-x_j)-n{\sum\limits_{i=1}^{n}f(x_i)=0$$ for integer values of n such that $n{\geq}2$, where f is a mapping from a vector space V to a Banach space Y.

• Kyungpook Mathematical Journal
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• v.13 no.2
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• pp.235-240
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• 1973

A k-dimensional vector bundle is a bundle ${\xi}=(E,P,B,F^k)$ with fibre $F^k$ satisfying the local triviality, where F is the field of real numbers R or complex numbers C ([1], [2] and [3]). Let $Vect_k(X)$ be the set consisting of all isomorphism classes of k-dimensional vector bundles over the topological space X. Then $Vect_F(X)=\{Vect_k(X)\}_{k=0,1,{\cdots}}$ is a semigroup with Whitney sum (${\S}1$). For a pair (X, A) of topological spaces, a difference isomorphism over (X, A) is a vector bundle morphism ([2], [3]) ${\alpha}:{\xi}_0{\rightarrow}{\xi}_1$ such that the restriction ${\alpha}:{\xi}_0{\mid}A{\longrightarrow}{\xi}_1{\mid}A$ is an isomorphism. Let $S_k(X,A)$ be the set of all difference isomorphism classes over (X, A) of k-dimensional vector bundles over X with fibre $F^k$. Then $S_F(X,A)=\{S_k(X,A)\}_{k=0,1,{\cdots}}$, is a semigroup with Whitney Sum (${\S}2$). In this paper, we shall prove a relation between $Vect_F(X)$ and $S_F(X,A)$ under some conditions (Theorem 2, which is the main theorem of this paper). We shall use the following theorem in the paper. THEOREM 1. Let ${\xi}=(E,P,B)$ be a locally trivial bundle with fibre F, where (B, A) is a relative CW-complex. Then all cross sections S of ${\xi}{\mid}A$ prolong to a cross section $S^*$ of ${\xi}$ under either of the following hypothesis: (H1) The space F is (m-1)-connected for each $m{\leq}dim$ B. (H2) There is a relative CW-complex (Y, X) such that $B=Y{\times}I$ and $A=(X{\times}I)$ ${\cap}(Y{\times}O)$, where I=[0, 1]. (For proof see p.21 [2]).

• East Asian mathematical journal
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• v.33 no.5
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• pp.571-585
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• 2017

Let M be a connected n-dimensional submanifold of a Euclidean space $E^{n+k}$ equipped with the induced metric and ${\Delta}$ its Laplacian. If the position vector x of M is decomposed as a sum of three vectors $x=x_1+x_2+x_0$ where two vectors $x_1$ and $x_2$ are non-constant eigen vectors of the Laplacian, i.e., ${\Delta}x_i={\lambda}_ix_i$, i = 1, 2 (${\lambda}_i{\in}R$) and $x_0$ is a constant vector, then, M is called a 2-type submanifold. In this paper we showed that a 2-type surface M in $E^3$ satisfies ${\langle}{\Delta}x,x-x_0{\rangle}=c$ for a constant c, where ${\langle},{\rangle}$ is the usual inner product in $E^3$, then M is an open part of a circular cylinder. Also we showed that if a quadric hypersurface M in a Euclidean space satisfies ${\langle}{\Delta}x,x{\rangle}=c$ for a constant c, then it is one of a minimal quadric hypersurface, a genaralized cone, a hypersphere, and a spherical cylinder.

• Journal of Microbiology and Biotechnology
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• v.13 no.3
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• pp.457-462
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• 2003

The complete nucleotide sequence of a plasmid, pMG1, isolated from Bifidobacterium longum MG1 has been determined. This plasmid, composed of 3,862 base pairs with 65.1% of G+C content. harbors two major open reading frames (ORF) encoding putative proteins of 29 kDa (ORF I) and 71 kDa (ORF II). ORF I showed relatively high amino acid sequence homology with replication proteins of other plasmids from Gr Im-positive and -negative bacteria. Upstream of ORF I, four sets of tandem repeat sequences resembling the iteron structure of related plasmids were found. S1 endonuclease treatment and Southern blot analysis revealed that pMG1 accumulates single-stranded DNA (ssDNA) intermediate, which indicate i the rolling circle replication (RCR) mechanism of this plasmid. Homology search indicated that ORF II encodes plasmid mobilization protein, and the presence of highly conserved oriT sequence in the upstream of this gene supported this assumption. RT-PCR showed that only ORF I is expressed in vivo. Based on these results, pMG 1 was exploited to construct a shuttle vector, pBES2. It was successfully transformed into Bifidobacterium and maintained stably.